Referências
Principais artigos
Mehta A, Dattani MT. Congenital disorders of the hypothalamic-pituitary axis. In: Brook CG, Clayton PE, Brown RS, et al., eds. Clinical pediatric endocrinology. 5th ed. Oxford, United Kingdom: Blackwell Publishing; 2005:62-89.
Hage C, Gan HW, Ibba A, et al. Advances in differential diagnosis and management of growth hormone deficiency in children. Nat Rev Endocrinol. 2021 Oct;17(10):608-24. Resumo
Grimberg A, DiVall SA, Polychronakos C, et al. Guidelines for growth hormone and insulin-like growth factor-I treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-I deficiency. Horm Res Paediatr. 2016;86(6):361-97.Texto completo Resumo
Sklar CA, Antal Z, Chemaitilly W, et al. Hypothalamic-pituitary and growth disorders in survivors of childhood cancer: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2018 Aug 1;103(8):2761-84.Texto completo Resumo
Segal TY, Mehta A, Anazodo A, et al. Role of gonadotropin-releasing hormone and human chorionic gonadotropin stimulation tests in differentiating patients with hypogonadotropic hypogonadism from those with constitutional delay of growth and puberty. J Clin Endocrinol Metab. 2009 Mar;94(3):780-5. Resumo
Dattani M, Preece M. Growth hormone deficiency and related disorders: insights into causation, diagnosis, and treatment. Lancet. 2004 Jun 12;363(9425):1977-87. Resumo
Ho KK, 2007 GH Deficiency Consensus Workshop Participants. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. Eur J Endocrinol. 2007 Dec;157(6):695-700.Texto completo Resumo
Artigos de referência
1. Regal M, Paramo C, Sierra SM, et al. Prevalence and incidence of hypopituitarism in an adult Caucasian population in northwestern Spain. Clin Endocrinol (Oxf). 2001 Dec;55(6):735-40. Resumo
2. Mehta A, Hindmarsh PC, Mehta H, et al. Congenital hypopituitarism: clinical, molecular and neuroradiological correlates. Clin Endocrinol (Oxf). 2009 Sep;71(3):376-82. Resumo
3. Arora RS, Alston RD, Eden TO, et al. Age-incidence patterns of primary CNS tumors in children, adolescents, and adults in England. Neuro Oncol. 2009 Aug;11(4):403-13.Texto completo Resumo
4. Mehta A, Dattani MT. Congenital disorders of the hypothalamic-pituitary axis. In: Brook CG, Clayton PE, Brown RS, et al., eds. Clinical pediatric endocrinology. 5th ed. Oxford, United Kingdom: Blackwell Publishing; 2005:62-89.
5. Alatzoglou KS, Webb EA, Le Tissier P, et al. Isolated growth hormone deficiency (GHD) in childhood and adolescence: recent advances. Endocr Rev. 2014 Jun;35(3):376-432.Texto completo Resumo
6. Craft WH, Underwoood LE, Van Wyk JJ. High incidence of perinatal insult in children with idiopathic hypopituitarism. J Pediatr. 1980 Mar;96(3 Pt 1):397-402. Resumo
7. Dattani MT, Robinson IC. The molecular basis for developmental disorders of the pituitary gland in man. Clin Genet. 2000 May;57(5):337-46. Resumo
8. Kelberman D, Rizzoti K, Lovell-Badge R, et al. Genetic regulation of pituitary gland development in human and mouse. Endocr Rev. 2009 Dec;30(7):790-829.Texto completo Resumo
9. Woods KS, Cundall M, Turton J, et al. Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism. Am J Hum Genet. 2005 May;76(5):833-49.Texto completo Resumo
10. Alatzoglou KS, Turton JP, Kelberman D, et al. Expanding the spectrum of mutations in GH1 and GHRHR: genetic screening in a large cohort of patients with congenital isolated growth hormone deficiency. J Clin Endocrinol Metab. 2009 Sep;94(9):3191-9.Texto completo Resumo
11. Argente J, Flores R, Gutiérrez-Arumí A, et al. Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency. EMBO Mol Med. 2014 Mar;6(3):299-306.Texto completo Resumo
