Evaluation of secondary amenorrhea

Amenorrhea is the transient or permanent absence of menstrual flow. There is no consensus on the definition of amenorrhea, but it may be subdivided into primary and secondary amenorrhea as follows:[1]Practice Committee of the American Society for Reproductive Medicine. Current evaluation of amenorrhea: a committee opinion. Fertil Steril. 2024 Jul;122(1):52-61. https://www.fertstert.org/article/S0015-0282(24)00082-7/fulltext http://www.ncbi.nlm.nih.gov/pubmed/38456861?tool=bestpractice.com ​​

• Primary amenorrhea: lack of menses by age 15 years in a patient with appropriate development of secondary sexual characteristics, or lack of menses within 5 years of breast development if breast development occurred before age 10 years

• Secondary amenorrhea: lack of menses for >3 months in a nonpregnant female who previously had regular menstrual cycles, or lack of menses for 6 months in a female who previously had irregular menstrual cycles.

Although attributes overlap between the two groups, the diagnostic approaches vary significantly.

Contemporary population-level evidence regarding the incidence and prevalence of amenorrhea is scarce.

The prevalence of secondary amenorrhea is estimated to be 3% to 4%; primary amenorrhea is considerably less common (<0.1%).[2]Timmreck LS, Reindollar RH. Contemporary issues in primary amenorrhea. Obstet Gynecol Clin North Am. 2003 Jun;30(2):287-302. http://www.ncbi.nlm.nih.gov/pubmed/12836721?tool=bestpractice.com [3]Pettersson F, Fries H, Nillius SJ. Epidemiology of secondary amenorrhea: incidence and prevalence rates. Am J Obstet Gynecol. 1973 Sep 1;117(1):80-6. http://www.ncbi.nlm.nih.gov/pubmed/4722382?tool=bestpractice.com [4]Münster K, Helm P, Schmidt L. Secondary amenorrhoea: prevalence and medical contact--a cross-sectional study from a Danish county. Br J Obstet Gynaecol. 1992 May;99(5):430-3. http://www.ncbi.nlm.nih.gov/pubmed/1622918?tool=bestpractice.com ​​

Prevalence of secondary amenorrhea appears to be higher among women who participate in physically demanding sports or disciplines, including cycling (56%), triathlon (40%), rhythmic gymnastics (31%), and ballet (20% to 23%).[5]Gimunová M, Paulínyová A, Bernaciková M, et al. The prevalence of menstrual cycle disorders in female athletes from different sports disciplines: a rapid review. Int J Environ Res Public Health. 2022 Oct 31;19(21):14243. https://pmc.ncbi.nlm.nih.gov/articles/PMC9658102 http://www.ncbi.nlm.nih.gov/pubmed/36361122?tool=bestpractice.com [6]Stokić E, Srdić B, Barak O. Body mass index, body fat mass and the occurrence of amenorrhea in ballet dancers. Gynecol Endocrinol. 2005 Apr;20(4):195-9. http://www.ncbi.nlm.nih.gov/pubmed/16019361?tool=bestpractice.com [7]Bacchi E, Spiazzi G, Zendrini G, et al. Low body weight and menstrual dysfunction are common findings in both elite and amateur ballet dancers. J Endocrinol Invest. 2013 May;36(5):343-6. http://www.ncbi.nlm.nih.gov/pubmed/23027765?tool=bestpractice.com ​​

Common causes of secondary amenorrhea include polycystic ovary syndrome, hypothalamic dysfunction, premature ovarian insufficiency, and hyperprolactinemia.[1]Practice Committee of the American Society for Reproductive Medicine. Current evaluation of amenorrhea: a committee opinion. Fertil Steril. 2024 Jul;122(1):52-61. https://www.fertstert.org/article/S0015-0282(24)00082-7/fulltext http://www.ncbi.nlm.nih.gov/pubmed/38456861?tool=bestpractice.com [8]Stuenkel CA, Gompel A, Davis SR, et al. Approach to the patient with new-onset secondary amenorrhea: is this primary ovarian insufficiency? J Clin Endocrinol Metab. 2022 Feb 17;107(3):825-35. https://academic.oup.com/jcem/article/107/3/825/6409726 http://www.ncbi.nlm.nih.gov/pubmed/34693971?tool=bestpractice.com [9]Mörö S, Kosola S, Holopainen E. Girls referred for amenorrhea: analysis of a patient series from a specialist center. Front Public Health. 2024;12:1304277. https://pmc.ncbi.nlm.nih.gov/articles/PMC10906086 http://www.ncbi.nlm.nih.gov/pubmed/38435281?tool=bestpractice.com ​​​

In general, amenorrhea accounts for a relatively small percentage of patient visits, even at highly specialized centers.

A prompt, comprehensive assessment is warranted unless the patient is pregnant, lactating, or using hormonal contraceptives, as amenorrhea is often the presenting sign of an underlying reproductive disorder. A delay in diagnosis and treatment may adversely impact health outcomes of such patients. For example, in polycystic ovary syndrome and hyperinsulinemia, behavioral and dietary modifications may prevent subsequent cardiovascular disease.