Sepse em adultos

Referências

Principais artigos

Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-10.Texto completo  Resumo

National Institute for Health and Care Excellence. Sepsis: recognition, diagnosis and early management. Sep 2017 [internet publication].Texto completo

Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021 Nov 1;49(11):e1063-143.Texto completo  Resumo

Artigos de referência

1. Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016 Feb 23;315(8):801-10.Texto completo  Resumo

2. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003 Apr;31(4):1250-6. Resumo

3. Nasa P, Juneja D, Singh O. Severe sepsis and septic shock in the elderly: an overview. World J Crit Care Med. 2012 Feb 4;1(1):23-30.Texto completo  Resumo

4. Castle SC, Norman DC, Yeh M, et al. Fever response in elderly nursing home residents: are the older truly colder? J Am Geriatr Soc. 1991 Sep;39(9):853-7. Resumo

5. National Institute for Health and Care Excellence. Sepsis: recognition, diagnosis and early management. Sep 2017 [internet publication].Texto completo

6. Singer M, Inada-Kim M, Shankar-Hari M. Sepsis hysteria: excess hype and unrealistic expectations. Lancet. 2019 Oct 26;394(10208):1513-4. Resumo

7. Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020 Jan 18;395(10219):200-11.Texto completo  Resumo

8. World Health Organization. Global report on the epidemiology and burden of sepsis. Sep 2020 [internet publication].Texto completo

9. Buchman TG, Simpson SQ, Sciarretta KL, et al. Sepsis among Medicare beneficiaries: 1. The burdens of sepsis, 2012-2018. Crit Care Med. 2020 Mar;48(3):276-88.Texto completo  Resumo

10. Rhee C, Jones TM, Hamad Y, et al. Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals. JAMA Netw Open. 2019 Feb 1;2(2):e187571.Texto completo  Resumo

11. Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003 Apr 17;348(16):1546-54.Texto completo  Resumo

12. Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit Care Med. 2001 Jul;29(suppl 7):S109-16. Resumo

13. Karlsson S, Varpula M, Ruokonen E. Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis Study. Intensive Care Med. 2007 Mar;33(3):435-43. Resumo

14. Blanco J, Muriel-Bombin A, Sagredo V, et al. Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care. 2008;12(6):R158.Texto completo  Resumo

15. Laupland KB, Gregson DB, Zygun DA, et al. Severe bloodstream infections: a population-based assessment. Crit Care Med. 2004 Apr;32(4):992-7. Resumo

16. Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med. 2006 Jan;34(1):15-21. Resumo

17. Annane D, Aegerter P, Jars-Guincestre MC, et al. Current epidemiology of septic shock: the CUB-Réa Network. Am J Respir Crit Care Med. 2003 Jul 15;168(2):165-72.Texto completo  Resumo

18. Pronovost P, Needham D, Berenholtz S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006 Dec 28;355(26):2725-32.Texto completo  Resumo

19. Arduino MJ, Tokars JI. Why is an infection control program needed in the hemodialysis setting? Nephrol News Issues. 2005 Jun;19(7):44;46-9. Resumo

20. Berenholtz SM, Milanovich S, Faircloth A, et al. Improving care for the ventilated patient. Jt Comm J Qual Saf. 2004 Apr;30(4):195-204. Resumo

21. World Health Organization. WHO guidelines on hand hygiene in health care. Jan 2009 [internet publication].Texto completo

22. Llop J, Badia MB, Comas D, et al. Colonization and bacteremia risk factors in parenteral nutrition catheterization. Clin Nutr. 2001 Dec;20(6):527-34. Resumo

23. Danai PA, Sinha S, Moss M, et al. Seasonal variation in the epidemiology of sepsis. Crit Care Med. 2007 Feb;35(2):410-5. Resumo

24. Raymond NJ, Blackmore TK, Humble MW, et al. Bloodstream infections in a secondary and tertiary care hospital setting. Intern Med J. 2006 Dec;36(12):765-72. Resumo

25. Gea-Banacloche JC, Opal SM, Jorgensen J, et al. Sepsis associated with immunosuppressive medications: an evidence based review. Crit Care Med. 2004 Nov;32(suppl 11):S578-90. Resumo

26. Cohen J, Brun-Buisson C, Torres A, et al. Diagnosis of infection in sepsis: an evidenced based review. Crit Care Med. 2004 Nov;32(11 Suppl):S466-94. Resumo

27. National Confidential Enquiry into Patient Outcome and Death. Just say sepsis! A review of the process of care received by patients with sepsis. Nov 2015 [internet publication].Texto completo

28. Pfaller MA, Messer SA, Hollis RJ, et al. Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location in the United States in 2001 to 2007. J Clin Microbiol. 2009 Oct;47(10):3185-90.Texto completo  Resumo

29. Vincent JL, Sakr Y, Sprung CL, et al. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006 Feb;34(2):344-53. Resumo

30. Levy MM, Dellinger RP, Townsend SR, et al. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med. 2010 Feb;38(2):367-74. Resumo

