Câncer orofaríngeo

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: head and neck cancers [internet publication].Texto completo

Amin MB, Edge SB, Greene FL, et al, eds. AJCC cancer staging manual. 8th ed. New York, NY: Springer International Publishing, 2017.

1. El-Naggar AK, Chan JKC, Grandis JR, et al. eds. WHO classification of head and neck tumours. WHO classification of tumours, 4th ed. Vol 9. IARC Press; 2017.

2. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: head and neck cancers [internet publication].Texto completo

3. Westra WH, Lewis JS Jr. Update from the 4th edition of the World Health Organization classification of head and neck tumours: oropharynx. Head Neck Pathol. 2017 Mar;11(1):41-7. Resumo

4. Badoual C. Update from the 5th edition of the World Health Organization classification of head and neck tumors: oropharynx and nasopharynx. Head Neck Pathol. 2022 Mar;16(1):19-30. Resumo

5. Mashiana SS, Navale P, Khandakar B, et al. Human papillomavirus genotype distribution in head and neck cancer: informing developing strategies for cancer prevention, diagnosis, treatment and surveillance. Oral Oncol. 2021 Feb;113:105109. Resumo

6. McIlwain WR, Sood AJ, Nguyen SA, et al. Initial symptoms in patients with HPV-positive and HPV-negative oropharyngeal cancer. JAMA Otolaryngol Head Neck Surg. 2014 May;140(5):441-7.Texto completo  Resumo

7. Liao CI, Francoeur AA, Kapp DS, et al. Trends in human papillomavirus-associated cancers, demographic characteristics, and vaccinations in the US, 2001-2017. JAMA Netw Open. 2022 Mar 1;5(3):e222530.Texto completo  Resumo

8. Centers for Disease Control and Prevention. HPV and oropharyngeal cancer. Sep 2023 [internet publication].Texto completo

9. Mourad M, Jetmore T, Jategaonkar AA, et al. Epidemiological trends of head and neck cancer in the United States: A SEER population study. J Oral Maxillofac Surg. 2017 May 22;75(12):2562-72.Texto completo  Resumo

10. Ryerson AB, Peters ES, Coughlin SS, et al. Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998-2003. Cancer. 2008 Nov 15;113(10 suppl):2901-9. Resumo

11. Gandini S, Botteri E, Iodice S, et al. Tobacco smoking and cancer: a meta-analysis. Int J Cancer. 2008 Jan 1;122(1):155-64.Texto completo  Resumo

12. Turati F, Garavello W, Tramacere I, et al. A meta-analysis of alcohol drinking and oral and pharyngeal cancers. Part 2: results by subsites. Oral Oncol. 2010 Oct;46(10):720-6. Resumo

13. Turati F, Garavello W, Tramacere I, et al. A meta-analysis of alcohol drinking and oral and pharyngeal cancers: results from subgroup analyses. Alcohol and Alcoholism. 2013 Jan-Feb;48(1):107-18.Texto completo  Resumo

14. Critchley JA, Unal B. Health effects associated with smokeless tobacco: a systematic review. Thorax. 2003 May;58(5):435-43.Texto completo  Resumo

15. Znaor A, Brennan P, Gajalakshmi V, et al. Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men. Int J Cancer. 2003 Jul 10;105(5):681-6.Texto completo  Resumo

16. D'Souza G, Kreimer AR, Viscidi R, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. 2007 May 10;356(19):1944-56.Texto completo  Resumo

17. Suk R, Mahale P, Sonawane K, et al. Trends in risks for second primary cancers associated with index human papillomavirus-associated cancers. JAMA Netw Open. 2018 Sep 7;1(5):e181999.Texto completo  Resumo

18. Hecht SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst. 1999 Jul 21;91(14):1194-210.Texto completo  Resumo

19. Baan R, Straif K, Grosse Y, et al. Carcinogenicity of alcoholic beverages. Lancet Oncol. 2007 Apr;8(4):292-3. Resumo

20. Hashibe M, Brennan P, Strange RC, et al. Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer. Cancer Epidemiol Biomarkers Prev. 2003 Dec;12(12):1509-17.Texto completo  Resumo

21. Wang X, Wang HK, McCoy JP, et al. Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6. RNA. 2009 Apr;15(4):637-47.Texto completo  Resumo

