尽可能在明确脓毒症后 6 个小时内，迅速控制感染源。
2016 年的共识定义标志着既往全身炎症反应综合征 (SIRS) 定义的转变，将脓毒症归类为在感染的情况下，存在两种或以上下列标准：体温>38.3°C (101°F) 或<36.0°C (96.8°F)；心动过速>90 次/分；呼吸急促>20 次/分或 PaCO₂ <4.3 kPa (32 mmHg)；无糖尿病患者出现高血糖（血糖>7.7 mmol/L [>140 mg/dL]）；精神状态急性改变；白细胞增多（白细胞计数>12×10⁹/L [12,000/μL]）；白细胞减少（白细胞计数<4×10⁹/L [4000/μL]）；或白细胞计数正常但伴有＞10% 的不成熟细胞。
在 1991 年的第一版国际共识定义中，将重症脓毒症定义为脓毒症伴有器官功能障碍、灌注不足或低血压；将脓毒性休克定义为尽管充分补液，但仍存在脓毒症伴低血压。
United Kingdom Sepsis Trust
Global Sepsis Alliance
Consultant in Critical Care and Anaesthesia
Heart of England NHS Foundation Trust
RD has received payment for consultancy on sepsis from Kimal Plc, manufacturers of vascular access devices, from the Northumbria Partnership, a patient safety collaborative, and, where annual leave or other income was compromised in fulfilling his charity duties, from the UK Sepsis Trust. RD has received sponsorship to attend and speak at one meeting from Abbott Diagnostics. He is CEO of the UK Sepsis Trust and Global Sepsis Alliance, and advises HM Government, the World Health Organisation and NHS England on sepsis. Each of these positions demands that he express opinion on strategies around the recognition and management of sepsis.
Consultant Acute Physician & Sepsis Lead
Department of Acute Medicine
Royal Hampshire County Hospital
Hampshire Hospitals NHS Foundation Trust
MIK is a national clinical advisor on sepsis to NHS England and a national clinical advisor on deterioration to NHS Improvement. He was reimbursed for a slide set by Relias Learning.
Specialty Registrar in Gastroenterology and General Medicine
Maidstone and Tunbridge Wells NHS Trust
AS is the clinical fellow to the National Medical Director at NHS Improvement. AS has been sponsored on two occasions by Dr Falk Pharma UK to attend specialist gastroenterology conferences abroad; there was no contractual obligation to disseminate product information.
Consultant in Emergency Medicine
University of Plymouth
Devon Air Ambulance Trust
TN is a clinical adviser to the UK Sepsis Trust.
Specialty Registrar in Emergency Medicine
EC declares that he has no competing interests.
Dr Ron Daniels, Dr Matt Inada-Kimand, Dr Aamir Saifuddin, Dr Tim Nutbeam, and Dr Edward Berry would like to gratefully acknowledge Dr Lewys Richmond and Dr Paul Kempen, previous contributors to this topic. LR and PK declare that they have no competing interests.
Professor of Medicine
Infectious Disease Division
Rhode Island Hospital
Alpert Medical School of Brown University
SMO declares that he has no competing interests.
NYU School of Medicine
Medical Director of Critical Care
Bellevue Hospital Center
LE serves as the guidelines co-chair and on the steering committee of the Surviving Sepsis Campaign.