Neonatal jaundice

Kemper AR, Newman TB, Slaughter JL, et al. Clinical practice guideline revision: management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2022 Sep 1;150(3):e2022058859.Full text

Woodgate P, Jardine LA. Neonatal jaundice: phototherapy. BMJ Clin Evid. 2015 May 22;2015:. Abstract

Slaughter JL, Kemper AR, Newman TB. Technical report: Diagnosis and management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2022 Sep 1;150(3):e2022058865.Full text  Abstract

Gu J, Zhu Y, Zhao J. The efficacy of intravenous fluid supplementation for neonatal hyperbilirubinemia: a meta-analysis of randomized controlled studies. J Matern Fetal Neonatal Med. 2019 Nov 17;1-6. Abstract

1. Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics. 1999 Jan;103(1):6-14. Abstract

2. Wong RJ, Stevenson DK. Neonatal hemolysis and risk of bilirubin-induced neurologic dysfunction. Semin Fetal Neonatal Med. 2015 Feb;20(1):26-30. Abstract

3. Smitherman H, Stark AR, Bhutani VK. Early recognition of neonatal hyperbilirubinemia and its emergent management. Semin Fetal Neonatal Med. 2006 Jun;11(3):214-24. Abstract

4. Greco C, Arnolda G, Boo NY, et al. Neonatal Jaundice in Low- and Middle-Income Countries: Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat. Neonatology. 2016;110(3):172-80.Full text  Abstract

5. Setia S, Villaveces A, Dhillon P, et al. Neonatal jaundice in Asian, white, and mixed-race infants. Arch Pediatr Adolesc Med. 2002 Mar;156(3):276-9.Full text  Abstract

6. Maisels MJ, Kring E. Transcutaneous bilirubin levels in the first 96 hours in a normal newborn population of > or = 35 weeks' gestation. Pediatrics. 2006 Apr;117(4):1169-73. Abstract

7. Kemper AR, Newman TB, Slaughter JL, et al. Clinical practice guideline revision: management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2022 Sep 1;150(3):e2022058859.Full text

8. Maisels MJ. What's in a name? Physiologic and pathologic jaundice: the conundrum of defining normal bilirubin levels in the newborn. Pediatrics. 2006 Aug;118(2):805-7. Abstract

9. Wang J, Yin J, Xue M, et al. Roles of UGT1A1 Gly71Arg and TATA promoter polymorphisms in neonatal hyperbilirubinemia: A meta-analysis. Gene. 2020 Apr 30;736:144409. Abstract

10. Klein CJ, Revenis M, Kusenda C, et al. Parenteral nutrition-associated conjugated hyperbilirubinemia in hospitalized infants. J Am Diet Assoc. 2010 Nov;110(11):1684-95. Abstract

11. Gottesman LE, Del Vecchio MT, Aronoff SC. Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects. BMC Pediatr. 2015 Nov 20;15:192.Full text  Abstract

12. Lain SJ, Roberts CL, Bowen JR, et al. Early discharge of infants and risk of readmission for jaundice. Pediatrics. 2015 Feb;135(2):314-21.Full text  Abstract

13. De Luca D, Jackson GL, Tridente A, et al. Transcutaneous bilirubin nomograms: a systematic review of population differences and analysis of bilirubin kinetics. Arch Pediatr Adolesc Med. 2009 Nov;163(11):1054-9.Full text  Abstract

14. Centers for Disease Control and Prevention. What are Jaundice and Kernicterus? Nov 2019 [internet publication].Full text

15. Bentz MG, Carmona N, Bhagwat MM, et al. Beyond "Asian": specific East and Southeast Asian races or ethnicities associated with jaundice readmission. Hosp Pediatr. 2018 May;8(5):269-73. Abstract

16. Porter ML, Dennis BL. Hyperbilirubinemia in the term newborn. Am Fam Physician. 2002 Feb 15;65(4):599-606.Full text  Abstract

17. Abu-Heija AT, Al-Bash M, Mathew M. Gestational and Pregestational Diabetes Mellitus in Omani Women: Comparison of obstetric and perinatal outcomes. Sultan Qaboos Univ Med J. 2015 Nov;15(4):e496-500.Full text  Abstract

18. Ghosh S, Ghosh K. Maternal and neonatal outcomes in gestational diabetes mellitus. J Indian Med Assoc. 2013 May;111(5):330-1, 336. Abstract

