Osteoporotic spinal compression fractures

References

Key articles

Kim DH, Vaccaro AR. Osteoporotic compression fractures of the spine: current options and considerations for treatment. Spine J. 2006 Sep-Oct;6(5):479-87. Abstract

American College of Radiology. ACR Appropriateness Criteria: management of vertebral compression fractures. 2022 [internet publication].Full text

LeBoff MS, Greenspan SL, Insogna KL, et al. The clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int. 2022 Oct;33(10):2049-102.Full text  Abstract

The North American Menopause Society Advisory Panel. The 2022 hormone therapy position statement of The North American Menopause Society. Menopause. 2022 Jul 1;29(7):767-94.Full text  Abstract

Reference articles

1. Kim DH, Vaccaro AR. Osteoporotic compression fractures of the spine: current options and considerations for treatment. Spine J. 2006 Sep-Oct;6(5):479-87. Abstract

2. Denis F. The three-column spine and its significance in the classification of acute thoracolumbar spinal injuries. Spine (Phila Pa 1976). 1983 Nov-Dec;8(8):817-31. Abstract

3. Sugita M, Watanabe N, Mikami Y, et al. Classification of vertebral compression fractures in the osteoporotic spine. J Spinal Disord Tech. 2005 Aug;18(4):376-81. Abstract

4. Wu CT, Lee SC, Lee ST, et al. Classification of symptomatic osteoporotic compression fractures of the thoracic and lumbar spine. J Clin Neuroscience. 2006 Jan;13(1):31-8. Abstract

5. McAfee PC, Yuan HA, Fredrickson BE, et al. The value of computed tomography in thoracolumbar fractures. An analysis of one hundred cases and a new classification. J Bone Joint Surg. 1983 Apr;65(4):461-73. Abstract

6. Kanis JA. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organization technical report series. Osteoporosis Int. 1994 Nov;4(6):368-81. Abstract

7. Wright NC, Looker AC, Saag KG, et al. The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res. 2014 Nov;29(11):2520-6.Full text  Abstract

8. Sarafrazi N, Wambogo EA, Shepherd JA. Osteoporosis or low bone mass in older adults: United States, 2017-2018. NCHS Data Brief. 2021 Mar;(405):1-8. Abstract

9. American College of Radiology. ACR Appropriateness Criteria: management of vertebral compression fractures. 2022 [internet publication].Full text

10. Cosman F, de Beur SJ, LeBoff MS, et al. Clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int. 2014 Oct;25(10):2359-81.Full text  Abstract

11. LeBoff MS, Greenspan SL, Insogna KL, et al. The clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int. 2022 Oct;33(10):2049-102.Full text  Abstract

12. Cauley JA, Lui LY, Ensrud KE, et al. Bone mineral density and the risk of incident nonspinal fractures in black and white women. JAMA. 2005 May 4;293(17):2102-8.Full text  Abstract

13. Liu XS, Walker MD, McMahon DJ, et al. Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus white women. J Bone Miner Res. 2011 Aug;26(8):1783-92.Full text  Abstract

14. Johnell O. Advances in osteoporosis: Better identification of risk factors can reduce morbidity and mortality. J Intern Med. 1996;239:299-304. Abstract

15. Iqbal MM, Sobhan T. Osteoporosis: a review. Mo Med. 2002 Jan;99(1):19-24. Abstract

16. Gold DT. The clinical impact of vertebral fractures: quality of life in women with osteoporosis. Bone. 1996 Mar;18(3 Suppl):185-9S. Abstract

17. Silverman SL. The clinical consequences of vertebral compression fracture. Bone. 1992;13 Suppl 2:S27-31. Abstract

18. North American Menopause Society. Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society. Menopause. 2021 Sep 1;28(9):973-97.Full text  Abstract

19. American College of Surgeons. Best practices guidelines. Spine injury. Mar 2022 [internet publication].Full text

20. Malik SA, Murphy M, Connolly P, et al. Evaluation of morbidity, mortality and outcome following cervical spine injuries in elderly patients. Eur Spine J. 2008 Apr;17(4):585-91. Abstract

21. Lane JM, Nydick M. Osteoporosis: current modes of prevention and treatment. J Am Acad Orthop Surg. 1999 Jan;7(1):19-31. Abstract

