Lactose intolerance and lactase deficiency

References

Key articles

Heyman MB; American Academy of Pediatrics, Committee on Nutrition. Lactose intolerance in infants, children, and adolescents. Pediatrics. 2006 Sep;118(3):1279-86.Full text  Abstract

Suchy FJ, Brannon PM, Carpenter TO, et al. National Institutes of Health Consensus Development Conference: lactose intolerance and health. Ann Intern Med. 2010 Jun 15;152(12):792-6.Full text  Abstract

Golden NH, Abrams SA, Committee on Nutrition. Optimizing bone health in children and adolescents. Pediatrics. 2014 Oct;134(4):e1229-43.Full text  Abstract

Reference articles

1. Matthews SB, Waud JP, Roberts AG, et al. Systemic lactose intolerance: a new perspective on an old problem. Postgrad Med J. 2005 Mar;81(953):167-73.Full text  Abstract

2. Heyman MB; American Academy of Pediatrics, Committee on Nutrition. Lactose intolerance in infants, children, and adolescents. Pediatrics. 2006 Sep;118(3):1279-86.Full text  Abstract

3. Lomer ME, Parkes GC, Sanderson JD. Lactose intolerance in clinical practice - myths and realities. Aliment Pharmacol Ther. 2008 Jan 15;27(2):93-103. Abstract

4. Storhaug CL, Fosse SK, Fadnes LT. Country, regional, and global estimates for lactose malabsorption in adults: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2017 Oct;2(10):738-46.Full text  Abstract

5. Suchy FJ, Brannon PM, Carpenter TO, et al. National Institutes of Health Consensus Development Conference: lactose intolerance and health. Ann Intern Med. 2010 Jun 15;152(12):792-6.Full text  Abstract

6. Misselwitz B, Butter M, Verbeke K, et al. Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management. Gut. 2019 Nov;68(11):2080-91.Full text  Abstract

7. Harvey L, Ludwig T, Hou AQ, et al. Prevalence, cause and diagnosis of lactose intolerance in children aged 1-5 years: a systematic review of 1995-2015 literature. Asia Pac J Clin Nutr. 2018;27(1):29-46.Full text  Abstract

8. Scrimshaw NS, Murray EB. The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance. Am J Clin Nutr. 1988 Oct;48(4 Suppl):1079-159. Abstract

9. Paige DM, Bayless TM, Mellitis ED, et al. Lactose intolerance in preschool black children. Am J Clin Nutr. 1977 Jul;30(7):1018-22. Abstract

10. Sahi T. Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol Suppl. 1994;202:7-20. Abstract

11. Gilat T, Kuhn R, Gelman E, et al. Lactase deficiency in Jewish communities in Israel. Am J Dig Dis. 1970 Oct;15(10):895-904.

12. Sahi T, Launiala K, Laitinen H. Hypolactasia in a fixed cohort of young Finnish adults. A follow-up study. Scand J Gastroenterol. 1983 Oct;18(7):865-70. Abstract

13. Johnson JD. The regional and ethnic distribution of lactose malabsorption. Genetic and adaptive hypothesis. Clinical and nutritional implications. Baltimore, MD: Johns Hopkins University Press; 1981:11-22.

14. Srinivasan R, Minocha A. When to suspect lactose intolerance. Symptomatic, ethnic, and laboratory clues. Postgrad Med. 1998 Sep;104(3):109-11,115-6,122-3. Abstract

15. Kretchmer N. Lactose and lactase. Sci Am. 1972 Oct;227(4):71-8. Abstract

16. Beja-Pereira A, Luikart G, England PR, et al. Gene-culture coevolution between cattle milk protein genes and human lactase genes. Nat Genet. 2003 Dec;35(4):311-3. Abstract

17. Rasinperä H, Saarinen K, Pelkonen A, et al. Molecularly defined adult-type hypolactasia in school-aged children with a previous history of cow's milk allergy. World J Gastroenterol. 2006 Apr 14;12(14):2264-8.Full text  Abstract

18. Swallow DM. Genetics of lactase persistence and lactose intolerance. Annu Rev Genet. 2003;37:197-219. Abstract

19. Mobassaleh M, Montgomery RK, Biller JA, et al. Development of carbohydrate absorption in the fetus and neonate. Pediatrics. 1985 Jan;75(1 Pt 2):160-6. Abstract

20. Harrington LK, Mayberry JF. A re-appraisal of lactose intolerance. Int J Clin Pract. 2008 Oct;62(10):1541-6. Abstract

