A flavivirus infection of the central nervous system characterised by a biphasic meningoencephalitis.
Transmission is usually by hard ticks of the Ixodes genus. It can also be acquired from consumption of raw (unpasteurised) milk or dairy products.
Disease onset is 4 to 28 days after a bite from an infected tick. Diagnosis is made based on immune status; seasonality; geographical, animal, and arthropod exposures; clinical findings; and radiographic abnormalities.
Treatment consists of supportive care and management of complications. Aciclovir is given empirically until herpes simplex/varicella zoster infection is ruled out.
Most patients recover fully without long-term sequelae.
Four widely used vaccines in paediatric and adult populations are available in Canada, Europe, and Russia.
Tick-borne encephalitis (TBE) is a flavivirus infection of the central nervous system, characterised by a biphasic meningoencephalitis. It is transmitted usually by hard ticks of the Ixodes genus. Disease onset is 4 to 28 days after a bite from an infected tick. TBE can also be acquired from consumption of raw (unpasteurised) dairy products.
History and exam
Ashley M. Croft, MA, MBBS, MSc, DTM&H, FFPHM
School of Pharmacy and Biomedical Science
University of Portsmouth
AMC declares that he has no competing interests.
John Williams, MRCP, DTM&H, DipHIVMed
Consultant Infectious Diseases Physician
The James Cook University Hospital
JW declares that he has no competing interests.
Charlie Easmon, MBBS, MRCP, MSc Public Health, DTM&H, DOccMed
Your Excellent Health Service
CE runs a private travel clinic.
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