Trastorno de ansiedad generalizada

American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.

Bandelow B, Sher L, Bunevicius R, et al; WFSBP Task Force on Mental Disorders in Primary Care; WFSBP Task Force on Anxiety Disorders, OCD and PTSD. Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care. Int J Psychiatry Clin Pract. 2012 Jun;16(2):77-84. Resumen

Bandelow B, Sagebiel A, Belz M, et al. Enduring effects of psychological treatments for anxiety disorders: meta-analysis of follow-up studies. Br J Psychiatry. 2018 Jun;212(6):333-8.Texto completo  Resumen

Slee A, Nazareth I, Bondaronek P, et al. Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis. Lancet. 2019 Feb 23;393(10173):768-77. Resumen

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.

2. World Health Organization. International classification of diseases, eleventh revision. 6B00: generalised anxiety disorder. 2022 [internet publication].Texto completo

3. Turner S, Mota N, Bolton J, et al. Self-medication with alcohol or drugs for mood and anxiety disorders: a narrative review of the epidemiological literature. Depress Anxiety. 2018 Sep;35(9):851-60.Texto completo  Resumen

4. Ruscio AM, Hallion LS, Lim CCW, et al. Cross-sectional comparison of the epidemiology of DSM-5 generalized anxiety disorder across the globe. JAMA Psychiatry. 2017 May 1;74(5):465-75.Texto completo  Resumen

5. Lieb R, Becker E, Altamura C. The epidemiology of generalized anxiety disorder in Europe. Eur Neuropsychopharmacol. 2005 Aug;15(4):445-52. Resumen

6. Stein DJ, Scott KM, de Jonge P, et al. Epidemiology of anxiety disorders: from surveys to nosology and back. Dialogues Clin Neurosci. 2017 Jun;19(2):127-36.Texto completo  Resumen

7. Bandelow B, Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci. 2015 Sep;17(3):327-35.Texto completo  Resumen

8. COVID-19 Mental Disorders Collaborators. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic. Lancet. 2021 Nov 6;398(10312):1700-12.Texto completo  Resumen

9. da Silva ML, Rocha RSB, Buheji M, et al. A systematic review of the prevalence of anxiety symptoms during coronavirus epidemics. J Health Psychol. 2021 Jan;26(1):115-25.Texto completo  Resumen

10. Remes O, Brayne C, van der Linde R, et al. A systematic review of reviews on the prevalence of anxiety disorders in adult populations. Brain Behav. 2016 Jun 5;6(7):e00497.Texto completo  Resumen

11. Grenier S, Payette MC, Gunther B, et al. Association of age and gender with anxiety disorders in older adults: a systematic review and meta-analysis. Int J Geriatr Psychiatry. 2019 Mar;34(3):397-407. Resumen

12. Dennis CL, Falah-Hassani K, Shiri R. Prevalence of antenatal and postnatal anxiety: systematic review and meta-analysis. Br J Psychiatry. 2017 May;210(5):315-23.Texto completo  Resumen

13. Fawcett EJ, Fairbrother N, Cox ML, et al. The prevalence of anxiety disorders during pregnancy and the postpartum period: a multivariate Bayesian meta-analysis. J Clin Psychiatry. 2019 Jul 23;80(4):18r12527.Texto completo  Resumen

14. Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994 Jan;51(1):8-19. Resumen

15. Alonso J, Angermeyer MC, Bemert S, et al. 12-month comorbidity and associated factors in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand Suppl. 2004;420:28-37. Resumen

16. Kalin NH. The critical relationship between anxiety and depression. Am J Psychiatry. 2020 May 1;177(5):365-7.Texto completo

17. Lamers F, van Oppen P, Comijs HC, et al. Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA). J Clin Psychiatry. 2011 Mar;72(3):341-8. Resumen

18. Brantley PJ, Mehan DJ Jr, Ames SC, et al. Minor stressors and generalized anxiety disorders among low income patients attending primary care clinics. J Nerv Ment Dis. 1999 Jul;187(7):435-40. Resumen

19. Lau AW, Edelstein BA, Larkin KT. Psychophysiological arousal in older adults: a critical review. Clin Psychol Rev. 2001 Jun;21(4):609-30. Resumen

20. Brown ES, Fulton MK, Wilkeson A, et al. The psychiatric sequelae of civilian trauma. Compr Psychiatry. 2000 Jan-Feb;41(1):19-23. Resumen

21. Penninx BW, Pine DS, Holmes EA, et al. Anxiety disorders. Lancet. 2021 Mar 6;397(10277):914-27.Texto completo  Resumen

22. Craske MG, Stein MB. Anxiety. Lancet. 2016 Dec 17;388(10063):3048-59. Resumen

23. Moreno-Peral P, Conejo-Cerón S, Motrico E, et al. Risk factors for the onset of panic and generalised anxiety disorders in the general adult population: a systematic review of cohort studies. J Affect Disord. 2014 Oct;168:337-48. Resumen

24. Möller EL, Nikolić M, Majdandžić M, et al. Associations between maternal and paternal parenting behaviors, anxiety and its precursors in early childhood: a meta-analysis. Clin Psychol Rev. 2016 Apr;45:17-33. Resumen

25. Hawker DSJ, Boulton MJ. Twenty years' research on peer victimization and psychosocial maladjustment: a meta-analytic review of cross-sectional studies. J Child Psychol Psychiatry. 2000 May;41(4):441-55. Resumen

26. Hettema JM, Neale NC, Kendler KS. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry. 2001 Oct;158(10):1568-78.Texto completo  Resumen

27. Middeldorf CM, Cath CD, Van Dyck R, et al. The co-morbidity of anxiety and depression in the perspective of genetic epidemiology: a review of twin and family studies. Psychol Med. 2005 May;35(5):611-24. Resumen

28. Gottschalk MG, Domschke K. Genetics of generalized anxiety disorder and related traits. Dialogues Clin Neurosci. 2017 Jun;19(2):159-68.Texto completo  Resumen

29. Kalk NJ, Melichar J, Holmes RB, et al. Central noradrenergic responsiveness to a clonidine challenge in generalized anxiety disorder: a single photon emission computed tomography study. J Psychopharmacol. 2012 Apr;26(4):452-60. Resumen