31. Vincent JL, Rello J, Marshall J, et al. International study of the prevalence and outcomes of infection in intensive care units. JAMA. 2009 Dec 2;302(21):2323-9.Texto completo  Resumo

32. Gauer RL. Early recognition and management of sepsis in adults: the first six hours. Am Fam Physician. 2013 Jul 1;88(1):44-53.Texto completo  Resumo

33. Russell JA. Management of sepsis. N Engl J Med. 2006 Oct 19;355(16):1699-713. Resumo

34. Shapiro NI, Wolfe RE, Moore RB, et al. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med. 2003 Mar;31(3):670-5. Resumo

35. Danai PA, Moss M, Mannino DM, et al. The epidemiology of sepsis in patients with malignancy. Chest. 2006 Jun;129(6):1432-40. Resumo

36. Page DB, Donnelly JP, Wang HE. Community-, healthcare-, and hospital-acquired severe sepsis hospitalizations in the University HealthSystem Consortium. Crit Care Med. 2015 Sep;43(9):1945-51.Texto completo  Resumo

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39. Centers for Disease Control and Prevention. Pregnancy mortality surveillance system. Mar 2023 [internet publication].Texto completo

40. Acosta CD, Knight M, Lee HC, et al. The continuum of maternal sepsis severity: incidence and risk factors in a population-based cohort study. PLoS One. 2013;8(7):e67175.Texto completo  Resumo

41. Plante LA, Pacheco LD, et al; Society for Maternal-Fetal Medicine (SMFM). SMFM Consult Series #47: sepsis during pregnancy and the puerperium. Am J Obstet Gynecol. 2019 Apr;220(4):B2-10.Texto completo  Resumo

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44. Montravers P, Dupont H, Gauzit R, et al. Candida as a risk factor for mortality in peritonitis. Crit Care Med. 2006 Mar;34(3):646-52. Resumo

45. Donelli G. Vascular catheter-related infection and sepsis. Surg Infect (Larchmt). 2006;7(suppl 2):S25-7. Resumo

46. Wenzel RP. Treating sepsis. N Engl J Med. 2002 Sep 26;347(13):966-7. Resumo

47. Tsujimoto H, Ono S, Efron PA, et al. Role of Toll-like receptors in the development of sepsis. Shock. 2008 Mar;29(3):315-21. Resumo

48. Hopkins P, Cohen J. Toll-like receptors: the key to the stable door? Crit Care. 2002 Apr;6(2):99-101.Texto completo  Resumo

49. Kumpf O, Giamarellos-Bourboulis EJ, Koch A, et al. Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Crit Care. 2010;14(3):R103.Texto completo  Resumo

50. Daniels R, Nutbeam T (eds). The ABC of sepsis. Chichester, West Sussex: Wiley-Blackwell; 2010.

51. Hauser B, Bracht H, Matejovic M, et al. Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studies. Anesth Analg. 2005 Aug;101(2):488-98. Resumo

52. Remick DG. Pathophysiology of sepsis. Am J Pathol. 2007 May;170(5):1435-44.Texto completo  Resumo

53. Faust SN, Heyderman RS, Levin M. Coagulation in severe sepsis: a central role for thrombomodulin and active protein C. Crit Care Med. 2001 Jul;29(suppl 7):S62-7;discussion S67-8. Resumo

54. Fourrier F, Chopin C, Goudemand J, et al. Septic shock, multiple organ failure, and disseminated intravascular coagulation: compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest. 1992 Mar;101(3):816-23. Resumo

55. Ince C. The microcirculation is the motor of sepsis. Crit Care. 2005;9(suppl 4):S13-9.Texto completo  Resumo

56. Balk RA. Severe sepsis and septic shock. Definitions, epidemiology, and clinical manifestations. Crit Care Clin. 2000 Apr;16(2):179-92. Resumo

57. Abraham E, Singer M. Mechanisms of sepsis-induced organ dysfunction. Crit Care Med. 2007 Oct;35(10):2408-16. Resumo

58. Waljee AK, Rogers MA, Lin P, et al. Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. BMJ. 2017 Apr 12;357:j1415.Texto completo  Resumo

59. Vogel TR, Dombrovskiy VY, Carson JL, et al. Postoperative sepsis in the United States. Ann Surg. 2010 Dec;252(6):1065-71.Texto completo  Resumo

60. Acosta CD, Kurinczuk JJ, Lucas DN, et al. Severe maternal sepsis in the UK, 2011-2012: a national case-control study. PLoS Med. 2014;11:e1001672.Texto completo  Resumo

61. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001 Nov 8;345(19):1368-77.Texto completo  Resumo

62. Gao F, Melody T, Daniels R, et al. The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study. Crit Care. 2005;9(6):R764-70.Texto completo  Resumo

63. Jones AE, Focht A, Horton JM, et al. Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock. Chest. 2007 Aug;132(2):425-32.Texto completo  Resumo

64. Puskarich MA, Marchick MR, Kline JA, et al. One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study. Crit Care. 2009;13(5):R167.Texto completo  Resumo

65. Daniels R, Nutbeam I, McNamara G, et al. The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study. Emerg Med J. 2011 Jun;28(6):507-12. Resumo

