Summary
Differentials
Common
- Infection
- Inflammatory conditions
- Chronic myeloid leukemia (CML)
- Essential thrombocythemia
- Polycythemia vera
- Primary myelofibrosis
- Pregnancy
Uncommon
- Platelet clumping
- Cryoglobulinemia
- Anemia
- Solid tumor malignancy
- Chronic bone marrow stimulation
- Asplenia
- Sweet syndrome
- Drug-induced hematopoiesis
- Chronic neutrophilic leukemia
- Hereditary neutrophilia
- Pelger-Huet abnormality
- Amegakaryocytic thrombocytopenia
- Trisomy 21 (Down syndrome)
- Leukocyte adhesion deficiency type I
- Familial cold autoinflammatory syndrome
- Chronic idiopathic neutrophilia
- Stress-induced demargination
- Drug-induced demargination
- Drug-induced decreased egress
Contributors
Authors
Devon Chabot-Richards, MD
Assistant Professor of Pathology
University of New Mexico Health Sciences Center
Albuquerque
NM
Disclosures
DCR declares that she has no competing interests.
Tracy I. George, MD
Professor of Pathology
University of New Mexico Health Sciences Center
Albuquerque
NM
Disclosures
TIG declares that she has received consulting fees from Wiley Blackwell as coeditor-in-chief for the International Journal of Laboratory Hematology, royalties from Wolters Kluwer for an atlas on peripheral blood smears, royalties from UpToDate, Inc. for an online chapter on automated hematology, and consulting fees from Roche Hematology.
Acknowledgements
Dr Devon Chabot-Richards and Dr Tracy I. George would like to gratefully acknowledge Dr Holbrook Kohrt, a previous contributor to this topic.
Disclosures
HK declares that he has no competing interests.
Peer reviewers
Carla Wilson, MD, PhD
Professor
Department of Pathology
University of New Mexico Health Sciences Center
Albuquerque
NM
Disclosures
CW declares that she has no competing interests.
Sherrie Perkins, MD, PhD
Professor of Pathology
Medical Director of Hematopathology
University of Utah Health Sciences and ARUP Laboratories
Salt Lake City
UT
Disclosures
SP declares that she has no competing interests.
John Reilly, BSc, MD, FRCP, FRCPath
Consultant Haematologist
Royal Hallamshire Hospital
Professor
University of Sheffield
Sheffield
UK
Disclosures
JR declares that he has no competing interests.
Priyanka Mehta, MD, MRCP, FRCPath
Consultant Haematologist
University Hospital Bristol
Bristol
UK
Disclosures
PM declares that she has no competing interests.
References
Key articles
Herring WB, Smith LG, Walker RI, et al. Hereditary neutrophilia. Am J Med. 1974 May;56(5):729-34. Abstract
Dale DC, Liles WC, Llewellyn C, et al. Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers. Am J Hematol. 1998 Jan;57(1):7-15.Full text Abstract
Nakagawa M, Terashima T, D'yachkova Y, et al. Glucocorticoid-induced granulocytosis: contribution of marrow release and demargination of intravascular granulocytes. Circulation. 1998 Nov 24;98(21):2307-13.Full text Abstract
Seebach JD, Morant R, Ruegg R, et al. The diagnostic value of the neutrophil left shift in predicting inflammatory and infectious disease. Am J Clin Pathol. 1997 May;107(5):582-91.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
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