30. Guo ZN, Lv S, Liu J, et al. Compromised dynamic cerebral autoregulation in patients with generalized anxiety disorder: a study using transfer function analysis. BMC Psychiatry. 2018 Jun 1;18(1):164.Texto completo  Resumen

31. Duits P, Cath DC, Lissek S, et al. Updated meta-analysis of classical fear conditioning in the anxiety disorders. Depress Anxiety. 2015 Apr;32(4):239-53. Resumen

32. Milad MR, Rosenbaum BL, Simon NM. Neuroscience of fear extinction: implications for assessment and treatment of fear-based and anxiety related disorders. Behav Res Ther. 2014 Nov;62:17-23. Resumen

33. Schienle A, Hettema JM, Cáceda R, et al. Neurobiology and genetics of generalized anxiety disorder. Psychiatr Ann. 2011 Feb;41(2):113-23.Texto completo

34. Saletu-Zyhlarz G, Saletu B, Anderer P, et al. Nonorganic insomnia in generalized anxiety disorder. 1. Controlled studies on sleep, awakening and daytime vigilance utilizing polysomnography and EEG mapping. Neuropsychobiology. 1997;36(3):117-29. Resumen

35. Fonzo GA, Ramsawh HJ, Flagan TM, et al. Common and disorder-specific neural responses to emotional faces in generalised anxiety, social anxiety and panic disorders. Br J Psychiatry. 2015 Mar;206(3):206-15.Texto completo  Resumen

36. Stein MB, Simmons AN, Feinstein JS, et al. Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. Am J Psychiatry. 2007 Feb;164(2):318-27.Texto completo  Resumen

37. Goossen B, van der Starre J, van der Heiden C. A review of neuroimaging studies in generalized anxiety disorder: "So where do we stand?" J Neural Transm (Vienna). 2019 Sep;126(9):1203-16. Resumen

38. Lawrence PJ, Murayama K, Creswell C. Systematic review and meta-analysis: anxiety and depressive disorders in offspring of parents with anxiety disorders. J Am Acad Child Adolesc Psychiatry. 2019 Jan;58(1):46-60.Texto completo  Resumen

39. Vachon DD, Krueger RF, Rogosch FA, et al. Assessment of the harmful psychiatric and behavioral effects of different forms of child maltreatment. JAMA Psychiatry. 2015 Nov;72(11):1135-42.Texto completo  Resumen

40. Fricchione G. Generalized anxiety disorder. N Engl J Med. 2004 Aug 12;351(7):675-82.

41. Grigsby AM, Anderson RJ, Freedland KE, et al. Prevalence of anxiety in adults with diabetes: a systematic review. J Psychosom Res. 2002 Dec;53(6):1053-60. Resumen

42. Rogers MP, White K, Warshaw MG, et al. Prevalence of medical illness in patients with anxiety disorders. Int J Psychiatry Med. 1994 Mar;24(1):83-96. Resumen

43. Schuch FB, Stubbs B, Meyer J, et al. Physical activity protects from incident anxiety: a meta-analysis of prospective cohort studies. Depress Anxiety. 2019 Sep;36(9):846-58. Resumen

44. Rapee RM, Kennedy SJ, Ingram M, et al. Altering the trajectory of anxiety in at-risk young children. Am J Psychiatry. 2010 Dec;167(12):1518-25.Texto completo  Resumen

45. Ginsburg GS. The Child Anxiety Prevention Study: intervention model and primary outcomes. J Consult Clin Psychol. 2009 Jun;77(3):580-7.Texto completo  Resumen

46. Alonso J, Liu Z, Evans-Lacko S, et al; WHO World Mental Health Survey Collaborators. Treatment gap for anxiety disorders is global: results of the World Mental Health Surveys in 21 countries. Depress Anxiety. 2018 Mar;35(3):195-208.Texto completo  Resumen

47. Olariu E, Forero CG, Castro-Rodriguez JI, et al. Detection of anxiety disorders in primary care: a meta-analysis of assisted and unassisted diagnoses. Depress Anxiety. 2015 Jul;32(7):471-84. Resumen

48. Baldwin DS, Anderson IM, Nutt DJ, et al. Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology. J Psychopharmacol. 2014 May;28(5):403-39. Resumen

49. Andrews G, Bell C, Boyce P, et al. Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder. Aust N Z J Psychiatry. 2018 Nov;52(12):1109-72.Texto completo

50. Katzman MA, Bleau P, Blier P, et al. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC Psychiatry. 2014 Jul;14 Suppl 1(suppl 1):S1.Texto completo  Resumen

51. Kessler RC, Ruscio AM, Shear K, et al. Epidemiology of anxiety disorders. Curr Top Behav Neurosci. 2010;2:21-35. Resumen

52. Pary R, Matuschka PR, Lewis S. Generalized anxiety disorder. South Med J. 2003 Jun;96(6):581-6. Resumen

53. National Institute for Health and Care Excellence. Antenatal and postnatal mental health: clinical management and service guidance. Feb 2020 [internet publication].Texto completo

54. American College of Obstetricians and Gynecologists. ACOG clinical practice guidelines no. 4: screening and diagnosis of mental health conditions during pregnancy and postpartum. Jun 2023 [internet publication].Texto completo

55. National Institute for Health and Care Excellence. Anxiety disorders. Feb 2014 [internet publication].Texto completo

56. Goldstein-Piekarski AN, Williams LM, Humphreys K. A trans-diagnostic review of anxiety disorder comorbidity and the impact of multiple exclusion criteria on studying clinical outcomes in anxiety disorders. Transl Psychiatry. 2016 Jun 28;6(6):e847.Texto completo  Resumen

57. Klein B, Rajendram R, Hrycko S, et al; Canadian Paediatric Society. Anxiety in children and youth: part 1 - diagnosis. Paediatr Child Health. 2023 Feb;28(1):37-51.Texto completo  Resumen

58. Walter HJ, Bukstein OG, Abright AR, et al. Clinical practice guideline for the assessment and treatment of children and adolescents with anxiety disorders. J Am Acad Child Adolesc Psychiatry. 2020 Oct;59(10):1107-24.Texto completo  Resumen

59. Fischer S, Ehlert U. Hypothalamic-pituitary-thyroid (HPT) axis functioning in anxiety disorders. A systematic review. Depress Anxiety. 2018 Jan;35(1):98-110. Resumen

60. Stone J, Burton C, Carson A. Recognising and explaining functional neurological disorder. BMJ. 2020 Oct 21;371:m3745.