12. Hage C, Gan HW, Ibba A, et al. Advances in differential diagnosis and management of growth hormone deficiency in children. Nat Rev Endocrinol. 2021 Oct;17(10):608-24. Resumo
13. Müller HL, Emser A, Faldum A, et al. Longitudinal study on growth and body mass index before and after diagnosis of childhood craniopharyngioma. J Clin Endocrinol Metab. 2004 Jul;89(7):3298-305.Texto completo Resumo
14. Honegger J, Buchfelder M, Fahlbusch R. Surgical treatment of craniopharyngiomas: endocrinological results. J Neurosurg. 1999 Feb;90(2):251-7. Resumo
15. Karavitaki N, Brufani C, Warner JT, et al. Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long-term follow-up. Clin Endocrinol (Oxf). 2005 Apr;62(4):397-409. Resumo
16. Mulder RL, Kremer LC, van Santen HM, et al. Prevalence and risk factors of radiation-induced growth hormone deficiency in childhood cancer survivors: a systematic review. Cancer Treat Rev. 2009 Nov;35(7):616-32. Resumo
17. Aimaretti G, Ambrosio MR, Di Somma C, et al. Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study. J Clin Endocrinol Metab. 2005 Nov;90(11):6085-92.Texto completo Resumo
18. Lieberman SA, Oberoi AL, Gilkison CR, et al. Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury. J Clin Endocrinol Metab. 2001 Jun;86(6):2752-6.Texto completo Resumo
19. Italian Working Group on Endocrine Complications in Non-endocrine Diseases. Multicentre study on prevalence of endocrine complications in thalassaemia major. Clin Endocrinol (Oxf). 1995 Jun;42(6):581-6. Resumo
20. Albanese A, Hamill G, Jones J, et al. Reversibility of physiological growth hormone secretion in children with psychosocial dwarfism. Clin Endocrinol (Oxf). 1994 May;40(5):687-92. Resumo
21. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999 Dec 9;402(6762):656-60. Resumo
22. Wit JM, Kamp GA, Rikken B. Spontaneous growth and response to growth hormone treatment in children with growth hormone deficiency and idiopathic short stature. Pediatr Res. 1996 Feb;39(2):295-302. Resumo
23. Ranke MB, Price DA, Albertsson-Wikland K, et al. Factors determining pubertal growth and final height in growth hormone treatment of idiopathic growth hormone deficiency: analysis of 195 patients of the Kabi Pharmacia International Growth Study. Horm Res. 1997;48(2):62-71. Resumo
24. Webb EA, O’Reilly MA, Clayden JD, et al. Effect of growth hormone deficiency on brain structure, motor function and cognition. Brain. 2012 Jan;135(pt 1):216-27. Resumo
25. Phillips JA 3rd, Hjelle BL, Seeburg PH, et al. Molecular basis for familial isolated growth hormone deficiency. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6372-5.Texto completo Resumo
26. Wajnrajch MP, Gertner JM, Harbison MD, et al. Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse. Nat Genet. 1996 Jan;12(1):88-90. Resumo
27. Carakushansky M, Whatmore AJ, Clayton PE, et al. A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency. Eur J Endocrinol. 2003 Jan;148(1):25-30.Texto completo Resumo
28. Moseley CT, Mullis PE, Prince MA, et al. An exon splice enhancer mutation causes autosomal dominant GH deficiency. J Clin Endocrinol Metab. 2002 Feb;87(2):847-52.Texto completo Resumo
29. Birkebaek NH, Patel L, Wright NB, et al. Endocrine status in patients with optic nerve hypoplasia: relationship to midline central nervous system abnormalities and appearance of the hypothalamic-pituitary axis on magnetic resonance imaging. J Clin Endocrinol Metab. 2003 Nov;88(11):5281-6.Texto completo Resumo
30. GH Research Society. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab. 2000 Nov;85(11):3990-3.Texto completo Resumo
