儿童脓毒症

参考文献

关键文献

Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005 Jan;6(1):2-8. 摘要

Weiss SL, Peters MJ, Alhazzani W, et al. Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med. 2020 Feb;21(2):e52-e106.全文  摘要

Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6:2-8. 摘要

National Institute for Health and Care Excellence. Sepsis: recognition, diagnosis and early management. July 2016. https://www.nice.org.uk (last accessed 2 March 2017).全文

National Institute for Health and Care Excellence. Sepsis: recognition, diagnosis and early management. Sep 2017 [internet publication].全文

Davis AL, Carcillo JA, Aneja RK, et al. American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock. Crit Care Med. 2017 Jun;45(6):1061-93.全文  摘要

参考文献

1. Bone RC. The sepsis syndrome: definition and general approach to management. Clin Chest Med. 1996 Jun;17(2):175-81. 摘要

2. Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013 Aug 29;369(9):840-51.全文  摘要

3. Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005 Jan;6(1):2-8. 摘要

4. World Health Organization Global Health Observatory. Causes of child mortality. 2017 [internet publication].

5. Weiss SL, Peters MJ, Alhazzani W, et al. Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med. 2020 Feb;21(2):e52-e106.全文  摘要

6. Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6:2-8. 摘要

7. National Institute for Health and Care Excellence. Sepsis: recognition, diagnosis and early management. July 2016. https://www.nice.org.uk (last accessed 2 March 2017).全文

8. Vergnano S, Sharland M, Kazembe P, et al. Neonatal sepsis: an international perspective. Arch Dis Child Fetal Neonatal Ed. 2005;90:F220-F224.全文  摘要

9. Stoll BJ, Gordon T, Korones SB, et al. Early-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 1996;129:72-80. 摘要

10. Stoll BJ, Gordon T, Korones SB, et al. Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 1996;129:63-71. 摘要

11. Behrman RE, Kliegman R, Jenson HB. Nelson textbook of pediatrics. Philadelphia: W.B. Saunders Co.; 2000:544.

12. Brierley J, Peters MJ. Distinct hemodynamic patterns of septic shock at presentation to pediatric intensive care. Pediatrics. 2008 Oct;122(4):752-9. 摘要

13. Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020 Jan 18;395(10219):200-211.全文  摘要

14. Watson RS, Carcillo JA, Linde-Zwirble WT, et al. The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med. 2003 Mar 1;167(5):695-701.全文  摘要

15. Hartman ME, Linde-Zwirble WT, Angus DC, et al. Trends in the epidemiology of pediatric severe sepsis. Pediatr Crit Care Med. 2013 Sep;14(7):686-93. 摘要

16. Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, et al. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018 Mar;6(3):223-230.全文  摘要

17. Ruth A, McCracken CE, Fortenberry JD, et al. Pediatric severe sepsis: current trends and outcomes from the Pediatric Health Information Systems database. Pediatr Crit Care Med. 2014 Nov;15(9):828-38. 摘要

18. Weiss SL, Fitzgerald JC, Pappachan J, et al. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med. 2015 May 15;191(10):1147-57.全文  摘要

19. Kissoon N, Uyeki TM. Sepsis and the global burden of disease in children. JAMA Pediatr. 2016 Feb;170(2):107-8. 摘要

20. Greenhow TL, Hung YY, Herz AM. Changing epidemiology of bacteremia in infants aged 1 week to 3 months. Pediatrics. 2012 Mar;129(3):e590-6. 摘要

21. Puopolo KM, Benitz WE, Zaoutis TE, et al. Management of neonates born at ≥35 0/7 weeks' gestation with suspected or proven early-onset bacterial sepsis. Pediatrics. 2018 Dec;142(6):.全文  摘要

22. Schrag SJ, Farley MM, Petit S, et al. Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014. Pediatrics. 2016 Dec;138(6):.全文  摘要

23. Stoll BJ, Puopolo KM, Hansen NI, et al. Early-onset neonatal sepsis 2015 to 2017, the rise of Escherichia coli, and the need for novel prevention strategies. JAMA Pediatr. 2020 Jul 1;174(7):e200593.全文  摘要

