Chancroid

References

Key articles

Steen R. Eradicating chancroid. Bull World Health Organ. 2001;79(9):818-26.Full text  Abstract

Spinola, SM. Chancroid and Haemophilus ducreyi. In: Holmes KK, Sparling PF, Stamm WE, et al, eds. Sexually transmitted diseases. 4th ed. New York, NY: McGraw-Hill, 2008:689-700.

Augenbraun MH. Genital skin and mucous membrane lesions. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 8th ed. Philadelphia, PA: Saunders; 2015:1341-8.

Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.Full text  Abstract

Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.Full text  Abstract

Reference articles

1. Trees DL, Morse SA. Chancroid and Haemophilus ducreyi: an update. Clin Microbiol Rev. 1995 Jul;8(3):357-75.Full text  Abstract

2. Roberts SA, Taylor SL. Haemophilus ducreyi: a newly recognised cause of chronic skin ulceration. Lancet Glob Health. 2014 Apr;2(4):e187-8. Abstract

3. Mitjà O, Lukehart SA, Pokowas G, et al. Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study. Lancet Glob Health. 2014 Apr;2(4):e235-41. Abstract

4. Spinola SM. Haemophilus ducreyi as a cause of skin ulcers. Lancet Glob Health. 2014 Jul;2(7):e387. Abstract

5. Marks M, Chi KH, Vahi V, et al. Haemophilus ducreyi associated with skin ulcers among children, Solomon Islands. Emerg Infect Dis. 2014 Oct;20(10):1705-7.Full text  Abstract

6. Gangaiah D, Webb KM, Humphreys TL, et al. Haemophilus ducreyi cutaneous ulcer strains are nearly identical to class I genital ulcer strains. PLoS Negl Trop Dis. 2015 Jul 6;9(7):e0003918.Full text  Abstract

7. Lewis DA, Mitjà O. Haemophilus ducreyi: from sexually transmitted infection to skin ulcer pathogen. Curr Opin Infect Dis. 2016 Feb;29(1):52-7. Abstract

8. González-Beiras C, Marks M, Chen CY, et al. Epidemiology of Haemophilus ducreyi infections. Emerg Infect Dis. 2016 Jan;22(1):1-8.Full text  Abstract

9. World Health Organization. Global prevalence and incidence of selected curable sexually transmitted diseases: overview and estimates. 1995 [internet publication].Full text

10. Steen R. Eradicating chancroid. Bull World Health Organ. 2001;79(9):818-26.Full text  Abstract

11. Centers for Disease Control and Prevention. Sexually transmitted diseases surveillance 2021. Apr 2022 [internet publication].Full text

12. Adams DA, Thomas KR, Jajosky RA, et al; Nationally Notifiable Infectious Conditions Group, CDC. Summary of notifiable infectious diseases and conditions - United States, 2015. MMWR Morb Mortal Wkly Rep. 2017 Aug 11;64(53):1-143.Full text  Abstract

13. Spinola, SM. Chancroid and Haemophilus ducreyi. In: Holmes KK, Sparling PF, Stamm WE, et al, eds. Sexually transmitted diseases. 4th ed. New York, NY: McGraw-Hill, 2008:689-700.

14. Sharma VK, Khandpur S. Changing patterns of sexually transmitted infections in India. Natl Med J India. 2004 Nov-Dec;17(6):310-9. Abstract

15. Morse SA. Chancroid and Haemophilus ducreyi. Clin Microbiol Rev. 1989 Apr;2(2):137-57.Full text  Abstract

16. Grant JC, González-Beiras C, Amick KM, et al. Multiple class I and class II haemophilus ducreyi strains cause cutaneous ulcers in children on an endemic island. Clin Infect Dis. 2018 Nov 13;67(11):1768-1774.Full text  Abstract

17. Houinei W, Godornes C, Kapa A, et al. Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea. PLoS Negl Trop Dis. 2017 May 10;11(5):e0004958.Full text  Abstract