19. Cosson E, Benchimol M, Carbillon L, et al. Universal rather than selective screening for gestational diabetes mellitus may improve fetal outcomes. Diabetes Metab. 2006 Apr;32(2):140-6.Full text  Abstract

20. Khatun N, Latif SA, Uddin MM. Infant outcomes of gestational diabetes mellitus. Mymensingh Med J. 2005 Jan;14(1):29-31. Abstract

21. Berk MA, Mimouni F, Miodovnik M, et al. Macrosomia in infants of insulin-dependent diabetic mothers. Pediatrics. 1989 Jun;83(6):1029-34. Abstract

22. Widness JA, Susa JB, Garcia JF, et al. Increased erythropoiesis and elevated erythropoietin in infants born to diabetic mothers and in hyperinsulinemic rhesus fetuses. J Clin Invest. 1981 Mar;67(3):637-42.Full text  Abstract

23. Singla DA, Sharma S, Sharma M, et al. Evaluation of risk factors for exchange range yyperbilirubinemia and neurotoxicity in neonates from hilly terrain of India. Int J Appl Basic Med Res. 2017 Oct-Dec;7(4):228-32.Full text  Abstract

24. Gundur NM, Kumar P, Sundaram V, et al. Natural history and predictive risk factors of prolonged unconjugated jaundice in the newborn. Pediatr Int. 2010 Oct;52(5):769-72.Full text  Abstract

25. Oral E, Gezer A, Cagdas A, et al. Oxytocin infusion in labor: the effect different indications and the use of different diluents on neonatal bilirubin levels. Arch Gynecol Obstet. 2003 Jan;267(3):117-20.Full text  Abstract

26. Olusanya BO, Slusher TM. Infants at risk of significant hyperbilirubinemia in poorly-resourced countries: evidence from a scoping review. World J Pediatr. 2015 Nov;11(4):293-9. Abstract

27. Muchowski KE. Evaluation and treatment of neonatal hyperbilirubinemia. Am Fam Physician. 2014 Jun 1;89(11):873-8. Abstract

28. Kuzniewicz MW, Escobar GJ, Wi S, et al. Risk factors for severe hyperbilirubinemia among infants with borderline bilirubin levels: a nested case-control study. J Pediatr. 2008 Aug;153(2):234-40.Full text  Abstract

29. Fonseca MJ, Severo M, Barros H, et al. Determinants of weight changes during the first 96 hours of life in full-term newborns. Birth. 2014 Jun;41(2):160-8.Full text  Abstract

30. Yang WC, Zhao LL, Li YC, et al. Bodyweight loss in predicting neonatal hyperbilirubinemia 72 hours after birth in term newborn infants. BMC Pediatr. 2013 Sep 21;13:145.Full text  Abstract

31. McDonald SJ, Middleton P. Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Cochrane Database Syst Rev. 2013 Jul 11;(7):CD004074.Full text  Abstract

32. Zhou J, Yang C, Zhu W, et al. Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study. Biomed Res Int. 2018;2018:7803175.Full text  Abstract

33. Queensland Clinical Guidelines. Maternity and neonatal clinical guideline: neonatal jaundice. Jun 2019 [internet publication].Full text

34. National Institute for Health and Care Excellence. Jaundice in newborn babies under 28 days. Oct 2023 [internet publication].Full text

35. National Association of Neonatal Nurses. Prevention of acute bilirubin encephalopathy and kernicterus in newborns. Position Statement #3049. NANN Board of Directors, March 2010. Adv Neonatal Care. 2010 Jun;10(3):112-8. Abstract

36. New South Wales Government. Neonatal - jaundice identification and management in neonates ≥32 weeks gestation. November 2016 [internet publication].Full text

37. Boo NY, Chang YF, Leong YX, et al. The point-of-care Bilistick method has very short turn-around-time and high accuracy at lower cutoff levels to predict laboratory-measured TSB. Pediatr Res. 2019 Aug;86(2):216-220.Full text  Abstract

38. Greco C, Iskander IF, Akmal DM, et al. Comparison between Bilistick System and transcutaneous bilirubin in assessing total bilirubin serum concentration in jaundiced newborns. J Perinatol. 2017 Sep;37(9):1028-1031.Full text  Abstract