22. Boffetta P, Hecht S, Gray N, et al. Smokeless tobacco and cancer. Lancet Oncol. 2008 Jul;9(7):667-75. Resumo

23. Chen YJ, Chang JT, Liao CT, et al. Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis. Cancer Sci. 2008 Aug;99(8):1507-14.Texto completo  Resumo

24. Chaturvedi AK, Engels EA, Anderson WF, et al. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol. 2008 Feb 1;26(4):612-9.Texto completo  Resumo

25. Hammarstedt L, Dahlstrand H, Lindquist D, et al. The incidence of tonsillar cancer in Sweden is increasing. Acta Otolaryngol. 2007 Sep;127(9):988-92. Resumo

26. Lee JJ, Jeng JH, Wang HM, et al. Univariate and multivariate analysis of prognostic significance of betel quid chewing in squamous cell carcinoma of buccal mucosa in Taiwan. J Surg Oncol. 2005 Jul 1;91(1):41-7. Resumo

27. Human papillomavirus vaccines: WHO position paper, December 2022. Wkly Epidemiol Rec. 2022 Dec 16;97(50):645-72.Texto completo

28. NHS. Who should have the HPV vaccine? May 2019 [internet publication].Texto completo  Resumo

29. Meites E, Szilagyi PG, Chesson HW, et al. Human papillomavirus vaccination for adults: updated recommendations of the Advisory Committee on Immunization Practices. MMWR Morb Mortal Wkly Rep. 2019 Aug 16;68(32):698-702.Texto completo  Resumo

30. Epstein JB, Gorsky M, Cabay RJ, et al. Screening for and diagnosis of oral premalignant lesions and oropharyngeal squamous cell carcinoma: role of primary care physicians. Can Fam Physician. 2008 Jun;54(6):870-5.Texto completo  Resumo

31. Nguyen NP, Vos P, Moltz CC, et al. Analysis of the factors influencing dysphagia severity upon diagnosis of head and neck cancer. Br J Radiol. 2008 Sep;81(969):706-10. Resumo

32. Nguyen NP, Vos P, Lee H, et al. Impact of tumor board recommendations on treatment outcome for locally advanced head and neck cancer. Oncology. 2008;75(3-4):186-91. Resumo

33. Nguyen NP, North D, Smith HJ, et al. Safety and effectiveness of prophylactic gastrostomy tubes for head and neck cancer patients undergoing chemoradiation. Surg Oncol. 2006 Dec;15(4):199-203. Resumo

34. Amin MB, Edge SB, Greene FL, et al, eds. AJCC cancer staging manual. 8th ed. New York, NY: Springer International Publishing, 2017.

35. Lenz M, Greess H, Baum U, et al. Oropharynx, oral cavity, floor of the mouth: CT or MRI. Eur J Radiol. 2000 Mar;33(3):203-15. Resumo

36. Zima AJ, Wesolowski JR, Ibrahim N, et al. Magnetic resonance imaging of oropharyngeal cancer. Top Magn Reson Imaging. 2007 Aug;18(4):237-42. Resumo

37. Wong RJ. Current status of FDG-PET for head and neck cancer. J Surg Oncol. 2008 Jun 15;97(8):649-52. Resumo

38. Branstetter BF 4th, Blodgett TM, Zimmer LA, et al. Head and neck malignancy: is PET/CT more accurate than PET or CT alone? Radiology. 2005 May;235(2):580-6. Resumo

39. Kim SJ, Pak K, Kim K. Diagnostic accuracy of F-18 FDG PET or PET/CT for detection of lymph node metastasis in clinically node negative head and neck cancer patients; A systematic review and meta-analysis. Am J Otolaryngol. 2019 Mar - Apr;40(2):297-305. Resumo

40. Heron DE, Andrade RS, Beriwal S, et al. PET-CT in radiation oncology: the impact on diagnosis, treatment planning, and assessment of treatment response. Am J Clin Oncol. 2008 Aug;31(4):352-62. Resumo

41. Balm AJ, van Velthuysen ML, Hoebers FJ, et al. Diagnosis and treatment of a neck node swelling suspicious for a malignancy: an algorithmic approach. Int J Surg Oncol. 2010 May 30;2010:581540.Texto completo  Resumo