31. Mehta A, Hindmarsh PC, Stanhope RG, et al. The role of growth hormone in determining birth size and early postnatal growth, using congenital growth hormone deficiency (GHD) as a model. Clin Endocrinol (Oxf). 2005 Aug;63(2):223-31. Resumo
32. Pena-Almazan S, Buchlis J, Miller S, et al. Linear growth characteristics of congenitally GH-deficient infants from birth to one year of age. J Clin Endocrinol Metab. 2001 Dec;86(12):5691-4.Texto completo Resumo
33. Esberg BH, Jacobsen BB. Isolated congenital growth hormone deficiency: severe hypoglycemia and neonatal giant cell hepatitis [in Danish]. Ugeskr Laeger. 1996 Nov 4;158(45):6467-9. Resumo
34. Ogilvy-Stuart AL. Growth hormone deficiency (GHD) from birth to 2 years of age: diagnostic specifics of GHD during the early phase of life. Horm Res. 2003;60(suppl 1):2-9.Texto completo Resumo
35. Binder G, Weidenkeller M, Blumenstock G, et al. Rational approach to the diagnosis of severe growth hormone deficiency in the newborn. J Clin Endocrinol Metab. 2010 May;95(5):2219-26. Resumo
36. Bosch I Ara L, Katugampola H, Dattani MT. Congenital hypopituitarism during the neonatal period: epidemiology, pathogenesis, therapeutic options, and outcome. Front Pediatr. 2021 Feb 2;8:600962.Texto completo Resumo
37. Van der Kaay DC, Van Heel WJ, Dudink J, et al. Transient diabetes insipidus in a preterm neonate and the challenge of desmopressin dosing. J Pediatr Endocrinol Metab. 2014 Jul;27(7-8):769-71. Resumo
38. Jagannathan J, Dumont AS, Jane JA Jr. Diagnosis and management of pediatric sellar lesions. Front Horm Res. 2006;34:83-104. Resumo
39. Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr. 1952 Apr;40(4):423-41. Resumo
40. Mitchell H, Dattani MT, Nanduri V, et al. Failure of IGF-I and IGFBP-3 to diagnose growth hormone insufficiency. Arch Dis Child. 1999 May;80(5):443-7.Texto completo Resumo
41. Sfeir JG, Kittah NEN, Tamhane SU, et al. Diagnosis of GH deficiency as a late effect of radiotherapy in survivors of childhood cancers. J Clin Endocrinol Metab. 2018 Aug 1;103(8):2785-93.Texto completo Resumo
42. Grimberg A, DiVall SA, Polychronakos C, et al. Guidelines for growth hormone and insulin-like growth factor-I treatment in children and adolescents: growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-I deficiency. Horm Res Paediatr. 2016;86(6):361-97.Texto completo Resumo
43. Shah A, Stanhope R, Matthew D. Hazards of pharmacological tests of growth hormone secretion in childhood. BMJ. 1992 Jan 18;304(6820):173-4.Texto completo Resumo
44. Sklar CA, Antal Z, Chemaitilly W, et al. Hypothalamic-pituitary and growth disorders in survivors of childhood cancer: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2018 Aug 1;103(8):2761-84.Texto completo Resumo
45. British Society for Paediatric Endocrinology and Diabetes. BSPED UK consensus national guidelines for sex hormone priming for growth hormone (GH) stimulation testing. Apr 2021 [internet publication].Texto completo
46. Binder G, Reinehr T, Ibáñez L, et al. GHD diagnostics in Europe and the US: an audit of national guidelines and practice. Horm Res Paediatr. 2019;92(3):150-6. Resumo
47. Tillmann V, Tang VW, Price DA, et al. Magnetic resonance imaging of the hypothalamic-pituitary axis in the diagnosis of growth hormone deficiency. J Pediatr Endocrinol Metab. 2000 Nov-Dec;13(9):1577-83. Resumo
48. Birkebaek NH, Patel L, Wright NB, et al. Optic nerve size evaluated by magnetic resonance imaging in children with optic nerve hypoplasia, multiple pituitary hormone deficiency, isolated growth hormone deficiency, and idiopathic short stature. J Pediatr. 2004 Oct;145(4):536-41. Resumo
