Constipation in children

References

Key articles

Rubin G, Dale A. Chronic constipation in children. BMJ. 2006 Nov 18;333(7577):1051-5.Full text  Abstract

Mulhem E, Khondoker F, Kandiah S. Constipation in children and adolescents: evaluation and treatment. Am Fam Physician. 2022 May 1;105(5):469-78. Abstract

Benninga MA, Faure C, Hyman PE, et al. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 2016 Feb 15 [Epub ahead of print]. Abstract

Hyams JS, Di Lorenzo C, Saps M, et al. Functional disorders: children and adolescents. Gastroenterology. 2016 Feb 15 [Epub ahead of print]. Abstract

National Institute for Health and Care Excellence. Constipation in children and young people: diagnosis and management. Jul 2017 [internet publication].Full text  Abstract

Reference articles

1. Rubin G, Dale A. Chronic constipation in children. BMJ. 2006 Nov 18;333(7577):1051-5.Full text  Abstract

2. Peeters B, Noens I, Philips EM, et al. Autism spectrum disorders in children with functional defecation disorders. J Pediatr. 2013 Sep;163(3):873-8. Abstract

3. McKeown C, Hisle-Gorman E, Eide M, et al. Association of constipation and fecal incontinence with attention-deficit/hyperactivity disorder. Pediatrics. 2013 Nov;132(5):e1210-5. Abstract

4. Waterham M, Kaufman J, Gibb S. Childhood constipation. Aust Fam Physician. 2017 Dec;46(12):908-12.Full text  Abstract

5. van den Berg MM, Benninga MA, Di Lorenzo C. Epidemiology of childhood constipation: a systematic review. Am J Gastroenterol. 2006 Oct;101(10):2401-9. Abstract

6. Loening-Baucke V. Prevalence rates for constipation and faecal and urinary incontinence. Arch Dis Child. 2007 Jun;92(6):486-9.Full text  Abstract

7. Lee WT, Ip KS, Chan JS, et al. Increased prevalence of constipation in pre-school children is attributable to under-consumption of plant foods: A community-based study. J Paediatr Child Health. 2008 Apr;44(4):170-5. Abstract

8. Froon-Torenstra D, Beket E, Khader AM, et al. Prevalence of functional constipation among Palestinian preschool children and the relation to stressful life events. PLoS One. 2018;13(12):e0208571.Full text  Abstract

9. Corazziari E, Staiano A, Miele E, et al. Bowel frequency and defecatory patterns in children: a prospective nationwide survey. Clin Gastroenterol Hepatol. 2005 Nov;3(11):1101-6.Full text  Abstract

10. Borowitz SM, Cox DJ, Kovatchev B, et al. Treatment of childhood constipation by primary care physicians: efficacy and predictors of outcome. Pediatrics. 2005 Apr;115(4):873-7. Abstract

11. Sommers T, Corban C, Sengupta N, et al. Emergency department burden of constipation in the United States from 2006 to 2011. Am J Gastroenterol. 2015 Apr;110(4):572-9. Abstract

12. Walter AW, Hovenkamp A, Devanarayana NM, et al. Functional constipation in infancy and early childhood: epidemiology, risk factors, and healthcare consultation. BMC Pediatr. 2019 Aug 15;19(1):285.Full text  Abstract

13. Mulhem E, Khondoker F, Kandiah S. Constipation in children and adolescents: evaluation and treatment. Am Fam Physician. 2022 May 1;105(5):469-78. Abstract

14. Partin JC, Hamill SK, Fischel JE, et al. Painful defecation and fecal soiling in children. Pediatrics. 1992 Jun;89(6 Pt 1):1007-9. Abstract

15. Comas Vives A, Polanco Allue I. Case-control study of risk factors associated with constipation. The FREI Study [in Spanish]. An Pediatr (Barc). 2005 Apr;62(4):340-5. Abstract

16. Kokx MO, Comstock JA, Facklam RR. Streptococcal perianal disease in children. Pediatrics. 1987 Nov;80(5):659-63. Abstract

17. Iacono G, Carroccio A, Cavataio F, et al. Chronic constipation as a symptom of cow milk allergy. J Pediatr. 1995 Jan;126(1):34-9. Abstract

18. Iacono G, Bonventre S, Scalici C, et al. Food intolerance and chronic constipation: manometry and histology study. Eur J Gastroenterol Hepatol. 2006 Feb;18(2):143-50. Abstract

19. Carroccio A, Iacono G. Review article: Chronic constipation and food hypersensitivity - an intriguing relationship. Aliment Pharmacol Ther. 2006 Nov 1;24(9):1295-304. Abstract

20. Finkel MA. Anogenital trauma in sexually abused children. Pediatrics. 1989 Aug;84(2):317-22. Abstract

21. Baroud E, Zar-Kessler C, Bender S. A child psychiatry perspective on encopresis. J Am Acad Child Adolesc Psychiatry. 2022 Jul;61(7):851-3. Abstract

22. Arden NH, Patriarca PA, Fasano MB, et al. The roles of vaccination and amantadine prophylaxis in controlling an outbreak of influenza A (H3N2) in a nursing home. Arch Intern Med. 1988 Apr;148(4):865-8. Abstract