22. Ross PD, Davis JW, Epstein RS, et al. Pre-existing fractures and bone mass may predict vertebral fracture incidence in women. Ann Intern Med. 1991 Jun 1;114(11):919-23. Abstract

23. Gunnes M, Lehmann EH, Mellstrom D, et al. The relationship between anthropometric measurements and fractures in women. Bone. 1996 Oct;19(4):407-13. Abstract

24. Riggs BL, Melton LJ 3rd. Involutional osteoporosis. N Engl J Med. 1986 Jun 26;314(26):1676-86. Abstract

25. Burger H, de Laet CE, van Daele PL, et al. Risk factors for increased bone loss in an elderly population: the Rotterdam Study. Am J Epidemiol. 1998 May 1;147(9):871-9. Abstract

26. Law MR, Hackshaw AK. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ. 1997 Oct 4;315(7112):841-6.Full text  Abstract

27. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001 Feb 14;285(6):785-95. Abstract

28. WHO Scientific Group on the Prevention and Management of Osteoporosis. Prevention and management of osteoporosis: report of a WHO scientific group. WHO technical report series no. 921. Geneva, Switzerland; 2003.

29. Dennison E, Eastell R, Fall CH, et al. Determinants of bone loss in elderly men and women: a prospective study. Osteoporos Int. 1999;10(5):384-91. Abstract

30. Jang HD, Hong JY, Han K, et al. Relationship between bone mineral density and alcohol intake: a nationwide health survey analysis of postmenopausal women. PLoS One. 2017 Jun 29;12(6):e0180132.Full text  Abstract

31. Kanis JA, Johansson H, Oden A, et al. A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res. 2004 Jun;19(6):893-9.Full text  Abstract

32. Mazziotti G, Angeli A, Bilezikian JP, et al. Glucocorticoid-induced osteoporosis: an update. Trends Endocrinol Metab. 2006 May-Jun;17(4):144-9. Abstract

33. Lakatos P. Thyroid hormones: beneficial or deleterious for bone? Calcif Tissue Int. 2003 Sep;73(3):205-9. Abstract

34. Jackson RD, LaCroix AZ, Gass M. Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006 Feb 16;354(7):669-83. Abstract

35. Ali T, Lam D, Bronze MS, et al. Osteoporosis in inflammatory bowel disease. Am J Med. 2009 Jul;122(7):599-604. Abstract

36. Nakchbandi IA, van der Merwe SW. Current understanding of osteoporosis associated with liver disease. Nat Rev Gastroenterol Hepatol. 2009 Nov;6(11):660-70. Abstract

37. Carda S, Cisari C, Invernizzi M, et al. Osteoporosis after stroke: a review of the causes and potential treatments. Cerebrovasc Dis. 2009;28(2):191-200.Full text  Abstract

38. Hofbauer LC, Busse B, Eastell R, et al. Bone fragility in diabetes: novel concepts and clinical implications. Lancet Diabetes Endocrinol. 2022 Mar;10(3):207-20. Abstract

39. Broersen LH, Pereira AM, Jørgensen JO, et al. Adrenal insufficiency in corticosteroids use: systematic review and meta-analysis. J Clin Endocrinol Metab. 2015 Jun;100(6):2171-80.Full text  Abstract

40. Shah R, Raji MA, Westra J, et al. Association of co-prescribing of opioid and benzodiazepine substitutes with incident falls and fractures among older adults: a cohort study. BMJ Open. 2021 Dec 30;11(12):e052057.Full text  Abstract

41. Tinetti ME, Han L, Lee DS, et al. Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern Med. 2014 Apr;174(4):588-95.Full text  Abstract

42. National Institute for Health and Care Excellence. Bisphosphonates for treating osteoporosis. April 2019 [internet publication].Full text

43. Lippuner K. Medical treatment of vertebral osteoporosis. Eur Spine J. 2003 Oct;12 Suppl 2:S132-41. Abstract

44. National Institute for Health and Care Excellence. Denosumab for the prevention of osteoporotic fractures in postmenopausal women. Oct 2010 [internet publication].Full text

45. European Medicines Agency. European Medicines Agency recommends limiting long-term use of calcitonin medicines. Jul 2012 [internet publication].Full text

46. Overman RA, Borse M, Gourlay ML. Salmon calcitonin use and associated cancer risk. Ann Pharmacother. 2013 Dec;47(12):1675-84. Abstract

