Infecção por vírus da imunodeficiência humana (HIV) na gestação

Panel on Treatment of HIV During Pregnancy and Prevention of Perinatal Transmission. Recommendations for the use of antiretroviral drugs during pregnancy and interventions to reduce perinatal HIV transmission in the United States. Jan 2023 [internet publication].Texto completo

The Panel on Treatment of Pregnant Women with HIV Infection and Prevention of Perinatal Transmission, US Department of Health and Human Services. Recommendations for the use of antiretroviral drugs in pregnant women with HIV infection and interventions to reduce perinatal HIV transmission in the United States. February 2021 [internet publication].Texto completo

1. Van de Perre P, Simonon A, Msellati P, et al. Postnatal transmission of human immunodeficiency virus type 1 from mother to infant. A prospective cohort study in Kigali, Rwanda. N Engl J Med. 1991 Aug 29;325(9):593-8. Resumo

2. UNAIDS. Women, adolescent girls and the HIV response. Mar 2020 [internet publication].Texto completo

3. UNAIDS. UNAIDS data 2022. Jan 2023 [internet publication].Texto completo

4. World Health Organization. Trends in maternal mortality 2000 to 2020: estimates by WHO, UNICEF, UNFPA, World Bank Group and UNDESA/Population Division​. Feb 2023 [internet publication].Texto completo

5. Centers for Disease Control and Prevention. HIV and women: HIV diagnoses. Aug 2022 [internet publication].Texto completo

6. World Health Organization. The Global Health Observatory. Data on the HIV/AIDS response [internet publication].Texto completo

7. UN Joint Programme on HIV/AIDS. WHO validates elimination of mother-to-child transmission of HIV and syphilis in Cuba. Jun 2015 [internet publication].Texto completo

8. Panel on Treatment of HIV During Pregnancy and Prevention of Perinatal Transmission. Recommendations for the use of antiretroviral drugs during pregnancy and interventions to reduce perinatal HIV transmission in the United States. Jan 2023 [internet publication].Texto completo

9. World Health Organization. Global guidance on criteria and processes for validation: elimination of mother-to-child transmission of HIV, syphilis and hepatitis B virus. Aug 2022 [internet publication].Texto completo

10. Centers for Disease Control and Prevention. HIV and pregnant women, infants, and children. Jan 2023 [internet publication].Texto completo

11. Louis J, Landon MB, Gersnoviez RJ, et al. Perioperative morbidity and mortality among human immunodeficiency virus infected women undergoing cesarean delivery. Obstet Gynecol. 2007 Aug;110(2 Pt 1):385-90. Resumo

12. Haeri S, Shauer M, Dale M, et al. Obstetric and newborn infant outcomes in human immunodeficiency virus-infected women who receive highly active antiretroviral therapy. Am J Obstet Gynecol. 2009 Sep;201(3):315.e1-5. Resumo

13. Suy A, Martínez E, Coll O, et al. Increased risk of pre-eclampsia and fetal death in HIV-infected pregnant women receiving highly active antiretroviral therapy. AIDS. 2006 Jan 2;20(1):59-66. Resumo

14. Parikh L, Timofeev J, Singh J, et al. Racial disparities in maternal and neonatal outcomes in HIV-1 positive mothers. Am J Perinatol. 2014 Jun;31(6):513-20. Resumo

15. Kourtis AP, Ellington S, Pazol K, et al. Complications of cesarean deliveries among HIV-infected women in the United States. AIDS. 2014 Nov 13;28(17):2609-18.Texto completo  Resumo

16. Nyamweya S, Hegedus A, Jaye A, et al. Comparing HIV-1 and HIV-2 infection: lessons for viral immunopathogenesis. Rev Med Virol. 2013 Jul;23(4):221-40. Resumo

17. Cao Y, Krogstad P, Korber BT, et al. Maternal HIV-1 viral load and vertical transmission of infection: the Ariel Project for the prevention of HIV transmission from mother to infant. Nat Med. 1997 May;3(5):549-52. Resumo

18. Lifson JD, Reyes GR, McGrath MS, et al. AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen. Science. 1986 May 30;232(4754):1123-7. Resumo

19. Ameisen JC, Capron A. Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis. Immunol Today. 1991 Apr;12(4):102-5. Resumo

20. Ameisen JC, Estaquier J, Idziorek T. From AIDS to parasite infection: pathogen-mediated subversion of programmed cell death as a mechanism for immune dysregulation. Immunol Rev. 1994 Dec;142:9-51. Resumo

21. Mofenson LM. Pregnancy and perinatal transmission of HIV infection. In: Holmes KK, Sparling PF, Stamm WE, et al, eds. Sexually transmitted diseases. 4th ed. New York, NY: McGraw-Hill; 2008:1659-93.