42. van den Brekel MW, Casteljins JA, Stel HV, et al. Modern imaging techniques and ultrasound-guided aspiration cytology for the assessment of neck node metastases: a prospective comparative study. Eur Arch Otorhinolaryngol. 1993;250(1):11-7. Resumo

43. Dabirmoghaddam P, Sharifkashany S, Mashali L. Ultrasound-guided fine needle aspiration cytology in the assessment of cervical metastasis in patients undergoing elective neck dissection. Iran J Radiol. 2014 Aug;11(3):e7928. Resumo

44. Lewis JS Jr, Beadle B, Bishop JA, et al. Human papillomavirus testing in head and neck carcinomas: guideline from the college of American pathologists. Arch Pathol Lab Med. 2018 May;142(5):559-97.Texto completo  Resumo

45. Guardiola E, Pivot X, Dassonville O, et al. Is routine triple endoscopy for head and neck carcinoma patients necessary in light of a negative chest computed tomography scan? Cancer. 2004 Nov 1;101(9):2028-33.Texto completo  Resumo

46. Hujala K, Sipilä J, Grenman R. Panendoscopy and synchronous second primary tumors in head and neck cancer patients. Eur Arch Otorhinolaryngol. 2005 Jan;262(1):17-20. Resumo

47. Guardiola E, Chaigneau L, Villanueva C, et al. Is there still a role for triple endoscopy as part of staging for head and neck cancer? Curr Opin Otolaryngol Head Neck Surg. 2006 Apr;14(2):85-8. Resumo

48. Erdi YE. Limits of tumor detectability in nuclear medicine and PET. Mol Imaging Radionucl Ther. 2012 Apr 1;21(1):23-8.Texto completo  Resumo

49. Miller FR, Karnad AB, Eng T, et al. Management of the unknown primary carcinoma: long-term follow-up on a negative PET scan and negative panendoscopy. Head Neck. 2008 Jan;30(1):28-34.Texto completo  Resumo

50. Pitchers M, Martin C. Delay in referral of oropharyngeal squamous cell carcinoma to secondary care correlates with a more advanced stage at presentation, and is associated with poorer survival. Br J Cancer. 2006 Apr 10;94(7):955-8.Texto completo  Resumo

51. Roosli C, Tschudi DC, Studer G, et al. Outcome of patients after treatment for a squamous cell carcinoma of the oropharynx. Laryngoscope. 2009 Mar;119(3):534-40. Resumo

52. Koivunen P, Rantala N, Hyrynkangas, et al. The impact of patient and professional diagnostic delays on survival in pharyngeal cancer. Cancer. 2001 Dec 1;92(11):2885-91.Texto completo  Resumo

53. Tromp DM, Brouha XD, Hordijk GJ, et al. Patient and tumour factors associated with advanced carcinomas of the head and neck. Oral Oncol. 2005 Mar;41(3):313-9. Resumo

54. van Bokhorst-de van der Schueren MA, van Leeuwen PA, Sauerwein HP, et al. Assessment of malnutrition parameters in head and neck cancer and their relation to postoperative complications. Head Neck. 1997 Aug;19(5):419-25. Resumo

55. Ho T, Zahurak M, Koch WM. Prognostic significance of presentation-to-diagnosis interval in patients with oropharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Jan;130(1):45-51.Texto completo  Resumo

56. Ichimura K, Tanaka T. Trismus in patients with malignant tumours in the head and neck. J Laryngol Otol. 1993 Nov;107(11):1017-20. Resumo

57. Nahmias C, Lemmens C, Faul D, et al. Does reducing CT artifacts from dental implants influence the PET interpretation in PET/CT studies of oral cancer and head and neck cancer? J Nucl Med. 2008 Jul;49(7):1047-52.Texto completo  Resumo

58. Gourin CG, Watts T, Willams HT, et al. Identification of distant metastases with PET-CT in patients with suspected recurrent head and neck cancer. Laryngoscope. 2009 Apr;119(4):703-6. Resumo

59. Pantvaidya GH, Agarwal JP, Deshpande MS, et al. PET-CT in recurrent head neck cancers: a study to evaluate impact on patient management. J Surg Oncol. 2009 Oct 1;100(5):401-3. Resumo

