The pituitary gland lies in the pituitary fossa (sella turcica), which is situated in the middle cranial fossa at the base of the brain. It is linked functionally to the hypothalamus by the pituitary stalk. The hypothalamus lies in a superior position to the pituitary gland, and the link between the two organs is critical for normal pituitary gland function.
The anterior pituitary secretes growth hormone, thyrotrophin or thyroid-stimulating hormone, corticotrophin or adrenocorticotrophic hormone, follicle-stimulating hormone, luteinising hormone, and prolactin. The posterior lobe secretes arginine vasopressin (also called antidiuretic hormone) and oxytocin.
Pituitary masses may be classified based on their underlying aetiology: for example, pituitary adenoma, pituitary hyperplasia, non-adenomatous tumours, and vascular, inflammatory, or infective lesions.
Most pituitary masses are caused by a pituitary adenoma; these are benign tumours arising from the anterior pituitary gland. Pituitary adenomas are classified as functional (hormone secreting) or non-functional, and can be further categorised by cell type or size, for example, microadenomas (<10 mm) or macroadenomas (>10 mm).
Pituitary masses may present with a clinical syndrome resulting from hypersecretion of ≥1 anterior pituitary hormones (e.g., Cushing's disease, acromegaly). Alternatively, they may present more insidiously with mass effect or with tumour expansion leading to compression of surrounding structures, including normal pituitary tissue, resulting in hypopituitarism. Functional pituitary tumours can produce a complex picture of combined hormonal excess and/or deficiencies.
Analyses using autopsy and radiological data suggest primary adenoma prevalence rates of 14.4% and 22.5%, respectively (yielding an overall estimated prevalence rate of 16.7%). Almost all of these are clinically silent microadenomas. The prevalence increases with age, and detection is more likely using high-resolution MRI sequences.
- Non-functional adenoma
- Gonadotrophin-secreting adenoma
- Lactotroph hyperplasia
- adrenocorticotropic hormone (ACTH)-secreting adenoma
- Growth hormone (GH)-secreting adenoma
- Thyroid stimulating hormone (TSH)-secreting adenoma
- Thyrotroph hyperplasia
- Gonadotroph hyperplasia
- Somatotroph hyperplasia
- Corticotroph hyperplasia
- Germ cell tumours
- Metastatic disease
- Lymphocytic hypophysitis
- Drug therapy-induced hypophysitis
- Pituitary abscess
- Pituitary apoplexy
- Cerebral aneurysm
- Rathke cleft cyst
- Empty sella syndrome
- Pituitary carcinoma
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