由烟酰胺腺嘌呤二核苷酸磷酸 (nicotinamide adenine dinucleotide, NADPH) 氧化酶成份的基因缺陷引发，该氧化酶是吞噬细胞发挥有效杀菌作用所必需的。
若找到人类白细胞抗原 (human leucocyte antigen, HLA) 基因型匹配的捐献者，应尽早进行造血干细胞移植。
体细胞基因治疗有效，至少可短暂性恢复 NADPH 氧化酶活性。
Consultant Clinical Immunologist
The Royal Free Hospital
DL participated in a one-off advisory board for and received support to attend a conference from Biotest (UK).
Dr David Lowe would like to gratefully acknowledge Dr Adrian Thrasher, Dr Rebecca A. Marsh, and Dr Jack J. Bleesing, previous contributors to this monograph. AT is an author of a number of references cited in this monograph. RAM and JJB declare that they have no competing interests. Dr Rebecca A. Marsh and Dr Jack J. Bleesing wish to thank Dan Marmer, Carrie Koenig, and the Cincinnati Children's Hospital Clinical Diagnostic Immunology Lab. They also wish to thank Steven M. Holland, MD, Thomas Fleisher, MD, and Anthony Segal, MD, PhD, for helpful correspondence.
Laboratory of Clinical Infectious Diseases
National Institute of Allergy and Infectious Diseases
SMH declares that he has no competing interests.
Reader in Paediatric Immunology & HSCT
Institute of Cellular Medicine
AG is an author of a reference cited in this monograph. AG declares that he has no competing interests.