24. Soeorg H, Huik K, Parm U, et al. Genetic relatedness of coagulase-negative Staphylococci from gastrointestinal tract and blood of preterm neonates with late-onset sepsis. Pediatr Infect Dis J. 2013 Apr;32(4):389-93. 摘要

25. Stoll BJ, Gordon T, Korones SB, et al. Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 1996 Jul;129(1):63-71. 摘要

26. Randolph AG, McCulloh RJ. Pediatric sepsis: important considerations for diagnosing and managing severeinfections in infants, children, and adolescents. Virulence. 2014 Jan 1;5(1):179-89.全文  摘要

27. UK Health Security Agency. Group A streptococcal infections: activity during the 2022 to 2023 season. 2023 [internet publication].全文

28. Lee CY, Chen PY, Huang FL, et al. Microbiologic spectrum and susceptibility pattern of clinical isolates from the pediatric intensive care unit in a single medical center - 6 years' experience. J Microbiol Immunol Infect. 2009 Apr;42(2):160-5. 摘要

29. Lee GM. Preventing infections in children and adults with asplenia. Hematology Am Soc Hematol Educ Program. 2020 Dec 4;2020(1):328-335.全文  摘要

30. AlFawaz T, Alzumar O, AlShahrani D, et al. Severity of Salmonella infection among sickle cell diseases pediatric patients: Description of the infection pattern. Int J Pediatr Adolesc Med. 2019 Sep;6(3):115-117.全文  摘要

31. Olupot-Olupot P, Engoru C, Nteziyaremye J, et al. The clinical spectrum of severe childhood malaria in Eastern Uganda. Malar J. 2020 Sep 3;19(1):322.全文  摘要

32. Gotts JE, Matthay MA. Sepsis: pathophysiology and clinical management. BMJ. 2016 May 23;353:i1585.全文  摘要

33. Hack CE, Zeerleder S. The endothelium in sepsis. Crit Care Med. 2001 Jul;29(7 suppl):S21-7. 摘要

34. Pathan N, Hemingway CA, Alizadeh AA, et al. Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet. 2004 Jan 17;363(9404):203-9. 摘要

35. Bantel H, Schulze-Osthoff K. Cell death in sepsis. Crit Care. 2009;13(4):173.全文  摘要

36. Brown GC, Borutaite V. Nitric oxide and mitochondrial respiration in the heart. Cardiovasc Res. 2007 Jul 15;75(2):283-90.全文  摘要

37. Singer M. The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence. 2014 Jan 1;5(1):66-72.全文  摘要

38. Bone RC, Grodzin CJ, Balk RA. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest. 1997 Jul;112(1):235-43. 摘要

39. Munford RS, Pugin J. Normal responses to injury prevent systemic inflammation and can be immunosuppressive. Am J Respir Crit Care Med. 2001 Feb;163(2):316-21.全文  摘要

40. Peters M, Petros A, Dixon G, et al. Acquired immunoparalysis in paediatric intensive care: prospective observational study. BMJ. 1999 Sep 4;319(7210):609-10.全文  摘要

41. Adib-Conquy M, Cavaillon JM. Compensatory anti-inflammatory response syndrome. Thromb Haemost. 2009 Jan;101(1):36-47. 摘要

42. Remick DG. Pathophysiology of sepsis. Am J Pathol. 2007 May;170(5):1435-44.全文  摘要

43. Yao TC, Wang JY, Chang SM, et al. Association of Oral Corticosteroid Bursts With Severe Adverse Events in Children. JAMA Pediatr. 2021 Jul 1;175(7):723-729.全文  摘要

44. Feudtner C, Christakis DA, Connell FA. Pediatric deaths attributable to complex chronic conditions: a population-based study of Washington State, 1980-1997. Pediatrics. 2000 Jul;106(1 Pt 2):205-9.全文  摘要

