Keloid

References

Key articles

Shih B, Bayat A. Genetics of keloid scarring. Arch Dermatol Res. 2010 Jul;302(5):319-39. Abstract

Burd A, Huang L. Hypertrophic response and keloid diathesis: two very different forms of scar. Plast Reconstr Surg. 2005 Dec;116(7):150e-7e. Abstract

Durani P, Bayat A. Levels of evidence for the treatment of keloid disease. J Plast Reconstr Aesthet Surg. 2008;61(1):4-17. Abstract

Guthmann R, Williams CC, De Groote S. Clinical inquiry: what treatment is best for hypertrophic scars and keloids? J Fam Pract. 2011 Dec;60(12):757-8. Abstract

Reference articles

1. Burd A. Keloid epidemiology: population based studies needed. J Plast Reconstr Aesthet Surg. 2006;59(1):105. Abstract

2. Ogawa R. Keloid and hypertrophic scarring may result from a mechanoreceptor or mechanosensitive nociceptor disorder. Med Hypotheses. 2008 Oct;71(4):493-500. Abstract

3. Akaishi S, Akimoto M, Ogawa R, et al. The relationship between keloid growth pattern and stretching tension: visual analysis using the finite element method. Ann Plast Surg. 2008 Apr;60(4):445-51. Abstract

4. Bayat A, Arscott G, Ollier WE, et al. Keloid disease: clinical relevance of single versus multiple site scars. Br J Plast Surg. 2005 Jan;58(1):28-37. Abstract

5. Marneros AG, Norris JE, Watanabe S, et al. Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11. J Invest Dermatol. 2004 May;122(5):1126-32.Full text  Abstract

6. Shih B, Bayat A. Genetics of keloid scarring. Arch Dermatol Res. 2010 Jul;302(5):319-39. Abstract

7. Robles DT, Moore E, Draznin M, et al. Keloids: pathophysiology and management. Dermatology Online J. 2007 Jul 13;13(3):9.Full text  Abstract

8. Butler PD, Longaker MT, Yang GP. Current progress in keloid research and treatment. J Am Coll Surg. 2008 Apr;206(4):731-41. Abstract

9. Mari W, Alsabri SG, Tabal N, et al. Novel insights on understanding of keloid scar: article review. J Am Coll Clin Wound Spec. 2016 Nov 30;7(1-3):1-7.Full text  Abstract

10. Gauglitz GG, Korting HC, Pavicic T, et al. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med. 2011 Jan-Feb;17(1-2):113-25.Full text  Abstract

11. Burd A, Huang L. Hypertrophic response and keloid diathesis: two very different forms of scar. Plast Reconstr Surg. 2005 Dec;116(7):150e-7e. Abstract

12. Durani P, Bayat A. Levels of evidence for the treatment of keloid disease. J Plast Reconstr Aesthet Surg. 2008;61(1):4-17. Abstract

13. Wolfram D, Tzankov A, Pülzl P, et al. Hypertrophic scars and keloids - a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg. 2009 Feb;35(2):171-81.Full text  Abstract

14. Ogawa R. The most current algorithms for the treatment and prevention of hypertrophic scars and keloids. Plast Reconstr Surg. 2010 Feb;125(2):557-68. Abstract

15. Guthmann R, Williams CC, De Groote S. Clinical inquiry: what treatment is best for hypertrophic scars and keloids? J Fam Pract. 2011 Dec;60(12):757-8. Abstract

16. O'Brien L, Jones DJ. Silicone gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev. 2013 Sep 12;(9):CD003826.Full text  Abstract

17. Martinsson T, Haegerstrand A, Dalsgaard CJ. Ropivacaine and lidocaine inhibit proliferation of non-transformed cultured adult human fibroblasts, endothelial cells, and keratinocytes. Agents Actions. 1993 Sep;40(1-2):78-85. Abstract

18. Eichhorn JH, Peterkofsky B. Local anesthetic-induced inhibition of collagen secretion in cultured cells under conditions where microtubules are not depolymerized by these agents. J Cell Biol. 1979 Apr;81(1):26-42.Full text  Abstract

19. Hochman B, Locali RF, Matsuoka PK, et al. Intralesional triamcinolone acetonide for keloid treatment: a systematic review. Aesthetic Plast Surg. 2008 Jul;32(4):705-9. Abstract

20. Bouzari N, Davis SC, Nouri K, et al. Laser treatment of keloids and hypertrophic scars. Int J Dermatol. 2007 Jan;46(1):80-8. Abstract

