Список литературы

Основные статьи

Cierny G 3rd, Mader JT, Penninck JJ. A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res. 2003 Sep;(414):7-24. Аннотация

National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. October 2019 [internet publication].Полный текст

Mader JT, Calhoun JH, Lazzarini L. Adult long bone osteomyelitis. In: Mader JT, Calhoun JH, eds. Musculoskeletal infections. New York, NY: Marcel Dekker; 2003:149-82.

Pineda C, Vargas A, Rodriguez AV. Imaging of osteomyelitis: current concepts. Infect Dis Clin North Am. 2006 Dec;20(4):789-825. Аннотация

Wang GL, Zhao K, Liu ZF, et al. A meta-analysis of fluorodeoxyglucose-positron emission tomography versus scintigraphy in the evaluation of suspected osteomyelitis. Nucl Med Commun. 2011 Dec;32(12):1134-42. Аннотация

Статьи, указанные как источники

1. Cierny G 3rd, Mader JT, Penninck JJ. A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res. 2003 Sep;(414):7-24. Аннотация

2. Hotchen AJ, Dudareva M, Ferguson JY, et al. The BACH classification of long bone osteomyelitis. Bone Joint Res. 2019 Oct;8(10):459-68.Полный текст  Аннотация

3. Hotchen AJ, Dudareva M, Corrigan RA, et al. Can we predict outcome after treatment of long bone osteomyelitis? Bone Joint J. 2020 Nov;102-B(11):1587-96. Аннотация

4. Glaudemans AWJM, Jutte PC, Cataldo MA, et al. Consensus document for the diagnosis of peripheral bone infection in adults: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement). Eur J Nucl Med Mol Imaging. 2019 Apr;46(4):957-70.Полный текст  Аннотация

5. Kremers HM, Nwojo ME, Ransom JE, et al. Trends in the epidemiology of osteomyelitis: a population-based study, 1969 to 2009. J Bone Joint Surg Am. 2015 May 20;97(10):837-45.Полный текст  Аннотация

6. Beronius M, Bergman B, Andersson R. Vertebral osteomyelitis in Goteborg, Sweden: a retrospective study of patients during 1990-95. Scand J Infect Dis. 2001;33(7):527-32. Аннотация

7. Broner FA, Garland DE, Zigler JE. Spinal infections in the immunocompromised host. Orthop Clin North Am. 1996 Jan;27(1):37-46. Аннотация

8. Saavedra-Lozano J, Falup-Pecurariu O, Faust SN, et al. Bone and joint infections. Pediatr Infect Dis J. 2017 Aug;36(8):788-99.Полный текст  Аннотация

9. Samara E, Spyropoulou V, Tabard-Fougère A, et al. Kingella kingae and osteoarticular infections. Pediatrics. 2019 Dec;144(6):e20191509.Полный текст  Аннотация

10. Le Saux N. Diagnosis and management of acute osteoarticular infections in children. [in fre]. Paediatr Child Health. 2018 Aug;23(5):336-43.Полный текст  Аннотация

11. Stewart PS, Costerton JW. Antibiotic resistance of bacteria in biofilms. Lancet. 2001 Jul 14;358(9276):135-8. Аннотация

12. Gristina AG, Costerton JW. Bacterial adherence and the glycocalyx and their role in musculoskeletal infection. Orthop Clin North Am. 1984 Jul;15(3):517-35. Аннотация

13. Davies DG, Parsek MR, Pearson JP. The involvement of cell-to-cell signals in the development of bacterial biofilm. Science. 1998 Apr 10;280(5361):295-8. Аннотация

14. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science. 1999 May 21;284(5418):1318-22. Аннотация

15. Costerton JW, Lewandowski Z, Caldwell DE, et al. Microbial biofilms. Annu Rev Microbiol. 1995;49:711-45. Аннотация

16. Trampuz A, Zimmerli W. Antimicrobial agents in orthopaedic surgery: prophylaxis and treatment. Drugs. 2006;66(8):1089-105. Аннотация

