MRSA is an important cause of infection in both healthy people in the community and in patients in healthcare institutions.
It is important to distinguish MRSA colonization from infection.
Healthcare-associated MRSA infections and community-associated MRSA infections exhibit important differences in antibiotic susceptibility.
Community-associated MRSA most commonly results in skin and soft-tissue infections and therapy can often be with oral antibiotics.
Healthcare-associated MRSA infections usually require treatment with intravenous antibiotics.
Isolation of patients with MRSA, through contact precautions, may help to prevent spread of infection.
MRSA is a type of Staphylococcus aureus that is resistant to most beta-lactam antibiotics, antistaphylococcal penicillins (e.g., methicillin, oxacillin), and cephalosporins. Methicillin resistance is defined as an oxacillin minimum inhibitory concentration of ≥4 micrograms/mL.  Oxacillin is in the same class as methicillin and was chosen as the agent for testing of S aureus sensitivity in the early 1990s. Methicillin is still used to describe resistance because of its historical role.  MRSA infections can include syndromes of bacteremia, pneumonia, endocarditis, joint infections, and skin or soft-tissue infections.
Associate Professor of Medicine
Rush University Medical Centre
KJP declares that he has no competing interests.
Dr Kyle J. Popovich would like to gratefully acknowledge Dr Dara Grennan, Dr Paul F. Roberts, and Dr R. John Presutti, the previous contributors to this topic. DG, PFR, and RJP declare that they have no competing interests.
Outpatient & Pediatric Dermatology
59th Medical Wing/ SGOMD
Lackland Air Force Base
CMH declares that he has no competing interests.
College of Medicine
University of Malawi
LK declares that she has no competing interests.
Cleveland Clinic Foundation
CR declares that she has no competing interests.
Southern General Hospital
AL declares that he has no competing interests.
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