Nausea and vomiting in pregnancy

References

Key articles

Goodwin TM. Hyperemesis gravidarum. Clin Obstet Gynecol. 1998 Sep;41(3):597-605. Abstract

Matthews A, Haas DM, O'Mathúna DP, et al. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2015 Sep 8;(9):CD007575.Full text  Abstract

Lee EJ, Frazier SK. The efficacy of acupressure for symptom management: a systematic review. J Pain Symptom Manage. 2011 Oct;42(4):589-603. Abstract

Thomson M, Corbin R, Leung L. Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis. J Am Board Fam Med. 2014 Jan-Feb;27(1):115-22.Full text  Abstract

American College of Obstetrics and Gynecology. ACOG practice bulletin no. 189: nausea and vomiting of pregnancy. Obstet Gynecol. 2018 Jan;131(1):e15-30. Abstract

Reference articles

1. Goodwin TM. Hyperemesis gravidarum. Clin Obstet Gynecol. 1998 Sep;41(3):597-605. Abstract

2. Gadsby R, Barnie-Adshead AM, Jagger C. A prospective study of nausea and vomiting during pregnancy. Br J Gen Pract. 1993 Jun;43(371):245-8.Full text  Abstract

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6. Buckwalter JG, Simpson SW. Psychological factors in the etiology and treatment of severe nausea and vomiting in pregnancy. Am J Obstet Gynecol. 2002 May;186(5 Suppl Understanding):S210-4. Abstract

7. Sherman PW, Flaxman SM. Nausea and vomiting of pregnancy in an evolutionary perspective. Am J Obstet Gynecol. 2002 May;186(5 Suppl Understanding):S190-7. Abstract

8. Walsh JW, Hasler WL, Nugent CE, et al. Progesterone and estrogen are potential mediators of gastric slow-wave dysrhythmias in nausea of pregnancy. Am J Physiol. 1996 Mar;270(3 Pt 1):G506-14. Abstract

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11. Depue RH, Bernstein L, Ross RK, et al. Hyperemesis gravidarum in relation to estradiol levels, pregnancy outcome, and other maternal factors: a seroepidemiologic study. Am J Obstet Gynecol. 1987 May;156(5):1137-41. Abstract

12. Goldberg D, Szilagyi A, Graves L. Hyperemesis gravidarum and Helicobacter pylori infection: a systematic review. Obstet Gynecol. 2007 Sep;110(3):695-703. Abstract

13. Walsh JW, Hasler WL, Nugent CE, et al. Progesterone and estrogen are potential mediators of gastric slow-wave dysrhythmias in nausea of pregnancy. Am J Physiol. 1996 Mar;270(3 Pt 1):G506-14. Abstract

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18. Matthews A, Haas DM, O'Mathúna DP, et al. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2015 Sep 8;(9):CD007575.Full text  Abstract

19. Rosen T, de Veciana M, Miller HS, et al. A randomized controlled trial of nerve stimulation for relief of nausea and vomiting in pregnancy. Obstet Gynecol. 2003 Jul;102(1):129-35. Abstract

20. Roscoe JA, Matteson SE. Acupressure and acustimulation bands for control of nausea: a brief review. Am J Obstet Gynecol. 2002 May;186(5 Suppl Understanding):S244-7. Abstract

21. Lee EJ, Frazier SK. The efficacy of acupressure for symptom management: a systematic review. J Pain Symptom Manage. 2011 Oct;42(4):589-603. Abstract

22. Allen TK, Habib AS. P6 stimulation for the prevention of nausea and vomiting associated with cesarean delivery under neuraxial anesthesia: a systematic review of randomized controlled trials. Anesth Analg. 2008 Oct;107(4):1308-12.Full text  Abstract

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24. Borelli F, Capasso R, Aviello G, et al. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol. 2005 Apr;105(4):849-56. Abstract

25. Niebyl JR, Goodwin TM. Overview of nausea and vomiting of pregnancy with an emphasis on vitamins and ginger. Am J Obstet Gynecol. 2002 May;186(5 Suppl Understanding):S253-5. Abstract

26. American College of Obstetricians and Gynecologists. Practice Bulletin: nausea and vomiting of pregnancy. Obstet Gynecol. 2004 Apr;103(4):803-14. Abstract

27. Mohammedbeigi R, Shahgeibi S, Soufizadeh N, et al. Comparing the effects of ginger and metoclopramide on the treatment of pregnancy nausea. Pak J Biol Sci. 2011 Aug 15;14(16):817-20. Abstract

28. Ding M, Leach M, Bradley H. The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: a systematic review. Women Birth. 2013 Mar;26(1):e26-30. Abstract

29. Thomson M, Corbin R, Leung L. Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis. J Am Board Fam Med. 2014 Jan-Feb;27(1):115-22.Full text  Abstract

30. Koren G, Clark S, Hankins GD, et al. Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. Am J Obstet Gynecol. 2010 Dec;203(6):571.e1-7. Abstract

31. Persaud N, Meaney C, El-Emam K, et al. Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: prespecified analyses and reanalysis. PLoS One. 2018 Jan 17;13(1):e0189978.Full text  Abstract

32. Leathem A. Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. Clin Pharm. 1986 Aug;5(8):660-8. Abstract

33. Gill SK, O'Brien L, Koren G. The safety of histamine 2 (H2) blockers in pregnancy: a meta-analysis. Dig Dis Sci. 2009 Sep;54(9):1835-8. Abstract

34. Herrell HE. Nausea and vomiting of pregnancy. Am Fam Physician. 2014 Jun 15;89(12):965-70.Full text  Abstract

35. Tan PC, Norazilah MJ, Omar SZ. Dextrose saline compared with normal saline rehydration of hyperemesis gravidarum: a randomized controlled trial. Obstet Gynecol. 2013 Feb;121(2 Pt 1):291-8.Full text  Abstract

