Last reviewed:December 2019
Last updated:May  2018

Summary

Definition

History and exam

Key diagnostic factors

  • skin patches, plaques, or tumours
  • poikiloderma
  • erythroderma

Other diagnostic factors

  • pruritus
  • hypopigmented skin lesions
  • unilesional acral site involvement
  • lymphadenopathy
  • constitutional symptoms
  • palmar-plantar keratoderma
  • alopecia
  • leonine facies
  • onychodystrophy
  • hepatomegaly
  • ectropion
  • bullous, granulomatous, ichthyosiform, and purpuric lesions

Risk factors

  • age >60 years
  • male gender
  • black ethnicity (mycosis fungoides); white ethnicity (Sézary's syndrome)
  • exposure to infectious agents
  • chromosomal abnormality
  • environmental exposure to industrial chemicals, herbicides, pesticides

Diagnostic investigations

Treatment algorithm

Contributors

Professor of Targeted Therapy and Oncology

University of Manchester

Manchester Academic Health Sciences Centre

Manchester

UK

Disclosures

TMI declares that he has no competing interests.

Consultant in Clinical Oncology

Christie NHS Foundation Trust

Manchester

UK

Disclosures

RC declares that he has no competing interests.

Consultant Dermatologist

Tameside Hospital Integrated Care Organisation NHS Trust

Manchester

UK

Disclosures

EP declares she has no competing interests.

Peer reviewersVIEW ALL

Assistant Professor

Department of Radiation Oncology

Duke University School of Medicine

Durham

NC

Disclosures

CK declares that he has no competing interests.

Professor and Head of Dermatology

Department of Medicine

New Jersey Medical School

Newark

NJ

Disclosures

RAS declares that he has no competing interests.

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