45. Fraser LK, Miller M, Hain R, et al. Rising national prevalence of life-limiting conditions in children in England. Pediatrics. 2012 Apr;129(4):e923-9.全文  摘要

46. Ge WJ, Mirea L, Yang J, et al; Canadian Neonatal Network. Prediction of neonatal outcomes in extremely preterm neonates. Pediatrics. 2013 Oct;132(4):e876-85. 摘要

47. Bateman SL, Seed PC. Procession to pediatric bacteremia and sepsis: covert operations and failures in diplomacy. Pediatrics. 2010 Jul;126(1):137-50.全文  摘要

48. Polin RA, Denson S, Brady MT; Committee on Fetus and Newborn; Committee on Infectious Diseases. Epidemiology and diagnosis of health care-associated infections in the NICU. Pediatrics. 2012 Apr;129(4):e1104-9.全文  摘要

49. Soman M, Green B, Daling J. Risk factors for early neonatal sepsis. Am J Epidemiol. 1985 May;121(5):712-9. 摘要

50. Herbst A, Källén K. Time between membrane rupture and delivery and septicemia in term neonates. Obstet Gynecol. 2007 Sep;110(3):612-8. 摘要

51. Sohn AH, Garrett DO, Sinkowitz-Cochran RL, et al; Pediatric Prevention Network. Prevalence of nosocomial infections in neonatal intensive care unit patients: results from the first national point-prevalence survey. J Pediatr. 2001 Dec;139(6):821-7. 摘要

52. National Institute for Health and Care Excellence. Sepsis: recognition, diagnosis and early management. Sep 2017 [internet publication].全文

53. Levine MM, Campbell JD, Kotloff KL. Overview of vaccines and immunisation. Br Med Bull. 2002;62:1-13.全文  摘要

54. Department of Health (UK). Meningococcal B vaccination programme to be introduced. Mar 2014 [internet publication].全文

55. Centers for Disease Control and Prevention. Meningococcal outbreaks. May 2019 [internet publication].全文

56. Wodi AP, Murthy N, Bernstein H, et al. Advisory Committee on Immunization Practices recommended immunization schedule for children and adolescents aged 18 years or younger - United States, 2022. MMWR Morb Mortal Wkly Rep. 2022 Feb 18;71(7):234-7.全文  摘要

57. World Health Organization. Decade of vaccines - global vaccine action plan 2011-2020. 2013 [internet publication].全文

58. Bion J, Richardson A, Hibbert P, et al; Matching Michigan Collaboration & Writing Committee. 'Matching Michigan': a 2-year stepped interventional programme to minimise central venous catheter-blood stream infections in intensive care units in England. BMJ Qual Saf. 2013 Feb;22(2):110-23.全文  摘要

59. Centers for Disease Control and Prevention. Recommendations for prevention and control of infections in neonatal intensive care unit patients: central line-associated blood stream infections. Feb 2022 [internet publication].全文

60. de Souza DC, Barreira ER, Faria LS. The epidemiology of sepsis in childhood. Shock. 2017 Jan;47(1S suppl 1):2-5. 摘要

61. Weiss SL, Parker B, Bullock ME, et al. Defining pediatric sepsis by different criteria: discrepancies in populations and implications for clinical practice. Pediatr Crit Care Med. 2012 Jul;13(4):e219-26. 摘要

62. Daniels R, Nutbeam T, McNamara G, et al. The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study. Emerg Med J. 2011 Jun;28(6):507-12.全文  摘要

63. Pantell RH, Roberts KB, Adams WG, et al. Evaluation and management of well-appearing febrile infants 8 to 60 days old. Pediatrics. 2021 Aug;148(2):.全文  摘要

64. Kim F, Polin RA, Hooven TA. Neonatal sepsis. BMJ. 2020 Oct 1;371:m3672.全文  摘要

65. Garcia-Prats JA, Cooper TR, Schneider VF, et al. Rapid detection of microorganisms in blood cultures of newborn infants utilizing an automated blood culture system. Pediatrics. 2000 Mar;105(3 Pt 1):523-7. 摘要

