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Last reviewed: 13 Feb 2025
Last updated: 07 Aug 2020

Summary

Definition

病史和体格检查

关键诊断因素

  • presence of risk factors
  • pain
  • oedema or swelling
  • skin discoloration
  • crepitus (gas gangrene)
完整详情

其他诊断因素

  • diminished pedal pulses and ankle-brachial index (ischaemic gangrene)
  • low-grade fever and chills (infectious gangrene)
完整详情

危险因素

  • diabetes mellitus
  • atherosclerosis (ischaemic gangrene)
  • smoking (ischaemic gangrene)
  • renal disease
  • drug and alcohol abuse
  • malignancy
  • trauma or abdominal surgery (infectious gangrene)
  • contaminated wounds (infectious gangrene)
  • immunosuppression (infectious gangrene)
  • malnutrition (infectious gangrene)
  • hypercoagulable states (ischaemic gangrene)
  • prolonged application of tourniquets (ischaemic gangrene)
  • community-acquired MRSA
完整详情

诊断性检查

首要检查

  • FBC
  • comprehensive metabolic panel
  • serum LDH
  • coagulation panel
  • blood cultures
  • serum CRP
  • plain x-rays
  • CT of affected site
  • MRI of affected site
  • Doppler ultrasonography
完整详情

需考虑的检查

  • surgical exploration and skin biopsy
  • CT angiography
  • magnetic resonance angiography (MRA)
  • CT chest and abdomen
  • antinuclear antibodies (ANA), lupus anticoagulant, anticardiolipin, and anti beta2 glycoprotein-1 antibodies
  • serum cold agglutinins
  • serum cryofibrinogens
  • plasma cryoglobulin
完整详情

治疗流程

初步治疗

necrotising fasciitis awaiting confirmation of microbial culture and sensitivity results

急症处理

confirmed type I necrotising fasciitis (polymicrobial)

confirmed type II necrotising fasciitis (monomicrobial)

gas gangrene

ischaemic gangrene

撰稿人

作者

Jason Jacob, MD

Attending Physician

Assistant Director

Department of Medicine

Hartford Hospital

Hartford

CT

利益声明

JJ declares that he has no competing interests.

Robert J. Gionfriddo, DO

Assistant Director

Department of Medicine

Hartford Hospital

Hartford

CT

Disclosures

RJG declares that he has no competing interests.

Acknowledgements

Dr Jason Jacob and Dr Robert J. Gionfriddo would like to gratefully acknowledge Dr William Tennant, Dr Badr Aljabri, Dr Mohammed Al-Omran, Dr Jose Contreras-Ruiz, and Dr Iris Galvan-Martinez, the previous contributors to this topic.

Disclosures

WT, BA, MA, JC, and IG declare that they have no competing interests.

Peer reviewers

Meryl Davis, MD

Consultant Vascular Surgeon

Royal Free Hampstead

London

UK

Disclosures

MD declares that she has no competing interests.

Charles Fox, MD

Vascular Surgeon

Department of Surgery

Walter Reed Army Medical Center

Washington

DC

Disclosures

CF declares that he has no competing interests.

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