Cholestasis of pregnancy

References

Key articles

Eloranta ML, Hakli T, Hiltunen M, et al. Association of single nucleotide polymorphisms of the bile salt sport pump gene with intrahepatic cholestasis of pregnancy. Scand J Gastroenterol. 2003 Jun;38(6):648-52. Abstract

Dixon PH, Weerasekera N, Linton KJ, et al. Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. Hum Mol Genet. 2000 May 1;9(8):1209-17.Full text  Abstract

European Association for the Study of the Liver. Clinical practice guidelines: management of cholestatic liver diseases. J Hepatol. 2009 Aug;51(2):237-67.Full text  Abstract

Glantz A, Marschall HU, Lammert F, et al. Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid. Hepatology. 2005;42:1399-1405.Full text  Abstract

Glantz A, Marschall HU, Lammert F, et al. Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid. Hepatology. 2005 Dec;42(6):1399-405.Full text  Abstract

Bacq Y, Sentilhes L, Reyes HB, et al. Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis. Gastroenterology. 2012 Dec;143(6):1492-501. Abstract

Fisk NM, Bye WB, Storey GN. Maternal features of obstetric cholestasis: 20 years experience at King George V Hospital. Aust N Z J Obstet Gynaecol. 1988 Aug;28(3):172-6. Abstract

Heinonen S, Kirkinen P. Pregnancy outcome with intrahepatic cholestasis. Obstet Gynecol. 1999 Aug;94(2):189-93. Abstract

Reference articles

1. Lammert F, Marschall HU, Glantz A, et al. Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. J Hepatol. 200;33:1012-1021. Abstract

2. Kenyon AP, Piercy CN, Girling J, et al. Obstetric cholestasis, outcome with active management: a series of 70 cases. BJOG. 2002;109:282-288. Abstract

3. Glantz A, Marschall HU, Mattsson LA. Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology. 2004 Aug;40(2):467-74. Abstract

4. Reyes H, Simon F. Intrahepatic cholestasis of pregnancy: an estrogen-related disease. Semin Liver Dis. 1993 Aug;13(3):289-301. Abstract

5. Lammert F, Marschall HU, Glantz A, et al. Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. J Hepatol. 2000 Dec;33(6):1012-21. Abstract

6. Kenyon AP, Piercy CN, Girling J, et al. Obstetric cholestasis, outcome with active management: a series of 70 cases. BJOG. 2002 Mar;109(3):282-8. Abstract

7. Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function and regulation. Physiol Rev. 2003 Apr;83(2):633-71.Full text  Abstract

8. Rosmorduc O, Hermelin B, Boelle PY, et al. ABCB4 gene mutation-associated cholelithiasis in adults. Gastroenterology. 2003 Aug;125(2):452-9. Abstract

9. Milkiewicz P, Gallagher R, Chambers J, et al. Obstetric cholestasis with elevated gamma glutamyl transpeptidase: incidence, presentation and treatment. J Gastroenterol Hepatol. 2003 Nov;18(11):1283-6. Abstract

10. Eloranta ML, Hakli T, Hiltunen M, et al. Association of single nucleotide polymorphisms of the bile salt sport pump gene with intrahepatic cholestasis of pregnancy. Scand J Gastroenterol. 2003 Jun;38(6):648-52. Abstract

11. Savander M, Ropponen A, Avela K, et al. Genetic evidence of heterogeneity in intrahepatic cholestasis of pregnancy. Gut. 2003 Jul;52(7):1025-9.Full text  Abstract

12. Kroumpouzos G, Cohen LM. Specific dermatoses of pregnancy: an evidence-based systematic review. Am J Obstet Gynecol. 2003 Apr;188(4):1083-92. Abstract

13. Dixon PH, Weerasekera N, Linton KJ, et al. Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. Hum Mol Genet. 2000 May 1;9(8):1209-17.Full text  Abstract

14. European Association for the Study of the Liver. Clinical practice guidelines: management of cholestatic liver diseases. J Hepatol. 2009 Aug;51(2):237-67.Full text  Abstract

15. Howard PJ, Murphy GM. Bile acid stress in mother and baby unit. Eur J Gastroenterol Hepatol. 2003 Mar;15(3):317-21. Abstract

16. Germain AM, Kato S, Carvajal JA, et al. Bile acids increase response and expression of human myometrial oxytocin receptor. Am J Obstet Gynecol. 2003 Aug;189(2):577-82. Abstract