60. Abgral R, Querellou S, Potard G, et al. Does 18-FDG PET/CT improve the detection of posttreatment recurrence of head and neck squamous cell carcinoma in patients negative for disease on clinical follow-up? J Nucl Med. 2009 Jan;50(1):24-9. Resumo

61. Connell CA, Corry J, Milner AD, et al. Clinical impact of, and prognostic stratification by, F-18 FDG PET/CT in head and neck mucosal squamous cell carcinoma. Head Neck. 2007 Nov;29(11):986-95. Resumo

62. Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982 Dec;5(6):649-55. Resumo

63. Epstein JB, Silverman S Jr., Epstein JD, et al. Analysis of oral lesion biopsies identified and evaluated by visual examination, chemoluminescence and toluidine blue. Oral Oncol. 2008 Jun;44(6):538-44. [Erratum in: Oral Oncol. 2008 Jun;44(6):615.] Resumo

64. NIH National Cancer Institute. Oral cavity, pharyngeal, and laryngeal cancer screening (PDQ®) - health professional version. May 2023 [internet publication].Texto completo

65. Cosmidis A, Rame JP, Dassonville O, et al; Groupement d'Etudes des Tumeurs de la Tête et du Cou (GETTEC). T1-T2 N0 oropharyngeal cancers treated with surgery alone: a GETTEC study. Eur Arch Otorhinolaryngol. 2004 May;261(5):276-81. Resumo

66. Parsons JT, Mendenhall WM, Stringer SP, et al. Squamous cell carcinoma of the oropharynx: surgery, radiotherapy, or both. Cancer. 2002 Jun 1;94(11):2967-80.Texto completo  Resumo

67. Soo KC, Tan EH, Wee J, et al. Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III/IV nonmetastatic squamous cell head and neck cancer: a randomised comparison. Br J Cancer. 2005 Aug 8;93(3):279-86.Texto completo  Resumo

68. Rieger J, Dickson N, Lemire R, et al. Social perception of speech in individuals with oropharyngeal reconstruction. J Psychosoc Oncol. 2006;24(4):33-51. Resumo

69. Rogers SN, Miller RD, Ali K, et al. Patients' perceived health status following primary surgery for oral and oropharyngeal cancer. Int J Oral Maxillofac Surg. 2006 Oct;35(10):913-9. Resumo

70. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006 Feb 9;354(6):567-78.Texto completo  Resumo

71. Xu Q, Huang S, Yang K. Combination immunochemotherapy for recurrent or metastatic head and neck squamous cell carcinoma: a systematic review and meta-analysis. BMJ Open. 2023 Jun 13;13(6):e069047.Texto completo  Resumo

72. Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008 Sep 11;359(11):1116-27.Texto completo  Resumo

73. Adelstein DJ, Ismaila N, Ku JA, et al. Role of treatment deintensification in the management of p16+ oropharyngeal cancer: ASCO provisional clinical opinion. J Clin Oncol. 2019 Jun 20;37(18):1578-89.Texto completo  Resumo

74. Nichols AC, Faquin WC, Westra WH, et al. HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg. 2009 Feb;140(2):228-34. Resumo

75. Lassen P, Eriksen JG, Hamilton-Dutoit S, et al. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol. 2009 Apr 20;27(12):1992-8. Resumo

76. Fakhry C, Westra W, Li S, et al. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008 Feb 20;100(4):261-9.Texto completo  Resumo

77. Parikh A, Lin D, Goyal N. Clinical outcomes of transoral robotic-assisted surgery for the management of head and neck cancer. Robot Surg. 2023 Feb 20;2(2015):95-105.Texto completo

78. Denittis AS, Machtay M, Rosenthal DI, et al. Advanced oropharyngeal cancer treated with surgery and radiotherapy: oncologic outcome and functional assessment. Am J Otolaryngol. 2001 Sep-Oct;22(5):329-35. Resumo

79. Lim YC, Hong HJ, Baek SJ, et al. Combined surgery and postoperative radiotherapy for oropharyngeal squamous cell carcinoma in Korea: analysis of 110 cases. Int J Oral Maxillofac Surg. 2008 Dec;37(12):1099-105. Resumo

80. Nguyen NP, Vos P, Smith HJ, et al. Concurrent chemoradiation for locally advanced oropharyngeal cancer. Am J Otolaryngol. 2007 Jan-Feb;28(1):3-8. Resumo

