References
Key articles
American Diabetes Association. Standards of care in diabetes - 2024. Diabetes Care. 2024 Jan;47(Supplement_1):S1-321.Full text
Shah AS, Zeitler PS, Wong J, et al. ISPAD clinical practice consensus guidelines 2022: type 2 diabetes in children and adolescents. Pediatr Diabetes. 2022 Nov;23(7):872-902. Abstract
Glaser N, Fritsch M, Priyambada L, et al. ISPAD clinical practice consensus guidelines 2022: diabetic ketoacidosis and hyperglycemic hyperosmolar state. Pediatr Diabetes. 2022 Nov;23(7):835-56. Abstract
Reference articles
1. American Diabetes Association. Standards of care in diabetes - 2024. Diabetes Care. 2024 Jan;47(Supplement_1):S1-321.Full text
2. Silverstein JH, Rosenbloom AL. Type 2 diabetes in children. Curr Diab Rep. 2001 Aug;1(1):19-27. Abstract
3. Kazlauskaite R, Evans AT, Mazzone T. Ethnic differences predicting ketonuria in patients with type 2 diabetes. J Diabetes Complications. 2005 Sep-Oct;19(5):284-90. Abstract
4. Kaufman FR, Shaw J. Type 2 diabetes in youth: rates, antecedents, treatment, problems and prevention. Pediatr Diabetes. 2007 Dec;8(suppl 9):4-6. Abstract
5. Diabetes Australia Guideline Development Consortium. National evidence based guideline for case detection and diagnosis of type 2 diabetes. Jun 2009 [internet publication].Full text
6. Centers for Disease Control and Prevention. National diabetes statistics report: estimates of diabetes and its burden in the United States. Jan 2022 [internet publication].Full text
7. Lawrence JM, Divers J, Isom S, et al. Trends in prevalence of type 1 and type 2 diabetes in children and adolescents in the US, 2001-2017. JAMA. 2021 Aug 24;326(8):717-27. Abstract
8. Savage PJ, Bennett PH, Senter RG, et al. High prevalence of diabetes in young Pima Indians. Diabetes. 1979 Oct;28(10):937-42. Abstract
9. Lascar N, Brown J, Pattison H, et al. Type 2 diabetes in adolescents and young adults. Lancet Diabetes Endocrinol. 2017 Aug 25;6(1):69-80. Abstract
10. Acton KJ, Burrows NR, Moore K, et al. Trends in diabetes prevalence among American Indian and Alaska native children, adolescents, and young adults. Am J Public Health. 2002 Sep;92(9):1485-90.Full text Abstract
11. Gahagan S, Silverstein J. Prevention and treatment of type 2 diabetes mellitus in children, with special emphasis on American Indian and Alaska Native children. American Academy of Pediatrics Committee on Native American Child Health. Pediatrics. 2003 Oct;112(4):e328. Abstract
12. Matyka KA. Type 2 diabetes in childhood: epidemiological and clinical aspects. Br Med Bull. 2008 Jun;86(1):59-75.Full text Abstract
13. Bhardwaj S, Misra A, Khurana L, et al. Childhood obesity in Asian Indians: a burgeoning cause of insulin resistance, diabetes and sub-clinical inflammation. Asia Pac J Clin Nutr. 2008;17(suppl 1):172-5. Abstract
14. Glaser NS, Jones KL. Non-insulin-dependent diabetes mellitus in Mexican-American children. West J Med. 1998 Jan;168(1):11-6.Full text Abstract
15. Neufeld ND, Raffel LF, Landon C, et al. Early presentation of type 2 diabetes in Mexican-American youth. Diabetes Care. 1998 Jan;21(1):80-6. Abstract
16. Pihoker C, Scott CR, Lensing SY. Non-insulin dependent diabetes mellitus in African-American youths of Arkansas. Clin Pediatr (Phila). 1998 Feb;37(2):97-102. Abstract
17. Upchurch SL, Brosnan CA, Meininger JC, et al. Characteristics of 98 children and adolescents diagnosed with type 2 diabetes by their health care provider at initial presentation. Diabetes Care. 2003 Jul;26(7):2209.Full text Abstract
18. Fazeli Farsani S, van der Aa MP, van der Vorst MM, et al. Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches. Diabetologia. 2013 Jul;56(7):1471-88. Abstract
19. Khanolkar AR, Amin R, Taylor-Robinson D, et al. Ethnic minorities are at greater risk for childhood-onset type 2 diabetes and poorer glycemic control in England and Wales. J Adolesc Health. 2016 Sep;59(3):354-61. Abstract
