Evaluation of recurrent miscarriage

Last reviewed: 13 Aug 2025
Last updated: 05 Sep 2025

Summary

Differentials

Common

  • Idiopathic recurrent miscarriage
  • Fetal chromosomal abnormality
  • Chronic endometritis
Full details

Uncommon

  • Parental chromosomal abnormality
  • Antiphospholipid syndrome
  • Cervical insufficiency
  • Uncontrolled diabetes mellitus
  • Uncontrolled thyroid dysfunction
  • Thrombophilias
  • Uterine abnormalities (e.g., bicornuate, septate, or arcuate uterus)
  • Bacterial vaginosis
  • Polycystic ovarian syndrome (PCOS)
  • Smoking, caffeine intake
Full details

Contributors

Authors

Winifred Mak, MD, PhD

Associate Professor

Women's health

Dell Medical School

University of Texas

Austin

Department of Reproductive Endocrinology and Infertility

University of Texas Health Science Center at San Antonio

San Antonio

TX

Disclosures

WM declares that she has received grants from NIH to study the role of sperm in recurrent pregnancy loss. She has served as a grand round speaker at Yale School of Medicine (Obstetrics and Gynecology), and as a postgraduate course speaker for the American Society of Reproductive Medicine.

Acknowledgements

Dr Winifred Mak would like to gratefully acknowledge Dr Ai-Wei Tang and Dr Siobhan Quenby, the previous contributors to this topic. AT declares that she has no competing interests. SQ is an author of a reference cited in this topic. SQ declares that she has no competing interests.

Peer reviewers

MaryEllen Pavone, MD, MSCI

Professor of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility

Northwestern University

Evanstan

IL

Disclosures

MP declares that she has no competing interests.

Sacha Krieg, MD, PhD

Associate Professor of Reproductive Endocrinology and Infertility

Oregon Health and Science University

Portland

OR

Disclosures

SK declares that she has no competing interests.

Justin C. Konje, MBBS, FMCOG, MRCOG, FWACS, MD, MBA

Professor of Obstetrics and Gynaecology

Leicester Royal Infirmary

Leicester

UK

Disclosures

JCK is an author of a reference cited in this topic.

Frederique van Dunné, MD, PHD, FRANZCOG

Obstetrician

Erasmus Medical Center

Rotterdam

The Netherlands

Disclosures

FVD declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

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Key articles

European Society of Human Reproduction and Embryology (ESHRE). Guideline on the management of recurrent pregnancy loss. Feb 2023 [internet publication].Full text

Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril. 2012 Nov;98(5):1103-11. Abstract

Royal College of Obstetricians and Gynaecologists. Recurrent miscarriage: green-top guideline no. 17. Jun 2023 [internet publication].Full text  Abstract

Jauniaux E, Farquharson RG, Christiansen OB, et al. Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Hum Reprod. 2006 Sep;21(9):2216-22.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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