Vitamin C deficiency

References

Key articles

Weise Prinzo Z. Scurvy and its prevention and control in major emergencies. 1999 [internet publication].Full text

Hodges RE, Hood J, Canham JE, et al. Clinical manifestations of ascorbic acid deficiency in man. Am J Clin Nutr. 1971 Apr;24(4):432-43. Abstract

Hirschmann JV, Raugi GJ. Adult scurvy. J Am Acad Dermatol. 1999 Dec;41(6):895-906. Abstract

Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA. 1999 Apr 21;281(15):1415-23. Abstract

Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of DRIs, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Chapter 5: vitamin C. In: Food and Nutrition Board, Institute of Medicine’s Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington DC: National Academy Press; 2000: 95-185.Full text  Abstract

Reference articles

1. Weise Prinzo Z. Scurvy and its prevention and control in major emergencies. 1999 [internet publication].Full text

2. Hodges RE, Hood J, Canham JE, et al. Clinical manifestations of ascorbic acid deficiency in man. Am J Clin Nutr. 1971 Apr;24(4):432-43. Abstract

3. Noble JM, Mandel A, Patterson MC. Scurvy and rickets masked by chronic neurologic illness: revisiting "psychologic malnutrition". Pediatrics. 2007 Mar;119(3):e783-90. Abstract

4. Hampl JS, Taylor CA, Johnston CS. Vitamin C deficiency and depletion in the United States: the Third National Health and Nutrition Examination Survey, 1988 to 1994. Am J Public Health. 2004 May;94(5):870-5.Full text  Abstract

5. Langlois K, Cooper M, Colapinto CK. Vitamin C status of Canadian adults: findings from the 2012/2013 Canadian Health Measures Survey. Health Rep. 2016 May 18;27(5):3-10.Full text  Abstract

6. Hagel AF, Albrecht H, Dauth W, et al. Plasma concentrations of ascorbic acid in a cross section of the German population. J Int Med Res. 2017 Jul 31;46(1):168-174.Full text  Abstract

7. McCall SJ, Clark AB, Luben RN, et al. Plasma Vitamin C Levels: Risk Factors for Deficiency and Association with Self-Reported Functional Health in the European Prospective Investigation into Cancer-Norfolk. Nutrients. 2019 Jul 9;11(7):.Full text  Abstract

8. Desenclos JC, Berry AM, Padt R, et al. Epidemiological patterns of scurvy among Ethiopian refugees. Bull World Health Organ. 1989;67(3):309-16.Full text  Abstract

9. Cheung E, Mutahar R, Assefa F, et al. An epidemic of scurvy in Afghanistan: assessment and response. Food Nutr Bull. 2003 Sep;24(3):247-55. Abstract

10. Assefa F, Jabarkhil MZ, Salama P, et al. Malnutrition and mortality in Kohistan District, Afghanistan, April 2001. JAMA. 2001 Dec 5;286(21):2723-8. Abstract

11. Giday J. Outbreak of scurvy among prisoners in South Ethiopia. Ethiop J Health Dev. 2012;26:60-2.Full text

12. Ververs M, Muriithi JW, Burton A, et al. Scurvy Outbreak Among South Sudanese Adolescents and Young Men - Kakuma Refugee Camp, Kenya, 2017-2018. MMWR Morb Mortal Wkly Rep. 2019 Jan 25;68(3):72-75.Full text  Abstract

13. Ratanachu-Ek S, Sukswai P, Jeerathanyasakun Y, et al. Scurvy in pediatric patients: a review of 28 cases. J Med Assoc Thai. 2003 Aug;86(Suppl 3):S734-40. Abstract

14. Olmedo JM, Yiannias JA, Windgassen EB, et al. Scurvy: a disease almost forgotten. Int J Dermatol. 2006 Aug;45(8):909-13. Abstract

15. Hirschmann JV, Raugi GJ. Adult scurvy. J Am Acad Dermatol. 1999 Dec;41(6):895-906. Abstract

16. Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA. 1999 Apr 21;281(15):1415-23. Abstract

17. Schleicher RL, Carroll MD, Ford ES, et al. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutr. 2009 Nov;90(5):1252-63.Full text  Abstract

18. Velandia B, Centor RM, McConnell V, et al. Scurvy is still present in developed countries. J Gen Intern Med. 2008 Aug;23(8):1281-4.Full text  Abstract