17. Brady RA, Leid JG, Calhoun JH, et al. Osteomyelitis and the role of biofilms in chronic infection. FEMS Immunol Med Microbiol. 2008 Jan;52(1):13-22. Аннотация

18. Tröbs R, Möritz R, Bühligen U, et al. Changing pattern of osteomyelitis in infants and children. Pediatr Surg Int. 1999 Jul;15(5-6):363-72. Аннотация

19. Wallace WC, Cinat M, Gornick WB, et al. Nosocomial infections in the surgical intensive care unit: a difference between trauma and surgical patients. Am Surg. 1999 Oct;65(10):987-90. Аннотация

20. Ottino G, De Paulis R, Pansini S, et al. Major sternal wound infection after open-heart surgery: a multivariate analysis of risk factors in 2579 consecutive operative procedures. Ann Thorac Surg. 1987 Aug;44(2):173-9. Аннотация

21. Lavery LA, Armstrong DG, Wunderlich RP, et al. Risk factors for foot infections in individuals with diabetes. Diabetes Care. 2006 Jun;29(6):1288-93.Полный текст  Аннотация

22. Expert Panel on Musculoskeletal Imaging., Walker EA, Beaman FD, et al. ACR Appropriateness Criteria® suspected osteomyelitis of the foot in patients with diabetes mellitus. J Am Coll Radiol. 2019 Nov;16(11s):S440-50.Полный текст  Аннотация

23. National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. October 2019 [internet publication].Полный текст

24. Lipsky BA, Senneville É, Abbas ZG, et al. Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update). Diabetes Metab Res Rev. 2020 Mar;36 Suppl 1:e3280.Полный текст  Аннотация

25. Sharkawy AA. Cervicofacial actinomycosis and mandibular osteomyelitis. Infect Dis Clin North Am. 2007 Jun;21(2):543-56. Аннотация

26. Lipsky BA, Berendt AR, Cornia PB, et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012 Jun;54(12):e132-73.Полный текст  Аннотация

27. Calhoun JH, Cantrell J, Cobos J, et al. Treatment of diabetic foot infections: Wagner classification, therapy, and outcome. Foot Ankle. 1988 Dec;9(3):101-6. Аннотация

28. Mitha A, Boulyana M, Hue V, et al; European French-speaking expert group. Consensus in diagnostic definitions for bone or joint infections in children by a Delphi method with European French-speaking experts. Acta Paediatr. 2012 Aug;101(8):e350-6. Аннотация

29. Mader JT, Calhoun JH, Lazzarini L. Adult long bone osteomyelitis. In: Mader JT, Calhoun JH, eds. Musculoskeletal infections. New York, NY: Marcel Dekker; 2003:149-82.

30. Dimaala J, Chaljub G, Oto A, et al. Odontoid osteomyelitis masquerading as a C2 fracture in an 18-month-old male with torticollis: CT and MRI features. Emerg Radiol. 2006 Jul;12(5):234-6. Аннотация

31. McKnight P, Friedman J. Torticollis due to cervical epidural abscess and osteomyelitis. Neurology. 1992 Mar;42(3 Pt 1):696-7. Аннотация

32. Ursprung WM, Kettner NW, Boesch R. Vertebral osteomyelitis: a case report of a patient presenting with acute low back pain. J Manipulative Physiol Ther. 2005 Nov-Dec;28(9):713-8. Аннотация

33. Buoncristiani AM, McCullen G, Shin AY, et al. An unusual cause of low back pain. Osteomyelitis of the spinous process. Spine (Phila Pa 1976). 1998 Apr 1;23(7):839-41. Аннотация

34. Schulak DJ, Rayhack JM, Lippert FG 3rd, et al. The erythrocyte sedimentation rate in orthopaedic patients. Clin Orthop Relat Res. 1982 Jul;(167):197-202. Аннотация

35. Carragee EJ, Kim D, van der Vlugt T, et al. The clinical use of erythrocyte sedimentation rate in pyogenic vertebral osteomyelitis. Spine (Phila Pa 1976). 1997 Sep 15;22(18):2089-93. Аннотация

