Kaposi's sarcoma
Last reviewed: 1 Jun 2022
Last updated: 19 Dec 2019
Summary
Definition
History and exam
Key diagnostic factors
- presence of risk factors
- age >50 years
- male sex
- geographic location: sub-Saharan Africa or the Mediterranean
- HIV infection
- HHV-8 (also known as Kaposi's sarcoma-associated herpesvirus [KSHV]) infection
- immunosuppression
- skin lesion
- oral lesion
- lymphadenopathy
- lymphoedema
More key diagnostic factors
Other diagnostic factors
- weight loss
- abdominal pain
- GI bleeding
- diarrhoea
- dyspnoea
- haemoptysis
- chest pain
- fever
Other diagnostic factors
Risk factors
- male sex
- HIV infection
- drug abuse
- immunosuppression therapy
- transplantation
- human herpesvirus-8 (HHV-8, also known as Kaposi's sarcoma-associated herpesvirus [KSHV]) infection
- central African ethnicity (Uganda, Malawi, Zambia, Zimbabwe, Swaziland)
- Jewish ethnicity
- Mediterranean ethnicity
- age <5 years or >50 years
More risk factors
Diagnostic investigations
1st investigations to order
- HIV test
- skin/mucosal biopsy
- lymph node biopsy
- fecal occult blood
- CXR
More 1st investigations to order
Investigations to consider
- CT scan
- MRI
- bronchoscopy
- GI endoscopy
- PET scan
- FBC
- renal function tests
- LFTs
More investigations to consider
Emerging tests
- human herpesvirus-8 (HHV-8, also known as Kaposi's sarcoma-associated herpesvirus [KSHV]) viraemia and serology
Treatment algorithm
ACUTE
epidemic AIDS-related KS
classic sporadic KS
iatrogenic and transplant-associated KS
African endemic KS
Contributors
Authors
David Aboulafia, MD
Attending Hematologist and Oncologist
Virginia Mason Clinical Professor of Medicine
Division of Hematology and Oncology
University of Washington
Seattle
WA
Disclosures
DA is the author of articles cited in this topic.
Acknowledgements
Dr David Aboulafia would like to gratefully acknowledge Dr Liron Pantanowitz and Dr Bruce J. Dezube, previous contributors to this topic.
Peer reviewers
Justin Stebbing, MA, MRCP, MRCPath, PhD
Consultant Medical Oncologist/Senior Lecturer
Department of Medical Oncology
Imperial College/Imperial Healthcare NHS Trust
Charing Cross Hospital
London
UK
Disclosures
JS declares that he has no competing interests.
Thierry Simonart, MD, PhD
Physician
Department of Dermatology
Erasme University Hospital
Brussels
Belgium
Disclosures
TS declares that he has no competing interests.
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