47. The North American Menopause Society Advisory Panel. The 2022 hormone therapy position statement of The North American Menopause Society. Menopause. 2022 Jul 1;29(7):767-94.Full text  Abstract

48. National Institute for Health and Care Excellence. Osteoporosis: assessing the risk of fragility fracture. Aug 2012 [internet publication].​Full text

49. US Preventive Services Task Force, Curry SJ, Krist AH, et al. Screening for osteoporosis to prevent fractures: US Preventive Services Task Force recommendation statement. JAMA. 2018 Jun 26;319(24):2521-31.Full text  Abstract

50. American College of Radiology. ACR appropriateness criteria: thoracic back pain​. 2024 [internet publication].Full text

51. Alsoof D, Anderson G, McDonald CL, et al. Diagnosis and management of vertebral compression fracture. Am J Med. 2022 Jul;135(7):815-21. Abstract

52. Johansson L, Svensson HK, Karlsson J, et al. Decreased physical health-related quality of life-a persisting state for older women with clinical vertebral fracture. Osteoporos Int. 2019 Oct;30(10):1961-71.Full text  Abstract

53. Ross PD. Clinical consequences of vertebral fractures. Am J Med. 1997 Aug 18;103(2a):30S-42S; discussion 42S-3S. Abstract

54. Fechtenbaum J, Cropet C, Kolta S, et al. The severity of vertebral fractures and health-related quality of life in osteoporotic postmenopausal women. Osteoporos Int. 2005 Dec;16(12):2175-9. Abstract

55. Harrison RA, Siminoski K, Vethanayagam D, et al. Osteoporosis-related kyphosis and impairments in pulmonary function: a systematic review. J Bone Miner Res. 2007 Mar;22(3):447-57.Full text  Abstract

56. Fechtenbaum J, Etcheto A, Kolta S, et al. Sagittal balance of the spine in patients with osteoporotic vertebral fractures. Osteoporos Int. 2016 Feb;27(2):559-67. Abstract

57. Royal Osteoporosis Society. Guidance for the management of symptomatic vertebral fragility fractures. May 2022 [internet publication].Full text

58. American College of Radiology. ACR–ASNR–SCBT-MR–SSR practice parameter for the performance of magnetic resonance imaging (MRI) of the adult spine. 2018 [internet publication].Full text

59. Ramachandran S, Clifton IJ, Collyns TA, et al. The treatment of spinal tuberculosis: a retrospective study. Int J Tuberc Lung Dis. 2005 May;9(5):541-4. Abstract

60. Kumar K, Halkar RK, Bartley SC, et al. Incremental benefit of SPECT + CT bone scans over conventional planar and SPECT bone scans in vertebroplasty. Indian J Nucl Med. 2011 Oct;26(4):181-4.Full text  Abstract

61. Li YB, Zheng X, Wang R, et al. SPECT-CT versus MRI in localizing active lesions in patients with osteoporotic vertebral compression fractures. Nucl Med Commun. 2018 Jul;39(7):610-7. Abstract

62. Lems WF, Paccou J, Zhang J, et al. Vertebral fracture: epidemiology, impact and use of DXA vertebral fracture assessment in fracture liaison services. Osteoporos Int. 2021 Mar;32(3):399-411.Full text  Abstract

63. Patel DM, Weinberg BD, Hoch MJ. CT myelography: clinical indications and imaging findings. Radiographics. 2020 Mar-Apr;40(2):470-84.Full text  Abstract

64. Rupp RE, Ebraheim NA, Coombs RJ. Magnetic resonance imaging differentiation of compression spine fractures or vertebral lesions caused by osteoporosis or tumor. Spine (Phila Pa 1976). 1995 Dec 1;20(23):2499-504. Abstract

65. Herkowitz HN, Garfin SR, Eismont FJ, et al. Rothman-Simeone: the spine, volume 2. Philadelphia, PA: Saunders-Elsevier; 2006:1408-9.