23. Roma E, Adamidis D, Nikolara R, et al. Diet and chronic constipation in children: the role of fiber. J Pediatr Gastroenterol Nutr. 1999 Feb;28(2):169-74. Abstract

24. Loening-Baucke V. Urinary incontinence and urinary tract infection and their resolution with treatment of chronic constipation of childhood. Pediatrics. 1997 Aug;100(2 Pt 1):228-32. Abstract

25. Philips EM, Peeters B, Teeuw AH, et al. Stressful life events in children with functional defecation disorders. J Pediatr Gastroenterol Nutr. 2015 Oct;61(4):384-92. Abstract

26. Fishman L, Lenders C, Fortunato C, et al. Increased prevalence of constipation and fecal soiling in a population of obese children. J Pediatr. 2004 Aug;145(2):253-4. Abstract

27. Cunningham C, Taylor HG, Minich NM, et al. Constipation in very-low-birth-weight children at 10 to 14 years of age. J Pediatr Gastroenterol Nutr. 2001 Jul;33(1):23-7. Abstract

28. Paul SP, Broad SR, Spray C. Idiopathic constipation in children clinical practice guidelines. Arch Dis Child Educ Pract Ed. 2016 Apr;101(2):65-9. Abstract

29. Heron J, Grzeda M, Tappin D, et al. Early childhood risk factors for constipation and soiling at school age: an observational cohort study. BMJ Paediatr Open. 2018;2(1):e000230.Full text  Abstract

30. Borowitz SM, Cox DJ, Tam A, et al. Precipitants of constipation during early childhood. J Am Board Fam Pract. 2003 May-Jun;16(3):213-8.Full text  Abstract

31. Young RJ, Beerman LE, Vanderhoof JA. Increasing oral fluids in chronic constipation in children. Gastroenterol Nurs. 1998 Jul-Aug;21(4):156-61. Abstract

32. Papadopoulou A. Clayden GS, Booth IW. The clinical value of solid marker transit studies in childhood constipation and soiling. Eur J Pediatr. 1994 Aug;153(8):560-4. Abstract

33. Di Pace MR, Catalano P, Caruso AM, et al. Is rectal disimpact always necessary in children with chronic constipation? Evaluation with pelvic ultrasound. Pediatr Surg Int. 2010 Jun;26(6):601-6. Abstract

34. Reid JR, Buonomo C, Moreira C, et al. The barium enema in constipation: comparison with rectal manometry and biopsy to exclude Hirschsprung's disease after the neonatal period. Pediatr Radiol. 2000 Oct;30(10):681-4. Abstract

35. Berger MY, Tabbers MM, Kurver MJ, et al. Value of abdominal radiography, colonic transit time, and rectal ultrasound scanning in the diagnosis of idiopathic constipation in children: a systematic review. J Pediatr. 2012 Jul;161(1):44-50.e1-2.Full text  Abstract

36. Benninga MA, Faure C, Hyman PE, et al. Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 2016 Feb 15 [Epub ahead of print]. Abstract

37. Hyams JS, Di Lorenzo C, Saps M, et al. Functional disorders: children and adolescents. Gastroenterology. 2016 Feb 15 [Epub ahead of print]. Abstract

38. National Institute for Health and Care Excellence. Constipation in children and young people: diagnosis and management. Jul 2017 [internet publication].Full text  Abstract

39. Tabbers MM, DiLorenzo C, Berger MY, et al. Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. J Pediatr Gastroenterol Nutr. 2014 Feb;58(2):258-74. Abstract

40. Benninga M, Candy DC, Catto-Smith AG, et al. The Paris Consensus on Childhood Constipation Terminology (PACCT) Group. J Pediatr Gastroenterol Nutr. 2005 Mar;40(3):273-5.Full text  Abstract

41. World Gastroenterology Organisation Global guidelines. Constipation: a global perspective. Nov 2010 [internet publication].Full text

42. Clayden GS, Keshtgar AS, Carcani-Rathwell I, et al. The management of chronic constipation and related faecal incontinence in childhood. Arch Dis Child Ed Pract. 2005;90:ep58-67.Full text

43. Tabbers MM, Boluyt N, Berger MY, et al. Nonpharmacologic treatments for childhood constipation: systematic review. Pediatrics. 2011 Oct;128(4):753-61. Abstract

44. Gordon M, MacDonald JK, Parker CE, et al. Osmotic and stimulant laxatives for the management of childhood constipation. Cochrane Database Syst Rev. 2016;(8):CD009118.Full text  Abstract

45. Lee-Robichaud H, Thomas K, Morgan J, et al. Lactulose versus polyethylene glycol for chronic constipation. Cochrane Database Syst Rev. 2010 Jul 7;(7):CD007570.Full text  Abstract

46. Zurad EG, Johanson JF. Over-the-counter laxative polyethylene glycol 3350: an evidence-based appraisal. Curr Med Res Opin. 2011 Jul;27(7):1439-52. Abstract

