Care of transgender adults

References

Key articles

World Health Organization. International statistical classification of diseases and health related problems (ICD). 11th revision. Jan 2022 [Internet publication].Full text

American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th edition (DSM-5). Washington, DC: American Psychiatric Publishing; 2022.

Coleman E, Radix AE, Bouman WP, et al. Standards of care for the health of transgender and gender diverse people, version 8. Int J Transgend Health. 2022;23(suppl 1):S1-S259.Full text  Abstract

Richards C, Barrett J. Trans and Non-binary Gender Healthcare for Psychiatrists, Psychologists, and Other Health Professionals. Cambridge, UK: Cambridge University Press; 2020.

Hembree WC, Cohen-Kettenis PT, Gooren L, et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2017 Nov 1;102(11):3869-903. Abstract

The American College of Obstetricians and Gynecologists. Health care for transgender and gender diverse individuals: ACOG Committee Opinion, Number 823. Obstet Gynecol. 2021 Mar 1;137(3):e75-88.Full text  Abstract

Reference articles

1. World Health Organization. International statistical classification of diseases and health related problems (ICD). 11th revision. Jan 2022 [Internet publication].Full text

2. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th edition (DSM-5). Washington, DC: American Psychiatric Publishing; 2022.

3. Winter S, Diamond M, Green J, et al. Transgender people: health at the margins of society. Lancet. 2016 Jul 23;388(10042):390-400. Abstract

4. Coleman E, Radix AE, Bouman WP, et al. Standards of care for the health of transgender and gender diverse people, version 8. Int J Transgend Health. 2022;23(suppl 1):S1-S259.Full text  Abstract

5. Practice Committee of the American Society for Reproductive Medicine. Inclusive language and environment to welcome lesbian, gay, bisexual, transgender, queer, questioning, intersex, and asexual+ patients. Fertil Steril. 2024 Jun;121(6):954-60. Abstract

6. Centers for Disease Control and Prevention. Transgender persons. Apr 2023 [internet publication].​Full text

7. Drummond KD, Bradley SJ, Peterson-Badali M, et al. A follow-up study of girls with gender identity disorder. Dev Psychol. 2008 Jan;44(1):34-45. Abstract

8. Wallien MS, Cohen-Kettenis PT. Psychosexual outcome of gender-dysphoric children. J Am Acad Child Adolesc Psychiatry. 2008 Dec;47(12):1413-23. Abstract

9. Singh D, Bradley SJ, Zucker KJ. A Follow-up study of boys with gender identity disorder. Front Psychiatry. 2021;12:632784.Full text  Abstract

10. Collin L, Reisner SL, Tangpricha V, et al. Prevalence of transgender depends on the "case" definition: a systematic review. J Sex Med. 2016 Apr;13(4):613-26.Full text

11. UK Parliament. ​2021 census: what do we know about the LGBT+ population? 16 Jan 2023 [internet publication].Full text

12. Van Der Miesen AI, Hurley H, De Vries AL. Gender dysphoria and autism spectrum disorder: a narrative review. Int Rev Psychiatry. 2016;28(1):70-80.Full text  Abstract

13. Glidden D, Bouman WP, Jones BA, et al. Gender dysphoria and autism spectrum disorder: a systematic review of the literature. Sex Med Rev. 2016 Jan;4(1):3-14. Abstract

14. Terada S, Matsumoto Y, Sato T, et al. Factors predicting psychiatric co-morbidity in gender-dysphoric adults. Psychiatry Res. 2012 Dec 30;200(2-3):469-74. Abstract

15. Bockting WO, Miner MH, Swinburne Romine RE, et al. Stigma, mental health, and resilience in an online sample of the US transgender population. Am J Public Health. 2013 May;103(5):943-51.Full text  Abstract

16. Swaab DF, Chung WC, Kruijver FP, et al. Sex differences in the human hypothalamus in the different stages of human life. Neurobiol Aging. 2003 May-Jun;24(suppl 1):S1-16. Abstract

17. American Psychiatric Association. Assessment and treatment of gender dysphoria and gender variant patients. 2018 [internet publication].Full text

18. Diamond M, Watson LA. Androgen insensitivity syndrome and Kleinfelter's syndrome: sex and gender considerations. Child Adolesc Psychiatr Clin N Am. 2004 Jul;13(3):623-40. Abstract