18. Marks M, Fookes M, Wagner J, et al. Direct whole-genome sequencing of cutaneous strains of Haemophilus ducreyi. Emerg Infect Dis. 2018 Apr;24(4):786-789.Full text  Abstract

19. Gangaiah D, Spinola SM. Haemophilus ducreyi cutaneous ulcer strains diverged from both class I and class II genital ulcer strains: implications for epidemiological studies. PLoS Negl Trop Dis. 2016 Dec;10(12):e0005259.Full text  Abstract

20. Van Howe RS. Genital ulcerative disease and sexually transmitted urethritis and circumcision: a meta-analysis. Int J STD AIDS. 2007 Dec;18(12):799-809. Abstract

21. Weiss HA, Thomas SL, Munabi SK, et al. Male circumcision and risk of syphilis, chancroid, and genital herpes: a systemic review and meta-analysis. Sex Transm Infect. 2006 Apr;82(2):101-10.Full text  Abstract

22. Marrazzo JM, Handsfield HH. Chancroid: new developments in an old disease. In: Remington JS, Swartz MN, eds. Current clinical topics in infectious diseases. Malden MA: Blackwell Science; 1995:129-52.

23. Greenblatt RM, Lukehart SA, Plummer FA, et al. Genital ulceration as a risk factor for human immunodeficiency virus infection. AIDS. 1988 Feb;2(1):47-50. Abstract

24. Augenbraun MH. Genital skin and mucous membrane lesions. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 8th ed. Philadelphia, PA: Saunders; 2015:1341-8.

25. Al-Tawfiq JA, Harezlak J, Katz BP, et al. Cumulative experience with Haemophilus ducreyi 35000 in the human model of experimental infection. Sex Transm Dis. 2000 Feb;27(2):111-4. Abstract

26. D'Costa LJ, Plummer FA, Bowmer I, et al. Prostitutes are a major reservoir of sexually transmitted diseases in Nairobi, Kenya. Sex Transm Dis. 1985 Apr-Jun;12(2):64-7. Abstract

27. Ronald AR, Plummer FA. Chancroid and granuloma inguinale. Clin Lab Med. 1989 Sep;9(3):535-43. Abstract

28. Plummer FA, D'Costa LJ, Nsanze H, et al. Epidemiology of chancroid and Haemophilus ducreyi in Nairobi, Kenya. Lancet. 1983 Dec 3;2(8362):1293-5. Abstract

29. Spinola SM, Bauer ME, Munson RS Jr. Immunopathogenesis of Haemophilus ducreyi infection (chancroid). Infect Immun. 2002 Apr;70(4):1667-76.Full text  Abstract

30. Bauer ME, Spinola SM. Localization of Haemophilus ducreyi at the pustular stage of disease in the human model of infection. Infect Immun. 2000 Apr;68(4):2309-14.Full text  Abstract

31. Bong CT, Harezlak J, Katz BP, et al. Men are more susceptible than women to pustule formation in the experimental model of Haemophilus ducreyi infection. Sex Transm Dis. 2002 Feb;29(2):114-8. Abstract

32. Spinola SM, Bong CT, Faber AL, et al. Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection. Infect Immun. 2003 Nov;71(11):6658-63.Full text  Abstract

33. Throm RE, Spinola SM. Transcription of candidate virulence genes of Haemophilus ducreyi during infection of human volunteers. Infect Immun. 2001 Mar;69(3):1483-7.Full text  Abstract

34. Dutro SM, Wood GE, Totten PA. Prevalence of, antibody response to, and immunity induced by Haemophilus ducreyi hemolysin. Infect Immun. 1999 Jul;67(7):3317-28.Full text  Abstract

35. Purven M, Lagergård T. Haemophilus ducreyi, a cytotoxin-producing bacterium. Infect Immun. 1992 Mar;60(3):1156-62.Full text  Abstract

36. Mount KL, Townsend CA, Bauer ME. Haemophilus ducreyi is resistant to human antimicrobial peptides. Antimicrob Agents Chemother. 2007 Sep;51(9):3391-3.Full text  Abstract