21. Treuder R, Tebbe B, Steinhoff M, et al. Familial aquagenic urticaria associated with familial lactose intolerance. J Am Acad Dermatol. 2002 Oct;47(4):611-3. Abstract

22. Campbell AK, Matthews SB. Darwin's illness revealed. Postgrad Med J. 2005 Apr;81(954):248-51.Full text  Abstract

23. Alpers DH. Diet and irritable bowel syndrome. Curr Opin Gastroenterol. 2006 Mar;22(2):136-9. Abstract

24. Suarez F, Levitt MD. Abdominal symptoms and lactose: the discrepancy between patients' claims and the results of blinded trials. Am J Clin Nutr. 1996 Aug;64(2):251-2. Abstract

25. Rana SV, Malik A. Hydrogen breath tests in gastrointestinal diseases. Indian J Clin Biochem. 2014 Oct;29(4):398-405.Full text  Abstract

26. Suarez FL, Savaiano D, Arbisi P, et al. Tolerance to the daily ingestion of two cups of milk by individuals claiming lactose intolerance. Am J Clin Nutr. 1997 May;65(5):1502-6. Abstract

27. Hammer HF, Fox MR, Keller J, et al. European guideline on indications, performance, and clinical impact of hydrogen and methane breath tests in adult and pediatric patients: European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Neurogastroenterology and Motility, and European Society for Paediatric Gastroenterology Hepatology and Nutrition consensus. United European Gastroenterol J. 2022 Feb;10(1):15-40.Full text  Abstract

28. Rezaie A, Buresi M, Lembo A, et al. Hydrogen and methane-based breath testing in gastrointestinal disorders: the North American consensus. Am J Gastroenterol. 2017 May;112(5):775-84. Abstract

29. Simrén M, Stotzer PO. Use and abuse of hydrogen breath tests. Gut. 2006 Mar;55(3):297-303.Full text  Abstract

30. Di Stefano M, Missanelli A, Miceli E, et al. Hydrogen breath test in the diagnosis of lactose malabsorption: accuracy of new versus conventional criteria. J Lab Clin Med. 2004 Dec;144(6):313-8. Abstract

31. Waud JP, Matthews SB, Campbell AK. Measurement of breath hydrogen and methane, together with lactase genotype, defines the current best practice for investigation of lactose sensitivity. Ann Clin Biochem. 2008 Jan;45(Pt 1):50-8. Abstract

32. Gupta SK, Chong SK, Fitzgerald JF. Disaccharidase activities in children: normal values and comparison based on symptoms and histological changes. J Pediatr Gastoenterol Nutr. 1999 Mar;28(3):246-51. Abstract

33. Koetse HA, Stellaard F, Bijleveld CM, et al. Non-invasive detection of low intestinal lactase activity in children by use of a combined 13Co2/H2 breath test. Scand J Gastroenterol. 1999 Jan;34(1):35-40. Abstract

34. Balsiger LM, Houben E, Vanuytsel T, et al. Added value of (13)C analysis in breath tests in H(2)-negative subjects to diagnose lactose malabsorption: a proof of concept study. Dig Dis Sci. 2024 Jun;69(6):2147-53. Abstract

35. Schirru E, Corona V, Usai-Satta P, et al. Genetic testing improves the diagnosis of adult type hypolactasia in the Mediterranean population of Sardinia. Eur J Clin Nutr. 2007 Oct;61(10):1220-5. Abstract

36. Högenauer C, Hammer HF, Mellitzer K, et al. Evaluation of a new DNA test compared with the lactose hydrogen breath test for the diagnosis of lactase non-persistence. Eur J Gastroenterol Hepatol. 2005 Mar;17(3):371-6. Abstract

37. Chatterjee S, Park S, Low K, et al. The degree of breath methane production in IBS correlates with the severity of constipation. Am J Gastroenterol. 2007 Apr;102(4):837-41. Abstract

38. Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med. 2002 Jan 17;346(3):180-8. Abstract

39. Dubé C, Rostom A, Sy R, et al. The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastroenterology. 2005 Apr;128(4 Suppl 1):S57-67. Abstract

40. Marsh MN. The immunopathology of small intestinal reaction in gluten-sensitivity. Immunol Invest. 1989 Jan-May;18(1-4):509-31. Abstract

41. McFarlane XA, Bhalla AK, Reeves DE, et al. Osteoporosis in treated adult coeliac disease. Gut. 1995 May;36(5):710-4.Full text  Abstract

