T-2 mycotoxin is the only mycotoxin known to have been used as a biological weapon.
In the event of aerosol exposure, first responders should wear personal protective equipment and evacuate the adjacent area. Decontamination and use of protective clothing are vital, as human-to-human transmission may occur via skin contact.
Diagnosis is clinical, based on signs and symptoms (which may include skin pain and blistering, vomiting and diarrhoea, respiratory symptoms, and bleeding) and a history of exposure to contaminated grains and/or droplets. Systemic symptoms may develop.
Mainstay of management is supportive care with aggressive fluid and electrolyte replacement. Mortality rates associated with untreated exposure vary from 10% to 16%.
T-2 mycotoxin is a group A trichothecene mycotoxin, mostly produced by Fusariumspecies of fungi. It is the only mycotoxin known to have been used as a biological weapon, although there is potential for others (such as diacetoxyscirpenol) to be used. Both of these mycotoxins are listed as Centers for Disease Control and Prevention (CDC) Federal Select Agents. The term 'modified mycotoxins' includes all possible derivatives of the 'parent' mycotoxin compound; these often occur in contaminated food and may also be toxicologically relevant.
Transmission is most commonly foodborne via ingestion of mouldy grain in situations where this has not been stored properly, causing mainly gastrointestinal symptoms which may be followed by a protracted illness with leukopenia and bone marrow depletion.
In chemical warfare, dispersal may be by droplets or aerosols, causing toxicity in seconds. The effects may be through inhalation (causing an acute syndrome of sore throat, bloody nasal discharge, dyspnoea, cough, and fever) and/or skin contact (causing blistering and systemic toxicity).
History and exam
Key diagnostic factors
- presence of risk factors
- burning pain (skin or mucosal contact)
- blistering rash (skin or mucosal contact)
Other diagnostic factors
- erythema (skin or mucosal contact)
- blurred vision/corneal damage (ocular exposure)
- vomiting (ingestion)
- diarrhoea (ingestion)
- dyspnoea (inhalation)
- cough (inhalation)
- nasal irritation (inhalation)
- necrosis (skin or mucosal contact)
- bleeding (inhalation)
- chest crackles and wheeze (inhalation)
- occupational exposure
- contaminated foods
- biological terrorism
- skin exposure
1st investigations to order
- clinical diagnosis
Investigations to consider
- pulse oxymetry
- arterial blood gases
- pulmonary function tests
- chest x-ray
- serum electrolytes
- coagulation studies
- mass spectrometry analysis of nasal, throat, or respiratory secretions
- serum, urine, or tissue samples for toxin analysis
- Other vesicant exposure
- Food poisoning (other causes)
- Hazardous materials (HAZMAT) and chemical, biological, radiological and nuclear (CBRN)
- Mycotoxins sampling guidance
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