39. Rohsiswatmo R, Oswari H, Amandito R, et al. Agreement test of transcutaneous bilirubin and bilistick with serum bilirubin in preterm infants receiving phototherapy. BMC Pediatr. 2018 Sep 29;18(1):315.Full text  Abstract

40. Kamineni B, Tanniru A, Vardhelli V, et al. Accuracy of Bilistick (a point-of-care device) to detect neonatal hyperbilirubinemia. J Trop Pediatr. 2020 Dec 1;66(6):630-636.Full text  Abstract

41. Fawaz R, Baumann U, Ekong U, et al. Guideline for the evaluation of cholestatic jaundice in infants: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2017 Jan;64(1):154-68.Full text  Abstract

42. Benchimol EI, Walsh CM, Ling SC, et al. Early diagnosis of neonatal cholestatic jaundice: test at 2 weeks. Can Fam Physician. 2009 Dec;55(12):1184-92.Full text  Abstract

43. Minuk L, Clarke G, Lieberman L. Approach to red blood cell antibody testing during pregnancy: answers to commonly asked questions. Can Fam Physician. 2020 Jul;66(7):491-8.Full text  Abstract

44. Bhutani VK, Johnson LH, Keren R. Diagnosis and management of hyperbilirubinemia in the term neonate: for a safer first week. Pediatr Clin North Am. 2004 Aug;51(4):843-61. Abstract

45. Mishra S, Chawla D, Agarwal R, et al. Transcutaneous bilirubinometry reduces the need for blood sampling in neonates with visible jaundice. Acta Paediatr. 2009 Dec;98(12):1916-9. Abstract

46. Canadian Paediatric Society. Guidelines for detection, management and prevention of hyperbilirubinemia in term and late preterm newborn infants. June 2007 (reaffirmed February 2018) [internet publication].Full text

47. Dijk PH, Hulzebos CV. An evidence-based view on hyperbilirubinaemia. Acta Paediatr. 2012 Apr;101(464):3-10. Abstract

48. Maisels MJ. Neonatal jaundice. Pediatr Rev. 2006 Dec;27(12):443-54. Abstract

49. Bhutani VK; Committee on Fetus and Newborn; American Academy of Pediatrics. Phototherapy to prevent severe neonatal hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2011 Oct;128(4):e1046-52. Reaffirmed Jan 2022.Full text  Abstract

50. Donneborg ML, Vandborg PK, Hansen BM, et al. Double versus single intensive phototherapy with LEDs in treatment of neonatal hyperbilirubinemia. J Perinatol. 2018 Feb;38(2):154-8.Full text  Abstract

51. Nuntnarumit P, Naka C. Comparison of the effectiveness between the adapted-double phototherapy versus conventional-single phototherapy. J Med Assoc Thai. 2002 Nov;85 Suppl 4:S1159-66. Abstract

52. Sarici SU, Alpay F, Unay B, et al. Double versus single phototherapy in term newborns with significant hyperbilirubinemia. J Trop Pediatr. 2000 Feb;46(1):36-9.Full text  Abstract

53. Mills JF, Tudehope D. Fibreoptic phototherapy for neonatal jaundice. Cochrane Database Syst Rev. 2001;(1):CD002060.Full text  Abstract

54. Kumar P, Murki S, Malik GK, et al. Light emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: a multi center randomized controlled trial. Indian Pediatr. 2010 Feb;47(2):131-7.Full text  Abstract

55. Woodgate P, Jardine LA. Neonatal jaundice: phototherapy. BMJ Clin Evid. 2015 May 22;2015:. Abstract

56. Gutta S, Shenoy J, Kamath SP, et al. Light emitting diode (LED) phototherapy versus conventional phototherapy in neonatal hyperbilirubinemia: a single blinded randomized control trial from coastal India. Biomed Res Int. 2019;2019:6274719.Full text  Abstract

57. Kumar P, Chawla D, Deorari A. Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates. Cochrane Database Syst Rev. 2011 Dec 7;(12):CD007969.Full text  Abstract

58. Tayman C, Tatli MM, Aydemir S, et al. Overhead is superior to underneath light-emitting diode phototherapy in the treatment of neonatal jaundice: a comparative study. J Paediatr Child Health. 2010 May;46(5):234-7. Abstract

59. Tridente A, De Luca D. Efficacy of light-emitting diode versus other light sources for treatment of neonatal hyperbilirubinemia: a systematic review and meta-analysis. Acta Paediatr. 2012 May;101(5):458-65. Abstract

60. Sarin M, Dutta S, Narang A. Randomized controlled trial of compact fluorescent lamp versus standard phototherapy for the treatment of neonatal hyperbilirubinemia. Indian Pediatr. 2006 Jul;43(7):583-90. Abstract

61. Slaughter JL, Kemper AR, Newman TB. Technical report: Diagnosis and management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2022 Sep 1;150(3):e2022058865.Full text  Abstract

62. Maimburg RD, Olsen J, Sun Y. Neonatal hyperbilirubinemia and the risk of febrile seizures and childhood epilepsy. Epilepsy Res. 2016 Aug;124:67-72. Abstract

63. Newman TB, Wu YW, Kuzniewicz MW, et al. Childhood seizures after phototherapy. Pediatrics. 2018 Oct;142(4):e20180648. Abstract

64. Morris BH, Oh W, Tyson JE, et al; NICHD Neonatal Research Network. Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med. 2008 Oct 30;359(18):1885-96.Full text  Abstract

65. Okwundu CI, Okoromah CA, Shah PS. Prophylactic phototherapy for preventing jaundice in preterm or low birth weight infants. Cochrane Database Syst Rev. 2012 Jan 18;(1):CD007966.Full text  Abstract

66. Van Rostenberghe H, Ho JJ, Lim CH, et al. Use of reflective materials during phototherapy for newborn infants with unconjugated hyperbilirubinaemia. Cochrane Database Syst Rev. 2020 Jul 1;7:CD012011.Full text  Abstract

67. Goyal P, Mehta A, Kaur J, et al. Fluid supplementation in management of neonatal hyperbilirubinemia: a randomized controlled trial. J Matern Fetal Neonatal Med. 2018 Oct;31(20):2678-84.Full text  Abstract

68. Gu J, Zhu Y, Zhao J. The efficacy of intravenous fluid supplementation for neonatal hyperbilirubinemia: a meta-analysis of randomized controlled studies. J Matern Fetal Neonatal Med. 2019 Nov 17;1-6. Abstract

69. Mitra S, Samanta M, Sarkar M, et al. Pre-exchange 5% albumin infusion in low birth weight neonates with intensive phototherapy failure: a randomized controlled trial. J Trop Pediatr. 2011 Jun;57(3):217-21. Abstract

70. Lai NM, Ahmad Kamar A, Choo YM, et al. Fluid supplementation for neonatal unconjugated hyperbilirubinaemia. Cochrane Database Syst Rev. 2017 Aug 1;(8):CD011891.Full text  Abstract

71. Dash N, Kumar P, Sundaram V, et al. Pre-exchange albumin administration in neonates with hyperbilirubinemia: a randomized controlled trial. Indian Pediatr. 2015 Sep;52(9):763-7. Abstract

72. Huizing K, Røislien J, Hansen T. Intravenous immune globulin reduces the need for exchange transfusions in Rhesus and AB0 incompatibility. Acta Paediatr. 2008 Oct;97(10):1362-5. Abstract

73. Beken S, Hirfanoglu I, Turkyilmaz C, et al. Intravenous immunoglobulin G treatment in ABO hemolytic disease of the newborn, is it myth or real? Indian J Hematol Blood Transfus. 2014 Mar;30(1):12-5.Full text  Abstract

74. Zwiers C, Scheffer-Rath ME, Lopriore E, et al. Immunoglobulin for alloimmune hemolytic disease in neonates. Cochrane Database Syst Rev. 2018 Mar 18;(3):CD003313.Full text  Abstract

75. Harpavat S, Garcia-Prats JA, Anaya C, et al. Diagnostic yield of newborn screening for biliary atresia using direct or conjugated bilirubin measurements. JAMA. 2020 Mar 24;323(12):1141-50.Full text  Abstract

76. Flaherman VJ, Maisels MJ, Academy of Breastfeeding Medicine. ABM Clinical Protocol #22: Guidelines for management of jaundice in the breastfeeding infant 35 weeks or more of gestation-revised 2017. Breastfeed Med. 2017 Jun;12(5):250-7.Full text  Abstract