61. Brown RJ, Reuber M. Psychological and psychiatric aspects of psychogenic non-epileptic seizures (PNES): a systematic review. Clin Psychol Rev. 2016 Apr;45:157-82. Resumen

62. US Preventive Services Task Force. Final recommentation statement: anxiety disorders in adults: screening. Jun 2023 [internet publication].Texto completo  Resumen

63. US Preventive Services Task Force. Final recommentation statement: anxiety in children and adolescents: screening. Oct 2022.Texto completo  Resumen

64. Gregory KD, Chelmow D, Nelson HD, et al; Women’s Preventive Services Initiative. Screening for anxiety in adolescent and adult women: a recommendation from the women's preventive services initiative. Ann Intern Med. 2020 Jul 7;173(1):48-56.Texto completo  Resumen

65. National Institute for Health and Care Excellence. Generalised anxiety disorder and panic disorder in adults: management. Jun 2020 [internet publication].Texto completo

66. Sinesi A, Maxwell M, O'Carroll R, et al. Anxiety scales used in pregnancy: systematic review. BJPsych Open. 2019 Jan;5(1):e5.Texto completo  Resumen

67. Manea L, Gilbody S, McMillan D. Optimal cut-off score for diagnosing depression with the Patient Health Questionnaire (PHQ-9): a meta-analysis. CMAJ. 2012 Feb 21;184(3):E191-6.Texto completo  Resumen

68. Plummer F, Manea L, Trepel D, et al. Screening for anxiety disorders with the GAD-7 and GAD-2: a systematic review and diagnostic metaanalysis. Gen Hosp Psychiatry. 2016 Mar-Apr;39:24-31. Resumen

69. Herr NR, Williams JW Jr, Benjamin S, et al. Does this patient have generalized anxiety or panic disorder?: the Rational Clinical Examination systematic review. JAMA. 2014 Jul 2;312(1):78-84. Resumen

70. Runyon K, Chesnut SR, Burley H. Screening for childhood anxiety: a meta-analysis of the screen for child anxiety related emotional disorders. J Affect Disord. 2018 Nov;240:220-9. Resumen

71. Piqueras JA, Martín-Vivar M, Sandin B, et al. The Revised Child Anxiety and Depression Scale: a systematic review and reliability generalization meta-analysis. J Affect Disord. 2017 Aug 15;218:153-69. Resumen

72. Bandelow B, Michaelis S, Wedekind D. Treatment of anxiety disorders. Dialogues Clin Neurosci. 2017 Jun;19(2):93-107.Texto completo  Resumen

73. Bandelow B, Sher L, Bunevicius R, et al; WFSBP Task Force on Mental Disorders in Primary Care; WFSBP Task Force on Anxiety Disorders, OCD and PTSD. Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care. Int J Psychiatry Clin Pract. 2012 Jun;16(2):77-84. Resumen

74. Bandelow B, Reitt M, Röver C, et al. Efficacy of treatments for anxiety disorders: a meta-analysis. Int Clin Psychopharmacol. 2015 Jul;30(4):183-92. Resumen

75. Schneider RL, Arch JJ, Wolitzky-Taylor KB. The state of personalized treatment for anxiety disorders: a systematic review of treatment moderators. Clin Psychol Rev. 2015 Jun;38:39-54. Resumen

76. Cuijpers P, Sijbrandij M, Koole SL, et al. The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta-analysis of direct comparisons. World Psychiatry. 2013 Jun;12(2):137-48.Texto completo  Resumen

77. Hofmann SG, Sawyer AT, Korte KJ, et al. Is it beneficial to add pharmacotherapy to cognitive-behavioral therapy when treating anxiety disorders? A meta-analytic review. Int J Cogn Ther. 2009 Jan 1;2(2):160-75.Texto completo  Resumen

78. Würz A, Sungur MZ. Combining cognitive behavioural therapy and pharmacotherapy in the treatment of anxiety disorders: true gains or false hopes? Bull Clin Psychopharmacol. 2009;19:436-46​.Texto completo

79. de Vries YA, de Jonge P, van den Heuvel E, et al. Influence of baseline severity on antidepressant efficacy for anxiety disorders: meta-analysis and meta-regression. Br J Psychiatry. 2016 Jun;208(6):515-21.Texto completo  Resumen

80. Cuijpers P, Sijbrandij M, Koole S, et al. Psychological treatment of generalized anxiety disorder: a meta-analysis. Clin Psychol Rev. 2014 Mar;34(2):130-40. Resumen

81. Bandelow B, Sagebiel A, Belz M, et al. Enduring effects of psychological treatments for anxiety disorders: meta-analysis of follow-up studies. Br J Psychiatry. 2018 Jun;212(6):333-8.Texto completo  Resumen

82. Borkovec TD, Ruscio AM. Psychotherapy for generalized anxiety disorder. J Clin Psychiatry. 2001;62 Suppl 11:37-45. Resumen

83. Covin R, Ouimet AJ, Seeds PM, et al. A meta-analysis of CBT for pathological worry among clients with GAD. J Anxiety Disord. 2008;22(1):108-16. Resumen

84. Haby MM, Donnelly M, Corry J, et al. Cognitive behavioural therapy for depression, panic disorder and generalized anxiety disorder: a meta-regression of factors that may predict outcome. Aust N Z J Psychiatry. 2006 Jan;40(1):9-19. Resumen

85. Carpenter JK, Andrews LA, Witcraft SM, et al. Cognitive behavioral therapy for anxiety and related disorders: a meta-analysis of randomized placebo-controlled trials. Depress Anxiety. 2018 Jun;35(6):502-14.Texto completo  Resumen

