Last reviewed: 31 Jun 2021
Last updated: 13 Aug 2019

Summary

Definition

History and exam

Key diagnostic factors

  • acute to subacute recurrent skin eruption
  • polymorphic, generalised, non-pruritic skin eruption

Other diagnostic factors

  • scars or pigment changes
  • immunosuppression
  • recent illness
  • family history of pityriasis lichenoides
  • headache
  • myalgias/arthralgias
  • malaise
  • burning/pruritus
  • multi-organ failure

Risk factors

  • childhood to early adult age
  • male sex
  • HIV

Diagnostic investigations

Investigations to consider

  • anti-streptolysin titres
  • Epstein-Barr virus IgM/IgG viral capsid antigen and nuclear antigen antibody
  • monospot or heterophil antibody test
  • hepatitis B surface antigen, anti-surface antibody, and anti-core IgM
  • hepatitis C virus antibody
  • HIV screening
  • rapid plasma reagin
  • throat cultures
  • toxoplasma Sabin-Feldman's dye test, indirect immunofluorescence/haemagglutination
  • erythrocyte sedimentation rate
  • CRP
  • serum LDH
  • WBC count
  • serum albumin

Treatment algorithm

Contributors

Authors

Amor Khachemoune, MD, CWS

Clinical Instructor in Dermatology

SUNY Downstate Medical Center

Brooklyn

NY

Disclosures

AK declares that he has no competing interests.

Marianna Blyumin-Karasik, MD

Dermatology Faculty

Department of Dermatology & Cutaneous Surgery

University of Miami

Miami

FL

Disclosures

MB-K declares that she has no competing interests.

Peer reviewers

Andrew D. Lee, MD

Resident

Department of Dermatology

Wake Forest University School of Medicine

Winston-Salem

NC

Disclosures

ADL declares that he has no competing interests.

Abdulhafez Selim, MD

Assistant Professor

King Fahd University of Petroleum and Minerals

Dhahran

Saudi Arabia

Disclosures

AS declares that he has no competing interests.

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