Criteria

Marsh criteria [39]

Histologic changes on small intestinal biopsy

  • 0: normal villous architecture with no increase in intraepithelial lymphocytes

  • I: normal villous architecture with increased intraepithelial lymphocytes

  • II: increased intraepithelial lymphocytes and crypt hyperplasia with normal villi

  • IIIa: increased intraepithelial lymphocytes and crypt hyperplasia with partial villous atrophy

  • IIIb: increased intraepithelial lymphocytes and crypt hyperplasia with subtotal villous atrophy

  • IIIc: increased intraepithelial lymphocytes and crypt hyperplasia with total villous atrophy.

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