19. Mertens MT, Gertner E. Rheumatic manifestations of scurvy: a report of three recent cases in a major urban center and a review. Semin Arthritis Rheum. 2011 Oct;41(2):286-90. Abstract

20. Holley AD, Osland E, Barnes J, et al. Scurvy: historically a plague of the sailor that remains a consideration in the modern intensive care unit. Intern Med J. 2011 Mar;41(3):283-5. Abstract

21. Delanghe JR, Langlois MR, De Buyzere ML. Vitamin C deficiency and scurvy are not only a dietary problem but are codetermined by the haptoglobin polymorphism. Clin Chem. 2007 Aug;53(8):1397-400. Abstract

22. Siegel C, Barker B, Kunstadter M. Conditioned oral scurvy due to megavitamin C withdrawal. J Periodontol. 1982 Jul;53(7):453-5. Abstract

23. Clark JW. Conditioned oral scurvy due to megavitamin C withdrawal. J Periodontol. 1983 Mar;54(3):182-3. Abstract

24. Halver JE, Hardy RW. L-ascorbyl-2-sulfate alleviates Atlantic salmon scurvy. Proc Soc Exp Biol Med. 1994 Sep;206(4):421-4. Abstract

25. Committee on Animal Nutrition, Board on Agriculture, National Research Council (NRC) USA. Nutrient requirements of fish. Washington, DC: National Academy Press; 1993:31-2.

26. Roy RN, Guha BC. Production of experimental scurvy in a bird species. Nature. 1958 Dec 13;182(4650):1689-90. Abstract

27. Montel-Hagen A, Kinet S, Manel N, et al. Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C. Cell. 2008 Mar 21;132(6):1039-48. Abstract

28. Kallner A, Hartmann D, Hornig D. Steady-state turnover and body pool of ascorbic acid in man. Am J Clin Nutr. 1979 Mar;32(3):530-9. Abstract

29. Linster CL, Van Schaftingen E. Vitamin C: biosynthesis, recycling and degradation in mammals. FEBS J. 2007 Jan;274(1):1-22.Full text  Abstract

30. Luchsinger JA, Noble JM, Scarmeas N. Diet and Alzheimer's disease. Curr Neurol Neurosci Rep. 2007 Sep;7(5):366-72. Abstract

31. Kris-Etherton PM, Lichtenstein AH, Howard BV, et al. Antioxidant vitamin supplements and cardiovascular disease. Circulation. 2004 Aug 3;110(5):637-41.Full text  Abstract

32. Geber J, Murphy E. Scurvy in the Great Irish Famine: evidence of vitamin C deficiency from a mid-19th century skeletal population. Am J Phys Anthropol. 2012 Aug;148(4):512-24.Full text  Abstract

33. Farah Z, Rettenmaier R, Atkins D. Vitamin content of camel milk. Int J Vitam Nutr Res. 1992;62(1):30-3. Abstract

34. Deligny C, Dehlinger V, Goëb V, et al. Paradoxical appearance of adult scurvy in Martinique, French West Indies. Eur J Intern Med. 2011 Apr;22(2):e7-8. Abstract

35. Marik PE, Liggett A. Adding an orange to the banana bag: vitamin C deficiency is common in alcohol use disorders. Crit Care. 2019 May 10;23(1):165.Full text  Abstract

36. Mosdøl A, Erens B, Brunner EJ. Estimated prevalence and predictors of vitamin C deficiency within UK's low-income population. J Public Health (Oxf). 2008 Dec;30(4):456-60.Full text  Abstract

37. Ahmad SA, Al Thobiti TA, El Toum M, et al. Florid Scurvy in an Autistic Child on a Ketogenic Diet. Pediatr Emerg Care. 2018 Nov 19;:. Abstract

38. Willmott NS, Bryan RA. Case report: scurvy in an epileptic child on a ketogenic diet with oral complications. Eur Arch Paediatr Dent. 2008 Sep;9(3):148-52. Abstract

39. Cole JA, Warthan MM, Hirano SA, et al. Scurvy in a 10-year-old boy. Pediatr Dermatol. 2011 Jul-Aug;28(4):444-6. Abstract

40. Estienne M, Bugiani M, Bizzi A, et al. Scurvy hidden behind neuropsychiatric symptoms. Neurol Sci. 2011 Dec;32(6):1091-3. Abstract

