最近审阅: 5 十一月 2020
最近更新: 27 九月 2017

小结

定义

病史和体格检查

关键诊断因素

  • 高龄
  • 无症状
  • 疲乏
  • 活动耐力下降
  • 苍白
  • 瘀点、紫癜
  • 细菌感染

其他诊断因素

  • 存在的危险因素
  • 自身免疫性疾病
  • 脾肿大
  • 肝肿大
  • 淋巴结肿大

危险因素

  • 年龄> 70 岁
  • 电离辐射
  • 烷化剂
  • 拓扑异构酶抑制剂
  • 既往造血干细胞移植
  • 烟草
  • 再生障碍性贫血
  • 阵发性睡眠性血红蛋白尿 (PNH)
  • 唐氏综合征(21 三体)
  • 先天性中性粒细胞减少
  • DNA 修复缺陷综合征

诊断性检查

首要检查

  • 全血细胞计数及分类
  • 网织红细胞计数
  • 红细胞内叶酸
  • 血清维生素 B12 水平
  • 铁检测
  • HIV 检测
  • 骨髓穿刺涂片和铁染色
  • 骨髓穿刺活检
  • 骨髓细胞遗传学分析
更多 首要检查

需考虑的检查

  • 血清促红细胞生成素
  • HLA 分型
  • 流式细胞学检查
更多 需考虑的检查

治疗流程

撰稿人

Staff Physician

VA Nebraska-Western Iowa Health Care System

Professor

Division of Oncology-Hematology

Department of Internal Medicine

University of Nebraska Medical Center

Omaha

NE

利益声明

AKG has received research grants from Amgen, AstraZeneca, Bristol-Myers Squibb, Janssen, Merck, New Link Genetics, and Pfizer. AKG has been reimbursed for consulting work for Ariad Pharmaceuticals, Biodesix, and Pfeizer. He is also in discussion with Fresenius-Kabi on a consulting contract for clinical trial development. None of the grants or payments relate to work involving myelodysplastic syndrome.

Assistant Professor

Division of Oncology-Hematology

University of Nebraska Medical Center

Omaha

NE

利益声明

AM declares that she has no competing interests.

同行评议者展开全部内容

Associate Professor of Medicine (Hematology) and Oncology

Division of Hematology

Department of Medicine

Mayo Clinic

Rochester

MN

利益声明

DPS declares that he has no competing interests.

Professor of Haematology

Queen Mary University

London

UK

利益声明

ACN declares that he has no competing interests.

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