Summary
Definition
History and exam
Key diagnostic factors
- weakness
- altered sensation
- sensory loss
- visual changes
- photophobia
- headache
- aphasia
- dysarthria
- ataxia
- sudden onset followed by progression
- vertigo
- nausea/vomiting
- altered level of consciousness/coma
- confusion
- gaze paresis
Risk factors
- hypertension
- advanced age
- male sex
- Asian, black, and/or Hispanic ethnicity
- family history of hemorrhagic stroke
- hemophilia
- cerebral amyloid angiopathy
- sickle cell disease
- autosomal dominant mutations in the COL4A1 gene
- hereditary hemorrhagic telangiectasia
- autosomal dominant mutations in the KRIT1, CCM2, or PDCD10 genes
- anticoagulation
- illicit sympathomimetic drugs
- vascular malformations
- Moyamoya disease
- pregnancy
- smoking
- nonsteroidal anti-inflammatory drugs (NSAIDs)
- obstructive sleep apnea
- diabetes mellitus
- heavy alcohol abuse
- cerebral vasculitis
- thrombocytopenia
- long sleep duration and poor sleep quality
- leukemia
Diagnostic tests
1st tests to order
- noncontrast head CT
- chemistry panel
- CBC
- clotting tests
- ECG
- platelet function test
- urine drug screen
- pregnancy test in women of childbearing age
- liver function test
- intracerebral hemorrhage (ICH) score
Tests to consider
- CT angiography (CTA) and venography
- magnetic resonance angiography and venography
- conventional (invasive) angiography
- MRI brain
- MRI brain with diffusion-weighted imaging (DWI) and gradient-echo sequence (GRE)
- MRI brain with susceptibility-weighted imaging (SWI)
Treatment algorithm
presumed hemorrhagic stroke
noncerebellar bleed: stable and alert
noncerebellar bleed: decompensating
<3 cm cerebellar bleed: stable and alert
>3 cm cerebellar bleed or drowsy/unstable
Contributors
Expert advisers
Raisa C. Martinez, MD
Neurocritical Care Unit
Department of Neurosciences
Wellstar Health System, Kennestone
Marietta
GA
Disclosures
RCM declares that she has no competing interests.
Acknowledgements
Dr Raisa Martinez would like to gratefully acknowledge Dr Fernando D. Goldenberg, Dr Alejandro Hornik, Dr Eric E. Smith, and Dr T. Dion Fung, the previous contributors to this topic.
Disclosures
EES is an author of a number of references cited in this topic. FDG, AH, and TDF declare that they have no competing interests.
Peer reviewers
Louis R. Caplan, MD
Lecturer in Neurology
Hospital Chief
Cerebrovascular/Stroke Division
Beth Israel Deaconess Medical Center
Division of Cerebrovascular/Stroke
Boston
MA
Divulgaciones
LRC declares that he has no competing interests.
Julien Morier, MD
Neurology Registrar
Neurology Service
Centre Hospitalier Universitaire Vaudois (CHUV)
Lausanne
Switzerland
Divulgaciones
JM declares that he has no competing interests.
Agradecimiento de los revisores por pares
Los temas de BMJ Best Practice se actualizan de forma continua de acuerdo con los desarrollos en la evidencia y en las guías. Los revisores por pares listados aquí han revisado el contenido al menos una vez durante la historia del tema.
Divulgaciones
Las afiliaciones y divulgaciones de los revisores por pares se refieren al momento de la revisión.
Referencias
Artículos principales
Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 Guideline for the management of patients with spontaneous intracerebral hemorrhage: a guideline from the American Heart Association/American Stroke Association. Stroke. 2022 Jul;53(7):e282-361.Texto completo Resumen
Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association. Stroke. 2021 Jul;52(7):e364-e467.Texto completo Resumen
Artículos de referencia
Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.

Diferenciales
- Ischemic stroke
- Hypertensive encephalopathy
- Hypoglycemia
Más DiferencialesGuías de práctica clínica
- Clinical guidelines for stroke management
- European Stroke Organisation (ESO) and European Association of Neurosurgical Societies (EANS) guideline on stroke due to spontaneous intracerebral haemorrhage
Más Guías de práctica clínicaCalculadoras
NIH Stroke Score
Más CalculadorasVideos
Venepuncture and phlebotomy: animated demonstration
How to perform an ECG: animated demonstration
Más vídeosFolletos para el paciente
Stroke caused by a blood clot: preventing another stroke
Stroke: treatment
More Folletos para el pacienteLog in or subscribe to access all of BMJ Best Practice
Use of this content is subject to our disclaimer