37. Madhivanan P, Hernandez A, Gogate A, et al. Alcohol use by men is a risk factor for the acquisition of sexually transmitted infections and human immunodeficiency virus from female sex workers in Mumbai, India. Sex Transm Dis. 2005 Nov;32(11):685-90. Abstract

38. O'Farrell N. Soap and water prophylaxis for limiting genital ulcer disease and HIV-1 infection in men in sub-Saharan Africa. Genitourin Med. 1993 Aug;69(4):297-300.Full text  Abstract

39. National Institute for Health and Care Excellence. Reducing sexually transmitted infections. June 2022 [internet publication].Full text

40. Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.Full text  Abstract

41. Ndinya-Achola JO, Kihara KN, Fisher LD, et al. Presumptive specific clinical diagnosis of genital ulcer disease (GUD) in a primary health care setting in Nairobi. Int J STD AIDS. 1996 May-Jun;7(3):201-5. Abstract

42. Chapel TA, Brown WJ, Jeffres C, et al. How reliable is the morphological diagnosis of penile ulcerations? Sex Transm Dis. 1977 Oct-Dec;4(4):150-2. Abstract

43. Behets FM, Andriamiadana J, Randrianasolo D, et al. Chancroid, primary syphilis, genital herpes, and lymphogranuloma venereum in Antananarivo, Madagascar. J Infect Dis. 1999 Oct;180(4):1382-5.Full text  Abstract

44. Dangor Y, Ballard RC, da L Exposto F, et al. Accuracy of clinical diagnosis of genital ulcer disease. Sex Transm Dis. 1990 Oct-Dec;17(4):184-9. Abstract

45. Behets FM, Liomba G, Lule G, et al. Sexually transmitted diseases and human immunodeficiency virus control in Malawi: a field study of genital ulcer disease. J Infect Dis. 1995 Feb;171(2):451-5. Abstract

46. Htun Y, Morse SA, Dangor Y, et al. Comparison of clinically directed, disease specific, and syndromic protocols for the management of genital ulcer disease in Lesotho. Sex Transm Infect. 1998 Jun;74 Suppl 1:S23-8. Abstract

47. Lewis DA. Chancroid: clinical manifestations, diagnosis, and management. Sex Transm Infect. 2003 Feb;79(1):68-71.Full text  Abstract

48. Dangor Y, Radebe F, Ballard RC. Transport media for Haemophilus ducreyi. Sex Transm Dis. 1993 Jan-Feb;20(1):5-9. Abstract

49. Alfa M. The laboratory diagnosis of Haemophilus ducreyi. Can J Infect Dis Med Microbiol. 2005 Jan;16(1):31-4.Full text  Abstract

50. Lewis DA. Diagnostic tests for chancroid. Sex Transm Infect. 2000 Apr;76(2):137-41.Full text  Abstract

51. Dylewski J, Nsanze H, Maitha G, et al. Laboratory diagnosis of Haemophilus ducreyi: sensitivity of culture media. Diagn Microbiol Infect Dis. 1986 Mar;4(3):241-5. Abstract

52. Morse SA, Trees DL, Htun Y, et al. Comparison of clinical diagnosis and standard laboratory and molecular methods for the diagnosis of genital ulcer disease in Lesotho: association with human immunodeficiency virus infection. J Infect Dis. 1997 Mar;175(3):583-9. Abstract

53. Totten PA, Kuypers JM, Chen CY, et al. Etiology of genital ulcer disease in Dakar, Senegal, and comparison of PCR and serologic assays for the detection of Haemophilus ducreyi. J Clin Microbiol. 2000 Jan;38(1):268-73.Full text  Abstract

54. Patterson K, Olsen B, Thomas C, et al. Development of a rapid immunodiagnostic test for Haemophilus ducreyi. J Clin Microbiol. 2002 Oct;40(10):3694-702.Full text  Abstract