36. Perry M. Erythrocyte sedimentation rate and C reactive protein in the assessment of suspected bone infection - are they reliable indexes? J R Coll Surg Edinb. 1996 Apr;41(2):116-8. Аннотация

37. Roine I, Faingezicht I, Arguedas A, et al. Serial serum C-reactive protein to monitor recovery from acute hematogenous osteomyelitis in children. Pediatr Infect Dis J. 1995 Jan;14(1):40-4. Аннотация

38. Unkila-Kallio L, Kallio MJ, Eskola J, et al. Serum C-reactive protein, erythrocyte sedimentation rate, and white blood cell count in acute hematogenous osteomyelitis of children. Pediatrics. 1994 Jan;93(1):59-62. Аннотация

39. Trampuz A, Piper KE, Hanssen AD, et al. Sonication of explanted prosthetic components in bags for diagnosis of prosthetic joint infection is associated with risk of contamination. J Clin Microbiol. 2006 Feb;44(2):628-31.Полный текст  Аннотация

40. Calhoun JH, Manring MM. Adult osteomyelitis. Infect Dis Clin North Am. 2005 Dec;19(4):765-86. Аннотация

41. Ericsson HM, Sherris JC. Antibiotic sensitivity testing: Report of an international collaborative study. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;217:(suppl 217):1. Аннотация

42. Trampuz A, Piper KE, Jacobson MJ, et al. Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med. 2007 Aug 16;357(7):654-63.Полный текст  Аннотация

43. Mackowiak PA, Jones SR, Smith JW. Diagnostic value of sinus tract cultures in chronic osteomyelitis. JAMA. 1978 Jun 30;239(26):2772-5. Аннотация

44. Morgenstern M, Athanasou NA, Ferguson JY, et al. The value of quantitative histology in the diagnosis of fracture-related infection. Bone Joint J. 2018 Jul;100-B(7):966-72. Аннотация

45. Expert Panel on Musculoskeletal Imaging:., Beaman FD, von Herrmann PF, et al. ACR Appropriateness Criteria® suspected osteomyelitis, septic arthritis, or soft tissue infection (excluding spine and diabetic foot). J Am Coll Radiol. 2017 May;14(5s):S326-37.Полный текст  Аннотация

46. Jevtic V. Vertebral infection. Eur Radiol. 2004 Mar;14(suppl 3):E43-52. Аннотация

47. Theodorou DJ, Theodorou SJ, Kakitsubata Y, et al. Imaging characteristics and epidemiologic features of atypical mycobacterial infections involving the musculoskeletal system. AJR Am J Roentgenol. 2001 Feb;176(2):341-9.Полный текст  Аннотация

48. Flemming D, Murphey M, McCarthy K. Imaging of the foot and ankle: summary and update. Curr Opin Orthop. 2005;16:54-9.

49. Pineda C, Vargas A, Rodriguez AV. Imaging of osteomyelitis: current concepts. Infect Dis Clin North Am. 2006 Dec;20(4):789-825. Аннотация

50. Butt WP. The radiology of infection. Clin Orthop Relat Res. 1973 Oct;(96):20-30. Аннотация

51. Jones AG, Francis MD, Davis MA. Bone scanning: radionuclidic reaction mechanisms. Semin Nucl Med. 1976 Jan;6(1):3-18. Аннотация

52. Kuhn JP, Berger PE. Computed tomographic diagnosis of osteomyelitis. Radiology. 1979 Feb;130(2):503-6. Аннотация

53. Wang GL, Zhao K, Liu ZF, et al. A meta-analysis of fluorodeoxyglucose-positron emission tomography versus scintigraphy in the evaluation of suspected osteomyelitis. Nucl Med Commun. 2011 Dec;32(12):1134-42. Аннотация

54. Carragee EJ. Pyogenic vertebral osteomyelitis. J Bone Joint Surg Am. 1997 Jun;79(6):874-80. Аннотация

55. Kesselring FO, Penn W. Radiological aspects of 'classic' primary osteosarcoma: value of some radiological investigations - a review. Diagn Imaging. 1982;51(2):78-92. Аннотация