86. Loerinc AG, Meuret AE, Twohig MP, et al. Response rates for CBT for anxiety disorders: need for standardized criteria. Clin Psychol Rev. 2015 Dec;42:72-82. Resumen

87. van Dis EAM, van Veen SC, Hagenaars MA, et al. Long-term outcomes of cognitive behavioral therapy for anxiety-related disorders: a systematic review and meta-analysis. JAMA Psychiatry. 2020 Mar 1;77(3):265-73.Texto completo  Resumen

88. Pinquart M, Duberstein PR. Treatment of anxiety disorders in older adults: a meta-analytic comparison of behavioral and pharmacological interventions. Am J Geriatr Psychiatry. 2007 Aug;15(8):639-51. Resumen

89. Thorp SR, Ayers CR, Nuevo R, et al. Meta-analysis comparing different behavioral treatments for late-life anxiety. Am J Geriatr Psychiatry. 2009 Feb;17(2):105-15.Texto completo  Resumen

90. Hendriks GJ, Oude Voshaar RC, Keijsers GP, et al. Cognitive-behavioural therapy for late-life anxiety disorders: a systematic review and meta-analysis. Acta Psychiatr Scand. 2008 Jun;117(6):403-11. Resumen

91. Hall J, Kellett S, Berrios R, et al. Efficacy of cognitive behavioral therapy for generalized anxiety disorder in older adults: systematic review, meta-analysis, and meta-regression. Am J Geriatr Psychiatry. 2016 Nov;24(11):1063-73. Resumen

92. Ye X, Bapuji SB, Winters SE, et al. Effectiveness of internet-based interventions for children, youth, and young adults with anxiety and/or depression: a systematic review and meta-analysis. BMC Health Serv Res. 2014 Jul 18;14:313.Texto completo  Resumen

93. Andrews G, Basu A, Cuijpers P, et al. Computer therapy for the anxiety and depression disorders is effective, acceptable and practical health care: an updated meta-analysis. J Anxiety Disord. 2018 Apr;55:70-8.Texto completo  Resumen

94. Coull G, Morris PG. The clinical effectiveness of CBT-based guided self-help interventions for anxiety and depressive disorders: a systematic review. Psychol Med. 2011 Nov;41(11):2239-52. Resumen

95. Newman MG, Szkodny LE, Llera SJ, et al. A review of technology-assisted self-help and minimal contact therapies for anxiety and depression: is human contact necessary for therapeutic efficacy? Clin Psychol Rev. 2011 Feb;31(1):89-103. Resumen

96. Saramago P, Gega L, Marshall D, et al. Digital interventions for generalized anxiety disorder (GAD): systematic review and network meta-analysis. Front Psychiatry. 2021 Dec 6;12:726222.Texto completo  Resumen

97. Lewis C, Pearce J, Bisson JI. Efficacy, cost-effectiveness and acceptability of self-help interventions for anxiety disorders: systematic review. Br J Psychiatry. 2012 Jan;200(1):15-21.Texto completo  Resumen

98. Firth J, Torous J, Nicholas J, et al. Can smartphone mental health interventions reduce symptoms of anxiety? A meta-analysis of randomized controlled trials. J Affect Disord. 2017 Aug 15;218:15-22.Texto completo  Resumen

99. Zalta AK. A meta-analysis of anxiety symptom prevention with cognitive-behavioral interventions. J Anxiety Disord. 2011 Jun;25(5):749-60. Resumen

100. Olthuis JV, Watt MC, Bailey K, et al. Therapist-supported internet cognitive behavioural therapy for anxiety disorders in adults. Cochrane Database Syst Rev. 2016 Mar 12;(3):CD011565.Texto completo  Resumen

101. Berryhill MB, Halli-Tierney A, Culmer N, et al. Videoconferencing psychological therapy and anxiety: a systematic review. Fam Pract. 2019 Jan 25;36(1):53-63.Texto completo  Resumen

102. Hoge EA, Bui E, Marques L, et al. Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity. J Clin Psychiatry. 2013 Aug;74(8):786-92.Texto completo  Resumen

103. Wong SY, Yip BH, Mak WW, et al. Mindfulness-based cognitive therapy v. group psychoeducation for people with generalised anxiety disorder: randomised controlled trial. Br J Psychiatry. 2016 Jul;209(1):68-75.Texto completo  Resumen

104. Rodrigues MF, Nardi AE, Levitan M. Mindfulness in mood and anxiety disorders: a review of the literature. Trends Psychiatry Psychother. 2017 Jul-Sep;39(3):207-15.Texto completo  Resumen

105. Huang J, Nigatu YT, Smail-Crevier R, et al. Interventions for common mental health problems among university and college students: a systematic review and meta-analysis of randomized controlled trials. J Psychiatr Res. 2018 Dec;107:1-10. Resumen

106. Haller H, Breilmann P, Schröter M, et al. A systematic review and meta-analysis of acceptance- and mindfulness-based interventions for DSM-5 anxiety disorders. Sci Rep. 2021 Oct 14;11(1):20385.Texto completo  Resumen

107. Hoge EA, Bui E, Mete M, et al. Mindfulness-based stress reduction vs escitalopram for the treatment of adults with anxiety disorders: a randomized clinical trial. JAMA Psychiatry. 2023 Jan 1;80(1):13-21. Resumen

108. Montero-Marin J, Garcia-Campayo J, López-Montoyo A, et al. Is cognitive-behavioural therapy more effective than relaxation therapy in the treatment of anxiety disorders? A meta-analysis. Psychol Med. 2018 Jul;48(9):1427-36. Resumen

109. Kim HS, Kim EJ. Effects of relaxation therapy on anxiety disorders: a systematic review and meta-analysis. Arch Psychiatr Nurs. 2018 Apr;32(2):278-84. Resumen

110. Hunot V, Churchill R, Teixeira V, et al. Psychological therapies for generalised anxiety disorder. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD001848.Texto completo  Resumen

111. Leichsenring F, Salzer S, Jaeger U, et al. Short-term psychodynamic psychotherapy and cognitive-behavioral therapy in generalized anxiety disorder: a randomized, controlled trial. Am J Psychiatry. 2009 Aug;166(8):875-81.Texto completo  Resumen

