腓骨肌萎缩症 (Charcot-Marie-Tooth, CMT) 又被称为遗传性运动感觉神经病 (hereditary motor and sensory neuropathy, HMSN)，包含了大部分的遗传性周围神经病变。神经传导检查指出患者的运动及感觉神经通常都将受累，且出现对称性改变。神经传导可以是脱髓鞘性（在尺神经中的传导速度＜38 m/s），或是轴突性（振幅减小，速度＞38 m/s），或者兼具两者。CMT 是一种遗传异质性疾病，已知有超过 90 种基因及位点在发生突变时会引起该病。
Clinical Assistant Professor (Affiliated)
Certified Genetic Counselor
Stanford Health Care
CES has been given honoraria by the Invitae Corporation for giving a webinar on CMT, and honoraria by the National Society of Genetic Counselors for giving a webinar on neuromuscular conditions. CES is an unpaid member of the Charcot-Marie-Tooth Association Advisory Board. CES has professional relationships with some authors of works found in this monograph.
Professor of Neurology
RAL is a consultant for Pharnext (currently doing a clinical trial in Charcot-Marie-Tooth disease), CSL Behring, and Axelacare. He is on the Medical Advisory Board for GBS-CIDP Foundation, MGFA, and MGF of Ca. He has done expert testimony related to GBS, CIDP, and other neurologic disorders, and educational talks for AAN, AANEM, CSL Behring, and Optioncare. With the exception of Pharnext, none of these relationships are related to Charcot-Marie-Tooth disease. RAL is an author of a number of references cited in this monograph.
Associate Professor (Doc)
Head of the DNA Laboratory
Department of Child Neurology
Second School of Medicine
and University Hospital Motol
PS declares that he has no competing interests.
Department of Neurology and Molecular and Human Genetics
Baylor College of Medicine
KS is an author of a reference cited in this monograph.