42. Treem WR. Congenital sucrase-isomaltase deficiency. J Pediatr Gastroenterol Nutr. 1995 Jul;21(1):1-14. Abstract

43. McNair A, Gudmand-Hoyer E, Jarnum S, et al. Sucrose malabsorption in Greenland. Br Med J. 1972 Apr 1;2(5804):19-21.Full text  Abstract

44. Peterson ML, Herber R. Intestinal sucrase deficiency. Trans Assoc Am Physicians. 1967;80:275-83.

45. Vandenplas Y, Koletzko S, Isolauri E, et al. Guidelines for the diagnosis and management of cow's milk protein allergy in infants. Arch Dis Child. 2007 Oct;92(10):902-8.Full text  Abstract

46. Matthai J, Sathiasekharan M, Poddar U, et al. Guidelines on diagnosis and management of cow's milk protein allergy. Indian Pediatr. 2020 Aug 15;57(8):723-9.Full text  Abstract

47. Duncombe VM, Bolin TD, Davis AE, et al. Histopathology in giardiasis: a correlation with diarrhoea. Aust N Z J Med. 1978 Aug;8(4):392-6. Abstract

48. Centers for Disease Control and Prevention. Stool specimens - detection of parasite antigens. Nov 2020 [internet publication].Full text

49. Parker TJ, Woolner JT, Prevost AT, et al. Irritable bowel syndrome: is the search for lactose intolerance justified. Eur J Gastroenterol Hepatol. 2001 Mar;13(3):219-25. Abstract

50. Westergaard H. Tropical sprue. Curr Treat Options Gastroenterol. 2004 Feb;7(1):7-11. Abstract

51. Ingle SB, Hinge Ingle CR. Eosinophilic gastroenteritis: an unusual type of gastroenteritis. World J Gastroenterol. 2013 Aug 21;19(31):5061-6.Full text  Abstract

52. Talley NJ, Shorter RG, Phillips SF, et al. Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut. 1990 Jan;31(1):54-8.Full text  Abstract

53. Corazza GR, Biagi F, Volta U, et al. Autoimmune enteropathy and villous atrophy in adults. Lancet. 1997 Jul 12;350(9071):106-9. Abstract

54. Dukowicz AC, Lacy BE, Levine GM. Small intestinal bacterial overgrowth: a comprehensive review. Gastroenterol Hepatol (NY). 2007 Feb;3(2):112-22.Full text  Abstract

55. Pardi DS. Diagnosis and management of microscopic colitis. Am J Gastroenterol. 2017 Jan;112(1):78-85. Abstract

56. ASGE Standards of Practice Committee, Coelho-Prabhu N, Forbes N, et al. Adverse events associated with EGD and EGD-related techniques. Gastrointest Endosc. 2022 Sep;96(3):389-401.e1. Abstract

57. Montalto M, Curigliano V, Santoro L, et al. Management and treatment of lactose malabsorption. World J Gastroenterol. 2006 Jan 14;12(2):187-91.Full text  Abstract

58. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30.Full text  Abstract

59. Deng Y, Misselwitz B, Dai N, et al. Lactose intolerance in adults: biological mechanism and dietary management. Nutrients. 2015 Sep 18;7(9):8020-35.Full text  Abstract

60. Farup PG, Monsbakken KW, Vandvik PO. Lactose malabsorption in a population with irritable bowel syndrome: prevalence and symptoms. A case-control study. Scand J Gastroenterol. 2004 Jul;39(7):645-9. Abstract

61. Fassio F, Facioni MS, Guagnini F. Lactose maldigestion, malabsorption, and intolerance: a comprehensive review with a focus on current management and future perspectives. Nutrients. 2018 Nov 1;10(11):1599.Full text  Abstract

62. Shaukat A, Levitt MD, Taylor BC, et al. Systematic review: effective management strategies for lactose intolerance. Ann Intern Med. 2010 Jun 15;152(12):797-803.Full text  Abstract

63. Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. N Engl J Med. 1995 Jul 6;333(1):1-4.Full text  Abstract

64. Facioni MS, Raspini B, Pivari F, et al. Nutritional management of lactose intolerance: the importance of diet and food labelling. J Transl Med. 2020 Jun 26;18(1):260.Full text  Abstract

65. Hertzler SR, Savaiano DA. Colonic adaptation to daily lactose feeding in lactose maldigesters reduces lactose intolerance. Am J Clin Nutr. 1996 Aug;64(2):232-6. Abstract

