Summary
Definition
History and exam
Key diagnostic factors
- occupational exposure to silica, coal, or beryllium
- history of smoking
Other diagnostic factors
- dyspnea on exertion
- cough
- normal chest exam
- crackles on chest auscultation
- chest tightness and/or wheezing
- prolonged expiration and wheezing on chest auscultation
- areas of dullness on chest percussion
- cyanosis
- barrel chest
- hemoptysis, fever, or night sweats
- clubbing of fingers and toes
- weight loss
- signs of rheumatoid arthritis or scleroderma
- signs of renal failure (e.g., weight gain, edema, hypertension)
Risk factors
- occupational exposure to silica
- occupational exposure to coal
- occupational exposure to beryllium
- high cumulative dose of inhaled silica or coal
- cigarette smoking
- glutamic acid at position 69 of the B1 chain of the HLA-DP molecule (chronic beryllium disease)
- high cumulative dose of inhaled beryllium
Diagnostic tests
1st tests to order
- chest x-ray (posteroanterior and lateral)
- spirometry
- beryllium lymphocyte proliferation test (BeLPT)
Tests to consider
- bronchoscopic biopsy and/or lavage
- high-resolution CT (HRCT) scan chest
- oxygen saturation
- arterial blood gas (ABG)
- lung biopsy
- test for tuberculosis (TB)
Treatment algorithm
acute secondary alveolar proteinosis (acute silicosis)
acute berylliosis
chronic silicosis, coal workers' lung, or chronic berylliosis
Contributors
Authors
Kenneth D. Rosenman, MD
Professor of Medicine
Division of Occupational and Environmental Medicine
Michigan State University
East Lansing
MI
Disclosures
KDR declares no competing interests.
Peer reviewers
Ware G. Kuschner, MD
Associate Professor of Medicine
Stanford University
Staff Physician
US Department of Veterans Affairs
Palo Alto Health Care System
Palo Alto
CA
Disclosures
WGK declares that he has no competing interests.
Harman Paintal, MBBS
Division of Pulmonary and Critical Care Medicine
Veterans Affairs Palo Alto Health Care System (VAPAHCS)
Palo Alto
CA
Disclosures
HP declares that he has no competing interests.
Francis Thien, MD, FRACP, FCCP
Professor
Box Hill Hospital and Monash University
Victoria
Australia
Disclosures
FT declares that he has no competing interests.
Edward L. Petsonk, MD
Professor of Medicine
Section of Pulmonary and Critical Care Medicine
West Virginia University School of Medicine
Morgantown
WV
Disclosures
ELP declares that he has no competing interests.
Christopher M. Barber, BM, BS, BMedSci, FRCP, MD, AFOM
Respiratory Consultant
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield
UK
Disclosures
CMB declares that he has no competing interests.
Carl J. Reynolds, MBBS, MRCP, BSc, MSc, PhD, DPMSA
Respiratory Consultant
Honorary Senior Clinical Lecturer
North Middlesex University Hospital
Imperial College London
UK
Disclosures
CJR declares that he has no competing interests.
Differentials
- Asbestosis
- Idiopathic pulmonary fibrosis
- Sarcoidosis
More DifferentialsGuidelines
- Medical surveillance guidelines: silica
- ACR Appropriateness Criteria: occupational lung diseases
More GuidelinesPatient information
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COPD: what treatments work?
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