最近审阅: 1 十一月 2020
最近更新: 14 十一月 2018

小结

定义

病史和体格检查

关键诊断因素

  • 哮喘、变应性鼻炎或鼻窦炎病史
  • 局灶性麻木或无力
  • 鼻腔渗出、鼻塞或面部痛
  • 高出皮面的紫癜及瘀点
  • 喘鸣
  • 咯血
  • 皮肤结节

其他诊断因素

  • 与用药的关系
  • 疲劳、关节痛、肌肉痛
  • 气短或咳嗽
  • 腹痛
  • 感觉或运动缺失
  • 呼吸急促
  • 啰音
  • 外周水肿
  • 端坐呼吸
  • 肝颈静脉回流征

危险因素

  • 哮喘、变应性鼻炎或鼻窦炎病史
  • 与用药的关系

诊断性检查

首要检查

  • 全血细胞计数 (FBC) 和分类计数
  • 血清抗中性粒细胞胞浆抗体(ANCA)
  • 血清 CRP
  • 红细胞沉降率
  • 血清尿素和肌酐
  • 尿液分析
  • 肺功能试验
  • 胸部 X 线检查
  • 超声心动图
更多 首要检查

需考虑的检查

  • 流式细胞仪检测外周血
  • FIP1L1/PDGFR alpha突变的分子检测
  • 血清 IgE 水平
  • 烟曲霉血清特异性 IgE 和 IgG
  • 大便培养以寻找寄生虫及虫卵
  • 弓蛔虫血清学检查
  • 胸部 CT
  • 肌电图
  • 支气管镜及支气管肺泡灌洗(BAL)
  • 受累组织活检
  • 下肢超声
  • CT 血管造影术
  • 骨髓活组织检查
  • 巯基嘌呤甲基转移酶水平
  • HIV 检测
更多 需考虑的检查

新兴检查

  • 心脏磁共振成像
  • 嗜酸粒细胞活化趋化因子-3
更多 新兴检查

治疗流程

撰稿人

Assistant Professor

Division of Pulmonary and Critical Care Medicine

Mayo Clinic

Rochester

MN

利益声明

KK is an author of a number of references cited in this topic and has developed educational material on Churg-Strauss syndrome for First Consult (Elsevier). KK has undertaken contractual research for GlaxoSmithKline (utilizing mepolizumab and sirukumab in asthma trials), but received no personal financial gain for this work.

Dr Karina Keogh would like to gratefully acknowledge Dr Garvan Kane, a previous contributor to this topic. GK is an author of a number of references cited in this topic.

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Professor of Rheumatology

NIHR Musculoskeletal Biomedical Research Unit

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science

University of Oxford

Oxford

UK

利益声明

RL has organisational financial interests with funds received for consultation and training on disease assessment in vasculitis for GlaxoSmithKline, Nordic, and Chemocentryx. RL has received personal funds for lectures on vasculitis from Roche and Nippon Kayaku. RL is an author of a reference cited in this topic.

Clinical Senior Lecturer in Renal Medicine

Centre for Translational Inflammation Research

University of Birmingham Research Laboratories

Queen Elizabeth Hospital Birmingham

Birmingham

UK

利益声明

MDM has been a paid consultant for Sphere Medical Ltd, and has received research grants and funding from GlaxoSmithKline and Novartis.

Assistant Professor of Medicine

Division of Rheumatology

Johns Hopkins University School of Medicine

Co-Director

Johns Hopkins Vasculitis Center

Baltimore

MD

利益声明

PS declares that he has no competing interests.

Professor of Clinical Rheumatology

Institute of Cellular Medicine

Newcastle University

Newcastle upon Tyne

Honorary Consultant Rheumatologist

The James Cook University Hospital

Middlesbrough

UK

利益声明

JVL is consultant for Roche, the manufacturer of rituximab, and has received speaker fees and reimbursements for attending several conferences.

Associate Professor and Director

Division of Rheumatology

University of Arkansas for Medical Sciences

Little Rock

AR

利益声明

RAO declares that he has no competing interests.

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