19. Peterson RE, Imparato-McGinley J, Gautier T, et al. Male pseudohermaphroditism due to steroid 5 alpha reductase deficiency. Am J Med. 1977 Feb;62(2):170-91. Abstract

20. Meyer-Bahlburg HF. Hormones and psychosexual differentiation: implications for the management of intersexuality, homosexuality and transsexuality. Clin Endocrinol Metab. 1982 Nov;11(3):681-701. Abstract

21. Dittmann RW, Kappes MH, Kappes ME, et al. Congenital adrenal hyperplasia II: gender-related behavior and attitudes in female salt-wasting and simple virilizing patients. Psychoneuroendocrinology. 1990;15(5-6):421-34. Abstract

22. Dittmann RW, Kappes MH, Kappes ME, et al. Gender related behavior and attitudes in female patients and sisters. Psychoneuroendocrinology. 1990;15(5-6):401-20. Abstract

23. Cohen-Kettenis PT, van Goozen SH, Doorn C, et al. Cognitive ability and cerebral lateralization in transsexuals. Psychoneuroendocrinology. 1998 Aug;23(6):631-41. Abstract

24. Heylens G, De Cuypere G, Zucker KJ, et al. Gender identity disorder in twins: a review of the case report literature. J Sex Med. 2012 Mar;9(3):751-7. Abstract

25. Bentz EK, Hefler LA, Kaufmann U, et al. A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female-to-male but not male-to-female transsexualism. Fertil Steril. 2008 Jul;90(1):56-9.Full text  Abstract

26. Pasterski V, Gilligan L, Curtis R. Traits of autism spectrum disorders in adults with gender dysphoria. Arch Sex Behav. 2014 Feb;43(2):387-93. Abstract

27. Richards C, Barrett J. Trans and Non-binary Gender Healthcare for Psychiatrists, Psychologists, and Other Health Professionals. Cambridge, UK: Cambridge University Press; 2020.

28. Le Vay S. The sexual brain. Boston, MA: MIT Press;1993.

29. Rametti G, Carrillo B, Gómez-Gil E et al. The microstructure of white matter in male to female transsexuals before cross-sex hormonal treatment. A DTI study. J Psychiatr Res. 2011 Jul;45(7):949-54. Abstract

30. Luders E, Sánchez FJ, Gaser C, et al. Regional gray matter variation in male-to-female transsexualism. Neuroimage. 2009 Jul 15;46(4):904-7. Abstract

31. Hembree WC, Cohen-Kettenis PT, Gooren L, et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2017 Nov 1;102(11):3869-903. Abstract

32. Royal College of Psychiatrists. Good practice guidelines for the assessment and treatment of adults with gender dysphoria​. Oct 2013 [internet publication].Full text

33. Nuttbrock L, Hwahng S, Bockting W, et al. Lifetime risk factors for HIV/sexually transmitted infections among male-to-female transgender persons. J Acquir Immune Defic Syndr. 2009 Nov 1;52(3):417-21.Full text  Abstract

34. Sevelius JM. Gender Affirmation: A framework for conceptualizing risk behavior among transgender women of color. Sex Roles. 2013 Jun 1;68(11-12):675-89. Abstract

35. Rotondi NK, Bauer GR, Scanlon K, et al. Nonprescribed hormone use and self-performed surgeries: "do-it-yourself" transitions in transgender communities in Ontario, Canada. Am J Public Health. 2013 Oct;103(10):1830-6.​Full text

36. Becerra Fernández A, de Luis Román DA, Piédrola Maroto G. Morbidity in transsexual patients with cross-gender hormone self-treatment [in Spanish]. Med Clin (Barc). 1999 Oct 23;113(13):484-7. Abstract

37. American Psychological Association. Guidelines for psychological practice with transgender and gender nonconforming people. Am Psychol. 2015 Dec;70(9):832-64.Full text  Abstract

38. Nik-Ahd F, Jarjour A, Figueiredo J, et al. Prostate-specific antigen screening in transgender patients. Eur Urol. 2023 Jan;83(1):48-54.Full text  Abstract

39. Chen H, Wiepjes CM, van Schoor NM, et al. Changes of vitamin D-binding protein, and total, bioavailable, and free 25-hydroxyvitamin D in transgender people. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2728-34.Full text  Abstract

40. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30.Full text  Abstract

41. Murad MH, Elamin MB, Garcia MZ, et al. Hormonal therapy and sex reassignment: a systematic review and meta-analysis of quality of life and psychosocial outcomes. Clin Endocrinol (Oxf). 2010 Feb;72(2):214-31. Abstract

42. Baker KE, Wilson LM, Sharma R, et al. Hormone therapy, mental health, and quality of life among transgender people: a systematic review. J Endocr Soc. 2021 Apr 1;5(4):bvab011.Full text  Abstract

43. Fisher AD, Castellini G, Ristori J, et al. Cross-sex hormone treatment and psychobiological changes in transsexual persons: two-year follow-up data. J Clin Endocrinol Metab. 2016 Nov;101(11):4260-9.Full text  Abstract

44. The American College of Obstetricians and Gynecologists. Health care for transgender and gender diverse individuals: ACOG Committee Opinion, Number 823. Obstet Gynecol. 2021 Mar 1;137(3):e75-88.Full text  Abstract

45. Safer JD, Coleman E, Feldman J, et al. Barriers to healthcare for transgender individuals. Curr Opin Endocrinol Diabetes Obes. 2016 Apr;23(2):168-71. Abstract

46. Schuster MA, Reisner SL, Onorato SE. Beyond bathrooms--meeting the health needs of transgender people. N Engl J Med. 2016 Jul 14;375(2):101-3. Abstract

47. British Medical Association. Managing patients with gender dysphoria. Wed 2023 [internet publication].Full text

48. Rosendale N, Goldman S, Ortiz GM, et al. Acute Clinical Care for Transgender Patients: A Review. JAMA Intern Med. 2018 Nov 1;178(11):1535-43. Abstract

49. Weyers S, Elaut E, De Sutter P, et al. Long-term assessment of the physical, mental, and sexual health among transsexual women. J Sex Med. 2009 Mar;6(3):752-60. Abstract

50. Haupt C, Henke M, Kutschmar A, et al. Antiandrogen or estradiol treatment or both during hormone therapy in transitioning transgender women. Cochrane Database Syst Rev. 2020 Nov 28;11:CD013138. Abstract

51. Vinogradova Y, Coupland C, Hippisley-Cox J. Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases. BMJ. 2019 Jan 9;364:k4810.Full text  Abstract

52. Dittrich R, Binder H, Cupisti S, et al. Endocrine treatment of male-to-female transsexuals using gonadotropin-releasing hormone agonist. Exp Clin Endocrinol Diabetes. 2005 Dec;113(10):586-92. Abstract

53. Patel KT, Adeel S, Rodrigues Miragaya J, et al. Progestogen use in gender-affirming hormone therapy: a systematic review. Endocr Pract. 2022 Dec;28(12):1244-52. Abstract

54. Traish AM, Gooren LJ. Safety of physiological testosterone therapy in women: lessons from female-to-male transsexuals (FMT) treated with pharmacological testosterone therapy. J Sex Med. 2010 Nov;7(11):3758-64. Abstract

55. Joint R, Chen ZE, Cameron S. Breast and reproductive cancers in the transgender population: a systematic review. BJOG. 2018 Nov;125(12):1505-12. Abstract

56. General Medical Council. Trans healthcare​. Jan 2024 [internet publication].Full text

57. Barrett J. Transsexualism and other disorders of gender identity: a practical guide to management. Abingdon, UK: Radcliffe Medical Publishing; 2007.

58. de Blok CJ, Wiepjes CM, van Velzen DM, et al. Mortality trends over five decades in adult transgender people receiving hormone treatment: a report from the Amsterdam cohort of gender dysphoria. Lancet Diabetes Endocrinol. 2021 Oct;9(10):663-70. Abstract

59. Trum HW, Hoebeke P, Gooren LJ. Sex reassignment of transsexual people from a gynecologist's and urologist's perspective. Acta Obstet Gynecol Scand. 2015 Jun;94(6):563-7.Full text  Abstract

60. British Medical Association. Inclusive care of trans and non-binary patients. Mar 2022 [internet publication].​Full text

61. UCSF Transgender Care. Guidelines for the primary and gender-affirming care of transgender and gender nonbinary people. Jun 2016 [internet publication].​Full text

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