Resumen
Definición
Anamnesis y examen
Principales factores de diagnóstico
- occupational exposure to silica, coal, or beryllium
- history of smoking
Otros factores de diagnóstico
- dyspnea on exertion
- cough
- normal chest exam
- crackles on chest auscultation
- chest tightness and/or wheezing
- prolonged expiration and wheezing on chest auscultation
- areas of dullness on chest percussion
- cyanosis
- barrel chest
- hemoptysis, fever, or night sweats
- clubbing of fingers and toes
- weight loss
- signs of rheumatoid arthritis or scleroderma
- signs of renal failure (e.g., weight gain, edema, hypertension)
Factores de riesgo
- occupational exposure to silica
- occupational exposure to coal
- occupational exposure to beryllium
- high cumulative dose of inhaled silica or coal
- cigarette smoking
- glutamic acid at position 69 of the B1 chain of the HLA-DP molecule (chronic beryllium disease)
- high cumulative dose of inhaled beryllium
Pruebas diagnósticas
Primeras pruebas diagnósticas para solicitar
- chest x-ray (posteroanterior and lateral)
- spirometry
- beryllium lymphocyte proliferation test (BeLPT)
Pruebas diagnósticas que deben considerarse
- bronchoscopic biopsy and/or lavage
- high-resolution CT (HRCT) scan chest
- oxygen saturation
- arterial blood gas (ABG)
- lung biopsy
- test for tuberculosis (TB)
Algoritmo de tratamiento
acute secondary alveolar proteinosis (acute silicosis)
acute berylliosis
chronic silicosis, coal workers' lung, or chronic berylliosis
Colaboradores
Autores
Kenneth D. Rosenman, MD
Professor of Medicine
Division of Occupational and Environmental Medicine
Michigan State University
East Lansing
MI
Divulgaciones
KDR declares no competing interests.
Revisores por pares
Ware G. Kuschner, MD
Associate Professor of Medicine
Stanford University
Staff Physician
US Department of Veterans Affairs
Palo Alto Health Care System
Palo Alto
CA
Divulgaciones
WGK declares that he has no competing interests.
Harman Paintal, MBBS
Division of Pulmonary and Critical Care Medicine
Veterans Affairs Palo Alto Health Care System (VAPAHCS)
Palo Alto
CA
Divulgaciones
HP declares that he has no competing interests.
Francis Thien, MD, FRACP, FCCP
Professor
Box Hill Hospital and Monash University
Victoria
Australia
Divulgaciones
FT declares that he has no competing interests.
Edward L. Petsonk, MD
Professor of Medicine
Section of Pulmonary and Critical Care Medicine
West Virginia University School of Medicine
Morgantown
WV
Divulgaciones
ELP declares that he has no competing interests.
Christopher M. Barber, BM, BS, BMedSci, FRCP, MD, AFOM
Respiratory Consultant
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield
UK
Divulgaciones
CMB declares that he has no competing interests.
Carl J. Reynolds, MBBS, MRCP, BSc, MSc, PhD, DPMSA
Respiratory Consultant
Honorary Senior Clinical Lecturer
North Middlesex University Hospital
Imperial College London
UK
Divulgaciones
CJR declares that he has no competing interests.
Agradecimiento de los revisores por pares
Los temas de BMJ Best Practice se actualizan de forma continua de acuerdo con los desarrollos en la evidencia y en las guías. Los revisores por pares listados aquí han revisado el contenido al menos una vez durante la historia del tema.
Divulgaciones
Las afiliaciones y divulgaciones de los revisores por pares se refieren al momento de la revisión.
Referencias
Artículos principales
Balmes JR, Abraham JL, Dweik RA, et al. An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease. Am J Respir Crit Care Med. 2014 Nov 15;190(10):e34-59.Texto completo Resumen
American College of Radiology. ACR Appropriateness Criteria: occupational lung diseases. 2019 [internet publication].Texto completo
National Institute for Occupational Safety and Health. Health effects of occupational exposure to respirable crystalline silica. Apr 2002 [internet publication].Texto completo
International Labour Office. Guidelines for the use of the ILO international classification of radiographs of pneumoconioses, revised edition. 2022 [internet publication].Texto completo
US Occupational Safety and Health Administration (OSHA). Final rule to protect workers from occupational exposure to respirable crystalline silica. Appendix B to §1926.1153 construction standard - medical surveillance guidelines. May 2019 [internet publication].Texto completo
Artículos de referencia
Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.

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- ACR Appropriateness Criteria: occupational lung diseases
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