Summary
Differentials
Common
- Quimioterapia
- Radioterapia
- Deficiencia de vitamina B12
- Deficiencia de ácido fólico
- Infiltración de médula ósea por neoplasia maligna no hematológica
- Linfoma no Hodgkin
- Tricoleucemia
- Leucemia linfocítica crónica
- Mielodisplasia
- Cirrosis
- Hepatitis B
- Hepatitis C
- Hepatitis autoinmune
- VIH
- Infección por citomegalovirus
- Infección por micobacterias
Uncommon
- Leucemia mieloide aguda
- Leucemia linfoblástica aguda (LLA)
- Mieloma múltiple
- Mielofibrosis
- Enfermedades de depósito lisosomal
- Anorexia nerviosa
- Enfermedad de injerto contra huésped (EICH)
- Intoxicación con metales pesados (arsénico)
- Infección por parvovirus en anemia falciforme (y otras anemias hemolíticas)
- Disqueratosis congénita (DC)
- Hemoglobinuria paroxística nocturna (HPN)
- Anemia aplásica idiopática
- Anemia de Fanconi
- Otras citopenias hereditarias poco frecuentes (p. ej., la anemia de Diamond-Blackfan, el síndrome de Shwachman-Diamond, la trombocitopenia amegacariocítica)
- Hipertensión portal idiopática
- Leucemia mieloide crónica
- Brucelosis
- Leishmaniasis
- Síndromes hemofagocíticos
- Pancitopenia inmune inducida por fármacos
- Síndrome de Evans con neutropenia asociada
- Síndrome linfoproliferativo autoinmunitario (SLPA)
- Lupus eritematoso sistémico
- artritis reumatoide
- Mononucleosis infecciosa
- Síndrome de Felty
Contributors
Authors
Jeffrey M. Lipton, MD, PhD
Frances and Thomas Gambino Professor of Pediatrics in Hematology/Oncology
Professor of Pediatrics and Molecular Medicine
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Professor, The Center for Autoimmune Musculoskeletal and Hematopoietic Diseases
Feinstein Institute for Medical Research
Director, Hematology/Oncology and Stem Cell Transplantation
Cohen Children's Medical Center of New York
Hyde Park
New York
Disclosures
JML has been reimbursed by Chiesi Farmaceutici S.p.A as a consultant.
Acknowledgements
Dr Jeffrey M. Lipton would like to gratefully acknowledge Dr Jeff K. Davies and Dr Eva C. Guinan, the previous contributors to this topic.
Disclosures
JKD and ECG declare that they have no competing interests.
Peer reviewers
Stella Davies, MD, PhD
Professor and Division Director
Cincinnati Children's Hospital Medical Center
Cincinnati
OH
Disclosures
SD declares that she has no competing interests.
Drew Provan, BSc, MBChB
Consultant Hematologist
Department of Hematology
The Royal London Hospital
London
UK
Disclosures
DP was medical director at GlaxoSmithKline 2005-2006.
Alfred P. Gillio, MD
Director
Bone Marrow Failure Clinic
Tomorrows Children's Institute
Hackensack University Medical Center
Hackensack
NJ
Disclosures
APG declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
Kulasekararaj A, Cavenagh J, Dokal I, et al. Guidelines for the diagnosis and management of adult aplastic anaemia: a British Society for Haematology guideline. Br J Haematol. 2024 Mar;204(3):784-804.Full text Abstract
Williams DA, Bennett C, Bertuch A, et al. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): an initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). Pediatr Blood Cancer. 2014 May;61(5):869-74.Full text Abstract
Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022 Jul;36(7):1703-19.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Guidelines
- Guidelines for the diagnosis and management of adult aplastic anaemia
- The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms
More GuidelinesPatient information
Leucemia (linfocítica aguda)
More Patient information
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