21. de las Alas JM, Siripunvarapon AH, Dofitas BL. Pulsed dye laser for the treatment of keloid and hypertrophic scars: a systematic review. Expert Rev Med Devices. 2012 Nov;9(6):641-50. Abstract

22. Jin R, Huang X, Li H, et al. Laser therapy for prevention and treatment of pathologic excessive scars. Plast Reconstr Surg. 2013 Dec;132(6):1747-58. Abstract

23. Leventhal D, Furr M, Reiter D. Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature. Arch Facial Plast Surg. 2006 Nov-Dec;8(6):362-8. Abstract

24. Mirmovich O, Gil T, Goldin I, et al. Pain evaluation and control during and following the treatment of hypertrophic scars and keloids by contact and intralesional cryosurgery - a preliminary study. J Eur Acad Dermatol Venereol. 2012 Apr;26(4):440-7. Abstract

25. Slemp AE, Kirschner RE. Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management. Curr Opin Pediatr. 2006 Aug;18(4):396-402. Abstract

26. Mankowski P, Kanevsky J, Tomlinson J, et al. Optimizing radiotherapy for keloids: a meta-analysis systematic review comparing recurrence rates between different radiation modalities. Ann Plast Surg. 2017;78(4):403-11. Abstract

27. Ogawa R, Yoshitatsu S, Yoshida K, et al. Is radiation therapy for keloids acceptable? The risk of radiation-induced carcinogenesis. Plast Reconstr Surg. 2009 Oct;124(4):1196-201. Abstract

28. Talmi YP, Orenstein A, Wolf M, et al. Use of mitomycin C for treatment of keloid: a preliminary report. Otolaryngol Head Neck Surg. 2005 Apr;132(4):598-601. Abstract

29. Saray Y, Güleç AT. Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study. Int J Dermatol. 2005 Sep;44(9):777-84. Abstract

30. Aggarwal H, Saxena A, Lubana PS, et al. Treatment of keloids and hypertrophic scars using bleomycin. J Cosmet Dermatol. 2008 Mar;7(1):43-9. Abstract

31. Uppal RS, Khan U, Kakar S, et al. The effects of a single dose of 5-fluorouracil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision. Plast Reconstr Surg. 2001 Oct;108(5):1218-24. Abstract

32. Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, et al. Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study. J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):474-9. Abstract

33. Burd A, Chan E. Keratinocyte-keloid interaction. Plast Reconstr Surg. 2002 Jul;110(1):197-202. Abstract

34. Bidic SM, Dauwe PB, Heller J, et al. Reconstructing large keloids with neodermis: a systematic review. Plast Reconstr Surg. 2012 Feb;129(2):380e-2e. Abstract

35. Nguyen KT, Shikowitz L, Kasabian AK, et al. A novel approach to keloid reconstruction with bilaminar dermal substitute and epidermal skin grafting. Plast Reconstr Surg. 2016 Jul;138(1):235-9. Abstract

36. Seo SH, Sung HW. Treatment of keloids and hypertrophic scars using topical and intralesional mitomycin C. J Eur Acad Dermatol Venereol. 2012 May;26(5):634-8. Abstract

37. Espinoza AF. Effectiveness of intralesional bleomycin for the treatment of patients with keloid scars. Comparative study with dexamethasone [in Spanish]. Dermatología Rev Mex. 2011;55(3):119-26.Full text

38. Naeini FF, Najafian J, Ahmadpour K. Bleomycin tattooing as a promising therapeutic modality in large keloids and hypertrophic scars. Dermatol Surg. 2006 Aug;32(8):1023-9. Abstract

39. Hatamipour E, Mehrabi S, Hatamipour M et al. Effects of combined intralesional 5-fluorouracil and topical silicone in prevention of keloids; a double blind randomized clinical trial study. Acta Med Iran. 2011;49(3):127-30. Abstract

40. Sadeghinia A, Sadeghinia S. Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids. Dermatol Surg. 2012 Jan;38(1):104-9. Abstract

41. Berman B, Kaufman J. Pilot study of the effect of postoperative imiquimod 5% cream on the recurrence rate of excised keloids. J Am Acad Dermatol. 2002 Oct;47(4 Suppl):S209-11. Abstract

42. Martin-García RF, Busquets AC. Postsurgical use of imiquimod 5% cream in the prevention of earlobe keloid recurrences: results of an open-label, pilot study. Dermatol Surg. 2005 Nov;31(11 Pt 1):1394-8. Abstract

43. Stashower ME. Successful treatment of earlobe keloids with imiquimod after tangential shave excision. Dermatol Surg. 2006 Mar;32(3):380-6. Abstract

44. Berman B, