小结
定义
病史和体格检查
关键诊断因素
- occupational exposure to silica, coal, or beryllium
- history of smoking
其他诊断因素
- dyspnea on exertion
- cough
- normal chest exam
- crackles on chest auscultation
- chest tightness and/or wheezing
- prolonged expiration and wheezing on chest auscultation
- areas of dullness on chest percussion
- cyanosis
- barrel chest
- hemoptysis, fever, or night sweats
- clubbing of fingers and toes
- weight loss
- signs of rheumatoid arthritis or scleroderma
- signs of renal failure (e.g., weight gain, edema, hypertension)
危险因素
- occupational exposure to silica
- occupational exposure to coal
- occupational exposure to beryllium
- high cumulative dose of inhaled silica or coal
- cigarette smoking
- glutamic acid at position 69 of the B1 chain of the HLA-DP molecule (chronic beryllium disease)
- high cumulative dose of inhaled beryllium
诊断性检查
首要检查
- chest x-ray (posteroanterior and lateral)
- spirometry
- beryllium lymphocyte proliferation test (BeLPT)
需考虑的检查
- bronchoscopic biopsy and/or lavage
- high-resolution CT (HRCT) scan chest
- oxygen saturation
- arterial blood gas (ABG)
- lung biopsy
- test for tuberculosis (TB)
治疗流程
acute secondary alveolar proteinosis (acute silicosis)
acute berylliosis
chronic silicosis, coal workers' lung, or chronic berylliosis
撰稿人
作者
Kenneth D. Rosenman, MD
Professor of Medicine
Division of Occupational and Environmental Medicine
Michigan State University
East Lansing
MI
利益声明
KDR declares no competing interests.
同行评议者
Ware G. Kuschner, MD
Associate Professor of Medicine
Stanford University
Staff Physician
US Department of Veterans Affairs
Palo Alto Health Care System
Palo Alto
CA
利益声明
WGK declares that he has no competing interests.
Harman Paintal, MBBS
Division of Pulmonary and Critical Care Medicine
Veterans Affairs Palo Alto Health Care System (VAPAHCS)
Palo Alto
CA
利益声明
HP declares that he has no competing interests.
Francis Thien, MD, FRACP, FCCP
Professor
Box Hill Hospital and Monash University
Victoria
Australia
利益声明
FT declares that he has no competing interests.
Edward L. Petsonk, MD
Professor of Medicine
Section of Pulmonary and Critical Care Medicine
West Virginia University School of Medicine
Morgantown
WV
利益声明
ELP declares that he has no competing interests.
Christopher M. Barber, BM, BS, BMedSci, FRCP, MD, AFOM
Respiratory Consultant
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield
UK
利益声明
CMB declares that he has no competing interests.
Carl J. Reynolds, MBBS, MRCP, BSc, MSc, PhD, DPMSA
Respiratory Consultant
Honorary Senior Clinical Lecturer
North Middlesex University Hospital
Imperial College London
UK
利益声明
CJR declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
参考文献
关键文献
Balmes JR, Abraham JL, Dweik RA, et al. An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease. Am J Respir Crit Care Med. 2014 Nov 15;190(10):e34-59.全文 摘要
American College of Radiology. ACR Appropriateness Criteria: occupational lung diseases. 2019 [internet publication].全文
National Institute for Occupational Safety and Health. Health effects of occupational exposure to respirable crystalline silica. Apr 2002 [internet publication].全文
International Labour Office. Guidelines for the use of the ILO international classification of radiographs of pneumoconioses, revised edition. 2022 [internet publication].全文
US Occupational Safety and Health Administration (OSHA). Final rule to protect workers from occupational exposure to respirable crystalline silica. Appendix B to §1926.1153 construction standard - medical surveillance guidelines. May 2019 [internet publication].全文
参考文献
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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