81. Adelstein DJ, Saxton JP, Lavertu P, et al. A phase III randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer: preliminary results. Head Neck. 1997 Oct;19(7):567-75. Resumo

82. Blanchard P, Baujat B, Holostenco V, et al. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site. Radiother Oncol. 2011 Jul;100(1):33-40. Resumo

83. Budach V, Stuschke M, Budach W, et al. Hyperfractionated accelerated chemoradiation with concurrent fluorouracil-mitomycin is more effective than dose-escalated hyperfractionated accelerated radiation therapy alone in locally advanced head and neck cancer: final results of the Radiotherapy Cooperative Clinical Trials Group of the German Cancer Society 95-06 Prospective Randomized Trial. J Clin Oncol. 2005 Feb 20;23(6):1125-35.Texto completo  Resumo

84. Tao Y, Auperin A, Sire C, et al. Improved outcome by adding concurrent chemotherapy to cetuximab and radiotherapy for locally advanced head and neck carcinomas: results of the GORTEC 2007-01 phase III randomized trial. J Clin Oncol. 2018 Nov;36(31):3084-90. Resumo

85. Gillison ML, Trotti AM, Harris J, et al. Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial. Lancet. 2018 Nov 15;393(10166):40-50. Resumo

86. Mehanna H, Robinson M, Hartley A, et al. Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial. Lancet. 2018 Nov 15;393(10166):51-60.Texto completo  Resumo

87. Bensadoun RJ, Benezery K, Dassonville O, et al. French multicenter phase III randomized study testing concurrent twice-a-day radiotherapy and cisplatin/5-fluorouracil chemotherapy (BiRCF) in unresectable pharyngeal carcinoma: results at 2 years (FNCLCC-GORTEC). Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):983-94. Resumo

88. Staar S, Rudat V, Stuetzer H, et al. Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy: results of a multicentric randomized German trial in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001 Aug 1;50(5):1161-71. [Erratum in: Int J Radiat Oncol Biol Phys 2001 Oct 1;51(2):569.] Resumo

89. Semrau R, Mueller RP, Stuetzer H, et al. Efficacy of intensified hyperfractionated and accelerated radiotherapy and concurrent chemotherapy with carboplatin and 5-fluorouracil: updated results of a randomized multicentric trial in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1308-16. Resumo

90. Denis F, Garaud P, Bardet E, et al. Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant chemoradiotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol. 2004 Jan 1;22(1):69-76.Texto completo  Resumo

91. Calais G, Alfonsi M, Bardet E, et al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst. 1999 Dec 15;91(24):2081-6.Texto completo  Resumo

92. Brizel DM, Albers ME, Fisher SR, et al. Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med. 1998 Jun 18;338(25):1798-804.Texto completo  Resumo

93. Pignon JP, le Maitre A, Maillard E, et al; MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol. 2009 Jul;92(1):4-14. Resumo

94. Posner MR, Hershock DM, Blajman CR, et al; TAX 324 Study Group. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med. 2007 Oct 25;357(17):1705-15.Texto completo  Resumo

95. Adelstein DJ, Li Y, Adams GL, et al. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol. 2003 Jan 1;21(1):92-8. Resumo

96. Blanchard P, Bourhis J, Lacas B, et al; Meta-Analysis of Chemotherapy in Head and Neck Cancer, Induction Project, Collaborative Group. Taxane-cisplatin-fluorouracil as induction chemotherapy in locally advanced head and neck cancers: an individual patient data meta-analysis of the meta-analysis of chemotherapy in head and neck cancer group. J Clin Oncol. 2013 Aug 10;31(23):2854-60.Texto completo  Resumo

97. Martins RG, Parvathaneni U, Bauman JE, et al. Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: a randomized phase II trial. J Clin Oncol. 2013 Apr 10;31(11):1415-21.Texto completo  Resumo

98. Mesia R, Henke M, Fortin A, et al. Chemoradiotherapy with or without panitumumab in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-1): a randomised, controlled, open-label phase 2 trial. Lancet Oncol. 2015 Feb;16(2):208-20. Resumo

99. Burtness B, Goldwasser MA, Flood W, et al. A phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol. 2005 Dec 1;23(34):8646-54. [Erratum in: J Clin Oncol. 2006 Feb 1;24(4):724.]Texto completo  Resumo

100. Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009 Feb 5;360(6):563-72.Texto completo  Resumo

101. Bumpous JM. Surgical salvage of cancer of the oropharynx after chemoradiation. Curr Oncol Rep. 2009 Mar;11(2):151-5. Resumo

102. Watkins JM, Shirai KS, Wahlquist AE, et al. Toxicity and survival outcomes of hyperfractionated split-course reirradiation and daily concurrent chemotherapy in locoregionally recurrent, previously irradiated head and neck cancers. Head Neck. 2009 Apr;31(4):493-502. Resumo

103. Seiwert TY, Burtness B, Mehra R, et al. Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial. Lancet Oncol. 2016 May 27;17(7):956-65. Resumo

104. Chow LQ, Haddad R, Gupta S, et al. Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: results from the phase Ib KEYNOTE-012 expansion cohort. J Clin Oncol. 2016 Sep 30;34(32):3838-45.Texto completo  Resumo

105. Burtness B, Harrington KJ, Greil R, et al. Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study. Lancet. 2019 Nov 23;394(10212):1915-28. Resumo

106. National Institute for Health and Care Excellence. Pembrolizumab for untreated metastatic or unresectable recurrent head and neck squamous cell carcinoma. Nov 2020 [internet publication].Texto completo

107. Ferris RL, Blumenschein G Jr, Fayette J, et al. Nivolumab for recurrent squamous-cell carcinoma of the head and neck. N Engl J Med. 2016 Nov 10;375(19):1856-67.Texto completo  Resumo

108. Harrington KJ, Ferris RL, Blumenschein G Jr, et al. Nivolumab versus standard, single-agent therapy of investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck (CheckMate 141): health-related quality-of-life results from a randomised, phase 3 trial. Lancet Oncol. 2017 Aug;18(8):1104-15. Resumo

109. National Institute for Health and Care Excellence. Nivolumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy. Oct 2021 [internet publication].Texto completo

110. Seiwert TY, Burtness B, Mehra R, et al. Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial. Lancet Oncol. 2016 May 27;17(7):956-65. Resumo

111. Brock PR, Maibach R, Childs M, et al. Sodium thiosulfate for protection from cisplatin-induced hearing loss. N Engl J Med. 2018 Jun 21;378(25):2376-85.Texto completo  Resumo

112. Meluch AA, Spigel D, Burris HA, et al. Combined modality therapy with radiation therapy (RT), chemotherapy, bevacizumab, and erlotinib in the treatment of patients (pts) with locally advanced squamous carcinoma of the head and neck. J Clin Oncol. 2009 May 20;27(15_suppl):6012.

113. Mercke C, Wickart-Johansson G, Sjodin H, et al. Upfront chemotherapy and accelerated radiotherapy with EGFR inhibition for locally advanced inoperable head and neck cancer. J Clin Oncol. 2009 May 20;27(15_suppl):6040.

114. Vermorken JB, Stöhlmacher-Williams J, Davidenko I, et al; SPECTRUM investigators. Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial. Lancet Oncol. 2013 Jul;14(8):697-710. Resumo

115. Pang E, Delic NC, Hong A, et al. Radiosensitization of oropharyngeal squamous cell carcinoma cells by human papillomavirus 16 oncoprotein E6∗I. Int J Radiat Oncol Biol Phys. 2011 Mar 1;79(3):860-5. Resumo

116. Young R, Rischin D, Fisher R, et al. Relationship between epidermal growth factor receptor status, p16(INK4A), and outcome in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2011 Jun;20(6):1230-7. Resumo

117. Nguyen NP, Ceizyk M, Vos P, et al. Feasibility of tomotherapy-based image-guided radiotherapy for locally advanced oropharyngeal cancer. PLoS One. 2013;8(3):e60268.Texto completo  Resumo

118. Rischin D, Young RJ, Fisher R, et al. Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial. J Clin Oncol. 2010 Sep 20;28(27):4142-8. Resumo

119. Ang KK, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010 Jul 1;363(1):24-35.Texto completo  Resumo

120. Nguyen NP, Ly BH, Betz M, et al. Importance of age as a prognostic factor fortonsillar carcinoma. Ann Surg Oncol. 2010 Oct;17(10):2570-7. Resumo