66. Kayange N, Kamugisha E, Mwizamholya DL, et al. Predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, Mwanza-Tanzania. BMC Pediatr. 2010 Jun 4;10:39.全文  摘要

67. Pammi M, Flores A, Versalovic J, et al. Molecular assays for the diagnosis of sepsis in neonates. Cochrane Database Syst Rev. 2017 Feb 25;(2):CD011926.全文  摘要

68. Borthwick EMJ, Hill CJ, Rabindranath KS, et al. High-volume haemofiltration for sepsis in adults. Cochrane Database Syst Rev. 2017 Jan 31;(1):CD008075.全文  摘要

69. Garcia-Alvarez M, Marik P, Bellomo R. Sepsis-associated hyperlactatemia. Crit Care. 2014 Sep 9;18(5):503.全文  摘要

70. Levi M, Toh CH, Thachil J, et al. Guidelines for the diagnosis and management of disseminated intravascular coagulation. Br J Haematol. 2009 Apr;145(1):24-33.全文  摘要

71. Pontrelli G, De Crescenzo F, Buzzetti R, et al. Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis. BMC Infect Dis. 2017 Apr 24;17(1):302.全文  摘要

72. Trippella G, Galli L, De Martino M, et al. Procalcitonin performance in detecting serious and invasive bacterial infections in children with fever without apparent source: a systematic review and meta-analysis. Expert Rev Anti Infect Ther. 2017 Nov;15(11):1041-1057.全文  摘要

73. Downes KJ, Fitzgerald JC, Weiss SL. Utility of procalcitonin as a biomarker for sepsis in children. J Clin Microbiol. 2020 Jun 24;58(7):.全文  摘要

74. Kaplan JM, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med. 2011 Mar;12(2):165-73.全文  摘要

75. Casado-Flores J, Blanco-Quirós A, Asensio J, et al. Serum procalcitonin in children with suspected sepsis: a comparison with C-reactive protein and neutrophil count. Pediatr Crit Care Med. 2003 Apr;4(2):190-5. 摘要

76. Brown JVE, Meader N, Cleminson J, et al. C-reactive protein for diagnosing late-onset infection in newborn infants. Cochrane Database Syst Rev. 2019 Jan 14;1:CD012126.全文  摘要

77. Stocker M, van Herk W, El Helou S, et al. Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns). Lancet. 2017 Aug 26;390(10097):871-81. 摘要

78. Dai J, Jiang W, Min Z, et al. Neutrophil CD64 as a diagnostic marker for neonatal sepsis: meta-analysis. Adv Clin Exp Med. 2017 Mar-Apr;26(2):327-32.全文  摘要

79. Shahkar L, Keshtkar A, Mirfazeli A, et al. The role of IL-6 for predicting neonatal sepsis: a systematic review and meta-analysis. Iran J Pediatr. 2011 Dec;21(4):411-7.全文  摘要

80. Shi J, Tang J, Chen D. Meta-analysis of diagnostic accuracy of neutrophil CD64 for neonatal sepsis. Ital J Pediatr. 2016 Jun 7;42(1):57.全文  摘要

81. Zhou M, Cheng S, Yu J, et al. Interleukin-8 for diagnosis of neonatal sepsis: a meta-analysis. PLoS One. 2015 May 21;10(5):e0127170.全文  摘要

82. Sun B, Liang LF, Li J, et al. A meta-analysis of interleukin-6 as a valid and accurate index in diagnosing early neonatal sepsis. Int Wound J. 2019 Apr;16(2):527-533.全文  摘要

83. National Institute for Health and Care Excellence. Fever in under 5s. Jul 2014 [internet publication].全文

84. National Institute for Health and Care Excellence. Neonatal infection: antibiotics for prevention and treatment. Apr 2021 [internet publication].全文

85. Martin K, Weiss SL. Initial resuscitation and management of pediatric septic shock. Minerva Pediatr. 2015 Apr;67(2):141-58.全文  摘要