56. Sajadi KR, Heck RK, Neel MD, et al. The incidence and prognosis of osteosarcoma skip metastases. Clin Orthop Relat Res. 2004;426:92-96. Аннотация

57. Gross T, Kaim AH, Regazzoni P, et al. Current concepts in post-traumatic osteomyelitis: a diagnostic challenge with new imaging options. J Trauma. 2002 Jun;52(6):1210-9. Аннотация

58. Howard-Jones AR, Isaacs D. Systematic review of duration and choice of systemic antibiotic therapy for acute haematogenous bacterial osteomyelitis in children. J Paediatr Child Health. 2013 Sep;49(9):760-8. Аннотация

59. Bouchoucha S, Gafsi K, Trifa M, et al. Intravenous antibiotic therapy for acute hematogenous osteomyelitis in children: short versus long course [in French]. Arch Pediatr. 2013 May;20(5):464-9. Аннотация

60. Atkins BL, Athanasou N, Deeks JJ, et al. Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty: the OSIRIS Collaborative Study Group. J Clin Microbiol. 1998 Oct;36(10):2932-9.Полный текст  Аннотация

61. Sheehy SH, Atkins BA, Bejon P, et al. The microbiology of chronic osteomyelitis: prevalence of resistance to common empirical anti-microbial regimens. J Infect. 2010 May;60(5):338-43. Аннотация

62. Cierny G 3rd, Mader JT. The surgical treatment of adult osteomyelitis. In: Evarts CMC, ed. Surgery of the musculoskeletal system. New York: Churchill Livingstone; 1983:4337-79.

63. Anthony JP, Mathes SJ, Alpert BS. The muscle flap in the treatment of chronic lower extremity osteomyelitis: results in patients over 5 years after treatment. Plast Reconstr Surg. 1991 Aug;88(2):311-8. Аннотация

64. May JW Jr, Jupiter JB, Gallico GG 3rd, et al. Treatment of chronic traumatic bone wounds. Microvascular free tissue transfer: a 13-year experience in 96 patients. Ann Surg. 1991 Sep;214(3):241-50.Полный текст  Аннотация

65. Mayberry-Carson KJ, Tober-Meyer B, Smith JK, et al. Bacterial adherence and glycocalyx formation in osteomyelitis experimentally induced with Staphylococcus aureus. Infect Immun. 1984 Mar;43(3):825-33.Полный текст  Аннотация

66. Walenkamp GH, Vree TB, van Rens TJ. Gentamicin-PMMA beads: pharmacokinetic and nephrotoxicological study. Clin Orthop Relat Res. 1986 Apr;(205):171-83. Аннотация

67. Buchholz HW, Elson RA, Heinert K. Antibiotic-loaded acrylic cement: current concepts. Clin Orthop Relat Res. 1984 Nov;(190):96-108. Аннотация

68. Cho SH, Song HR, Koo KH, et al. Antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis. Bull Hosp Jt Dis. 1997;56(3):140-4. Аннотация

69. Evans RP, Nelson CL. Gentamicin-impregnated polymethylmethacrylate beads compared with systemic antibiotic therapy in the treatment of chronic osteomyelitis. Clin Orthop Relat Res. 1993 Oct;(295):37-42. Аннотация

70. Walenkamp GH, Kleijn LL, de Leeuw M. Osteomyelitis treated with gentamicin-PMMA beads: 100 patients followed for 1-12 years. Acta Orthop Scand. 1998 Oct;69(5):518-22. Аннотация

71. Neut D, van de Belt H, van Horn JR, et al. Residual gentamicin-release from antibiotic-loaded polymethylmethacrylate beads after 5 years of implantation. Biomaterials. 2003 May;24(10):1829-31. Аннотация

72. Kendall RW, Duncan CP, Smith JA, et al. Persistence of bacteria on antibiotic loaded acrylic depots: a reason for caution. Clin Orthop Relat Res. 1996 Aug;(329):273-80. Аннотация