22. Cooper ER, Charurat M, Mofenson L, et al; Women and Infants' Transmission Study Group. Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission. J Acquir Immune Defic Syndr. 2002 Apr 15;29(5):484-94. Resumo

23. Magder LS, Mofenson L, Paul ME, et al. Risk factors for in utero and intrapartum transmission of HIV. J Acquir Immune Defic Syndr. 2005 Jan 1;38(1):87-95. Resumo

24. De Cock KM, Fowler MG, Mercier E, et al. Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice. JAMA. 2000 Mar 1;283(9):1175-82. Resumo

25. Wabwire-Mangen F, Gray RH, Mmiro FA, et al. Placental membrane inflammation and risks of maternal-to-child transmission of HIV-1 in Uganda. J Acquir Immune Defic Syndr. 1999 Dec 1;22(4):379-85. Resumo

26. Van Dyke RB, Korber BT, Popek E, et al. The Ariel Project: a prospective cohort study of maternal-child transmission of human immunodeficiency virus type 1 in the era of maternal antiretroviral therapy. J Infect Dis. 1999 Feb;179(2):319-28. [Erratum in: J Infect Dis. 1999 Mar;179(3):754.] Resumo

27. Farquhar C, Rowland-Jones S, Mbori-Ngacha D, et al. Human leukocyte antigen (HLA) B*18 and protection against mother-to-child HIV type 1 transmission. AIDS Res Hum Retroviruses. 2004 Jul;20(7):692-7. Resumo

28. Kostrikis LG, Neumann AU, Thomson B, et al. A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants. J Virol. 1999 Dec;73(12):10264-71.Texto completo  Resumo

29. LaRussa P, Magder LS, Pitt J, et al; Women and Infants Transmission Study. Association of HIV-1 viral phenotype in the MT-2 assay with perinatal HIV transmission. J Acquir Immune Defic Syndr. 2002 May 1;30(1):88-94. Resumo

30. Renjifo B, Gilbert P, Chaplin B, et al; Tanzanian Vitamin and HIV Study Group. Preferential in-utero transmission of HIV-1 subtype C as compared to HIV-1 subtype A or D. AIDS. 2004 Aug 20;18(12):1629-36. Resumo

31. Winchester R, Pitt J, Charurat M, et al. Mother-to-child transmission of HIV-1: strong association with certain maternal HLA-B alleles independent of viral load implicates innate immune mechanisms. J Acquir Immune Defic Syndr. 2004 Jun 1;36(2):659-70. Resumo

32. Yang C, Li M, Newman RD, et al. Genetic diversity of HIV-1 in western Kenya: subtype-specific differences in mother-to-child transmission. AIDS. 2003 Jul 25;17(11):1667-74. Resumo

33. Rouzioux C, Costagliola D, Burgard M, et al. Estimated timing of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission by use of a Markov model. The HIV Infection in Newborns French Collaborative Study Group. Am J Epidemiol. 1995 Dec 15;142(12):1330-7. Resumo

34. Kourtis AP, Bulterys M, Nesheim SR, et al. Understanding the timing of HIV transmission from mother to infant. JAMA. 2001 Feb 14;285(6):709-12. Resumo

35. Tersmette M, Gruters RA, de Wolf F, et al. Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates. J Virol. 1989 May;63(5):2118-25.Texto completo  Resumo

36. Schwartz S, Felber BK, Fenyo EM, et al. Rapidly and slowly replicating human immunodeficiency virus type 1 isolates can be distinguished according to target-cell tropism in T-cell and monocyte cell lines. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7200-3.Texto completo  Resumo

37. Fenyo EM, Albert J, Asjo B. Replicative capacity, cytopathic effect and cell tropism of HIV. AIDS. 1989;3 (suppl 1):S5-12. Resumo

38. Shapiro RL, Hughes MD, Ogwu A, et al. Antiretroviral regimens in pregnancy and breast-feeding in Botswana. N Engl J Med. 2010 Jun 17;362(24):2282-94. Resumo

39. Fowler MG, Newell ML. Breast-feeding and HIV-1 transmission in resource-limited settings. J Acquir Immune Defic Syndr. 2002 Jun 1;30(2):230-9. Resumo

40. Leroy V, Karon JM, Alioum A, et al; West Africa PMTCT Study Group. Twenty-four month efficacy of a maternal short-course zidovudine regimen to prevent mother-to-child transmission of HIV-1 in West Africa. AIDS. 2002 Mar 8;16(4):631-41. Resumo

