Last reviewed: 22 Sep 2020
Last updated: 01 Mar 2019

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • bleeding
  • absence of systemic symptoms
  • absence of medicines that cause thrombocytopenia
  • absent splenomegaly or hepatomegaly
  • absent lymphadenopathy

Risk factors

  • women of childbearing age
  • age <10 or >65 years

Diagnostic investigations

Investigations to consider

  • HIV serology
  • Helicobacter pylori breath test or stool antigen test
  • hepatitis C serology
  • thyroid function tests
  • quantitative immunoglobulins
  • bone marrow biopsy/aspiration
  • pregnancy test
More investigations to consider

Treatment algorithm

Contributors

Consultant Haematologist

University College London Hospitals

London

UK

Disclosures

MS has received honoraria from Novartis. MS is the author of a paper cited in this topic.

Dr Marie Scully would like to gratefully acknowledge Professor Francesco Rodeghiero and Dr Marco Ruggeri, previous contributors to this topic.

Disclosures

FR received fees for speaking and has been reimbursed by GSK and Amgen, the manufacturer of eltrombopag and romiplostim, for attending several conferences, and also received fees for consulting from GSK and Shionogi. FR and MR are authors of a number of references cited in this topic.

Peer reviewersVIEW ALL

Professor

Director of Benign Hematology

Cleveland Clinic

Cleveland

OH

Disclosures

KM declares that he has no competing interests.

Assistant Professor

Division of Oncology-Hematology

Department of Internal Medicine

University of Nebraska Medical Center

Omaha

NE

Disclosures

SKR declares that he has no competing interests.

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