73. Fleiter N, Walter G, Bösebeck H, et al. Clinical use and safety of a novel gentamicin-releasing resorbable bone graft substitute in the treatment of osteomyelitis/osteitis. Bone Joint Res. 2014 Jul;3(7):223-9.Полный текст  Аннотация

74. McKee MD, Wild LM, Schemitsch EH, et al. The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma. 2002 Oct;16(9):622-7. Аннотация

75. Gitelis S, Brebach GT. The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. J Orthop Surg (Hong Kong). 2002 Jun;10(1):53-60. Аннотация

76. Chang W, Colangeli M, Colangeli S, et al. Adult osteomyelitis: debridement versus debridement plus Osteoset T pellets. Acta Orthop Belg. 2007 Apr;73(2):238-43. Аннотация

77. McKee MD, Li-Bland EA, Wild LM, et al. A prospective, randomized clinical trial comparing an antibiotic-impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion. J Orthop Trauma. 2010 Aug;24(8):483-90. Аннотация

78. Humm G, Noor S, Bridgeman P, et al. Adjuvant treatment of chronic osteomyelitis of the tibia following exogenous trauma using OSTEOSET(®)-T: a review of 21 patients in a regional trauma centre. Strategies Trauma Limb Reconstr. 2014 Nov;9(3):157-61.Полный текст  Аннотация

79. Ferguson JY, Dudareva M, Riley ND, et al. The use of a biodegradable antibiotic-loaded calcium sulphate carrier containing tobramycin for the treatment of chronic osteomyelitis: a series of 195 cases. Bone Joint J. 2014 Jun;96-B(6):829-36. Аннотация

80. Romanò CL, Logoluso N, Meani E, et al. A comparative study of the use of bioactive glass S53P4 and antibiotic-loaded calcium-based bone substitutes in the treatment of chronic osteomyelitis: a retrospective comparative study. Bone Joint J. 2014 Jun;96-B(6):845-50. Аннотация

81. McNally MA, Ferguson JY, Lau AC, et al. Single-stage treatment of chronic osteomyelitis with a new absorbable, gentamicin-loaded, calcium sulphate/hydroxyapatite biocomposite: a prospective series of 100 cases. Bone Joint J. 2016 Sep;98-B(9):1289-96. Аннотация

82. Daculsi G, Passuti N. Effect of the macroporosity for osseous substitution of calcium phosphate ceramics. Biomaterials. 1990 Jul;11:86-7. Аннотация

83. Blokhuis TJ, Termaat MF, den Boer FC, et al. Properties of calcium phosphate ceramics in relation to their in vivo behavior. J Trauma. 2000 Jan;48(1):179-86. Аннотация

84. Campana V, Milano G, Pagano E, et al. Bone substitutes in orthopaedic surgery: from basic science to clinical practice. J Mater Sci Mater Med. 2014 Oct;25(10):2445-61.Полный текст  Аннотация

85. McNally M, Nagarajah K. Osteomyelitis. Orthop Trauma. 2010;24(6):416-29.

86. Sigmund IK, Ferguson J, Govaert GAM, et al. Comparison of ilizarov bifocal, acute shortening and relengthening with bone transport in the treatment of infected, segmental defects of the tibia. J Clin Med. 2020 Jan 28;9(2):279.Полный текст  Аннотация

87. McNally MA, Small JO, Tofighi HG, et al. Two-stage management of chronic osteomyelitis of the long bones: the Belfast technique. J Bone Joint Surg Br. 1993 May;75(3):375-80. Аннотация

88. Cierny G 3rd, Zorn KE. Segmental tibial defects: comparing conventional and Ilizarov methodologies. Clin Orthop Relat Res. 1994 Apr;(301):118-23. Аннотация

89. Beals RK, Bryant RE. The treatment of chronic open osteomyelitis of the tibia in adults. Clin Orthop Relat Res. 2005 Apr;(433):212-7. Аннотация

90. Cierny G 3rd, DiPasquale D. Treatment of chronic infection. J Am Acad Orthop Surg. 2006;14(10 Spec No.):S105-10. Аннотация