86. Macrae D, Grieve R, Allen E, et al. A randomized trial of hyperglycemic control in pediatric intensive care. N Engl J Med. 2014 Jan 9;370(2):107-18.全文  摘要

87. Deep A, Sagar H, Goonasekera C, et al. Evolution of acute kidney injury and its association with systemic hemodynamics in children with fluid-refractory septic shock. Crit Care Med. 2018 Jul;46(7):e677-83. 摘要

88. Liguoro I, Pilotto C, Bonanni M, et al. SARS-COV-2 infection in children and newborns: a systematic review. Eur J Pediatr. 2020 Jul;179(7):1029-46.全文  摘要

89. Salazar ML, Eiland LS. Intrathecal baclofen withdrawal resembling serotonin syndrome in an adolescent boy with cerebral palsy. Pediatr Emerg Care. 2008 Oct;24(10):691-3. 摘要

90. Vergnano S, Sharland M, Kazembe P, et al. Neonatal sepsis: an international perspective. Arch Dis Child Fetal Neonatal Ed. 2005 May;90(3):F220-4.全文  摘要

91. Koenig JM, Keenan WJ. Group B streptococcus and early-onset sepsis in the era of maternal prophylaxis. Pediatr Clin North Am. 2009 Jun;56(3):689-708.全文  摘要

92. Centers for Disease Control and Prevention (CDC). Perinatal group B streptococcal disease after universal screening recommendations - United States, 2003-2005. MMWR Morb Mortal Wkly Rep. 2007 Jul 20;56(28):701-5.全文  摘要

93. Prevention of Group B Streptococcal Early-Onset Disease in Newborns: ACOG Committee Opinion, Number 797. Obstet Gynecol. 2020 Feb;135(2):e51-e72.全文  摘要

94. Pearson GA, ed. Why children die: a pilot study 2006; England (South West, North East and West Midlands), Wales and Northern Ireland. London: CEMACH; 2008.

95. Parliamentary and Health Service Ombudsman. Time to act: severe sepsis - rapid diagnosis and treatment saves lives. 2013 [internet publication].全文

96. Davis AL, Carcillo JA, Aneja RK, et al. American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock. Crit Care Med. 2017 Jun;45(6):1061-93.全文  摘要

97. Paul R, Neuman MI, Monuteaux MC, et al. Adherence to PALS sepsis guidelines and hospital length of stay. Pediatrics. 2012 Aug;130(2):e273-80.全文  摘要

98. Paul R, Melendez E, Stack A, et al. Improving adherence to PALS septic shock guidelines. Pediatrics. 2014 May;133(5):e1358-66.全文  摘要

99. Larsen GY, Mecham N, Greenberg R. An emergency department septic shock protocol and care guideline for children initiated at triage. Pediatrics. 2011 Jun;127(6):e1585-92. 摘要

100. Cruz AT, Perry AM, Williams EA, et al. Implementation of goal-directed therapy for children with suspected sepsis in the emergency department. Pediatrics. 2011 Mar;127(3):e758-66. 摘要

101. Chong SL, Ong GY, Venkataraman A, et al. The golden hours in paediatric septic shock--current updates and recommendations. Ann Acad Med Singapore. 2014 May;43(5):267-74. 摘要

102. Shekerdemian L, Bohn D. Cardiovascular effects of mechanical ventilation. Arch Dis Child. 1999 May;80(5):475-80.全文  摘要

103. Akech S, Ledermann H, Maitland K. Choice of fluids for resuscitation in children with severe infection and shock: systematic review. BMJ. 2010 Sep 2;341:c4416.全文  摘要

104. Carcillo JA. Intravenous fluid choices in critically ill children. Curr Opin Crit Care. 2014 Aug;20(4):396-401. 摘要

105. Medeiros DN, Ferranti JF, Delgado AF, et al. Colloids for the initial management of severe sepsis and septic shock in pediatric patients: a systematic review. Pediatr Emerg Care. 2015 Nov;31(11):e11-6. 摘要