112. Creswell C, Cruddace S, Gerry S, et al. Treatment of childhood anxiety disorder in the context of maternal anxiety disorder: a randomised controlled trial and economic analysis. Health Technol Assess. 2015 May;19(38):1-184.Texto completo  Resumen

113. Roszkowska J, Geraci SA. Management of insomnia in the geriatric patient. Am J Med. 2010 Dec;123(12):1087-90. Resumen

114. Roy-Byrne P, Veitengruber JP, Bystritsky A, et al. Brief intervention for anxiety in primary care patients. J Am Board Fam Med. 2009 Mar-Apr;22(2):175-86.Texto completo  Resumen

115. Kandola A, Vancampfort D, Herring M, et al. Moving to beat anxiety: epidemiology and therapeutic issues with physical activity for anxiety. Curr Psychiatry Rep. 2018 Jul 24;20(8):63.Texto completo  Resumen

116. Aylett E, Small N, Bower P. Exercise in the treatment of clinical anxiety in general practice - a systematic review and meta-analysis. BMC Health Serv Res. 2018 Jul 16;18(1):559.Texto completo  Resumen

117. Sabourin BC, Stewart SH, Watt MC, et al. Running as interoceptive exposure for decreasing anxiety sensitivity: replication and extension. Cogn Behav Ther. 2015;44(4):264-74. Resumen

118. Singh B, Olds T, Curtis R, et al. Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews. Br J Sports Med. 2023 Feb 16 [Epub ahead of print].Texto completo  Resumen

119. Cramer H, Lauche R, Anheyer D, et al. Yoga for anxiety: a systematic review and meta-analysis of randomized controlled trials. Depress Anxiety. 2018 Sep;35(9):830-43.Texto completo  Resumen

120. van Boeijen CA, van Balkom AJ, van Oppen P, et al. Efficacy of self-help manuals for anxiety disorders in primary care: a systematic review. Fam Pract. 2005 Apr;22(2):192-6.Texto completo  Resumen

121. Haug T, Nordgreen T, Öst LG, et al. Self-help treatment of anxiety disorders: a meta-analysis and meta-regression of effects and potential moderators. Clin Psychol Rev. 2012 Jul;32(5):425-45. Resumen

122. Health Quality Ontario. Psychotherapy for major depressive disorder and generalized anxiety disorder: a health technology assessment. Ont Health Technol Assess Ser. 2017 Nov 13;17(15):1-167.Texto completo  Resumen

123. Zhang A, Park S, Sullivan JE, et al. The effectiveness of problem-solving therapy for primary care patients' depressive and/or anxiety disorders: a systematic review and meta-analysis. J Am Board Fam Med. 2018 Jan-Feb;31(1):139-50.Texto completo  Resumen

124. Kelson J, Rollin A, Ridout B, et al. Internet-delivered acceptance and commitment therapy for anxiety treatment: systematic review. J Med Internet Res. 2019 Jan 29;21(1):e12530.Texto completo  Resumen

125. Marker I, Norton PJ. The efficacy of incorporating motivational interviewing to cognitive behavior therapy for anxiety disorders: a review and meta-analysis. Clin Psychol Rev. 2018 Jun;62:1-10. Resumen

126. White KS, Payne LA, Gorman JM, et al. Does maintenance CBT contribute to long-term treatment response of panic disorder with or without agoraphobia? A randomized controlled clinical trial. J Consult Clin Psychol. 2013 Feb;81(1):47-57.Texto completo  Resumen

127. Craske MG, Roy-Byrne P, Stein MB, et al. CBT intensity and outcome for panic disorder in a primary care setting. Behav Ther. 2006 Jun;37(2):112-9. Resumen

128. Wilson H, Mannix S, Oko-osi H, et al. The impact of medication on health-related quality of life in patients with generalized anxiety disorder. CNS Drugs. 2015 Jan;29(1):29-40. Resumen

129. Schmitt R, Gazalle FK, Lima MS, et al. The efficacy of antidepressants for generalized anxiety disorder: a systematic review and meta-analysis. Braz J Psychiatry. 2005 Mar;27(1):18-24.Texto completo  Resumen

130. Slee A, Nazareth I, Bondaronek P, et al. Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis. Lancet. 2019 Feb 23;393(10173):768-77. Resumen

131. Gale C, Oakley-Browne M. Generalized anxiety disorder. Clin Evid. 2005 Dec;(14):1253-69.

132. Szuhany KL, Simon NM. Anxiety disorders: a review. JAMA. 2022 Dec 27;328(24):2431-45. Resumen

133. Sinclair LI, Christmas DM, Hood SD, et al. Antidepressant-induced jitteriness/anxiety syndrome: systematic review. Br J Psychiatry. 2009 Jun;194(6):483-90. Resumen

134. Jakubovski E, Johnson JA, Nasir M, et al. Systematic review and meta-analysis: dose-response curve of SSRIs and SNRIs in anxiety disorders. Depress Anxiety. 2019 Mar;36(3):198-212. Resumen

135. Baldwin D, Woods R, Lawson R, et al. Efficacy of drug treatments for generalised anxiety disorder: systematic review and meta-analysis. BMJ. 2011 Mar 11;342:d1199.Texto completo  Resumen

136. Schuurmans J, Comijs H, Emmelkamp PM, et al. Long-term effectiveness and prediction of treatment outcome in cognitive behavioral therapy and sertraline for late-life anxiety disorders. Int Psychogeriatr. 2009 Dec;21(6):1148-59. Resumen

137. Ipser, JC, Stein DJ, Hawkridge S, et al. Pharmacotherapy for anxiety disorders in children and adolescents. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD005170.Texto completo  Resumen

138. Dobson ET, Strawn JR. Pharmacotherapy for pediatric generalized anxiety disorder: a systematic evaluation of efficacy, safety and tolerability. Paediatr Drugs. 2016 Feb;18(1):45-53.Texto completo  Resumen

139. Khan AY, Macaluso M. Duloxetine for the treatment of generalized anxiety disorder: a review. Neuropsychiatr Dis Treat. 2009;5:23-31.Texto completo  Resumen