20. Oester IM, Kloppenborg JT, Olsen BS, et al. Type 2 diabetes mellitus in Danish children and adolescents in 2014. Pediatr Diabetes. 2016 Aug;17(5):368-73. Abstract
21. Neu A, Feldhahn L, Ehehalt S, et al. No change in type 2 diabetes prevalence in children and adolescents over 10 years: update of a population-based survey in South Germany. Pediatr Diabetes. 2018 Jun;19(4):637-9. Abstract
22. Fagot-Campagna A, Pettitt DJ, Engelgau MM, et al. Type 2 diabetes among North American children and adolescents: an epidemiological review and a public health perspective. J Pediatr. 2000 May;136(5):664-72. Abstract
23. Ogden CL, Carroll MD, Flegal KM. High body mass index for age among US children and adolescents, 2003-2006. JAMA. 2008 May 28;299(20):2401-5.Full text Abstract
24. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr. 2005 May;146(5):693-700. Abstract
25. Strauss RS, Pollack HA. Epidemic increase in childhood overweight, 1986-1998. JAMA. 2001 Dec 12;286(22):2845-8.Full text Abstract
26. Miller J, Rosenbloom A, Silverstein J. Childhood obesity. J Clin Endocrinol Metab. 2004 Sep;89(9):4211-8.Full text Abstract
27. Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet. 2011 Jul 9;378(9786):169-81. Abstract
28. Ornoy A. Prenatal origin of obesity and its complication: gestational diabetes, maternal overweight and the paradoxical effects of fetal growth restriction and macrosomia. Reprod Toxicol. 2011 Sep;32(2):205-12. Abstract
29. Drash AM. Relationship between diabetes mellitus and obesity in the child. Metabolism. 1973 Feb;22(2):337-44. Abstract
30. Caprio S, Tamborlane WV. Metabolic impact of obesity in childhood. Endocrinol Metab Clin North Am. 1999 Dec;28(4):731-47. Abstract
31. Rosenbloom AL, Wheeler L, Bianchi R, et al. Age-adjusted analysis of insulin responses during normal and abnormal oral glucose tolerance tests in children and adolescents. Diabetes. 1975 Sep;24(9):820-8. Abstract
32. Hsueh WA, Quiñones MJ. Role of endothelial dysfunction in insulin resistance. Am J Cardiol. 2003 Aug 18;92(4a):10J-7J. Abstract
33. Foster GD, Linder B, Baranowski T, et al; HEALTHY Study Group. A school-based intervention for diabetes risk reduction. N Engl J Med. 2010 Jul 29;363(5):443-53.Full text Abstract
34. Dabelea D, Hanson RL, Lindsay RS, et al. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes. 2000 Dec;49(12):2208-11.Full text Abstract
35. Ibáñez L, Suárez L, Lopez-Bermejo A, et al. Early development of visceral fat excess after spontaneous catch-up growth in children with low birth weight. J Clin Endocrinol Metab. 2008 Mar;93(3):925-8. Abstract
36. Ibáñez L, Ong K, Dunger DB, et al. Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children. J Clin Endocrinol Metab. 2006 Jun;91(6):2153-8. Abstract
37. Mericq V, Ong KK, Bazaes R, et al. Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children. Diabetologia. 2005 Dec;48(12):2609-14. Abstract
38. Mayer-Davis EJ, Dabelea D, Lamichhane AP, et al. Breast-feeding and type 2 diabetes in the youth of three ethnic groups: the SEARCH for diabetes in youth case-control study. Diabetes Care. 2008 Mar;31(3):470-5.Full text Abstract
39. Koletzko B. Long-term consequences of early feeding on later obesity risk. Nestle Nutr Workshop Ser Pediatr Program. 2006;58:1-18. Abstract
40. Hanis CL, Boerwinkle E, Chakraborty R. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet. 1996 Jun;13(2):161-6. Abstract
41. Cox NJ, Frigge M, Nicolae DL, et al. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat Genet. 1999 Feb;21(2):213-5. Abstract
42. Lee S, Bacha F, Gungor N, et al. Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers. J Pediatr. 2008 Feb;152(2):177-84. Abstract
43. Hamdy O, Porramatikul S, Al-Ozairi E. Metabolic obesity: the paradox between visceral and subcutaneous fat. Curr Diabetes Rev. 2006 Nov;2(4):367-73. Abstract