77. Thayyil S, Milligan DW. Single versus double volume exchange transfusion in jaundiced newborn infants. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD004592.Full text  Abstract

78. Reddy P, Najundaswamy S, Mehta R, et al. Tin-mesoporphyrin in the treatment of severe hyperbilirubinemia in a very-low-birth-weight infant. J Perinatol. 2003 Sep;23(6):507-8. Abstract

79. Drummond GS, Kappas A. Chemoprevention of severe neonatal hyperbilirubinemia. Semin Perinatol. 2004 Oct;28(5):365-8. Abstract

80. Bhutani VK, Poland R, Meloy LD, et al. Clinical trial of tin mesoporphyrin to prevent neonatal hyperbilirubinemia. J Perinatol. 2016 Jul;36(7):533-9.Full text  Abstract

81. Slusher TM, Olusanya BO, Vreman HJ, et al. A randomized trial of phototherapy with filtered sunlight in African neonates. N Engl J Med. 2015 Sep 17;373(12):1115-24.Full text  Abstract

82. Paumgartner G, Beuers U. Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease. Clin Liver Dis. 2004 Feb;8(1):67-81. Abstract

83. Kotb MA, Mosallam D, Basanti CWS, et al. Ursodeoxycholic acid use is associated with significant risk of morbidity and mortality in infants with cholestasis: a strobe compliant study. Medicine (Baltimore). 2020 Feb;99(7):e18730.Full text  Abstract

84. Gholitabar M, McGuire H, Rennie J, et al. Clofibrate in combination with phototherapy for unconjugated neonatal hyperbilirubinaemia. Cochrane Database Syst Rev. 2012 Dec 12;(12):CD009017.Full text  Abstract

85. Xiong T, Chen D, Duan Z, et al. Clofibrate for unconjugated hyperbilirubinemia in neonates: a systematic review. Indian Pediatr. 2012 Jan;49(1):35-41.Full text  Abstract

86. Kumar P, Adhisivam B, Vishnu Bhat B. Clofibrate as an adjunct to phototherapy for unconjugated hyperbilirubinemia in term neonates. Indian J Pediatr. 2017 Oct;84(10):763-7.Full text  Abstract

87. Eghbalian F, Hasanpour-Dehkordi A, Raeisi R. The effects of clofibrate on neonatal jaundice: a systematic review. Int J Prev Med. 2022 Jan 19;13:3.Full text  Abstract

88. World Health Organization. Postnatal care of the mother and newborn. October 2013 [internet publication].Full text

89. World Health Organization. Pocket book of hospital care for children: guidelines for the management of common childhood illnesses. 2013 [internet publication].Full text

90. Dey SK, Islam S, Jahan I, et al. Association of hyperbilirubinemia requiring phototherapy or exchange transfusion with hearing impairment among admitted term and late preterm newborn in a NICU. Mymensingh Med J. 2020 Apr;29(2):405-413. Abstract

91. Bhandari V, Narang A, Mann SB, et al. Brain stem electric response audiometry in neonates with hyperbilirubinemia. Indian J Pediatr. 1993 May-Jun;60(3):409-13. Abstract

92. Funato M, Teraoka S, Tamai H, et al. Follow-up study of auditory brainstem responses in hyperbilirubinemic newborns treated with exchange transfusion. Acta Paediatr Jpn. 1996 Feb;38(1):17-21.Full text  Abstract

93. Mandour YM, El Sayed MA, El Sayed Morgan A, et al. Audiological assessment of neonatal hyperbilirubinemia. Int J Pediatr Otorhinolaryngol. 2020 Aug;135:110126. Abstract

94. Karimzadeh P, Fallahi M, Kazemian M, et al. Bilirubin induced encephalopathy. Iran J Child Neurol. 2020 Winter;14(1):7-19.Full text  Abstract

95. Blumovich A, Mangel L, Yochpaz S, et al. Risk factors for readmission for phototherapy due to jaundice in healthy newborns: a retrospective, observational study. BMC Pediatr. 2020 May 26;20(1):248.Full text  Abstract

96. Khadem Al-Hosseini M, Rahideh ST, Saadati A, et al. The effect of vitamin C supplementation in the last month of pregnancy on neonatal bilirubin levels; A double-blind randomized clinical trial. Complement Ther Med. 2020 May;50:102359. Abstract