49. Hussain K, Hindmarsh P, Aynsley-Green A. Spontaneous hypoglycemia in childhood is accompanied by paradoxically low serum growth hormone and appropriate cortisol counterregulatory hormonal responses. J Clin Endocrinol Metab. 2003 Aug;88(8):3715-23.Texto completo Resumo
50. Mehta A, Hindmarsh PC, Stanhope RG, et al. Is the thyrotropin-releasing hormone test necessary in the diagnosis of central hypothyroidism in children? J Clin Endocrinol Metab. 2003 Dec;88(12):5696-703.Texto completo Resumo
51. van Tijn DA, de Vijlder JJ, Vulsma T. Role of the thyrotropin-releasing hormone stimulation test in diagnosis of congenital central hypothyroidism in infants. J Clin Endocrinol Metab. 2008 Feb;93(2):410-9.Texto completo Resumo
52. Persani L, Brabant G, Dattani M, et al. 2018 European Thyroid Association (ETA) guidelines on the diagnosis and management of central hypothyroidism. Eur Thyroid J. 2018 Oct;7(5):225-37.Texto completo Resumo
53. Mehta A, Hindmarsh PC, Dattani MT. An update on the biochemical diagnosis of congenital ACTH insufficiency. Clin Endocrinol (Oxf). 2005 Mar;62(3):307-14. Resumo
54. Segal TY, Mehta A, Anazodo A, et al. Role of gonadotropin-releasing hormone and human chorionic gonadotropin stimulation tests in differentiating patients with hypogonadotropic hypogonadism from those with constitutional delay of growth and puberty. J Clin Endocrinol Metab. 2009 Mar;94(3):780-5. Resumo
55. Turton JP, Mehta A, Raza J, et al. Mutations within the transcription factor PROP1 are rare in a cohort of patients with sporadic combined pituitary hormone deficiency (CPHD). Clin Endocrinol (Oxf). 2005 Jul;63(1):10-8. Resumo
56. Skuse D, Albanese A, Stanhope R, et al. A new stress-related syndrome of growth failure and hyperphagia in children, associated with reversibility of growth-hormone insufficiency. Lancet. 1996 Aug 10;348(9024):353-8. Resumo
57. Saggese G, Ranke MB, Saenger P, et al. Diagnosis and treatment of growth hormone deficiency in children and adolescents: towards a consensus. Ten years after the Availability of Recombinant Human Growth Hormone Workshop held in Pisa, Italy, 27-28 March 1998. Horm Res. 1998;50(6):320-40. Resumo
58. Dattani M, Preece M. Growth hormone deficiency and related disorders: insights into causation, diagnosis, and treatment. Lancet. 2004 Jun 12;363(9425):1977-87. Resumo
59. Deal CL, Tony M, Höybye C, et al. Growth Hormone Research Society workshop summary: consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome. J Clin Endocrinol Metab. 2013 Jun;98(6):E1072-87.Texto completo Resumo
60. Blum WF, Ross JL, Zimmermann AG, et al. GH treatment to final height produces similar height gains in patients with SHOX deficiency and Turner syndrome: results of a multicenter trial. J Clin Endocrinol Metab. 2013 Aug;98(8):E1383-92. Resumo
61. Rappaport R, Mugnier E, Limoni C, et al; French Serono Study Group. A 5-year prospective study of growth hormone (GH)-deficient children treated with GH before the age of 3 years. J Clin Endocrinol Metab. 1997 Feb;82(2):452-6.Texto completo Resumo
62. Saggese G, Federico G, Barsanti S, et al. The effect of administering gonadotropin-releasing hormone agonist with recombinant-human growth hormone (GH) on the final height of girls with isolated GH deficiency: results from a controlled study. J Clin Endocrinol Metab. 2001 May;86(5):1900-4.Texto completo Resumo
63. Alatzoglou KS, Dattani MT. Genetic causes and treatment of isolated growth hormone deficiency: an update. Nat Rev Endocrinol. 2010 Oct;6(10):562-76. Resumo
