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Pneumoconioses

Última revisão: 27 Sep 2025
Última atualização: 17 Jan 2025

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • occupational exposure to silica, coal, or beryllium
  • history of smoking
Detalhes completos

Outros fatores diagnósticos

  • dyspnea on exertion
  • cough
  • normal chest exam
  • crackles on chest auscultation
  • chest tightness and/or wheezing
  • prolonged expiration and wheezing on chest auscultation
  • areas of dullness on chest percussion
  • cyanosis
  • barrel chest
  • hemoptysis, fever, or night sweats
  • clubbing of fingers and toes
  • weight loss
  • signs of rheumatoid arthritis or scleroderma
  • signs of renal failure (e.g., weight gain, edema, hypertension)
Detalhes completos

Fatores de risco

  • occupational exposure to silica
  • occupational exposure to coal
  • occupational exposure to beryllium
  • high cumulative dose of inhaled silica or coal
  • cigarette smoking
  • glutamic acid at position 69 of the B1 chain of the HLA-DP molecule (chronic beryllium disease)
  • high cumulative dose of inhaled beryllium
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • chest x-ray (posteroanterior and lateral)
  • spirometry
  • beryllium lymphocyte proliferation test (BeLPT)
Detalhes completos

Investigações a serem consideradas

  • bronchoscopic biopsy and/or lavage
  • high-resolution CT (HRCT) scan chest
  • oxygen saturation
  • arterial blood gas (ABG)
  • lung biopsy
  • test for tuberculosis (TB)
Detalhes completos

Algoritmo de tratamento

AGUDA

acute secondary alveolar proteinosis (acute silicosis)

acute berylliosis

CONTÍNUA

chronic silicosis, coal workers' lung, or chronic berylliosis

Colaboradores

Autores

Kenneth D. Rosenman, MD

Professor of Medicine

Division of Occupational and Environmental Medicine

Michigan State University

East Lansing

MI

Declarações

KDR declares no competing interests.

Revisores

Ware G. Kuschner, MD

Associate Professor of Medicine

Stanford University

Staff Physician

US Department of Veterans Affairs

Palo Alto Health Care System

Palo Alto

CA

Declarações

WGK declares that he has no competing interests.

Harman Paintal, MBBS

Division of Pulmonary and Critical Care Medicine

Veterans Affairs Palo Alto Health Care System (VAPAHCS)

Palo Alto

CA

Declarações

HP declares that he has no competing interests.

Francis Thien, MD, FRACP, FCCP

Professor

Box Hill Hospital and Monash University

Victoria

Australia

Declarações

FT declares that he has no competing interests.

Edward L. Petsonk, MD

Professor of Medicine

Section of Pulmonary and Critical Care Medicine

West Virginia University School of Medicine

Morgantown

WV

Declarações

ELP declares that he has no competing interests.

Christopher M. Barber, BM, BS, BMedSci, FRCP, MD, AFOM

Respiratory Consultant

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield

UK

Declarações

CMB declares that he has no competing interests.

Carl J. Reynolds, MBBS, MRCP, BSc, MSc, PhD, DPMSA

Respiratory Consultant

Honorary Senior Clinical Lecturer

North Middlesex University Hospital

Imperial College London

UK

Declarações

CJR declares that he has no competing interests.

Créditos aos pareceristas

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Declarações

As afiliações e declarações dos pareceristas referem--se ao momento da revisão.

Referências

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Principais artigos

Balmes JR, Abraham JL, Dweik RA, et al. An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease. Am J Respir Crit Care Med. 2014 Nov 15;190(10):e34-59.Texto completo  Resumo

American College of Radiology. ACR Appropriateness Criteria: occupational lung diseases. 2019 [internet publication].Texto completo

National Institute for Occupational Safety and Health. Health effects of occupational exposure to respirable crystalline silica. Apr 2002 [internet publication].Texto completo

International Labour Office. Guidelines for the use of the ILO international classification of radiographs of pneumoconioses, revised edition. 2022 [internet publication].Texto completo

US Occupational Safety and Health Administration (OSHA). Final rule to protect workers from occupational exposure to respirable crystalline silica. Appendix B to §1926.1153 construction standard - medical surveillance guidelines. May 2019 [internet publication].Texto completo

Artigos de referência

Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
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