91. Tsang ST, Mills LA, Frantzias J, et al. Exchange nailing for nonunion of diaphyseal fractures of the tibia: our results and an analysis of the risk factors for failure. Bone Joint J. 2016 Apr;98-B(4):534-41.Полный текст  Аннотация

92. Mader JT, Ortiz M, Calhoun JH. Update on the diagnosis and management of osteomyelitis. Clin Podiatr Med Surg. 1996 Oct;13(4):701-24. Аннотация

93. Li HK, Rombach I, Zambellas R, et al. Oral versus intravenous antibiotics for bone and joint infection. N Engl J Med. 2019 Jan 31;380(5):425-36.Полный текст  Аннотация

94. Goldman, RJ. Hyperbaric oxygen therapy for wound healing and limb salvage: a systematic review. PM R. 2009;1:471-489. Аннотация

95. Mooney JF 3rd, Argenta LC, Marks MW, et al. Treatment of soft tissue defects in pediatric patients using the V.A.C. system. Clin Orthop Relat Res. 2000;376:26-31. Аннотация

96. Webb LX, Wagner W, Carroll D, et al. Osteomyelitis and intraosteoblastic Staphylococcus aureus. J Surg Orthop Adv. 2007;16:73-78. Аннотация

97. Ellington JK, Harris M, Hudson MC, et al. Intracellular Staphylococcus aureus and antibiotic resistance: implications for treatment of staphylococcal osteomyelitis. J Orthop Res. 2006;24:87-93. Аннотация

98. Rao N, Crossett LS, Sinha RK, et al. Long-term suppression of infection in total joint arthroplasty. Clin Orthop Relat Res. 2003;414:55-60. Аннотация

99. Slover CM, Rodvold KA, Danziger LH. Tigecycline: a novel broad-spectrum antimicrobial. Ann Pharmacother. 2007;41:965-972. Аннотация

100. Rice DA, Mendez-Vigo L. Daptomycin in bone and joint infections: a review of the literature. Arch Orthop Trauma Surg. 2009:129:1495-1504. Аннотация

101. Razonable RR, Osmon DR, Steckelberg JM. Linezolid therapy for orthopedic infections. Mayo Clin Proc. 2004;79:1137-1144. Аннотация

102. Rayner CR, Baddour LM, Birmingham MC, et al. Linezolid in treatment of osteomyelitis: results of compassionate use experience. Infection. 2004;32:8-14. Аннотация

103. Rao N, Ziran BH, Hall RA, et al. Successful treatment of chronic bone and joint infections with oral Linezolid. Clin Orthop Relat Res. 2004;427:67-71. Аннотация

104. Rao N, Hamilton CW. Efficacy and safety of Linezolid for Gram-positive orthopedic infections: a prospective case series. Diagn Microbiol Infect Dis. 2007;59:173-179. Аннотация

105. Lamp KC, Friedrich LV, Mendez-Vigo L, et al. Clinical experience with daptomycin for the treatment of patients with osteomyelitis. Am J Med. 2007;120(Suppl 1):S13-S20. Аннотация

106. Holtom PD, Zalavras CG, Lamp KC, et al. Clinical experience with daptomycin treatment of foot or ankle osteomyelitis: a preliminary study. Clin Orthop Relat Res. 2007;461:35-39. Аннотация

107. Crompton JA, North DS, McConnell SA, et al. Safety and efficacy of daptomycin in the treatment of osteomyelitis: results from the CORE Registry. J Chemother. 2009;21:414-420. Аннотация

108. Chiappini E, Conti C, Galli L, et al. Clinical efficacy and tolerability of linezolid in pediatric patients: a systematic review. Clin Ther. 2010;32:66-88. Аннотация

109. Graham DR, Keldermans MM, Klemm LW, et al. Infectious complications among patients receiving home intravenous therapy with peripheral, central, or peripherally placed central venous catheters. Am J Med. 1991 Sep 16;91(3B):95S-100S. Аннотация

110. Evans RP, Nelson CL, Harrison BH. The effect of wound environment on the incidence of acute osteomyelitis. Clin Orthop Relat Res. 1993 Jan;(286):289-97. Аннотация

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