Summary
Definition
病史和体格检查
关键诊断因素
- presence of risk factors
- pain
- oedema or swelling
- skin discoloration
- crepitus (gas gangrene)
其他诊断因素
- diminished pedal pulses and ankle-brachial index (ischaemic gangrene)
- low-grade fever and chills (infectious gangrene)
危险因素
- diabetes mellitus
- atherosclerosis (ischaemic gangrene)
- smoking (ischaemic gangrene)
- renal disease
- drug and alcohol abuse
- malignancy
- trauma or abdominal surgery (infectious gangrene)
- contaminated wounds (infectious gangrene)
- immunosuppression (infectious gangrene)
- malnutrition (infectious gangrene)
- hypercoagulable states (ischaemic gangrene)
- prolonged application of tourniquets (ischaemic gangrene)
- community-acquired MRSA
诊断性检查
首要检查
- FBC
- comprehensive metabolic panel
- serum LDH
- coagulation panel
- blood cultures
- serum CRP
- plain x-rays
- CT of affected site
- MRI of affected site
- Doppler ultrasonography
需考虑的检查
- surgical exploration and skin biopsy
- CT angiography
- magnetic resonance angiography (MRA)
- CT chest and abdomen
- antinuclear antibodies (ANA), lupus anticoagulant, anticardiolipin, and anti beta2 glycoprotein-1 antibodies
- serum cold agglutinins
- serum cryofibrinogens
- plasma cryoglobulin
治疗流程
necrotising fasciitis awaiting confirmation of microbial culture and sensitivity results
confirmed type I necrotising fasciitis (polymicrobial)
confirmed type II necrotising fasciitis (monomicrobial)
gas gangrene
ischaemic gangrene
撰稿人
作者
Jason Jacob, MD
Attending Physician
Assistant Director
Department of Medicine
Hartford Hospital
Hartford
CT
利益声明
JJ declares that he has no competing interests.
Robert J. Gionfriddo, DO
Assistant Director
Department of Medicine
Hartford Hospital
Hartford
CT
Disclosures
RJG declares that he has no competing interests.
Acknowledgements
Dr Jason Jacob and Dr Robert J. Gionfriddo would like to gratefully acknowledge Dr William Tennant, Dr Badr Aljabri, Dr Mohammed Al-Omran, Dr Jose Contreras-Ruiz, and Dr Iris Galvan-Martinez, the previous contributors to this topic.
Disclosures
WT, BA, MA, JC, and IG declare that they have no competing interests.
Peer reviewers
Meryl Davis, MD
Consultant Vascular Surgeon
Royal Free Hampstead
London
UK
Disclosures
MD declares that she has no competing interests.
Charles Fox, MD
Vascular Surgeon
Department of Surgery
Walter Reed Army Medical Center
Washington
DC
Disclosures
CF declares that he has no competing interests.
Differentials
- Staphylococcal skin lesions
- Erysipelas
- Cellulitis
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