最近审阅: 6 十一月 2020
最近更新: 11 三月 2020

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 意识状态改变
  • 肌肉强直
  • 自主神经功能障碍
  • 体温过高
  • 精神病史

其他诊断因素

  • 铁缺乏史
  • Wilson 病史

危险因素

  • 暴露于抗精神病药物
  • 突然停用多巴胺能药物
  • 脑结构异常
  • 老年
  • 已患有激越
  • 静坐不能
  • 男性
  • 铁缺乏症
  • 紧张症
  • 已患有脱水
  • 多巴胺拮抗剂和其他抗精神病药暴露

诊断性检查

首要检查

  • 全血细胞计数(FBC)
  • 血清肌酸激酶
  • 基础代谢检查
  • 脑部 CT 扫描
  • 脑部 MRI
  • 肌红蛋白水平和尿液分析
  • 尿液培养
  • 血液培养
  • 腰椎穿刺:
  • 毒理学筛查
  • 胸部 X 线检查
更多 首要检查

治疗流程

急性处理
进行中

撰稿人

Associate Professor

Harvard Medical School

Boston

MA

利益声明

RJG is a member of the Neuroleptic Malignant Syndrome Professional Advisory Board, and has given expert testimony in medical malpractice tort claims in which NMS was alleged. He is an author of several references cited in this topic.

Dr Ronald J. Gurrera would like to gratefully acknowledge Dr Peter F. Buckley, a previous contributor to this topic. PFB is on the advisory board (a voluntary, uncompensated role) of the Neuroleptic Malignant Syndrome Information Service. He is also a consultant to Janssen Pharmaceutica and the National Institute of Mental Health (NIMH). He is conducting or has recently conducted research with funding support from AstraZeneca, NIMH, Janssen Pharmaceutica, Pfizer, Solvay, and Wyeth. Previous consultancy and research support has been from Abbott, Alamo Pharmaceuticals, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Lundbeck, Janssen Pharmaceutica, Merck, NIMH, Roche Diagnostics, Pfizer, Solvay, and Wyeth. PFB has no patents or stock in any company. He is an author of several references cited in this topic. PFB is a co-investigator on a study also involving Dr John Lauriello and Dr Daniel R. Wilson, who were reviewers for this topic.

同行评议者展开全部内容

Consultant Psychiatrist

Honorary Senior Clinical Lecturer

Royal Cornhill Hospital

Aberdeen

UK

利益声明

AH declares that she has no competing interests.

Professor and Chair

Department of Psychiatry

University of Missouri-Columbia

Columbia

MO

利益声明

JL declares that he has no competing interests.

Assistant Professor

Department of Psychiatry

University of Missouri-Columbia

Columbia

MO

利益声明

GG declares that he has no competing interests.

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