41. Wiktor SZ, Ekpini E, Karon JM, et al. Short-course oral zidovudine for prevention of mother-to-child transmission of HIV-1 in Abidjan, Côte d'Ivoire: a randomised trial. Lancet. 1999 Mar 6;353(9155):781-5. Resumo

42. John-Stewart G, Mbori-Ngacha D, Ekpini R, et al; Ghent IAS Working Group on HIV in Women and Children. Breast-feeding and transmission of HIV-1. J Acquir Immune Defic Syndr. 2004 Feb 1;35(2):196-202. Resumo

43. World Health Organization. Guideline: updates on HIV and infant feeding. 2016 [internet publication].Texto completo

44. Baggaley RF, Boily MC, White RG, et al. Risk of HIV-1 transmission for parenteral exposure and blood transfusion: a systematic review and meta-analysis. AIDS. 2006 Apr 4;20(6):805-12.Texto completo  Resumo

45. Centers for Disease Control and Prevention. HIV infection and HIV-associated behaviors among injecting drug users - 20 cities, United States, 2009. MMWR Morb Mortal Wkly Rep. 2012 Mar 2;61(8):133-8.Texto completo  Resumo

46. World Health Organization. HIV/AIDS: people who inject drugs [internet publication].Texto completo

47. Boily MC, Baggaley RF, Wang L, et al. Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies. Lancet Infect Dis. 2009 Feb;9(2):118-29.Texto completo  Resumo

48. Jin F, Jansson J, Law M, et al. Per-contact probability of HIV transmission in homosexual men in Sydney in the era of HAART. AIDS. 2010 Mar 27;24(6):907-13.Texto completo  Resumo

49. Bell DM. Occupational risk of human immunodeficiency virus infection in health care workers: an overview. Am J Med. 1997 May 19;102(5B):9-15. Resumo

50. Sexton J, Garnett G, Røttingen JA. Metaanalysis and metaregression in interpreting study variability in the impact of sexually transmitted diseases on susceptibility to HIV infection. Sex Transm Dis. 2005 Jun;32(6):351-7. Resumo

51. Braunstein SL, van de Wijgert JH, Nash D. HIV incidence in sub-Saharan Africa: a review of available data with implications for surveillance and prevention planning. AIDS Rev. 2009 Jul-Sep;11(3):140-56. Resumo

52. van de Wijgert JH, Morrison CS, Brown J, et al. Disentangling contributions of reproductive tract infections to HIV acquisition in African Women. Sex Transm Dis. 2009 Jun;36(6):357-64. Resumo

53. Ward H, Rönn M. Contribution of sexually transmitted infections to the sexual transmission of HIV. Curr Opin HIV AIDS. 2010 Jul;5(4):305-10.Texto completo  Resumo

54. Devries KM, Kishor S, Johnson H, et al. Intimate partner violence during pregnancy: analysis of prevalence data from 19 countries. Reprod Health Matters. 2010 Nov;18(36):158-70. Resumo

55. Cavanaugh CE, Hansen NB, Sullivan TP. HIV sexual risk behavior among low-income women experiencing intimate partner violence: the role of posttraumatic stress disorder. AIDS Behav. 2010 Apr;14(2):318-27.Texto completo  Resumo

56. Machtinger EL, Wilson TC, Haberer JE, et al. Psychological trauma and PTSD in HIV-positive women: a meta-analysis. AIDS Behav. 2012 Nov;16(8):2091-100. Resumo

57. Varghese B, Maher JE, Peterman TA, et al. Reducing the risk of sexual HIV transmission: quantifying the per-act risk for HIV on the basis of choice of partner, sex act, and condom use. Sex Transm Dis. 2002 Jan;29(1):38-43. Resumo

58. Baggaley RF, White RG, Boily MC. Systematic review of orogenital HIV-1 transmission probabilities. Int J Epidemiol. 2008 Dec;37(6):1255-65.Texto completo  Resumo

59. Bassett MT, McFarland WC, Ray S, et al. Risk factors for HIV infection at enrollment in an urban male factory cohort in Harare, Zimbabwe. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):287-93. Resumo

60. Chattopadhya D, Riley LW, Kumari S. Behavioural risk factors for acquisition of HIV infection and knowledge about AIDS among male professional blood donors in Delhi. Bull World Health Organ. 1991;69(3):319-23. Resumo

61. US Department of Health and Human Services, Health Resources and Services Administration. A guide to the clinical care of women with HIV. 2013 [internet publication].Texto completo

