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Pneumoconioses

Evidencia revisada por última vez: 1 Jun 2026
Tema actualizado por última vez: 17 Jan 2025

Resumen

Definición

Anamnesis y examen

Principales factores de diagnóstico

  • occupational exposure to silica, coal, or beryllium
  • history of smoking
Todos los datos

Otros factores de diagnóstico

  • dyspnea on exertion
  • cough
  • normal chest exam
  • crackles on chest auscultation
  • chest tightness and/or wheezing
  • prolonged expiration and wheezing on chest auscultation
  • areas of dullness on chest percussion
  • cyanosis
  • barrel chest
  • hemoptysis, fever, or night sweats
  • clubbing of fingers and toes
  • weight loss
  • signs of rheumatoid arthritis or scleroderma
  • signs of renal failure (e.g., weight gain, edema, hypertension)
Todos los datos

Factores de riesgo

  • occupational exposure to silica
  • occupational exposure to coal
  • occupational exposure to beryllium
  • high cumulative dose of inhaled silica or coal
  • cigarette smoking
  • glutamic acid at position 69 of the B1 chain of the HLA-DP molecule (chronic beryllium disease)
  • high cumulative dose of inhaled beryllium
Todos los datos

Pruebas diagnósticas

Primeras pruebas diagnósticas para solicitar

  • chest x-ray (posteroanterior and lateral)
  • spirometry
  • beryllium lymphocyte proliferation test (BeLPT)
Todos los datos

Pruebas diagnósticas que deben considerarse

  • bronchoscopic biopsy and/or lavage
  • high-resolution CT (HRCT) scan chest
  • oxygen saturation
  • arterial blood gas (ABG)
  • lung biopsy
  • test for tuberculosis (TB)
Todos los datos

Algoritmo de tratamiento

Agudo

acute secondary alveolar proteinosis (acute silicosis)

acute berylliosis

En curso

chronic silicosis, coal workers' lung, or chronic berylliosis

Colaboradores

Autores

Kenneth D. Rosenman, MD

Professor of Medicine

Division of Occupational and Environmental Medicine

Michigan State University

East Lansing

MI

Divulgaciones

KDR declares no competing interests.

Revisores por pares

Ware G. Kuschner, MD

Associate Professor of Medicine

Stanford University

Staff Physician

US Department of Veterans Affairs

Palo Alto Health Care System

Palo Alto

CA

Divulgaciones

WGK declares that he has no competing interests.

Harman Paintal, MBBS

Division of Pulmonary and Critical Care Medicine

Veterans Affairs Palo Alto Health Care System (VAPAHCS)

Palo Alto

CA

Divulgaciones

HP declares that he has no competing interests.

Francis Thien, MD, FRACP, FCCP

Professor

Box Hill Hospital and Monash University

Victoria

Australia

Divulgaciones

FT declares that he has no competing interests.

Edward L. Petsonk, MD

Professor of Medicine

Section of Pulmonary and Critical Care Medicine

West Virginia University School of Medicine

Morgantown

WV

Divulgaciones

ELP declares that he has no competing interests.

Christopher M. Barber, BM, BS, BMedSci, FRCP, MD, AFOM

Respiratory Consultant

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield

UK

Divulgaciones

CMB declares that he has no competing interests.

Carl J. Reynolds, MBBS, MRCP, BSc, MSc, PhD, DPMSA

Respiratory Consultant

Honorary Senior Clinical Lecturer

North Middlesex University Hospital

Imperial College London

UK

Divulgaciones

CJR declares that he has no competing interests.

Agradecimiento de los revisores por pares

Los temas de BMJ Best Practice se actualizan de forma continua de acuerdo con los desarrollos en la evidencia y en las guías. Los revisores por pares listados aquí han revisado el contenido al menos una vez durante la historia del tema.

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Referencias

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Artículos principales

Balmes JR, Abraham JL, Dweik RA, et al. An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease. Am J Respir Crit Care Med. 2014 Nov 15;190(10):e34-59.Texto completo  Resumen

American College of Radiology. ACR Appropriateness Criteria: occupational lung diseases. 2019 [internet publication].Texto completo

National Institute for Occupational Safety and Health. Health effects of occupational exposure to respirable crystalline silica. Apr 2002 [internet publication].Texto completo

International Labour Office. Guidelines for the use of the ILO international classification of radiographs of pneumoconioses, revised edition. 2022 [internet publication].Texto completo

US Occupational Safety and Health Administration (OSHA). Final rule to protect workers from occupational exposure to respirable crystalline silica. Appendix B to §1926.1153 construction standard - medical surveillance guidelines. May 2019 [internet publication].Texto completo

Artículos de referencia

Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
  • Pneumoconioses images
  • Diferenciales

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    • Idiopathic pulmonary fibrosis
    • Sarcoidosis
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  • Guías de práctica clínica

    • Medical surveillance guidelines: silica​
    • ACR Appropriateness Criteria: occupational lung diseases
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  • Folletos para el paciente

    COPD: what is it?

    COPD: questions to ask your doctor

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