47. Wang Y, Wang B, Jiang X, et al. Polyethylene glycol 4000 treatment for children with constipation: a randomized comparative multicenter study. Exp Ther Med. 2012 May;3(5):853-6.Full text  Abstract

48. Gomes PB, Duarte MA, Melo Mdo C. Comparison of the effectiveness of polyethylene glycol 4000 without electrolytes and magnesium hydroxide in the treatment of chronic functional constipation in children. J Pediatr (Rio J). 2011 Jan-Feb;87(1):24-8. Abstract

49. Mendoza J, Legido J, Rubio S, et al. Systematic review: the adverse effects of sodium phosphate enema. Aliment Pharmacol Ther. 2007 Jul 1;26(1):9-20.Full text  Abstract

50. Candy DC, Edwards D, Geraint M. Treatment of faecal impaction with polyethylene glycol plus electrolytes (PEG + E) followed by a double-blind comparison of PEG + E versus lactulose as maintenance therapy. J Pediatr Gastroenterol Nutr. 2006 Jul;43(1):65-70. Abstract

51. Zar-Kessler C, Kuo B, Cole E, et al. Benefit of pelvic floor physical therapy in pediatric patients with dyssynergic defecation constipation. Dig Dis. 2019;37(6):478-85.Full text  Abstract

52. Church JT, Simha S, Wild LC, et al. Antegrade continence enemas improve quality of life in patients with medically-refractory encopresis. J Pediatr Surg. 2017 May;52(5):778-82. Abstract

53. Caruso AM, Milazzo MPM, Bommarito D, et al. Advanced management protocol of transanal irrigation in order to improve the outcome of pediatric patients with fecal incontinence. Children (Basel). 2021 Dec 11;8(12):1174.Full text  Abstract

54. US Food and Drug Administration. FDA warns of possible harm from exceeding recommended dose of over-the-counter sodium phosphate products to treat constipation. January 2014 [internet publication].Full text

55. van Mill MJ, Koppen IJN, Benninga MA. Controversies in the management of functional constipation in children. Curr Gastroenterol Rep. 2019 Apr 25;21(6):23.Full text  Abstract

56. Hoffman JM, Tyler K, MacEachern SJ, et al. Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity. Gastroenterology. 2012 Apr;142(4):844-54.e4.Full text  Abstract

57. Mugie SM, Korczowski B, Bodi P, et al. Prucalopride is no more effective than placebo for children with functional constipation. Gastroenterology. 2014 Dec;147(6):1285-95.e1.Full text  Abstract

58. Hussain SZ, Labrum B, Mareya S, et al. Safety of lubiprostone in pediatric patients with functional constipation: a nonrandomized, open-label Trial. J Pediatr Gastroenterol Nutr. 2021 Nov 1;73(5):572-8.Full text  Abstract

59. Hyman PE, Di Lorenzo C, Prestridge LL, et al. Lubiprostone for the treatment of functional constipation in children. J Pediatr Gastroenterol Nutr. 2014 Mar;58(3):283-91.Full text  Abstract

60. Benninga MA, Hussain SZ, Sood MR, et al. Lubiprostone for pediatric functional constipation: randomized, controlled, double-blind study with long-term extension. Clin Gastroenterol Hepatol. 2022 Mar;20(3):602-10.e5.Full text  Abstract

61. Halleran DR, Lu PL, Ahmad H, et al. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: a large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019 Nov;54(11):2305-10. Abstract

62. Zar-Kessler C, Kuo B, Belkind-Gerson J. Botulinum toxin injection for childhood constipation is safe and can be effective regardless of anal sphincter dynamics. J Pediatr Surg. 2018 Apr;53(4):693-7. Abstract

63. Wallace C, Sinopoulou V, Gordon M, et al. Probiotics for treatment of chronic constipation in children. Cochrane Database Syst Rev. 2022 Mar 29;3(3):CD014257.Full text  Abstract

64. Lu ML, He J, Lu S. Electrical stimulation therapy for slow transit constipation in children: a systematic review. Int J Colorectal Dis. 2015 May;30(5):697-702. Abstract

65. Sulkowski JP, Nacion KM, Deans KJ, et al. Sacral nerve stimulation: a promising therapy for fecal and urinary incontinence and constipation in children. J Pediatr Surg. 2015 Oct;50(10):1644-7. Abstract

66. Besendörfer M, Kohl M, Schellerer V, et al. A pilot study of non-invasive sacral nerve stimulation in treatment of constipation in childhood and adolescence. Front Pediatr. 2020;8:169.Full text  Abstract

67. van Ginkel R, Reitsma JB, Büller HA, et al. Childhood constipation: longitudinal follow-up beyond puberty. Gastroenterology. 2003 Aug;125(2):357-63. Abstract

68. Staiano A, Andreotti MR, Greco L, et al. Long-term follow-up of children with chronic idiopathic constipation. Dig Dis Sci. 1994 Mar;39(3):561-4. Abstract

69. Zanetti G, Marchiori E, Gasparetto TD, et al. Lipoid pneumonia in children following aspiration of mineral oil used in the treatment of constipation: high-resolution CT findings in 17 patients. Pediatric Radiol. 2007 Nov;37(11):1135-9. Abstract

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