36. Eboue C, Carlier-Guerin C, de La Sayette V, et al. A rare complication of vomiting in pregnancy: Wernicke's encephalopathy. J Gynecol Obstet Biol Reprod. 2006 Dec;35(8 Pt 1):822-5. Abstract

37. Kashifard M, Basirat Z, Kashifard M, et al. Ondansetrone or metoclopromide? Which is more effective in severe nausea and vomiting of pregnancy? A randomized trial double-blind study. Clin Exp Obstet Gynecol. 2013;40(1):127-30. Abstract

38. Huybrechts KF, Hernández-Díaz S, Straub L, et al. Association of maternal first-trimester ondansetron use with cardiac malformations and oral clefts in offspring. JAMA. 2018 Dec 18;320(23):2429-37.Full text  Abstract

39. European Medicines Agency. PRAC recommendations on signals: adopted at the 8-11 July 2019 PRAC meeting. Aug 2019 [internet publication].Full text

40. UK Teratology Information Service. Ondansetron: official response statement to PRAC recommendations. Sep 2019 [internet publication].Full text

41. Medicines and Healthcare products Regulatory Agency. Drug safety update. Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy. Jan 2020 [internet publication].Full text

42. Royal College of Obstetricians and Gynaecologists (RCOG). Green-top guideline No. 69: management of nausea and vomiting of pregnancy and hyperemesis gravidarum. Jun 2016 [internet publication].Full text

43. Einarson A, Maltepe C, Boskovic R, et al. Treatment of nausea and vomiting in pregnancy: an updated algorithm. Can Fam Physician. 2007 Dec;53(12):2109-11.Full text  Abstract

44. Pasternak B, Hviid A. Use of proton-pump inhibitors in early pregnancy and the risk of birth defects. N Engl J Med. 2010 Nov 25;363(22):2114-23. Abstract

45. Lai T, Wu M, Liu J, et al. Acid-suppressive drug use during pregnancy and the risk of childhood asthma: a meta-analysis. Pediatrics. 2018 Feb;141(2):e20170889. Abstract

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47. Safari HR, Fassett MJ, Souter IC, et al. The efficacy of methylprednisolone in the treatment of hyperemesis gravidarum: a randomized, double-blind, controlled study. Am J Obstet Gynecol. 1998 Oct;179(4):921-4. Abstract

48. Hsu JJ, Clark-Glena R, Nelson DK, et al. Nasogastric enteral feeding in the management of hyperemesis gravidarum. Obstet Gynecol. 1996 Sep;88(3):343-6. Abstract

49. European Medicines Agency. European Medicines Agency recommends changes to the use of metoclopramide. Jul 2013 [internet publication].Full text

50. American College of Obstetrics and Gynecology. ACOG practice bulletin no. 189: nausea and vomiting of pregnancy. Obstet Gynecol. 2018 Jan;131(1):e15-30. Abstract

51. Campbell K, Rowe H, Azzam H, et al. The management of nausea and vomiting of pregnancy. J Obstet Gynaecol Can. 2016 Dec;38(12):1127-37. Abstract

52. Brandes JM. First-trimester nausea and vomiting as related to outcome of pregnancy. Obstet Gynecol. 1967 Sep;30(3):427-31. Abstract

53. Jarnfelt-Samsioe A, Samsioe G, Velinder GM. Nausea and vomiting in pregnancy - a contribution to its epidemiology. Gynecol Obstet Invest. 1983;16(4):221-9. Abstract

54. Weigel MM, Weigel RM. Nausea and vomiting of early pregnancy and pregnancy outcome. An epidemiologic study. Br J Obstet Gynaecol. 1989 Nov;96(11):1304-11. Abstract

55. Zhang J, Cai WW. Severe vomiting during pregnancy: antenatal correlates and fetal outcomes. Epidemiology. 1991 Nov;2(6):454-7. Abstract

56. Wood P, Murray A, Sinha B, et al. Wernicke's encephalopathy induced by hyperemesis gravidarum. Case reports. Br J Obstet Gynaecol. 1983 Jun;90(6):583-6. Abstract

57. Gross S, Librach C, Cecutti A. Maternal weight loss associated with hyperemesis gravidarum: a predictor of fetal outcome. Am J Obstet Gynecol. 1989 Apr;160(4):906-9. Abstract

58. Bailit JL. Hyperemesis gravidarum: epidemiologic findings from a large cohort. Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):811-4. Abstract

59. Nguyen N, Deitel M, Lacy E. Splenic avulsion in a pregnant patient with vomiting. Can J Surg. 1995 Oct;38(5):464-5. Abstract

60. Eroglu A, Kurkcuoglu C, Karaoglanoglu N, et al. Spontaneous esophageal rupture following severe vomiting in pregnancy. Dis Esophagus. 2002;15(3):242-3. Abstract

61. Liang SG, Ooka F, Santo A, et al. Pneumomediastinum following esophageal rupture associated with hyperemesis gravidarum. J Obstet Gynaecol Res. 2002 Jun;28(3):172-5. Abstract

62. Togay-Isikay C, Yigit A, Mutluer N. Wernicke's encephalopathy due to hyperemesis gravidarum: an under-recognised condition. Aust N Z J Obstet Gynaecol. 2001 Nov;41(4):453-6. Abstract

63. Phayphet M, Rafat C, Andreux F, et al. Hyperemesis gravidarum: a rare cause of Wernicke encephalopathy [in French]. Presse Med. 2007 Dec;36(12 Pt 1):1759-61. Abstract

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