41. Kamel AY, Dave NJ, Zhao VM, et al. Micronutrient Alterations During Continuous Renal Replacement Therapy in Critically Ill Adults: A Retrospective Study. Nutr Clin Pract. 2017 Dec 18;33(3):439-446. Abstract

42. Riess KP, Farnen JP, Lambert PJ, et al. Ascorbic acid deficiency in bariatric surgical population. SSurg Obes Relat Dis. 2009 Jan-Feb;5(1):81-6. Abstract

43. Clements RH, Katasani VG, Palepu R, et al. Incidence of vitamin deficiency after laparoscopic Roux-en-Y gastric bypass in a university hospital setting. Am Surg. 2006 Dec;72(12):1196-202. Abstract

44. Gan R, Eintracht S, Hoffer LJ. Vitamin C deficiency in a university teaching hospital. J Am Coll Nutr. 2008 Jun;27(3):428-33. Abstract

45. Sharma Y, Miller M, Shahi R, et al. Vitamin C deficiency in Australian hospitalised patients: an observational study. Intern Med J. 2019 Feb;49(2):189-196. Abstract

46. Wu JR, Song EK, Moser DK, et al. Dietary Vitamin C Deficiency Is Associated With Health-Related Quality of Life and Cardiac Event-free Survival in Adults With Heart Failure. J Cardiovasc Nurs. 2019 Jan/Feb;34(1):29-35. Abstract

47. Song EK, Kang SM. Vitamin C Deficiency, High-Sensitivity C-Reactive Protein, and Cardiac Event-Free Survival in Patients With Heart Failure. J Cardiovasc Nurs. 2018 Jan/Feb;33(1):6-12. Abstract

48. Rasheed M, Simmons G, Fisher B, et al. Reduced plasma ascorbic acid levels in recipients of myeloablative conditioning and hematopoietic cell transplantation. Eur J Haematol. 2019 Aug 1;103(4):329-334. Abstract

49. Kletzel M, Powers K, Hayes M. Scurvy: a new problem for patients with chronic GVHD involving mucous membranes; an easy problem to resolve. Pediatr Transplant. 2014 Aug;18(5):524-6. Abstract

50. Tengco LW, Rayco-Solon P, Solon JA, et al. Determinants of anemia among preschool children in the Philippines. J Am Coll Nutr. 2008 Apr;27(2):229-43. Abstract

51. Perkins A, Sontheimer C, Otjen JP, et al. Scurvy Masquerading as Juvenile Idiopathic Arthritis or Vasculitis with Elevated Inflammatory Markers: A Case Series. J Pediatr. 2019 Dec 13;:.Full text  Abstract

52. Hood J, Hodges RE. Ocular lesions in scurvy. Am J Clin Nutr. 1969 May;22(5):559-67. Abstract

53. Sauberlich HE, Skala JH, Dowdy RP. Laboratory tests for the assessment of nutritional status. Cleveland: CRC Press; 1974.

54. Duggan CP, Westra SJ, Rosenberg AE. Case records of the Massachusetts General Hospital. Case 23-2007. A 9-year-old boy with bone pain, rash, and gingival hypertrophy. N Engl J Med. 2007 Jul 26;357(4):392-400. Abstract

55. Choi SW, Park SW, Kwon YS, et al. MR imaging in a child with scurvy: a case report. Korean J Radiol. 2007 Sep-Oct;8(5):443-7.Full text  Abstract

56. Gulko E, Collins LK, Murphy RC, et al. MRI findings in pediatric patients with scurvy. Skeletal Radiol. 2015 Feb;44(2):291-7. Abstract

57. Online Mendelian Inheritance in Man. #309400: Menkes disease. August 2015 [internet publication].Full text

58. Hodges RE. Ascorbic acid. In: Goodhart RS, Shils ME, eds. Modern nutrition in health and disease, 6th edition. Philadelphia, PA: Lea and Febiger; 1980.

59. Strametz R, Weberschock T, Erler A, et al. Critical view: parenteral administration of vitamins in asymptomatic patients. Z Allgemeinmed. 2008;84:502-6.

60. Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of DRIs, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Chapter 5: vitamin C. In: Food and Nutrition Board, Institute of Medicine’s Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington DC: National Academy Press; 2000: 95-185.Full text  Abstract

61. Dionne CE, Laurin D, Desrosiers T, et al. Serum vitamin C and spinal pain: a nationwide study. Pain. 2016 Nov;157(11):2527-35. Abstract

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