Hypertriglyceridaemia

Last reviewed: 21 Apr 2022
Last updated: 03 Oct 2018

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • lipaemia retinalis
  • eruptive xanthoma
More key diagnostic factors

Other diagnostic factors

  • obesity/overweight
  • diabetes
  • coronary artery disease
  • angina/claudication
  • abdominal pain and other features of pancreatitis
Other diagnostic factors

Risk factors

  • family history of hyperlipidaemia
  • family history of diabetes
  • overweight/obese patients
  • high-saturated-fat diet
  • high-carbohydrate diet
  • insulin resistance
  • liver disease
  • hypothyroidism
  • renal disease
  • excessive alcohol consumption
  • HIV infection
  • cystic fibrosis
  • medications
  • Cushing's syndrome
  • acute spinal cord injury
  • inflammatory/immune disorders
  • anorexia nervosa
  • organ transplant
More risk factors

Diagnostic investigations

1st investigations to order

  • fasting triglycerides
More 1st investigations to order

Investigations to consider

  • thyroid-stimulating hormone
  • fasting plasma glucose
  • urea, creatinine
  • serum albumin
  • liver function tests
  • serum protein electrophoresis
  • computed tomography abdomen
More investigations to consider

Treatment algorithm

ACUTE

chylomicronaemia

ONGOING

with clinical atherosclerotic cardiovascular disease ≤75 years

with clinical atherosclerotic cardiovascular disease >75 years

without clinical atherosclerotic cardiovascular disease: low-density lipoprotein cholesterol ≥4.92 mmol/L (≥190 mg/dL)

without clinical atherosclerotic cardiovascular disease: 40-75 years without diabetes mellitus (low-density lipoprotein cholesterol 1.81-4.87 mmol/L [70-189 mg/dL])

without clinical atherosclerotic cardiovascular disease: 40-75 years with diabetes mellitus (low-density lipoprotein cholesterol 1.81-4.87 mmol/L [70-189 mg/dL])

triglycerides ≥5.7 mmol/L (≥500 mg/dL)

Contributors

Authors

David Alexander Leaf, MD, MPH

Professor of Medicine

Playa Vista Medical Center

Los Angeles

CA

Disclosures

DAL is an author of several references cited in this monograph.

Peer reviewers

Mahi Lakshmi Ashwath, MD

Assistant Professor of Medicine

Division of Cardiology

Heart and Vascular Center

Metro Health Medical Center

Case Western Reserve University

Cleveland

OH

Disclosures

MLA declares that he has no competing interests.

  • Hypertriglyceridaemia images
  • Differentials

    • Diabetes
    • Liver disease
    • Hypothyroidism
    More Differentials
  • Guidelines

    • Familial hypercholesterolaemia: identification and management
    • Risk estimation and the prevention of cardiovascular disease
    More Guidelines
  • Patient leaflets

    High cholesterol

    More Patient leaflets
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