Last reviewed: 5 Feb 2021
Last updated: 05 Dec 2018
Summary
Differentials
Common
- Eating disorders or female athlete triad
- Emotional or physical stress
- Post-contraception with depot medroxyprogesterone
- Hyperprolactinaemia
- Polycystic ovary syndrome (PCOS)
- Idiopathic premature ovarian failure
- Post-chemoradiation ovarian failure
- Chromosomal abnormality (Fragile X carrier, Turner's syndrome mosaic)
- Non-classic congenital adrenal hyperplasia
- Hypothyroidism
Uncommon
- Malnutrition or chronic disease state
- Empty sella syndrome
- Sheehan's syndrome (postpartum pituitary necrosis)
- Post-encephalitis
- Androgen-producing ovarian tumour
- Autoimmune premature ovarian failure
- Androgen-producing adrenal tumour
- Cushing's syndrome
- Asherman's syndrome
- Drug-induced
Contributors
Authors

Associate Professor of Obstetrics and Gynaecology
University of Toronto Faculty of Medicine
Head of Gynaecology and Minimally Invasive Surgery
Sinai Health System
Site Chief of Gynaecology
Women’s College Hospital
Toronto
Canada
Disclosures
MJS reports that he is a consultant for Medtronic, and he is on the advisory boards at AbbVie and Allergan. He has also been a moderator for Bayer.
Peer reviewers
Professor
Department of Obstetrics, Gynecology, and Reproductive Sciences
Vice Chairman
Reproductive Sciences
Director
Division of Reproductive Endocrinology and Infertility
University of Pittsburgh
Pittsburgh
PA
Disclosures
JSS declares that he has no competing interests.
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