17. Monte MJ, Villanueva GR, Macias RI, et al. Effect of maternal obstructive cholestasis during pregnancy on the biliary transport of horseradish peroxidase in the rat offspring. Clin Sci (Lond). 2003 Sep;105(3):347-53.Full text  Abstract

18. Reyes H, Sjovall J. Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy. Ann Med. 2000 Mar;32(2):94-106. Abstract

19. Serrano MA, Macias RI, Vallejo M, et al. Effect of ursodeoxycholic acid on the impairment induced by maternal cholestasis in the rat placenta-maternal liver tandem excretory pathway. J Pharmacol Exp Ther. 2003 May;305(2):515-24.Full text  Abstract

20. Mottino AD, Veggi LM, Wood M, et al. Biliary secretion of glutathione in estradiol 17beta-D-glucuronide-induced cholestasis. J Pharmacol Exp Ther. 2003 Oct;307(1):306-13.Full text  Abstract

21. Saleh MM, Abdo KR. Intrahepatic cholestasis of pregnancy: review of the literature and evaluation of current evidence. J Womens Health (Larchmt). 2007 Jul-Aug;16(6):833-41. Abstract

22. Lopez J, Glasinovic JC, Marinovic I, et al. Clinical and laboratory characterization in 100 cases of pregnancy cholestasis. Rev Chil Obstet Ginecol. 1982;47(4):215-21. Abstract

23. Tran TT, Ahn J, Reau NS. ACG clinical guideline: Liver disease and pregnancy. Am J Gastroenterol. 1982;47(4):215-21.Full text  Abstract

24. Glantz A, Marschall HU, Mattsson LA. Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology. 2004;40:467-474. Abstract

25. Milkiewicz P, Gallagher R, Chambers J, et al. Obstetric cholestasis with elevated gamma glutamyl transpeptidase: incidence, presentation and treatment. J Gastroenterol Hepatol. 2003;18:1283-1286. Abstract

26. Kroumpouzos G, Cohen LM. Specific dermatoses of pregnancy: an evidence-based systematic review. Am J Obstet Gynecol. 2003;188:1083-1092. Abstract

27. Reyes H, Simon F. Intrahepatic cholestasis of pregnancy: an estrogen-related disease. Semin Liver Dis. 1993;13:289-301. Abstract

28. Reyes H, Sjovall J. Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy. Ann Med. 2000;32:94-106. Abstract

29. Lopez J, Glasinovic JC, Marinovic I, et al. Clinical and laboratory characterization in 100 cases of pregnancy cholestasis. Rev Chil Obstet Ginecol. 1982;47:215-221. Abstract

30. Locatelli A, Roncaglia N, Arreghini A, et al. Hepatitis C virus infection is associated with a higher incidence of cholestasis in pregnancy. Br J Obstet Gynaecol. 1999;106:498-500. Abstract

31. Glantz A, Marschall HU, Lammert F, et al. Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid. Hepatology. 2005;42:1399-1405.Full text  Abstract

32. Warren JE, Blaylock RC, Silver RM. Plasmapheresis for the treatment of intrahepatic cholestasis of pregnancy refractory to medical treatment. Am J Obstet Gynecol. 2005;192:2088-2089. Abstract

33. Glantz A, Marschall HU, Lammert F, et al. Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid. Hepatology. 2005 Dec;42(6):1399-405.Full text  Abstract

34. Palma J, Reyes H, Ribalta J, et al. Ursodeoxycholic acid in treatment of cholestasis of pregnancy: a randomized, double blinded study controlled with placebo. J Hepatol. 1997 Dec;27(6):1022-8. Abstract

35. Bacq Y, Sentilhes L, Reyes HB, et al. Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis. Gastroenterology. 2012 Dec;143(6):1492-501. Abstract

36. Fisk NM, Bye WB, Storey GN. Maternal features of obstetric cholestasis: 20 years experience at King George V Hospital. Aust N Z J Obstet Gynaecol. 1988 Aug;28(3):172-6. Abstract

37. Heinonen S, Kirkinen P. Pregnancy outcome with intrahepatic cholestasis. Obstet Gynecol. 1999 Aug;94(2):189-93. Abstract

38. Nicastri PL, Diaferia A, Tartagni M, et al. A randomized placebo-controlled trial of ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy. Br J Obstet Gynaecol. 1998 Nov;105(11):1205-7. Abstract

39. Binser T, Salaj P, Zima T, et al. Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy. J Perinat Med. 2006;34(5):383-91. Abstract

40. Royal College of Obstetrics and Gynaecologists. Obstetric cholestasis. Green-top guideline 43. April 2011. [internet publication].Full text

Use of this content is subject to our disclaimer