Assessment of liver dysfunction

Last reviewed: 27 Apr 2022
Last updated: 10 Feb 2022

Summary

Differentials

Common

  • Hepatitis C virus infection
  • Hepatitis B virus infection
  • Hepatitis A virus infection
  • Alcohol-related liver disease
  • Paracetamol overdose
  • Non-paracetamol medications
  • Non-alcoholic fatty liver disease
  • Gilbert's syndrome
  • Haemochromatosis
  • Choledocholithiasis
Full details

Uncommon

  • Hepatitis E
  • Hepatitis D
  • Epstein-Barr virus infection
  • Herpes simplex virus infection
  • Cytomegalovirus infection
  • HIV infection
  • Sepsis
  • Extrapulmonary tuberculosis
  • Toxins
  • Alpha-1 antitrypsin deficiency
  • Wilson's disease
  • Autoimmune hepatitis
  • Primary biliary cholangitis
  • Primary sclerosing cholangitis
  • Hepatocellular carcinoma
  • Liver metastases
  • Pancreatic cancer
  • Cholangiocarcinoma
  • Hodgkin's lymphoma
  • Non-Hodgkin's lymphoma
  • Shock
  • Portal vein thrombosis
  • Budd-Chiari syndrome
  • Intrahepatic cholestasis of pregnancy
  • Haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome
  • Acute fatty liver of pregnancy
Full details

Contributors

Authors

Stevan A. Gonzalez, MD, MS

Associate Professor

Department of Internal Medicine

TCU and UNTHSC School of Medicine

Medical Director of Liver Transplantation

Annette C. and Harold C. Simmons Transplant Institute

Baylor Scott & White All Saints Medical Center

Fort Worth

TX

Disclosures

SAG declares that he has no competing interests.

Acknowledgements

Dr Stevan A. Gonzalez would like to gratefully acknowledge Dr Jeremy Cobbold, Dr William D. Carey, and Dr Achuthan Sourianarayanane, the previous contributors to this topic.

Disclosures

WDC is an author of a number of references cited in this topic. JC and AS declare that they have no competing interests.

Peer reviewers

Joseph K. Lim, MD

Assistant Professor of Medicine

Director

Yale Viral Hepatitis Program

Section of Digestive Diseases

Yale School of Medicine

New Haven

CT

Disclosures

JKL declares that he has no competing interests.

Philip Newsome, PhD, FRCPE

Senior Lecturer in Hepatology & Honorary Consultant Physician

Liver Research Group

Institute of Biomedical Research

The Medical School

University of Birmingham

Birmingham

UK

Disclosures

PN declares that he has no competing interests.

Marlyn Mayo, MD

Associate Professor of Medicine

Division of Digestive and Liver Diseases

University of Texas Southwestern Medical Center

Dallas

TX

Disclosures

MM is an author of a reference cited in this topic.

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