Assessment of clubbing

Last reviewed: 5 Apr 2025
Last updated: 25 Jun 2024

Summary

Differentials

Common

  • Lung cancer
  • Bronchiectasis
  • Lung abscess
  • Empyema
  • Congenital heart disease
  • Infective endocarditis
  • Hypersensitivity pneumonitis (extrinsic allergic alveolitis)
Full details

Uncommon

  • Cystic fibrosis
  • Interstitial pulmonary fibrosis
  • Sarcoidosis
  • Asbestosis
  • Pleural mesothelioma
  • Cavitating pulmonary tuberculosis (TB)
  • Pulmonary metastases
  • Atrial myxoma
  • Axillary artery aneurysm
  • Brachial arteriovenous malformations
  • Thyroid acropachy
  • Acromegaly
  • Severe secondary hyperparathyroidism
  • Hodgkin's lymphoma
  • Disseminated chronic myeloid leukaemia
  • Ulcerative colitis
  • Crohn's disease
  • Primary biliary cholangitis
  • Cirrhosis
  • Thyroid cancer
  • Thymus cancer
  • Lipoid pneumonia
  • Pulmonary artery sarcoma
  • Ulcerative oesophagitis
  • Achalasia
  • Coeliac disease
  • Tropical sprue
  • Leiomyoma of the oesophagus
  • Familial clubbing
  • Pachydermoperiostosis (primary hypertrophic osteoarthropathy)
  • Secondary hypertrophic osteoarthropathy
  • Palmoplantar keratoderma
  • Pregnancy
  • Pseudoclubbing
  • Myelofibrosis
Full details

Contributors

Authors

Murlidhar Rajagopalan, MD
Murlidhar Rajagopalan

Senior Consultant Dermatologist and Coordinator

Apollo Hospitals

Chennai

India

Disclosures

MR declares that he has no competing interests.

Robert A. Schwartz, MD, MPH, DSc (Hon), FRCP Edin, FAAD
Robert A. Schwartz

Professor & Head

Dermatology

Rutgers New Jersey Medical School

Newark

NJ

Disclosures

RAS declares that he has no competing interests.

Peer reviewers

Krishna Sundar, MD, FCCP

Associate Professor (Clinical)

Department of Medicine

University of Utah

Director

Pulmonary and Critical Care Research

IHC Urban South

Utah Valley Pulmonary Clinic

UT

Disclosures

KS declares that he has no competing interests.

Santhanam Lakshminarayanan, MD

Assistant Professor of Medicine

Director

Rheumatology Fellowship

University of Connecticut Health Center

Farmington

CT

Disclosures

SL declares that he has no competing interests.

References

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Key articles

Sarkar M, Mahesh DM, Madabhavi I. Digital clubbing. Lung India. 2012 Oct;29(4):354-62.Full text  Abstract

Callemeyn J, Van Haecke P, Peetermans WE, et al. Clubbing and hypertrophic osteoarthropathy: insights in diagnosis, pathophysiology, and clinical significance. Acta Clin Belg. 2016 Jun;71(3):123-30. Abstract

Raghu G, Remy-Jardin M, Richeldi L, et al. Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an official ATS/ERS/JRS/ALAT clinical practice guideline. Am J Respir Crit Care Med. 2022 May 1;205(9):e18-47.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
  • Assessment of clubbing images
  • Guidelines

    • Suspected cancer: recognition and referral
    • Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an official ATS/ERS/JRS/ALAT clinical practice guideline
    More Guidelines
  • Patient information

    Bronchiectasis: what is it?

    Lung cancer (non-small-cell)

    More Patient information
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