121. Le Scodan R, Pommier P, Ardiet JM, et al. Exclusive brachytherapy for T1 and T2 squamous cell carcinomas of the velotonsillar area: results in 44 patients. Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):441-8. Resumo

122. Levendag P, Nijdam W, Noever I, et al. Brachytherapy versus surgery in carcinoma of tonsillar fossa and/or soft palate: late adverse sequelae and performance status: can we be more selective and obtain better tissue sparing? Int J Radiat Oncol Biol Phys. 2004 Jul 1;59(3):713-24. Resumo

123. Bernier J, Domenge C, Ozsahin M, et al; European Organization for Research and Treatment of Cancer Trial 22931. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004 May 6;350(19):1945-52.Texto completo  Resumo

124. Guha S, Kelly CG, Guha R, et al. Intensity modulated radiation therapy (IMRT) in the treatment of squamous carcinoma of the oropharynx: an overview. J Cancer Sci Ther. 2012;4(4):77-83.Texto completo

125. Grønhøj C, Jensen JS, Wagner S, et al. Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study. Oncotarget. 2019 Jul 23;10(45):4655-63.Texto completo  Resumo

126. Elhalawani H, Mohamed ASR, Elgohari B, et al. Tobacco exposure as a major modifier of oncologic outcomes in human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma. BMC Cancer. 2020 Sep 23;20(1):912.Texto completo  Resumo

127. McCombe D, Lyons B, Winkler R, et al. Speech and swallowing following radial forearm flap reconstruction of major soft palate defect. Br J Plast Surg. 2005 Apr;58(3):306-11. Resumo

128. Gillespie MB, Eisele DW. The uvulopalatal flap for reconstruction of the soft palate. Laryngoscope. 2000 Apr;110(4):612-5. Resumo

129. Erkal HS, Serin M, Amdur RJ, et al. Squamous cell carcinoma of soft palate treated with radiation therapy alone or followed by planned neck dissection. Int J Radiat Oncol Biol Phys. 2001 Jun 1;50(2):359-66. Resumo

130. Kazi R, Prasad VM, Kanagalingam J, et al. Analysis of formant frequencies in patients with oral and oropharyngeal cancers treated by glossectomy. Int J Lang Commun Disord. 2007 Sep-Oct;42(5):521-32. Resumo

131. Harrison LB, Zelefsky MJ, Armstrong JG, et al. Performance status after treatment for squamous cell cancer of the base of tongue: a comparison of primary radiation therapy versus primary surgery. Int J Radiat Oncol Biol Phys. 1994 Nov 15;30(4):953-7. Resumo

132. Nguyen NP, Moltz CC, Frank C, et al. Effectiveness of the cough reflex in patients with aspiration following radiation for head and neck cancer. Lung. 2007 Sep-Oct;185(5):243-8. Resumo

133. Kam MK, Leung SF, Zee B, et al. Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early stage nasopharyngeal carcinoma patients. J Clin Oncol. 2007 Nov 1;25(31):4873-9.Texto completo  Resumo

134. Helson L, Okonkwo E, Anton L, et al. cis-Platinum ototoxicity. Clin Toxicol. 1978;13(4):469-78. Resumo

135. Bokemeyer C, Berger CC, Hartmann JT, et al. Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer. Br J Cancer. 1998 Apr;77(8):1355-62.Texto completo  Resumo

136. Melamed LB, Selim MA, Schuchman D. Cisplatin ototoxicity in gynecologic cancer patients. A preliminary report. Cancer. 1985 Jan 1;55(1):41-3. Resumo

137. Hitchcock YJ, Tward JD, Szabo A, et al. Relative contributions of radiation and cisplatin-based chemotherapy to sensorineural hearing loss in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):779-88. Resumo

138. Jereczek-Fossa BA, Zarowski A, Milani F, et al. Radiotherapy-induced ear toxicity. Cancer Treat Rev. 2003 Oct;29(5):417-30. Resumo

139. van der Molen L, van Rossum MA, Burkhead LM, et al. A randomized preventive rehabilitation trial in advanced head and neck cancer patients treated with chemoradiotherapy: feasibility, compliance, and short-term effects. Dysphagia. 2010 Jul 11;26(2):155-70.Texto completo  Resumo