Recovery for AKI is variable and depends on cause of injury and the severity and duration of AKI.[150][151]

There is an independent association of AKI with a higher risk of death.[9][150][152] In-hospital mortality rates associated with AKI vary from 6% to 80%, and there is increased long-term mortality in those with AKI surviving hospitalization.[152]

Up to 6% of patients admitted to the intensive care unit have AKI requiring renal replacement therapy.[16][150][153] In hospital, when AKI requires dialysis, mortality exceeds 50%; those with multiorgan failure are at greatest risk.[13][16][153] Mortality rates are high due to death from underlying disease and complications, not just the AKI.

Five-year survival rates in patients with AKI requiring renal replacement therapy range from 15% to 35% (less than 10% of those patients are dialysis-dependent).[154]

AKI is irreversible in approximately 5% to 7% of adults and as many as 16% of older adult patients.[155] There is controversy as to whether prior AKI is a major risk factor leading to future chronic kidney disease, but evidence increasingly favors a strong association.[156][157][158][159]

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