140. Brawman-Mintzer O, Knapp RG, Rynn M, et al. Sertraline treatment for generalized anxiety disorder: a randomized, double-blind, placebo-controlled study. J Clinical Psychiatry. 2006 Jun;67(6):874-81. Resumen

141. Allgulander C, Florea I, Huusom AK. Prevention of relapse in generalized anxiety disorder by escitalopram treatment. Int J Neuropsychopharmacol. 2006 Oct;9(5):495-505. Resumen

142. Garakani A, Murrough JW, Freire RC, et al. Pharmacotherapy of anxiety disorders: current and emerging treatment options. Front Psychiatry. 2020 Dec 23;11:595584.Texto completo  Resumen

143. Allgulander C, Nutt D, Detke M, et al. A non-inferiority comparison of duloxetine and venlafaxine in the treatment of adult patients with generalized anxiety disorder. J Psychopharmacol. 2008 Jun;22(4):417-25. Resumen

144. Allgulander C, Hartford J, Russell J, et al. Pharmacotherapy of generalized anxiety disorder: results of duloxetine treatment from a pooled analysis of three clinical trials. Curr Med Res Opin. 2007 Jun;23(6):1245-52. Resumen

145. Wu WY, Wang G, Ball SG, et al. Duloxetine versus placebo in the treatment of patients with generalized anxiety disorder in China. Chin Med J (Engl). 2011 Oct;124(20):3260-8. Resumen

146. Chessick CA, Allen MH, Thase M, et al. Azapirones for generalized anxiety disorder. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD006115.Texto completo  Resumen

147. Boschen MJ. A meta-analysis of the efficacy of pregabalin in the treatment of generalized anxiety disorder. Can J Psychiatry. 2011 Sep;56(9):558-66. Resumen

148. Wensel TM, Powe KW, Cates ME. Pregabalin for the treatment of generalized anxiety disorder. Ann Pharmacother. 2012 Mar;46(3):424-9. Resumen

149. Rickels K, Shiovitz TM, Ramey TS, et al. Adjunctive therapy with pregabalin in generalized anxiety disorder patients with partial response to SSRI or SNRI treatment. Int Clin Psychopharmacol. 2012 May;27(3):142-50. Resumen

150. Generoso MB, Trevizol AP, Kasper S, et al. Pregabalin for generalized anxiety disorder: an updated systematic review and meta-analysis. Int Clin Psychopharmacol. 2017 Jan;32(1):49-55. Resumen

151. Buoli M, Caldiroli A, Serati M. Pharmacokinetic evaluation of pregabalin for the treatment of generalized anxiety disorder. Expert Opin Drug Metab Toxicol. 2017 Mar;13(3):351-9. Resumen

152. Bonnet U, Scherbaum N. How addictive are gabapentin and pregabalin? A systematic review. Eur Neuropsychopharmacol. 2017 Dec;27(12):1185-215. Resumen

153. Public Health England, NHS England. Pregabalin and gabapentin: advice for prescribers on the risk of misuse. Dec 2014 [internet publication].Texto completo

154. Shammas E. Controlled comparison of bromazepam, amitriptyline, and placebo in anxiety-depressive neurosis. Dis Nerv Syst. 1977 Mar;38(3):201-7. Resumen

155. Goldberg HL, Finnery RJ. The use of doxepin in the treatment of symptoms of anxiety neurosis and accompanying depression: a collaborative controlled study. Am J Psychiatry. 1972 Jul;129(1):74-7.

156. LaLonde CD, Van Lieshout RJ. Treating generalized anxiety disorder with second generation antipsychotics: a systematic review and meta-analysis. J Clin Psychopharmacol. 2011 Jun;31(3):326-33. Resumen

157. Maneeton N, Maneeton B, Woottiluk P, et al. Quetiapine monotherapy in acute treatment of generalized anxiety disorder: a systematic review and meta-analysis of randomized controlled trials. Drug Des Devel Ther. 2016 Jan 12;10:259-76.Texto completo  Resumen

158. Donnelly K, Bracchi R, Hewitt J, et al. Benzodiazepines, Z-drugs and the risk of hip fracture: a systematic review and meta-analysis. PLoS One. 2017 Apr 27;12(4):e0174730.Texto completo  Resumen

159. Née M, Avalos M, Luxcey A, et al. Prescription medicine use by pedestrians and the risk of injurious road traffic crashes: a case-crossover study. PLoS Med. 2017 Jul 18;14(7):e1002347.Texto completo  Resumen

160. Gomez AF, Barthel AL, Hofmann SG. Comparing the efficacy of benzodiazepines and serotonergic anti-depressants for adults with generalized anxiety disorder: a meta-analytic review. Expert Opin Pharmacother. 2018 Jun;19(8):883-94.Texto completo  Resumen

161. Silberman E, Balon R, Starcevic V, et al. Benzodiazepines: it's time to return to the evidence. Br J Psychiatry. 2021 Mar;218(3):125-7.Texto completo  Resumen

162. Balon R, Chouinard G, Cosci F, et al. International task force on benzodiazepines. Psychother Psychosom. 2018;87(4):193-4.Texto completo

163. Krystal JH, Stossel S, Krystal AD. Restricting benzodiazepines to short-term prescription. JAMA Psychiatry. 2015 Jul;72(7):734-5.