66. Eadala P, Waud JP, Matthews SB, et al. Quantifying the "hidden" lactose in drugs used for the treatment of gastrointestinal conditions. Aliment Pharmacol Ther. 2009 Mar 15;29(6):677-87. Abstract

67. Moore BJ. Dairy foods: are they politically correct? Nutr Today. 2003 May-Jun;38(3):82-90. Abstract

68. Zheng X, Chu H, Cong Y, et al. Self-reported lactose intolerance in clinic patients with functional gastrointestinal symptoms: prevalence, risk factors, and impact on food choices. Neurogastroenterol Motil. 2015 Aug;27(8):1138-46. Abstract

69. Montalto M, Nucera G, Santoro L, et al. Effect of exogenous beta-galactosidase in patients with lactose malabsorption and intolerance: a crossover double-blind placebo-controlled study. Eur J Clin Nutr. 2005 Apr;59(4):489-93.Full text  Abstract

70. Ojetti V, Gigante G, Gabrielli M, et al. The effect of oral supplementation with Lactobacillus reuteri or tilactase in lactose intolerant patients: randomized trial. Eur Rev Med Pharmacol Sci. 2010 Mar;14(3):163-70. Abstract

71. He T, Priebe MG, Zhong Y, et al. Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. J Appl Microbiol. 2008 Feb;104(2):595-604. Abstract

72. Leis R, de Castro MJ, de Lamas C, et al. Effects of prebiotic and probiotic supplementation on lactase deficiency and lactose intolerance: a systematic review of controlled trials. Nutrients. 2020 May 20;12(5):1487.Full text  Abstract

73. Oak SJ, Jha R. The effects of probiotics in lactose intolerance: a systematic review. Crit Rev Food Sci Nutr. 2019;59(11):1675-83. Abstract

74. Jackson KA, Savaiano DA. Lactose maldigestion, calcium intake, and osteoporosis in African-, Asian-, and Hispanic-Americans. J Am Coll Nutr. 2001 Apr;20(2 Suppl):198-207S. Abstract

75. Golden NH, Abrams SA, Committee on Nutrition. Optimizing bone health in children and adolescents. Pediatrics. 2014 Oct;134(4):e1229-43.Full text  Abstract

76. Ruchkina IN, Fadeeva NA, Parfenov AI, et al. The role of small bowel microflora in the development of secondary lactase deficiency and the possibilities of its treatment with probiotics [in Russian]. Ter Arkh. 2013;85(2):21-6. Abstract

77. Erasmus HD, Ludwig-Auser HM, Paterson PG, et al. Enhanced weight gain in preterm infants receiving lactase-treated feeds: a randomized, double-blind, controlled trial. J Pediatr. 2002 Oct;141(4):532-7. Abstract

78. Gorduza EV, Indrei LL, Gorduza VM. Nutrigenomics in postgenomic era. Rev Med Chir Soc Med Nat Iasi. 2008 Jan-Mar;112(1):152-64. Abstract

79. Porzi M, Burton-Pimentel KJ, Walther B, et al. Development of personalized nutrition: applications in lactose intolerance diagnosis and management. Nutrients. 2021 Apr 29;13(5):1503.Full text  Abstract

80. Pratelli G, Tamburini B, Badami GD, et al. Cow's milk: a benefit for human health? omics tools and precision nutrition for lactose intolerance management. Nutrients. 2024 Jan 22;16(2):320.Full text  Abstract

81. Obermayer-Pietsch BM, Bonelli CM, Walter DE, et al. Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res. 2004 Jan;19(1):42-7. Abstract

82. Bergholdt HKM, Larsen MK, Varbo A, et al. Lactase persistence, milk intake, hip fracture and bone mineral density: a study of 97 811 Danish individuals and a meta-analysis. J Intern Med. 2018 Sep;284(3):254-69.Full text  Abstract

83. Zieren HU, Zippel K, Zieren J, et al. Quality of life after surgical treatment of gastric carcinoma. Eur J Surg. 1998 Feb;164(2):119-25.Full text  Abstract

84. Feskanich D, Meyer HE, Fung TT, et al. Milk and other dairy foods and risk of hip fracture in men and women. Osteoporos Int. 2018 Feb;29(2):385-96. Abstract

85. LeBoff MS, Greenspan SL, Insogna KL, et al. The clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int. 2022 Oct;33(10):2049-102.Full text  Abstract

86. Bhatnagar S, Aggarwal R. Lactose intolerance. BMJ. 2007 Jun 30;334(7608):1331-2. Abstract

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