62. Thomson KA, Hughes J, Baeten JM, et al. Increased risk of HIV acquisition among women throughout pregnancy and during the postpartum period: a prospective per-coital-act analysis among women with HIV-infected partners. J Infect Dis. 2018 Jun 5;218(1):16-25.Texto completo  Resumo

63. Branson BM, Handsfield HH, Lampe MA, et al. Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. MMWR Morb Mortal Wkly Rep. 2006 Sep 22;55(RR-14):1-17.Texto completo  Resumo

64. Moodley D, Lombard C, Govender V, et al. Pregnancy and neonatal safety outcomes of timing of initiation of daily oral tenofovir disoproxil fumarate and emtricitabine pre-exposure prophylaxis for HIV prevention (CAP016): an open-label, randomised, non-inferiority trial. Lancet HIV. 2023 Mar;10(3):e154-63. Resumo

65. World Health Organization. WHO continues to support its conditional recommendation for the dapivirine vaginal ring as an additional prevention option for women at substantial risk of HIV. Dec 2021 [internet publication].Texto completo

66. Cutler B, Justman J. Vaginal microbicides and the prevention of HIV transmission. Lancet Infect Dis. 2008 Nov;8(11):685-97.Texto completo  Resumo

67. Wiysonge CS, Shey MS, Shang J, et al. Vaginal microbicides for preventing mother-to-child transmission of HIV infection: no evidence of an effect or evidence of no effect? S Afr Med J. 2007 Jul;97(7):530-3. Resumo

68. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010 Sep 3;329(5996):1168-74.Texto completo  Resumo

69. Holmes KK, Levine R, Weaver M. Effectiveness of condoms in preventing sexually transmitted infections. Bull World Health Organ. 2004 Jun;82(6):454-61.Texto completo  Resumo

70. French PP, Latka M, Gollub EL, et al. Use-effectiveness of the female versus the male condom in preventing sexually transmitted diseases in women. Sex Transm Dis. 2003 May;30(5):433-9. Resumo

71. Centers for Disease Control and Prevention (CDC); Association of Public Health Laboratories. Laboratory testing for the diagnosis of HIV infection: updated recommendations. Jun 2014 [internet publication].Texto completo

72. Pilcher CD, Fiscus SA, Nguyen TQ, et al. Detection of acute infections during HIV testing in North Carolina. N Engl J Med. 2005 May 5;352(18):1873-83.Texto completo  Resumo

73. Centers for Disease Control and Prevention. HIV: What is the HIV window period? Jun 2022 [internet publication].Texto completo

74. Connor EM, Sperling RS, Gelber R, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N Engl J Med. 1994 Nov 3;331(18):1173-80.Texto completo  Resumo

75. Kovacs A, Xu J, Rasheed S, et al. Comparison of a rapid nonisotopic polymerase chain reaction assay with four commonly used methods for the early diagnosis of human immunodeficiency virus type 1 infection in neonates and children. Pediatr Infect Dis J. 1995 Nov;14(11):948-54. Resumo

76. Kaplan EH, Heimer R. HIV incidence among New Haven needle exchange participants: updated estimates from syringe tracking and testing data. J Acquir Immune Def Syndr Hum Retrovirol. 1995 Oct 1;10(2):175-6. Resumo

77. Chadwick EG, Ezeanolue EE, and Committee on Pediatric AIDS. Evaluation and management of the infant exposed to HIV in the United States. Pediatrics. 2020 Nov;146(5):e2020029058.Texto completo  Resumo

78. Townsend CL, Cortina-Borja M, Peckham CS, et al. Antiretroviral therapy and premature delivery in diagnosed HIV-infected women in the United Kingdom and Ireland. AIDS. 2007 May 11;21(8):1019-26. Resumo

79. Schulte J, Dominguez K, Sukalac T, et al. Declines in low birth weight and preterm birth among infants who were born to HIV-infected women during an era of increased use of maternal antiretroviral drugs: pediatric spectrum of HIV disease, 1989-2004. Pediatrics. 2007 Apr;119(4):e900-6. Resumo

80. Ravizza M, Martinelli P, Bucceri A, et al. Treatment with protease inhibitors and coinfection with hepatitis C virus are independent predictors of preterm delivery in HIV-infected pregnant women. J Infect Dis. 2007 Mar 15;195(6):913-4.Texto completo  Resumo

81. Grosch-Woerner I, Puch K, Maier RF, et al. Increased rate of prematurity associated with antenatal antiretroviral therapy in a German/Austrian cohort of HIV-1-infected women. HIV Med. 2008 Jan;9(1):6-13.Texto completo  Resumo

82. Kourtis AP, Schmid CH, Jamieson DJ, et al. Use of antiretroviral therapy in pregnant HIV-infected women and the risk of premature delivery: a meta-analysis. AIDS.2007 Mar 12;21(5):607-15. Resumo

