Emerging treatments

Novel therapeutic agents

The use of novel therapeutic agents, including atrial natriuretic peptide, theophylline, insulin-like growth factor, epidermal growth factor, free radical oxygen scavengers, antibodies to adhesion molecules, and prostaglandins, has been reviewed. None have been shown to be beneficial in human AKI.[17] The protective effect of statins (administered either pre-intervention or chronically) is debated,[108][109][110] [ Cochrane Clinical Answers logo ] but results from recent studies are disappointing.[111][112][113] Controlled hypothermia and recombinant alkaline phosphatase infusion may be of benefit.[114][115] Erythropoietin does not appear to exert nephroprotective effects,[116] and treatment with thyroid hormone has been associated with worse outcomes than other possible treatments for patients with established AKI; its role in preventing AKI was not adequately investigated.[117] Remote ischemic preconditioning appeared to hold promise to prevent AKI, but two systematic reviews (including more than 28 randomized controlled trials) cast doubt on the value of the treatment.[89][118][119] [ Cochrane Clinical Answers logo ]

Use of this content is subject to our disclaimer