Last reviewed: 27 Aug 2021
Last updated: 08 Apr 2021

Summary

Differentials

Common

  • Diabetes mellitus
  • Hypothyroidism
  • Vitamin B12 deficiency
  • Toxin/drug induced
  • Idiopathic polyneuropathy
  • Radiculopathy

Uncommon

  • Guillain-Barre syndrome
  • Cauda equina syndrome
  • Mononeuritis multiplex (vasculitic neuropathy)
  • Chronic inflammatory demyelinating polyradiculoneuropathy
  • Acromegaly
  • HIV
  • Hepatitis C
  • Diphtheria
  • Leprosy
  • Sjögren's syndrome
  • Systemic lupus erythematosus
  • Monoclonal gammopathy
  • Amyloidosis
  • Chronic renal failure
  • Paraneoplastic polyneuropathy
  • Thiamine deficiency
  • Pyridoxine (vitamin B6) deficiency or toxicity
  • Lyme disease
  • Vitamin E deficiency
  • Copper deficiency
  • Charcot-Marie-Tooth neuropathy
  • Acute intermittent porphyria
  • Adrenomyeloneuropathy
  • Mitochondrial neuropathy
  • Fabry's disease
  • Refsum's disease
  • Tangier's disease
  • Critical illness polyneuropathy and myopathy
  • Coeliac disease and gluten sensitivity
  • Plexopathy

Contributors

Authors

Maxwell H Levy, MD

Assistant Professor

Department of Neurology

Tulane University

New Orleans

LA

Disclosures

MHL declares that he has no competing interests.

John D England, MD, FAAN

Richard M Paddison Professor

Chair, Department of Neurology

Editor-in-Chief for Journal of the Neurological Sciences

Louisiana State University Health Sciences Center School of Medicine

New Orleans

LA

Disclosures

JDE is the Editor-in-Chief for the Journal of the Neurological Sciences. JDE is on the speakers' bureau for Grifols and Takeda. JDE is an author of articles cited in this topic.

Acknowledgements

Dr John D England and Dr Maxwell H Levy would like to gratefully acknowledge Dr Jeffrey W. Ralph, the previous contributor to this topic.

Disclosures

JWR declares that he has no competing interests.

Peer reviewers

Yuen So, MD, PhD

Professor

Neurology and Neurological Sciences

Stanford University

Stanford

CA

Disclosures

YS is an author of a reference cited in this topic.

Raad Shakir, FRCP

Consultant Neurologist

Chief of Service

Neurosciences/Head and Neck Directorate

Imperial Healthcare Trust

Charing Cross Hospital

London

UK

Disclosures

RS declares that he has no competing interests.

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