44. Straczkowski M, Kowalska I. The role of skeletal muscle sphingolipids in the development of insulin resistance. Rev Diabet Stud. 2008 Spring;5(1):13-24.Full text Abstract
45. Vozarova B, Stefan N, Lindsay RS, et al. High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes. 2002 Jun;51(6):1889-95.Full text Abstract
46. Ndumele CE, Rangaswami J, Chow SL, et al. Cardiovascular-kidney-metabolic health: a presidential advisory from the American Heart Association. Circulation. 2023 Nov 14;148(20):1606-35.Full text Abstract
47. Arslanian SA, Saad R, Lewy V, et al. Hyperinsulinemia in African-American children: decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity. Diabetes. 2002 Oct;51(10):3014-9.Full text Abstract
48. Ogata BN, Hayes D. Position of the Academy of Nutrition and Dietetics: nutrition guidance for healthy children ages 2 to 11 years. J Acad Nutr Diet. 2014 Aug;114(8):1257-76. Abstract
49. Mead E, Brown T, Rees K, et al. Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years. Cochrane Database Syst Rev. 2017 Jun 22;(6):CD012651.Full text Abstract
50. Kleber M, deSousa G, Papcke S, et al. Impaired glucose tolerance in obese white children and adolescents: three to five year follow-up in untreated patients. Exp Clin Endocrinol Diabetes. 2011 Mar;119(3):172-6. Abstract
51. Weiss R, Taksali SE, Tamborlane WV, et al. Predictors of changes in glucose tolerance status in obese youth. Diabetes Care. 2005 Apr;28(4):902-9.Full text Abstract
52. Azzopardi P, Brown AD, Zimmet P, et al. Type 2 diabetes in young Indigenous Australians in rural and remote areas: diagnosis, screening, management and prevention. Med J Aust. 2012 Jul 2;197(1):32-6. Abstract
53. Jones AG, Hattersley AT. The clinical utility of C-peptide measurement in the care of patients with diabetes. Diabet Med. 2013 Jul;30(7):803-17.Full text Abstract
54. Leighton E, Sainsbury CA, Jones GC. A practical review of C-peptide testing in diabetes. Diabetes Ther. 2017 Jun;8(3):475-87.Full text Abstract
55. Chiang JL, Maahs DM, Garvey KC, et al. Type 1 diabetes in children and adolescents: a position statement by the American Diabetes Association. Diabetes Care. 2018 Sep;41(9):2026-44.Full text Abstract
56. Hadtstein C, Wühl E, Soergel M, et al; German Study Group for Pediatric Hypertension. Normative values for circadian and ultradian cardiovascular rhythms in childhood. Hypertension. 2004 Mar;43(3):547-54.Full text Abstract
57. Brickman WJ, Huang J, Silverman BL, et al. Acanthosis nigricans identifies youth at high risk for metabolic abnormalities. J Pediatr. 2010 Jan;156(1):87-92. Abstract
58. Pihoker C, Gilliam LK, Ellard S, et al; SEARCH for Diabetes in Youth Study Group. Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth. J Clin Endocrinol Metab. 2013 Oct;98(10):4055-62.Full text Abstract
59. Peixoto-Barbosa R, Reis AF, Giuffrida FMA. Update on clinical screening of maturity-onset diabetes of the young (MODY). Diabetol Metab Syndr. 2020;12:50.Full text Abstract
60. Sanyoura M, Philipson LH, Naylor R. Monogenic diabetes in children and adolescents: recognition and treatment options. Curr Diab Rep. 2018 Jun 22;18(8):58.Full text Abstract
61. Greeley SA, Naylor RN, Philipson LH, et al. Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment. Curr Diab Rep. 2011 Dec;11(6):519-32.Full text Abstract
62. Hampl SE, Hassink SG, Skinner AC, et al. Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity. Pediatrics. 2023 Feb 1;151(2):e2022060640.Full text Abstract
63. Shah AS, Zeitler PS, Wong J, et al. ISPAD clinical practice consensus guidelines 2022: type 2 diabetes in children and adolescents. Pediatr Diabetes. 2022 Nov;23(7):872-902. Abstract
64. Glaser N, Fritsch M, Priyambada L, et al. ISPAD clinical practice consensus guidelines 2022: diabetic ketoacidosis and hyperglycemic hyperosmolar state. Pediatr Diabetes. 2022 Nov;23(7):835-56. Abstract