83. European Collaborative Study, Swiss Mother and Child HIV Cohort Study. Combination antiretroviral therapy and duration of pregnancy. AIDS. 2000 Dec 22;14(18):2913-20. Resumo

84. Lorenzi P, Spicher VM, Laubreau B, et al. Antiretroviral therapies in pregnancy: maternal, fetal, and neonatal effects. Swiss HIV Cohort Study, the Swiss Collaborative HIV and Pregnancy Study, the Swiss Neonatal HIV Study. AIDS. 1998 Dec 24;12(18):F241-7. Resumo

85. Szyld EG, Warley EM, Freimanis L, et al. Maternal antiretroviral drugs during pregnancy and infant low birth weight and preterm birth. AIDS. 2006 Nov 28;20(18):2345-53. Resumo

86. World Health Organization. Update of recommendations on first- and second-line antiretroviral regimens. Jul 2019 [internet publication].Texto completo

87. Patel K, Huo Y, Jao J, et al. Dolutegravir in pregnancy as compared with current HIV regimens in the United States. N Engl J Med. 2022 Sep 1;387(9):799-809.Texto completo  Resumo

88. ACOG Committee on Obstetric Practice. ACOG committee opinion: scheduled cesarean delivery and the prevention of vertical transmission of HIV infection. Number 234, May 2000 (replaces number 219, August 1999). Int J Gynaecol Obstet. 2001 Jun;73(3):279-81. Resumo

89. Flynn PM, Taha TE, Cababasay M, et al. Prevention of HIV-1 transmission through breastfeeding: efficacy and safety of maternal antiretroviral therapy versus infant nevirapine prophylaxis for duration of breastfeeding in HIV-1-infected women with high CD4 cell count (IMPAACT PROMISE): a randomized, open-label, clinical trial. J Acquir Immune Defic Syndr. 2018 Apr 1;77(4):383-92.Texto completo  Resumo

90. Luoga E, Vanobberghen F, Bircher R, et al. Brief report: no HIV transmission from virally suppressed mothers during breastfeeding in rural Tanzania. J Acquir Immune Defic Syndr. 2018 Sep 1;79(1):e17-e20.Texto completo  Resumo

91. Cutler B, Justman J. Vaginal microbicides and the prevention of HIV transmission. Lancet Infect Dis. 2008 Nov;8(11):685-97.Texto completo  Resumo

92. Wiysonge CS, Shey MS, Shang J, et al. Vaginal microbicides for preventing mother-to-child transmission of HIV infection: no evidence of an effect or evidence of no effect? S Afr Med J. 2007 Jul;97(7):530-3. Resumo

93. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010 Sep 3;329(5996):1168-74.Texto completo  Resumo

94. Baeten JM, Palanee-Phillips T, Brown ER, et al. Use of a vaginal ring containing dapivirine for HIV-1 prevention in women. N Engl J Med. 2016 Dec 1;375(22):2121-2132.Texto completo  Resumo

95. Nel A, van Niekerk N, Kapiga S, et al. Safety and efficacy of a dapivirine vaginal ring for HIV prevention in women. N Engl J Med. 2016 Dec 1;375(22):2133-2143.Texto completo  Resumo

96. The Panel on Treatment of Pregnant Women with HIV Infection and Prevention of Perinatal Transmission, US Department of Health and Human Services. Recommendations for the use of antiretroviral drugs in pregnant women with HIV infection and interventions to reduce perinatal HIV transmission in the United States. February 2021 [internet publication].Texto completo

97. Brocklehurst P, French R. The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and meta-analysis. Br J Obstet Gynaecol. 1998 Aug;105(8):836-48. Resumo

98. Leroy V, Ladner J, Nyiraziraje M, et al. Effect of HIV-1 infection on pregnancy outcome in women in Kigali, Rwanda 1992-1994. Pregnancy and HIV Study Group. AIDS. 1998 Apr 16;12(6):643-50. Resumo

99. Martin R, Boyer P, Hammill H, et al. Incidence of premature birth and neonatal respiratory disease in infants of HIV-positive mothers. The Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodeficiency Virus Infection Study Group. J Pediatr. 1997 Dec;131(6):851-6. Resumo

100. Puchalski Ritchie LM, van Lettow M, Pham B, et al. What interventions are effective in improving uptake and retention of HIV-positive pregnant and breastfeeding women and their infants in prevention of mother to child transmission care programmes in low-income and middle-income countries? A systematic review and meta-analysis. BMJ Open. 2019 Jul 29;9(7):e024907.Texto completo  Resumo