Goodpasture 病

最后审阅: 4 六月 2022
最后更新: 06 八月 2019

小结

定义

病史和体格检查

关键诊断因素

  • 尿量减少
  • 咯血
  • 水肿
更多 关键诊断因素

其他诊断因素

  • 男性
  • 20至30岁或60至70岁
  • 呼吸短促
  • 咳嗽
  • 发热
  • 恶心
  • 肺部听诊湿啰音
其他诊断因素

危险因素

  • HLA-DRB1或DR4
更多 危险因素

诊断性检查

首要检查

  • 肾功能检查
  • 肾脏活检
  • 抗肾小球基底膜(抗-GBM)抗体滴度
  • 抗中性粒细胞胞质抗体 (ANCA)
  • 血清补体(C3和C4)
  • 抗核抗体
  • 冷球蛋白
  • 肝炎病毒检测
  • 抗链球菌溶血素O滴度
  • 凝血筛查
更多 首要检查

治疗流程

初步治疗

可逆性肾病或任何肺部受累

不可逆性肾病

撰稿人

作者

Richard G. Phelps, BChir

Senior Lecturer and Honorary Consultant in Nephrology

University of Edinburgh and Edinburgh Royal Infirmary

Edinburgh

UK

利益声明

RGP has helped Genzyme develop educational materials for neurologists regarding the increased risk of Goodpasture's disease with alemtuzumab use. RGP has published an article on post-alemtuzumab nephritis in which employees of Genzyme were co-authors.

鸣谢

Dr Richard G. Phelps would like to gratefully acknowledge Professor Andre A. Kaplan and Dr Michael S. Gersch, previous contributors to this topic. AAK has received honoraria in 2013 to speak about plasma exchange from Gambro and Alexion (Gambro manufactures products for plasma exchange and Alexion manufactures a complement cascade inhibitor). MSG declares that he has no competing interests.

同行评议者

Dorin-Bogdan Borza, PhD

Assistant Professor of Medicine

Division of Nephrology

Department of Medicine

Vanderbilt University School of Medicine

Nashville

TN

利益声明

DBB declares that she has no competing interests.

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