64. Fradkin JE, Schonberger LB, Mills JL, et al. Creutzfeldt-Jakob disease in pituitary growth hormone recipients in the United States. JAMA. 1991 Feb 20;265(7):880-4. Resumo
65. Mauras N, Attie KM, Reiter EO, et al; Genentech, Inc. Cooperative Study Group. High dose recombinant human growth hormone (GH) treatment of GH-deficient patients in puberty increases near-final height: a randomized, multicenter trial. J Clin Endocrinol Metab. 2000 Oct;85(10):3653-60.Texto completo Resumo
66. Mericq MV, Eggers M, Avila A, et al. Near final height in pubertal growth hormone (GH)-deficient patients treated with GH alone or in combination with luteinizing hormone-releasing hormone analog: results of a prospective, randomized trial. J Clin Endocrinol Metab. 2000 Feb;85(2):569-73.Texto completo Resumo
67. Stanhope R, Albanese A, Hindmarsh P, et al. The effects of growth hormone therapy on spontaneous sexual development. Horm Res. 1992;38(suppl 1):9-13. Resumo
68. Porretti S, Giavoli C, Ronchi C, et al. Recombinant human GH replacement therapy and thyroid function in a large group of adult GH-deficient patients: when does L-T(4) therapy become mandatory? J Clin Endocrinol Metab. 2002 May;87(5):2042-5. Resumo
69. Mehta A, Hindmarsh PC. The use of somatropin (recombinant growth hormone) in children of short stature. Paediatr Drugs. 2002;4(1):37-47. Resumo
70. Swerdlow AJ, Cooke R, Albertsson-Wikland K, et al. Description of the SAGhE cohort: a large European study of mortality and cancer incidence risks after childhood treatment with recombinant growth hormone. Horm Res Paediatr. 2015;84(3):172-83.Texto completo Resumo
71. Swerdlow AJ, Higgins CD, Adlard P, et al. Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: a cohort study. Lancet. 2002 Jul 27;360(9329):273-7. Resumo
72. Ma J, Pollak MN, Giovannucci E, et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst. 1999 Apr 7;91(7):620-5.Texto completo Resumo
73. Hankinson SE, Willett WC, Colditz GA, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet. 1998 May 9;351(9113):1393-6. Resumo
74. Chan JM, Stampfer MJ, Giovannucci EL. What causes prostate cancer? A brief summary of the epidemiology. Semin Cancer Biol. 1998 Aug;8(4):263-73. Resumo
75. Furstenberger G, Senn HJ. Insulin-like growth factors and cancer. Lancet Oncol. 2002 May;3(5):298-302. Resumo
76. Palmqvist R, Hallmans G, Rinaldi S, et al. Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden. Gut. 2002 May;50(5):642-6.Texto completo Resumo
77. Yuen KCJ, Biller BMK, Radovick S, et al. American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care. Endocr Pract. 2019 Nov;25(11):1191-232.Texto completo Resumo
78. Hawcutt DB, Bellis J, Price V, et al. Growth hormone prescribing and initial BMI SDS: increased biochemical adverse effects and costs in obese children without additional gain in height. PLoS One. 2017 Jul 17;12(7):e0181567.Texto completo Resumo
79. National Institute for Health and Care Excellence. Somatrogon for treating growth disturbance in children and young people aged 3 years and over [TA863]. Feb 2023 [internet publication].Texto completo
80. Amato G, Carella C, Fazio S, et al. Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. J Clin Endocrinol Metab. 1993 Dec;77(6):1671-6. Resumo
81. Carroll PV, Christ ER, Bengtsson BA, et al. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee. J Clin Endocrinol Metab. 1998 Feb;83(2):382-95.Texto completo Resumo
82. Maghnie M, Ghirardello S, Genovese E. Magnetic resonance imaging of the hypothalamus-pituitary unit in children suspected of hypopituitarism: who, how and when to investigate. J Endocrinol Invest. 2004 May;27(5):496-509. Resumo