106. Food and Drug Administration. Labeling changes on mortality, kidney injury, and excess bleeding with hydroxyethyl starch products. Jul 2021 [internet publication].全文

107. European Medicines Agency. PRAC recommends suspending hydroxyethyl-starch solutions for infusion from the market. Feb 2022 [internet publication].全文

108. Zarychanski R, Abou-Setta AM, Turgeon AF, et al. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA. 2013 Feb 20;309(7):678-88.全文  摘要

109. Medicines and Healthcare Regulatory Agency. Drug safety update: Hydroxyethyl starch intravenous Infusions. Dec 2014 [internet publication].全文

110. Lewis SR, Pritchard MW, Evans DJ, et al. Colloids versus crystalloids for fluid resuscitation in critically ill people. Cochrane Database Syst Rev. 2018 Aug 3;8:CD000567.全文  摘要

111. Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021 Nov 1;49(11):e1063-143.全文  摘要

112. Maitland K, Kiguli S, Opoka RO, et al. Mortality after fluid bolus in African children with severe infection. N Engl J Med. 2011 Jun 30;364(26):2483-95.全文  摘要

113. Li D, Li X, Cui W, et al. Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock. Cochrane Database Syst Rev. 2018 Dec 10;12:CD010593.全文  摘要

114. National Institute for Health and Care Excellence. Intravenous fluid therapy in children and young people in hospital. Jun 2020 [internet publication].全文

115. Bagshaw SM, Brophy PD, Cruz D, et al. Fluid balance as a biomarker: impact of fluid overload on outcome in critically ill patients with acute kidney injury. Crit Care. 2008;12(4):169.全文  摘要

116. Boschee ED, Cave DA, Garros D, et al. Indications and outcomes in children receiving renal replacement therapy in pediatric intensive care. J Crit Care. 2014 Feb;29(1):37-42. 摘要

117. Academy of Medical Royal Colleges. Statement on the initial antimicrobial treatment of sepsis V2.0. Oct 2022 [internet publication].全文

118. Nauclér P, Huttner A, van Werkhoven CH, et al. Impact of time to antibiotic therapy on clinical outcome in patients with bacterial infections in the emergency department: implications for antimicrobial stewardship. Clin Microbiol Infect. 2021 Feb;27(2):175-81.全文  摘要

119. Klompas M, Calandra T, Singer M. Antibiotics for Sepsis-Finding the Equilibrium. JAMA. 2018 Oct 9;320(14):1433-4. 摘要

120. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006 Jun;34(6):1589-96. 摘要

121. Wang XD, Huo XM, Xu MX, et al. Clinical research of timing of application of antibiotics in septic shock of pediatric patients [in Chinese]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013 Apr;25(4):207-10. 摘要

122. Weiss SL, Fitzgerald JC, Balamuth F, et al. Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med. 2014 Nov;42(11):2409-17.全文  摘要

123. Klein Klouwenberg PM, Cremer OL, van Vught LA, et al. Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: a cohort study. Crit Care. 2015 Sep 7;19(1):319.全文  摘要

124. Heffner AC, Horton JM, Marchick MR, et al. Etiology of illness in patients with severe sepsis admitted to the hospital from the emergency department. Clin Infect Dis. 2010 Mar 15;50(6):814-20.全文  摘要

125. Strich JR, Heil EL, Masur H. Considerations for empiric antimicrobial therapy in sepsis and septic shock in an era of antimicrobial resistance. J Infect Dis. 2020 Jul 21;222(suppl 2):S119-31.全文  摘要

126. Korang SK, Safi S, Nava C, et al. Antibiotic regimens for early-onset neonatal sepsis. Cochrane Database Syst Rev. 2021 May 17;5:CD013837.全文  摘要

127. Simmons ML, Durham SH, Carter CW. Pharmacological management of pediatric patients with sepsis. AACN Adv Crit Care. 2012 Oct-Dec;23(4):437-48. 摘要

128. National Institute for Health and Care Excellence. Neutropenic sepsis: prevention and management in people with cancer. Sep 2012 [internet publication].全文

