Goodpasture 病的确定依据是存在 IV 型胶原 α-3 链自身抗体。 该病表现为急进性肾功能不全，通常合并肺出血。 咯血和肾衰竭并发（肺肾综合征）有多种病因，但当肾病是急进性肾小球肾炎时，约 15% 的病例为 Goodpasture 病，剩余的主要是抗中性粒细胞胞质抗体血管炎。
Goodpasture 病，亦称抗肾小球基底膜抗体（抗 GBM）病，是肺肾综合征（Goodpasture 综合征）的重要病因。 肺肾综合征包括肾小球肾炎和肺出血。Goodpasture 病的病因是 IV 型胶原 α-3 链自身抗体。这类胶原主要存在于肺泡和肾小球的基底膜中。
Richard G. Phelps, BChir
Senior Lecturer and Honorary Consultant in Nephrology
University of Edinburgh and Edinburgh Royal Infirmary
RGP has helped Genzyme develop educational materials for neurologists regarding the increased risk of Goodpasture's disease with alemtuzumab use. RGP has published an article on post-alemtuzumab nephritis in which employees of Genzyme were co-authors.
Dr Richard G. Phelps would like to gratefully acknowledge Professor Andre A. Kaplan and Dr Michael S. Gersch, previous contributors to this topic. AAK has received honoraria in 2013 to speak about plasma exchange from Gambro and Alexion (Gambro manufactures products for plasma exchange and Alexion manufactures a complement cascade inhibitor). MSG declares that he has no competing interests.
Dorin-Bogdan Borza, PhD
Assistant Professor of Medicine
Division of Nephrology
Department of Medicine
Vanderbilt University School of Medicine
DBB declares that she has no competing interests.