164. Shinfuku M, Kishimoto T, Uchida H, et al. Effectiveness and safety of long-term benzodiazepine use in anxiety disorders: a systematic review and meta-analysis. Int Clin Psychopharmacol. 2019 Sep;34(5):211-21. Resumen

165. Gale C, Glue P, Guaiana G, et al. Influence of covariates on heterogeneity in Hamilton Anxiety Scale ratings in placebo-controlled trials of benzodiazepines in generalized anxiety disorder: systematic review and meta-analysis. J Psychopharmacol. 2019 May;33(5):543-7. Resumen

166. Petrushevska T, Jakovski Z, Poposka V, et al. Drug-related deaths between 2002 and 2013 with accent to methadone and benzodiazepines. J Forensic Leg Med. 2015 Apr;31:12-8. Resumen

167. Lintzeris N, Nielsen S. Benzodiazepines, methadone and buprenorphine: interactions and clinical management. Am J Addict. 2010 Jan-Feb;19(1):59-72. Resumen

168. Jones CM, McAninch JK. Emergency department visits and overdose deaths from combined use of opioids and benzodiazepines. Am J Prev Med. 2015 Oct;49(4):493-501. Resumen

169. Kennedy KM, O'Riordan J. Prescribing benzodiazepines in general practice. Br J Gen Pract. 2019 Mar;69(680):152-3.Texto completo

170. Batelaan NM, Bosman RC, Muntingh A, et al. Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials. BMJ. 2017 Sep 13;358:j3927.Texto completo  Resumen

171. Van Leeuwen E, van Driel ML, Horowitz MA, et al. Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults. Cochrane Database Syst Rev. 2021 Apr 15;(4):CD013495.Texto completo  Resumen

172. Mancini M, Perna G, Rossi A, et al. Use of duloxetine in patients with an anxiety disorder, or with comorbid anxiety and major depressive disorder: a review of the literature. Expert Opin Pharmacother. 2010 May;11(7):1167-81. Resumen

173. Youssef NA, Rich CL. Does acute treatment with sedatives/hypnotics for anxiety in depressed patients affect suicide risk? A literature review. Ann Clin Psychiatry. 2008 Jul-Sep;20(3):157-69. Resumen

174. Bobbitt S, Kawamura A, Saunders N, et al; Canadian Paediatric Society. Anxiety in children and youth: part 2 - the management of anxiety disorders. Paediatr Child Health. 2023 Feb;28(1):52-66.Texto completo  Resumen

175. Crowe K, McKay D. Efficacy of cognitive-behavioral therapy for childhood anxiety and depression. J Anxiety Disord. 2017 Jun;49:76-87. Resumen

176. Guidelines and Protocols Advisory Committee; British Columbia Medical Association. Anxiety and depression in children and youth - diagnosis and treatment. Mar 2010 [internet publication].Texto completo

177. Wang Z, Whiteside SPH, Sim L, et al. Comparative effectiveness and safety of cognitive behavioral therapy and pharmacotherapy for childhood anxiety disorders: a systematic review and meta-analysis. JAMA Pediatr. 2017 Nov 1;171(11):1049-56.Texto completo  Resumen

178. James AC, Reardon T, Soler A, et al. Cognitive behavioural therapy for anxiety disorders in children and adolescents. Cochrane Database Syst Rev. 2020 Nov 16;(11):CD013162.Texto completo  Resumen

179. Mahdi M, Jhawar S, Bennett SD, et al. Cognitive behavioral therapy for childhood anxiety disorders: what happens to comorbid mood and behavioral disorders? A systematic review. J Affect Disord. 2019 May 15;251:141-8. Resumen

180. Griffiths KM. SPARX computerised CBT is as effective as usual care for mild-to-moderate depression in help seeking adolescents. Evid Based Ment Health. 2012 Nov;15(4):90.

181. National Institute for Health and Care Excellence. ​Guided self-help digital cognitive behavioural therapy for children and young people with mild to moderate symptoms of anxiety or low mood: early value assessment. Feb 2023 [internet publication].Texto completo

182. Monga S, Rosenbloom BN, Tanha A, et al. Comparison of child-parent and parent-only cognitive-behavioral therapy programs for anxious children aged 5 to 7 years: short- and long-term outcomes. J Am Acad Child Adolesc Psychiatry. 2015 Feb;54(2):138-46. Resumen

183. Donoghue K, Stallard P, Kucia J. The clinical practice of cognitive behavioural therapy for children and young people with a diagnosis of Asperger's syndrome. Clin Child Psychol Psychiatry. 2011 Jan;16(1):89-102. Resumen

184. Walkup JT, Albano AM, Piacentini J, et al. Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. N Engl J Med. 2008 Dec 25;359(26):2753-66.Texto completo  Resumen

185. Dobson ET, Bloch MH, Strawn JR. Efficacy and tolerability of pharmacotherapy for pediatric anxiety disorders: a network meta-analysis. J Clin Psychiatry. 2019 Jan 29;80(1):17r12064.

186. Locher C, Koechlin H, Zion SR, et al. Efficacy and safety of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and placebo for common psychiatric disorders among children and adolescents: a systematic review and meta-analysis. JAMA Psychiatry. 2017 Oct 1;74(10):1011-20.Texto completo  Resumen

187. Strawn JR, Mills JA, Sauley BA, et al. The impact of antidepressant dose and class on treatment response in pediatric anxiety disorders: a meta-analysis. J Am Acad Child Adolesc Psychiatry. 2018 Apr;57(4):235-44.Texto completo  Resumen

188. Bridge JA, Iyengar S, Salary CB, et al. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. JAMA. 2007 Apr 18;297(15):1683-96. Resumen

189. Gale CK, Millichamp J. Generalised anxiety disorder in children and adolescents. BMJ Clin Evid. 2016 Jan 13;2016.Texto completo  Resumen

190. Hathaway EE, Walkup JT, Strawn JR. Antidepressant treatment duration in pediatric depressive and anxiety disorders: how long is long enough? Curr Probl Pediatr Adolesc Health Care. 2018 Feb;48(2):31-9.Texto completo  Resumen

191. American College of Obstetricians and Gynecologists. Treatment and management of mental health conditions during pregnancy and postpartum. Jun 2023 [internet publication].Texto completo

192. Maguire PN, Clark GI, Wootton BM. The efficacy of cognitive behavior therapy for the treatment of perinatal anxiety symptoms: a preliminary meta-analysis. J Anxiety Disord. 2018 Dec;60:26-34. Resumen

193. Bayrampour H, Trieu J, Tharmaratnam T. Effectiveness of eHealth interventions to reduce perinatal anxiety: a systematic review and meta-analysis. J Clin Psychiatry. 2019 Jan 22;80(1):18r12386. Resumen

194. McAllister-Williams RH, Baldwin DS, Cantwell R, et al. British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017. J Psychopharmacol. 2017 May;31(5):519-52. Resumen