66. Yealy DM, Mohr NM, Shapiro NI, et al. Early care of adults with suspected sepsis in the emergency department and out-of-hospital environment: a consensus-based task force report. Ann Emerg Med. 2021 Jul;78(1):1-19.Texto completo  Resumo

67. Sundén-Cullberg J, Rylance R, Svefors J, et al. Fever in the emergency department predicts survival of patients with severe sepsis and septic shock admitted to the ICU. Crit Care Med. 2017 Apr;45(4):591-9. Resumo

68. Esper AM, Moss M, Lewis CA, et al. The role of infection and comorbidity: factors that influence disparities in sepsis. Crit Care Med. 2006 Oct;34(10):2576-82.Texto completo  Resumo

69. Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021 Nov 1;49(11):e1063-143.Texto completo  Resumo

70. Churpek MM, Snyder A, Han X, et al. Quick Sepsis-related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores for detecting clinical deterioration in infected patients outside the intensive care unit. Am J Respir Crit Care Med. 2017 Apr 1;195(7):906-11.Texto completo  Resumo

71. Fernando SM, Tran A, Taljaard M, et al. Prognostic accuracy of the Quick Sequential Organ Failure Assessment for mortality in patients with suspected infection: a systematic review and meta-analysis. Ann Intern Med. 2018 Feb 20;168(4):266-75. Resumo

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73. Goulden R, Hoyle MC, Monis J, et al. qSOFA, SIRS and NEWS for predicting inhospital mortality and ICU admission in emergency admissions treated as sepsis. Emerg Med J. 2018 Jun;35(6):345-9.Texto completo  Resumo

74. Keep JW, Messmer AS, Sladden R, et al. National early warning score at emergency department triage may allow earlier identification of patients with severe sepsis and septic shock: a retrospective observational study. Emerg Med J. 2016 Jan;33(1):37-41. Resumo

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77. NHS England. Sepsis guidance implementation advice for adults. Sep 2017 [internet publication].Texto completo

78. Academy of Medical Royal Colleges. ​Statement on the initial antimicrobial treatment of sepsis. Oct ​2022 [internet publication].Texto completo

79. American College of Emergency Physicians (ACEP) Expert Panel on Sepsis. DART: an evidence-driven tool to guide the early recognition and treatment of sepsis and septic shock. 2016 [internet publication].Texto completo

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85. Schuetz P, Birkhahn R, Sherwin R, et al. Serial procalcitonin predicts mortality in severe sepsis patients: results from the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study. Crit Care Med. 2017 May;45(5):781-9.Texto completo  Resumo

86. Kip MM, Kusters R, Ijzerman MJ, et al. A PCT algorithm for discontinuation of antibiotic therapy is a cost-effective way to reduce antibiotic exposure in adult intensive care patients with sepsis. J Med Econ. 2015;18(11):944-53. Resumo

87. Merx MW, Weber C. Sepsis and the heart. Circulation. 2007 Aug 14;116(7):793-802.Texto completo  Resumo

88. Nguyen HB, Rivers EP, Knoblich BP, et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med. 2004 Aug;32(8):1637-42. Resumo

89. Jones AE, Shapiro NI, Trzeciak S, et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010 Feb 24;303(8):739-46.Texto completo  Resumo

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92. Shehabi Y, Sterba M, Garrett PM, et al. Procalcitonin algorithm in critically ill adults with undifferentiated infection or suspected sepsis: a randomized controlled trial. Am J Respir Crit Care Med. 2014 Nov 15;190(10):1102-10.Texto completo  Resumo

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126. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension prior to initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006 Jun;34(6):1589-96. Resumo

127. Kalil AC, Johnson DW, Lisco SJ, et al. Early goal-directed therapy for sepsis: a novel solution for discordant survival outcomes in clinical trials. Crit Care Med. 2017 Apr;45(4):607-14. Resumo

128. Gaieski DF, Mikkelsen ME, Band RA, et al. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med. 2010 Apr;38(4):1045-53. Resumo

129. Johnston AN, Park J, Doi SA, et al. Effect of immediate administration of antibiotics in patients with sepsis in tertiary care: a systematic review and meta-analysis. Clin Ther. 2017 Jan;39(1):190-202;e6. Resumo

130. National Institute for Health Research. NIHR Alert: giving immediate antibiotics reduces deaths from sepsis. Apr 2017 [internet publication].Texto completo

131. Sherwin R, Winters ME, Vilke GM, et al. Does early and appropriate antibiotic administration improve mortality in emergency department patients with severe sepsis or septic shock? J Emerg Med. 2017 Oct;53(4):588-95. Resumo

132. Baghdadi JD, Brook RH, Uslan DZ, et al. Association of a care bundle for early sepsis management with mortality among patients with hospital-onset or community-onset sepsis. JAMA Intern Med. 2020 May 1;180(5):707-16. Resumo

133. Bisarya R, Song X, Salle J, et al. Antibiotic timing and progression to septic shock among patients in the ED with suspected infection. Chest. 2022 Jan;161(1):112-20. Resumo

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