65. Peña AS, Curran JA, Fuery M, et al. Screening, assessment and management of type 2 diabetes mellitus in children and adolescents: Australasian Paediatric Endocrine Group guidelines. Med J Aust. 2020 Jul;213(1):30-43.Full text Abstract
66. Viner R, White B, Christie D. Type 2 diabetes in adolescents: a severe phenotype posing major clinical challenges and public health burden. Lancet. 2017 Jun 3;389(10085):2252-60. Abstract
67. Copeland KC, Silverstein J, Moore KR, et al. Management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents. Pediatrics. 2013 Feb;131(2):364-82.Full text Abstract
68. Simmons D, Voyle J, Rush E, et al. The New Zealand experience in peer support interventions among people with diabetes. Fam Pract. 2010 Jun;27(suppl 1):i53-61.Full text Abstract
69. Neyman A, Hannon TS, Committee on Nutrition. Low-carbohydrate diets in children and adolescents with or at risk for diabetes. Pediatrics. 2023 Oct 1;152(4):e2023063755.Full text Abstract
70. Willi SM, Martin K, Datko FM, et al. Treatment of type 2 diabetes in childhood using a very-low-calorie diet. Diabetes Care. 2004 Feb;27(2):348-53.Full text Abstract
71. Dela F, von Linstow ME, Mikines KJ, et al. Physical training may enhance beta-cell function in type 2 diabetes. Am J Physiol Endocrinol Metab. 2004 Nov;287(5):E1024-31.Full text Abstract
72. Marwick TH, Hordern MD, Miller T, et al. Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation. 2009 Jun 30;119(25):3244-62.Full text Abstract
73. McCall A, Raj R. Exercise for prevention of obesity and diabetes in children and adolescents. Clin Sports Med. 2009 Jul;28(3):393-421. Abstract
74. Christie D, Strange V, Allen E, et al. Maximising engagement, motivation and long term change in a structured intensive education programme in diabetes for children, young people and their families: Child and Adolescent Structured Competencies Approach to Diabetes Education (CASCADE). BMC Pediatr. 2009 Sep 15;9:57.Full text Abstract
75. Misra A, Nigam P, Hills AP, et al. Consensus physical activity guidelines for Asian Indians. Diabetes Technol Ther. 2012 Jan;14(1):83-98. Abstract
76. Johnson ST, Newton AS, Chopra M, et al. In search of quality evidence for lifestyle management and glycemic control in children and adolescents with type 2 diabetes: a systematic review. BMC Pediatr. 2010 Dec 23;10:97.Full text Abstract
77. Zeitler P, Hirst K, Pyle L, et al; TODAY Study Group. A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med. 2012 Jun 12;366(24):2247-56.Full text Abstract
78. Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009 Jan;32(1):193-203.Full text Abstract
79. Tamborlane WV, Barrientos-Pérez M, Fainberg U, et al; Ellipse Trial Investigators. Liraglutide in children and adolescents with type 2 diabetes. N Engl J Med. 2019 Aug 15;381(7):637-46.Full text Abstract
80. Tamborlane WV, Bishai R, Geller D, et al. Once-weekly exenatide in youth with type 2 diabetes. Diabetes Care. 2022 Aug 1;45(8):1833-40.Full text Abstract
81. Arslanian SA, Hannon T, Zeitler P, et al. Once-weekly dulaglutide for the treatment of youths with type 2 diabetes. N Engl J Med. 2022 Aug 4;387(5):433-43.Full text Abstract
82. Laffel LM, Danne T, Klingensmith GJ, et al. Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial. Lancet Diabetes Endocrinol. 2023 Mar;11(3):169-81.Full text Abstract
83. McCall AL, Lieb DC, Gianchandani R, et al. Management of individuals with diabetes at high risk for hypoglycemia: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2023 Feb 15;108(3):529-62.Full text Abstract
84. Medicines and Healthcare products Regulatory Agency (UK). GLP-1 receptor agonists: reports of diabetic ketoacidosis when concomitant insulin was rapidly reduced or discontinued. Jun 2019 [internet publication].Full text
85. World Gastroenterology Organisation and International Federation for the Surgery of Obesity and Metabolic Diseases. Obesity. 2023 [internet publication].Full text