66. National Institute for Health and Care Excellence. Raloxifene for the primary prevention of osteoporotic fragility fractures in postmenopausal women. Feb 2018 [internet publication].Full text

67. Camacho PM, Petak SM, Binkley N, et al. American Association of Clinical Endocrinologists/ American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis: 2020 update. Endor Pract. 2020 May;26(suppl 1):1-46.Full text  Abstract

68. Toward Optimized Practice. Diagnosis and management of osteoporosis. Feb 2016 [internet publication].Full text

69. Borgeat A, Ofner C, Saporito A, et al. The effect of nonsteroidal anti-inflammatory drugs on bone healing in humans: a qualitative, systematic review. J Clin Anesth. 2018 Jun 15;49:92-100. Abstract

70. Marquez-Lara A, Hutchinson ID, Nuñez F Jr, et al. Nonsteroidal anti-inflammatory drugs and bone-healing: a systematic review of research quality. JBJS Rev. 2016 Mar 15;4(3):01874474-201603000-00005.Full text  Abstract

71. McCarberg BH. NSAIDs in the older patient: balancing benefits and harms. Pain Med. 2013 Dec;14 Suppl 1:S43-4.Full text  Abstract

72. Davis A, Robson J. The dangers of NSAIDs: look both ways. Br J Gen Pract. 2016 Apr;66(645):172-3.Full text  Abstract

73. Ma XL, Xing D, Ma JX, et al. Balloon kyphoplasty versus percutaneous vertebroplasty in treating osteoporotic vertebral compression fracture: grading the evidence through a systematic review and meta-analysis. Eur Spine J. 2012 Sep;21(9):1844-59. Abstract

74. Kanayama M, Oha F, Iwata A, et al. Does balloon kyphoplasty improve the global spinal alignment in osteoporotic vertebral fracture? Int Orthop. 2015 Jun;39(6):1137-43. Abstract

75. Yokoyama K, Kawanishi M, Yamada M, et al. In not only vertebroplasty but also kyphoplasty, the resolution of vertebral deformities depends on vertebral mobility. AJNR Am J Neuroradiol. 2013 Jul;34(7):1474-8.Full text  Abstract

76. Yokoyama K, Kawanishi M, Yamada M, et al. Postoperative change in sagittal balance after Kyphoplasty for the treatment of osteoporotic vertebral compression fracture. Eur Spine J. 2015 Apr;24(4):744-9. Abstract

77. Tanigawa N, Kariya S, Komemushi A, et al. Added value of percutaneous vertebroplasty: effects on respiratory function. AJR Am J Roentgenol. 2012 Jan;198(1):W51-4.Full text  Abstract

78. Barr JD, Jensen ME, Hirsch JA, et al. Position statement on percutaneous vertebral augmentation: a consensus statement developed by the Society of Interventional Radiology (SIR), American Association of Neurological Surgeons (AANS) and the Congress of Neurological Surgeons (CNS), American College of Radiology (ACR), American Society of Neuroradiology (ASNR), American Society of Spine Radiology (ASSR), Canadian Interventional Radiology Association (CIRA), and the Society of NeuroInterventional Surgery (SNIS). J Vasc Interv Radiol. 2014 Feb;25(2):171-81.Full text  Abstract

79. Ebeling PR, Akesson K, Bauer DC, et al. The efficacy and safety of vertebral augmentation: a second ASBMR task force report. J Bone Miner Res. 2019 Jan;34(1):3-21.Full text  Abstract

80. National Institute for Health and Care Excellence. Percutaneous vertebroplasty and percutaneous balloon kyphoplasty for treating osteoporotic vertebral compression fractures. April 2013. http://guidance.nice.org.uk/TA279 (last accessed 22 March 2017).Full text

81. Anderson PA, Froyshteter AB, Tontz WL Jr. Meta-analysis of vertebral augmentation compared with conservative treatment for osteoporotic spinal fractures. J Bone Miner Res. 2013 Feb;28(2):372-82. Abstract

82. Mattie R, Laimi K, Yu S, et al. Comparing percutaneous vertebroplasty and conservative therapy for treating osteoporotic compression fractures in the thoracic and lumbar spine: a systematic review and meta-analysis. J Bone Joint Surg Am. 2016 Jun 15;98(12):1041-51. Abstract

83. Buchbinder R, Johnston RV, Rischin KJ, et al. Percutaneous vertebroplasty for osteoporotic vertebral compression fracture. Cochrane Database Syst Rev. 2018 Apr 4;(4):CD006349.Full text  Abstract