195. Massachusetts General Hospital Center for Women’s Mental Health. Psychiatric disorders during pregnancy. 2013 [internet publication].Texto completo

196. Yonkers KA, Gilstad-Hayden K, Forray A, et al. Association of panic disorder, generalized anxiety disorder, and benzodiazepine treatment during pregnancy with risk of adverse birth outcomes. JAMA Psychiatry. 2017 Nov 1;74(11):1145-52.Texto completo  Resumen

197. Medicines and Healthcare products Regulatory Agency. SSRI/SNRI antidepressant medicines: small increased risk of postpartum haemorrhage when used in the month before delivery. Jan 2021 [internet publication].Texto completo

198. Rai D, Lee B, Dalman C, et al. Antidepressants during pregnancy and autism in offspring: population based cohort study. BMJ. 2017 Jul 19;358:j2811.Texto completo  Resumen

199. Kaplan YC, Keskin-Arslan E, Acar S, et al. Maternal SSRI discontinuation, use, psychiatric disorder and the risk of autism in children: a meta-analysis of cohort studies. Br J Clin Pharmacol. 2017 Dec;83(12):2798-806.Texto completo  Resumen

200. Brown HK, Hussain-Shamsy N, Lunsky Y, et al. The association between antenatal exposure to selective serotonin reuptake inhibitors and autism: a systematic review and meta-analysis. J Clin Psychiatry. 2017 Jan;78(1):e48-58. Resumen

201. Andrade C. Safety of pregabalin in pregnancy. J Clin Psychiatry. 2018 Oct 2;79(5):18f12568.Texto completo  Resumen

202. Ray S, Stowe ZN. The use of antidepressant medication in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2014 Jan;28(1):71-83. Resumen

203. Andrews G, Hobbs MJ. The effect of the draft DSM-5 criteria for GAD on prevalence and severity. Aust N Z J Psychiatry. 2010 Sep;44(9):784-90. Resumen

204. Knekt P, Lindfors O, Laaksonen MA, et al; Helsinki Psychotherapy Study Group. Quasi-experimental study on the effectiveness of psychoanalysis, long-term and short-term psychotherapy on psychiatric symptoms, work ability and functional capacity during a 5-year follow-up. J Affect Disord. 2011 Jul;132(1-2):37-47. Resumen

205. Cirillo P, Gold AK, Nardi AE, et al. Transcranial magnetic stimulation in anxiety and trauma-related disorders: a systematic review and meta-analysis. Brain Behav. 2019 Jun;9(6):e01284.Texto completo  Resumen

206. Cox J, Thakur B, Alvarado L, et al. Repetitive transcranial magnetic stimulation for generalized anxiety and panic disorders: a systematic review and meta-analysis. Ann Clin Psychiatry. 2022 Aug;34(3):152-6, e10-7. Resumen

207. Glue P, Neehoff S, Sabadel A, et al. Effects of ketamine in patients with treatment-refractory generalized anxiety and social anxiety disorders: exploratory double-blind psychoactive-controlled replication study. J Psychopharmacol. 2020 Mar;34(3):267-72. Resumen

208. Tully JL, Dahlén AD, Haggarty CJ, et al. Ketamine treatment for refractory anxiety: a systematic review. Br J Clin Pharmacol. 2022 Oct;88(10):4412-26.Texto completo  Resumen

209. Short B, Fong J, Galvez V, et al. Side-effects associated with ketamine use in depression: a systematic review. Lancet Psychiatry. 2018 Jan;5(1):65-78. Resumen

210. Stein DJ, Ahokas A, Jarema M, et al. Efficacy and safety of agomelatine (10 or 25 mg/day) in non-depressed out-patients with generalized anxiety disorder: a 12-week, double-blind, placebo-controlled study. Eur Neuropsychopharmacol. 2017 May;27(5):526-37.Texto completo  Resumen

211. Stein DJ, Ahokas A, Márquez MS, et al. Agomelatine in generalized anxiety disorder: an active comparator and placebo-controlled study. J Clin Psychiatry. 2014 Apr;75(4):362-8. Resumen

212. Springer KS, Levy HC, Tolin DF. Remission in CBT for adult anxiety disorders: a meta-analysis. Clin Psychol Rev. 2018 Apr;61:1-8. Resumen

213. Kessler RC, DuPont RL, Berglund P, et al. Impairment in pure and comorbid generalized anxiety disorder and major depression at 12 months in two national surveys. Am J Psychiatry. 1999 Dec;156(12):1915-23.Texto completo  Resumen

214. Hall WD, Mant A, Mitchell PB, et al. Association between antidepressant prescribing and suicide in Australia, 1991-2000: trend analysis. BMJ. 2003 May 10;326(7397):1008.Texto completo  Resumen

215. Whooley MA, Simon GE. Managing depression in medical outpatients. N Engl J Med. 2000 Dec 28;343(26):1942-50.

216. Glasheen C, Richardson GA, Fabio A. A systematic review of the effects of postnatal maternal anxiety on children. Arch Womens Ment Health. 2010 Feb;13(1):61-74.Texto completo  Resumen

217. Field T. Prenatal anxiety effects: a review. Infant Behav Dev. 2017 Nov;49:120-8. Resumen

218. Adamson B, Letourneau N, Lebel C. Prenatal maternal anxiety and children's brain structure and function: a systematic review of neuroimaging studies. J Affect Disord. 2018 Dec 1;241:117-26. Resumen

219. Cohen JM, Wood ME, Hernández-Díaz S, et al. Paternal antidepressant use as a negative control for maternal use: assessing familial confounding on gestational length and anxiety traits in offspring. Int J Epidemiol. 2019 Oct 1;48(5):1665-72.Texto completo  Resumen

220. Davidson JR, Wittchen HU, Llorca PM, et al. Duloxetine treatment for relapse prevention in adults with generalized anxiety disorder: a double-blind placebo-controlled trial. Eur Neuropsychopharmacol. 2008 Sep;18(9):673-81. Resumen

221. Feltner D, Wittchen HU, Kavoussi R, et al. Long-term efficacy of pregabalin in generalized anxiety disorder. Int Clin Psychopharmacol. 2008 Jan;23(1):18-28. Resumen