129. European Medicines Agency. Quinolone- and fluoroquinolone-containing medicinal products. Nov 2018 [internet publication].全文

130. Medicines and Healthcare products Regulatory Agency. Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects. Mar 2019 [internet publication].全文

131. US Food and Drug Administration. FDA drug safety communication: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. Jul 2016 [internet publication].全文

132. US Food and Drug Administration. FDA drug safety communication. FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients. Dec 2018 [internet publication].全文

133. US Food and Drug Administration. FDA drug safety communication. FDA reinforces safety information about serious low blood sugar levels and mental health side effects with fluoroquinolone antibiotics; requires label changes. Jul 2018 [internet publication].全文

134. Ninis N, Phillips C, Bailey L, et al. The role of healthcare delivery in the outcome of meningococcal disease in children: case-control study of fatal and non-fatal cases. BMJ. 2005 Jun 25;330(7506):1475.全文  摘要

135. Sanfilippo F, La Rosa V, Grasso C, et al. Echocardiographic parameters and mortality in pediatric sepsis: a systematic review and m,eta-analysis. Pediatr Crit Care Med. 2021 Mar 1;22(3):251-61. 摘要

136. Ozturk MA, Gunes T, Koklu E, et al. Oral nystatin prophylaxis to prevent invasive candidiasis in neonatal intensive care unit. Mycoses. 2006 Nov;49(6):484-92. 摘要

137. Hsieh E, Smith PB, Jacqz-Aigrain E, et al. Neonatal fungal infections: when to treat? Early Hum Dev. 2012 May;88(suppl 2):S6-10.全文  摘要

138. El-Wiher N, Cornell TT, Kissoon N, et al. Management and treatment guidelines for sepsis in pediatric patients. Open Inflamm J. 2011 Oct 7;4(suppl 1-M11):101-9.全文  摘要

139. Malosh RE, Martin ET, Heikkinen T, et al. Efficacy and safety of oseltamivir in children: Systematic review and individual patient data meta-analysis of randomized controlled trials. Clin Infect Dis. 2018 May 2;66(10):1492-1500.全文  摘要

140. Karam O, Tucci M, Ducruet T, et al. Red blood cell transfusion thresholds in pediatric patients with sepsis. Pediatr Crit Care Med. 2011 Sep;12(5):512-8. 摘要

141. Holst LB, Haase N, Wetterslev J, et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med. 2014 Oct 9;371(15):1381-91.全文  摘要

142. Zimmerman JJ. A history of adjunctive glucocorticoid treatment for pediatric sepsis: moving beyond steroid pulp fiction toward evidence-based medicine. Pediatr Crit Care Med. 2007 Nov;8(6):530-9. 摘要

143. Aneja R, Carcillo JA. What is the rationale for hydrocortisone treatment in children with infection-related adrenal insufficiency and septic shock? Arch Dis Child. 2007 Feb;92(2):165-9.全文  摘要

144. Ohlsson A, Lacy JB. Intravenous immunoglobulin for suspected or proven infection in neonates. Cochrane Database Syst Rev. 2015 Mar 27;(3):CD001239.全文  摘要

145. Alejandria MM, Lansang MD, Dans LF, et al. Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. Cochrane Database Syst Rev. 2013 Sep 16;(9):CD001090.全文  摘要

146. INIS Collaborative Group, Brocklehurst P, Farrell B, King A, et al. Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med. 2011 Sep 29;365(13):1201-11.全文  摘要

147. Parks T, Wilson C, Curtis N, et al. Polyspecific intravenous immunoglobulin in clindamycin-treated patients with streptococcal toxic shock syndrome: A systematic review and meta-analysis. Clin Infect Dis. 2018 Oct 15;67(9):1434-1436.全文  摘要

148. Marlow N, Morris T, Brocklehurst P, et al. A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: outcomes at 2 years. Arch Dis Child Fetal Neonatal Ed. 2013 Jan;98(1):F46-53.全文  摘要