84. Clark W, Bird P, Diamond T, et al. Cochrane vertebroplasty review misrepresented evidence for vertebroplasty with early intervention in severely affected patients. BMJ Evid Based Med. 2020 Jun;25(3):85-9.Full text  Abstract

85. Rousing R, Andersen MO, Jespersen SM, et al. Percutaneous vertebroplasty compared to conservative treatment in patients with painful acute or subacute osteoporotic vertebral fractures: three-months follow-up in a clinical randomized study. Spine (Phila Pa 1976). 2009 Jun 1;34(13):1349-54. Abstract

86. Clark W, Bird P, Gonski P, et al. Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. 2016 Aug 17;388(10052):1408-16. Abstract

87. Ong T, Kantachuvesiri P, Sahota O, et al. Characteristics and outcomes of hospitalised patients with vertebral fragility fractures: a systematic review. Age Ageing. 2018 Jan 1;47(1):17-25.Full text  Abstract

88. Felder-Puig R, Piso B, Guba B, et al. Kyphoplasty and vertebroplasty for the management of osteoporotic vertebral compression fractures: a systematic review [in German]. Orthopade. 2009 Jul;38(7):606-15. Abstract

89. Lee MJ, Dumonski M, Cahill P, et al. Percutaneous treatment of vertebral compression fractures: a meta-analysis of complications. Spine (Phila Pa 1976). 2009 May 15;34(11):1228-32. Abstract

90. Taylor RS, Fritzell P, Taylor RJ. Balloon kyphoplasty in the management of vertebral compression fractures: an updated systematic review and meta-analysis. Eur Spine J. 2007 Aug;16(8):1085-100.Full text  Abstract

91. Wardlaw D, Cummings SR, Van Meirhaeghe J, et al. Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial. Lancet. 2009 Mar 21;373(9668):1016-24. Abstract

92. Tsoumakidou G, Too CW, Koch G, et al. CIRSE guidelines on percutaneous vertebral augmentation. Cardiovasc Intervent Radiol. 2017 Jan 19;40(3):331-42. Abstract

93. Muijs SP, van Erkel AR, Dijkstra PD. Treatment of painful osteoporotic vertebral compression fractures: a brief review of the evidence for percutaneous vertebroplasty. J Bone Joint Surg Br. 2011 Sep;93(9):1149-53. Abstract

94. Kallmes DF, Comstock BA, Heagerty PJ, et al. A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med. 2009 Aug 6;361(6):569-79.Full text  Abstract

95. Buchbinder R, Osborne RH, Ebeling PR, et al. A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med. 2009 Aug 6;361(6):557-68.Full text  Abstract

96. National Institute for Health and Care Excellence. Raloxifene and teriparatide for the secondary prevention of osteoporotic fragility fractures in postmenopausal women. Feb 2018 [internet publication].Full text

97. National Institute for Health and Care Excellence. Romosozumab for treating severe osteoporosis - technology appraisal guidance [TA791]. May 2022 [internet publication].Full text

98. Gregson CL, Armstrong DJ, Bowden J, et al. UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos. 2022 Apr 5;17(1):58.Full text  Abstract

99. Lindsay R, Silverman SL, Cooper C, et al. Risk of new vertebral fracture in the year following a fracture. JAMA. 2001 Jan 17;285(3):320-3.Full text  Abstract

100. Lyles KW, Gold DT, Shipp KM, et al. Association of osteoporotic vertebral compression fractures with impaired functional status. Am J Med. 1993 Jun;94(6):595-601. Abstract

101. Choe DH, Marom EM, Ahrar K, et al. Pulmonary embolism of polymethyl methacrylate during percutaneous vertebroplasty and kyphoplasty. AJR Am J Roentgenol. 2004 Oct;183(4):1097-102. Abstract

102. Watts NB, Harris ST, Genant HK. Treatment of painful osteoporotic vertebral fractures with percutaneous vertebroplasty or kyphoplasty. Osteoporos Int. 2001;12(6):429-37. Abstract

103. National Institute for Health and Care Excellence. Rehabilitation after traumatic injury. Jan 2022 [internet publication].Full text

104. Gibbs JC, MacIntyre NJ, Ponzano M, et al. Exercise for improving outcomes after osteoporotic vertebral fracture. Cochrane Database Syst Rev. 2019 Jul 5;7(7):CD008618.Full text  Abstract

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