83. Léger J, Danner S, Simon D, et al. Do all patients with childhood-onset growth hormone deficiency (GHD) and ectopic neurohypophysis have persistent GHD in adulthood? J Clin Endocrinol Metab. 2005 Feb;90(2):650-6.Texto completo Resumo
84. Pellini C, di Natale B, De Angelis R, et al. Growth hormone deficiency in children: role of magnetic resonance imaging in assessing aetiopathogenesis and prognosis in idiopathic hypopituitarism. Eur J Pediatr. 1990 May;149(8):536-41. Resumo
85. Bozzola M, Mengarda F, Sartirana P, et al. Long-term follow-up evaluation of magnetic resonance imaging in the prognosis of permanent GH deficiency. Eur J Endocrinol. 2000 Oct;143(4):493-6.Texto completo Resumo
86. Chen S, Léger J, Garel C, et al. Growth hormone deficiency with ectopic neurohypophysis: anatomical variations and relationship between the visibility of the pituitary stalk asserted by magnetic resonance imaging and anterior pituitary function. J Clin Endocrinol Metab. 1999 Jul;84(7):2408-13.Texto completo Resumo
87. Conway GS, Szarras-Czapnik M, Racz K, et al. Treatment for 24 months with recombinant human GH has a beneficial effect on bone mineral density in young adults with childhood-onset GH deficiency. Eur J Endocrinol. 2009 Jun;160(6):899-907. Resumo
88. de Boer H, Blok GJ, Van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocr Rev. 1995 Feb;16(1):63-86. Resumo
89. Rosen T, Wiren L, Wilhelmsen L, et al. Decreased psychological well-being in adult patients with growth hormone deficiency. Clin Endocrinol (Oxf). 1994 Jan;40(1):111-6. Resumo
90. Attanasio AF, Shavrikova EP, Blum WF, et al. Quality of life in childhood onset growth hormone-deficient patients in the transition phase from childhood to adulthood. J Clin Endocrinol Metab. 2005 Aug;90(8):4525-9.Texto completo Resumo
91. Moock J, Albrecht C, Friedrich N, et al. Health-related quality of life and IGF-1 in GH-deficient adult patients on GH replacement therapy: analysis of the German KIMS data and the Study of Health in Pomerania. Eur J Endocrinol. 2009 Jan;160(1):17-24. Resumo
92. Colao A, Di Somma C, Spiezia S, et al. Growth hormone treatment on atherosclerosis: results of a 5-year open, prospective, controlled study in male patients with severe growth hormone deficiency. J Clin Endocrinol Metab. 2008 Sep;93(9):3416-24.Texto completo Resumo
93. Rosen T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 1990 Aug 4;336(8710):285-8. Resumo
94. Bülow B, Hagmar L, Eskilsson J, et al. Hypopituitary females have a high incidence of cardiovascular morbidity and an increased prevalence of cardiovascular risk factors. J Clin Endocrinol Metab. 2000 Feb;85(2):574-84.Texto completo Resumo
95. Tomlinson JW, Holden N, Hills RK, et al. Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet. 2001 Feb 10;357(9254):425-31. Resumo
96. Møller N, Jørgensen JO. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev. 2009 Apr;30(2):152-77. Resumo
97. Ho KK, 2007 GH Deficiency Consensus Workshop Participants. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. Eur J Endocrinol. 2007 Dec;157(6):695-700.Texto completo Resumo
98. Molitch ME, Clemmons DR, Malozowski S, et al. Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jun;96(6):1587-609.Texto completo Resumo
99. de Boer H, van der Veen EA. Why retest young adults with childhood-onset growth hormone deficiency? J Clin Endocrinol Metab. 1997 Jul;82(7):2032-6.Texto completo Resumo
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