149. Carr R, Brocklehurst P, Doré CJ, et al. Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial. Lancet. 2009 Jan 17;373(9659):226-33. 摘要

150. Korang SK, Safi S, Nava C, et al. Antibiotic regimens for late-onset neonatal sepsis. Cochrane Database Syst Rev. 2021 May 8;5:CD013836.全文  摘要

151. Harris E, Schulzke SM, Patole SK. Pentoxifylline in preterm neonates: a systematic review. Paediatr Drugs. 2010 Oct 1;12(5):301-11. 摘要

152. Pammi M, Haque KN. Pentoxifylline for treatment of sepsis and necrotizing enterocolitis in neonates. Cochrane Database Syst Rev. 2015 Mar 9;(3):CD004205.全文  摘要

153. Adel M, Awad HA, Abdel-Naim AB, et al. Effects of pentoxifylline on coagulation profile and disseminated intravascular coagulation incidence in Egyptian septic neonates. J Clin Pharm Ther. 2010 Jun;35(3):257-65. 摘要

154. Skarda DE, Mulier KE, Myers DE, et al. Dynamic near-infrared spectroscopy measurements in patients with severe sepsis. Shock. 2007 Apr;27(4):348-53. 摘要

155. Mesquida J, Masip J, Gili G, et al. Thenar oxygen saturation measured by near infrared spectroscopy as a noninvasive predictor of low central venous oxygen saturation in septic patients. Intensive Care Med. 2009 Jun;35(6):1106-9. 摘要

156. Lima A, van Bommel J, Jansen TC, et al. Low tissue oxygen saturation at the end of early goal-directed therapy is associated with worse outcome in critically ill patients. Crit Care. 2009;13(suppl 5):S13.全文  摘要

157. Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time? Crit Care Med. 1998 Dec;26(12):2078-86. 摘要

158. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001 Jul;29(7):1303-10. 摘要

159. Watson RS, Carcillo JA. Scope and epidemiology of pediatric sepsis. Pediatr Crit Care Med. 2005 May;6(3 suppl):S3-5. 摘要

160. Fiser RT, West NK, Bush AJ, et al. Outcome of severe sepsis in pediatric oncology patients. Pediatr Crit Care Med. 2005 Sep;6(5):531-6. 摘要

161. Inwald DP, Tasker RC, Peters MJ, et al; Paediatric Intensive Care Society Study Group (PICS-SG). Emergency management of children with severe sepsis in the United Kingdom: the results of the Paediatric Intensive Care Society sepsis audit. Arch Dis Child. 2009 May;94(5):348-53. 摘要

162. Han YY, Carcillo JA, Dragotta MA, et al. Early reversal of pediatric-neonatal septic shock by community physicians is associated with improved outcome. Pediatrics. 2003 Oct;112(4):793-9. 摘要

163. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med. 1999 Jan 21;340(3):207-14. 摘要

164. Hollenberg SM, Ahrens TS, Annane D, et al. Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med. 2004 Sep;32(9):1928-48. 摘要

165. Haller S, Deindl P, Cassini A, et al. Neurological sequelae of healthcare-associated sepsis in very-low-birthweight infants: umbrella review and evidence-based outcome tree. Euro Surveill. 2016;21(8):30143. 摘要

166. Kukreti V, Shamim M, Khilnani P. Intensive care unit acquired weakness in children: critical illness neuropathy and myopathy. Indian J Crit Care Med. 2014 Feb;18(2):95-101.全文  摘要

167. Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med. 2011 Jan 20;364(3):255-64.全文  摘要

168. Drop LJ, Laver MB. Low plasma ionized calcium and response to calcium therapy in critically ill man. Anesthesiology. 1975 Sep;43(3):300-6. 摘要

169. van de Wetering MD, van Woensel JB, Lawrie TA. Prophylactic antibiotics for preventing Gram positive infections associated with long-term central venous catheters in oncology patients. Cochrane Database Syst Rev. 2013 Nov 25;(11):CD003295.全文  摘要

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