86. Poliakin L, Roberts A, Thompson KJ, et al. Outcomes of adolescents compared with young adults after bariatric surgery: an analysis of 227,671 patients using the MBSAQIP data registry. Surg Obes Relat Dis. 2020 Oct;16(10):1463-73. Abstract
87. Inge TH, Courcoulas AP, Jenkins TM, et al. Weight loss and health status 3 years after bariatric surgery in adolescents. N Engl J Med. 2016 Jan 14;374(2):113-23.Full text Abstract
88. Inge TH, Miyano G, Bean J, et al. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics. 2009 Jan;123(1):214-22. Abstract
89. Tamborlane WV, Laffel LM, Shehadeh N, et al. Efficacy and safety of dapagliflozin in children and young adults with type 2 diabetes: a prospective, multicentre, randomised, parallel group, phase 3 study. Lancet Diabetes Endocrinol. 2022 May;10(5):341-50.Full text Abstract
90. Blonde L, Umpierrez GE, Reddy SS, et al. American Association of Clinical Endocrinology Clinical Practice Guideline: developing a diabetes mellitus comprehensive care plan-2022 update. Endocr Pract. 2022 Oct;28(10):923-1049.Full text Abstract
91. Association of Diabetes Care & Education Specialists. Management of children with diabetes in the school setting. 2016 [internet publication].Full text
92. Adeyemi A, Rascati K, Strassels S. The need for oral antidiabetic treatment adherence studies in the pediatric population. Clin Ther. 2010 Jul;32(7):1306-7.Full text Abstract
93. Kawahara R, Amemiya T, Yoshino M, et al. Dropout of young non-insulin-dependent diabetics from diabetic care. Diabetes Res Clin Pract. 1994 Jul;24(3):181-5. Abstract
94. Rosenbloom AL. Hyperglycemic hyperosmolar state: an emerging pediatric problem. J Pediatr. 2010 Feb;156(2):180-4. Abstract
95. Marx N, Federici M, Schütt K, et al. 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. Eur Heart J. 2023 Oct 14;44(39):4043-140.Full text
96. TODAY Study Group. Rapid rise in hypertension and nephropathy in youth with type 2 diabetes: the TODAY clinical trial. Diabetes Care. 2013 Jun;36(6):1735-41.Full text Abstract
97. Bjornstad P, Drews KL, Caprio S, et al; TODAY Study Group. Long-term complications in youth-onset type 2 diabetes. N Engl J Med. 2021 Jul 29;385(5):416-26.Full text Abstract
98. Adler AI. Treating high blood pressure in diabetes: the evidence. Semin Vasc Med. 2002 May;2(2):127-37. Abstract
99. TODAY Study Group. Lipid and inflammatory cardiovascular risk worsens over 3 years in youth with type 2 diabetes: the TODAY clinical trial. Diabetes Care. 2013 Jun;36(6):1758-64.Full text Abstract
100. Haffner SM, Alexander CM, Cook TJ, et al. Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels: subgroup analyses in the Scandinavian Simvastatin Survival Study. Arch Intern Med. 1999 Dec 13-27;159(22):2661-7.Full text Abstract
101. Svensson M, Sundkvist G, Arnqvist HJ, et al. Signs of nephropathy may occur early in young adults with diabetes despite modern diabetes management: results from the nationwide population-based Diabetes Incidence Study in Sweden (DISS). Diabetes Care. 2003 Oct;26(10):2903-9.Full text Abstract
102. Maahs DM, Snively BM, Bell RA, et al. Higher prevalence of elevated albumin excretion in youth with type 2 than type 1 diabetes: the SEARCH for Diabetes in Youth study. Diabetes Care. 2007 Oct;30(10):2593-8.Full text Abstract
103. International Diabetes Federation. IDF guideline on oral health for people with diabetes. 2009; updated 2017 [internet publication].Full text
104. Shaw JE, Punjabi NM, Wilding JP, et al. Sleep-disordered breathing and type 2 diabetes: a report from the International Diabetes Federation Taskforce on Epidemiology and Prevention. Diabetes Res Clin Pract. 2008 Jul;81(1):2-12. Abstract
105. Betts P, Brink SJ, Swift PG, et al. Management of children with diabetes requiring surgery. Pediatr Diabetes. 2007 Aug;8(4):242-7. Abstract
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