WHO case definitions of SARS in the post outbreak period
Clinical case definition requires all of the following:
Fever (≥100.4°F [38°C])
One or more symptoms of lower respiratory tract illness: cough, difficulty breathing, SOB
Radiologic evidence of lung infiltrates consistent with pneumonia or respiratory distress syndrome
No alternative diagnosis that can fully explain the illness.
Laboratory case definition:
Positive laboratory findings of SARS coronavirus (CoV), based on either or both of the following diagnostic criteria:
PCR positive from at least 2 different clinical specimens or the same specimen collected on 2 or more occasions during the course of the illness
Seroconversion between acute and convalescent phase sera and virus isolation.
CDC updated interim case definition for SARS
Early respiratory illness
Two or more of the following features: fever, chills, rigors, myalgia, headache, diarrhea, sore throat, rhinorrhea.
Mild to moderate respiratory illness
Fever (≥100.4°F [38°C]) plus 1 or more symptoms of lower respiratory tract illness: cough, dyspnea, difficulty breathing.
Severe respiratory illness
Mild to moderate respiratory illness plus radiologic evidence of lung infiltrates consistent with pneumonia or ARDS.
History of recent travel, within 10 days of the onset of symptoms, to a foreign or domestic location with documented or suspected recent transmission of SARS; or
Close contact with a person confirmed with or suspected of having SARS.
Detection of serum antibodies to SARS-CoV; or
Isolation in cell culture of SARS-CoV from a clinical specimen; or
Detection of SARS-CoV RNA by reverse-transcription polymerase chain reaction (RT-PCR) testing with subsequent confirmation in a reference laboratory.
Probable case of SARS-CoV
Patient meets the clinical criteria for severe respiratory illness and the epidemiologic criteria for likely exposure to SARS-CoV.
Confirmed case of SARS-CoV
Patient has a clinically compatible respiratory illness (early, mild to moderate, or severe) that is confirmed by the laboratory.
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