55. Chui L, Albritton W, Paster B, et al. Development of the polymerase chain reaction for diagnosis of chancroid. J Clin Microbiol. 1993 Mar;31(3):659-64.Full text  Abstract

56. Orle KA, Gates CA, Martin DH, et al. Simultaneous PCR detection of Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus types 1 and 2 from genital ulcers. J Clin Microbiol. 1996 Jan;34(1):49-54.Full text  Abstract

57. Mackay IM, Harnett G, Jeoffreys N, et al. Detection and discrimination of herpes simplex viruses, Haemophilus ducreyi, Treponema pallidum, and Calymmatobacterium (Klebsiella) granulomatis from genital ulcers. Clin Infect Dis. 2006 May 15;42(10):1431-8.Full text  Abstract

58. Roy-Leon JE, Lauzon WD, Toye B, et al. In vitro and in vivo activity of combination antimicrobial agents on Haemophilus ducreyi. J Antimicrob Chemother. 2005 Sep;56(3):552-8.Full text  Abstract

59. Knapp JS, Back AF, Babst AF, et al. In vitro susceptibilities of isolates of Haemophilus ducreyi from Thailand and from the United States to currently recommended and newer agents for the treatment of chancroid. Antimicrob Agents Chemother. 1993 Jul;37(7):1552-5.Full text  Abstract

60. Lubwama SW, Plummer FA, Ndinya-Achola J, et al. Isolation and identification of Haemophilus ducreyi in a clinical laboratory. J Med Microbiol. 1986 Sep;22(2):175-8. Abstract

61. Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.Full text  Abstract

62. Elkins C, Yi K, Olsen B, et al. Development of a serological test for Haemophilus ducreyi for seroprevalence studies. J Clin Microbiol. 2000 Apr;38(4):1520-6.Full text  Abstract

63. Black CM, Morse SA. The use of molecular techniques for the diagnosis and epidemiologic study of sexually transmitted diseases. Curr Infect Dis Rep. 2000 Feb;2(1):31-43. Abstract

64. Lautenschlager S, Kemp M, Christensen JJ, et al. 2017 European guideline for the management of chancroid. Int J STD AIDS. 2017 Mar;28(4):324-329. Abstract

65. O'Farrell N, Lazaro N. UK National guideline for the management of chancroid 2014. Int J STD AIDS. 2014 Dec;25(14):975-83.Full text  Abstract

66. Fleming DT, Wasserheit JN. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm Infect. 1999 Feb;75(1):3-17.Full text  Abstract

67. Romero L, Huerfano C, Grillo-Ardila CF. Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults. Cochrane Database Syst Rev. 2017 Dec 11;(12):CD012492.Full text  Abstract

68. Annan NT, Lewis DA. Treatment of chancroid in resource-poor countries. Expert Rev Anti Infect Ther. 2005 Apr;3(2):295-306. Abstract

69. Schmid GP. Treatment of chancroid, 1997. Clin Infect Dis. 1999 Jan;28 Suppl 1:S14-20.Full text  Abstract

70. McClean H, Radcliffe K, Sullivan A, et al. 2012 BASHH statement on partner notification for sexually transmissible infections. Int J STD AIDS. 2013 Apr;24(4):253-61. Abstract

71. Al-Tawfiq JA, Palmer KL, Chen CY, et al. Experimental infection of human volunteers with Haemophilus ducreyi does not confer protection against subsequent challenge. J Infect Dis. 1999 May;179(5):1283-7.Full text  Abstract

72. Afonina G, Leduc I, Nepluev I, et al. Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid. Infect Immun. 2006 Apr;74(4):2224-32.Full text  Abstract

73. de Sarom A, Kumar Jaiswal A, Tiwari S, et al. Putative vaccine candidates and drug targets identified by reverse vaccinology and subtractive genomics approaches to control Haemophilus ducreyi, the causative agent of chancroid. J R Soc Interface. 2018 May;15(142):20180032.Full text  Abstract

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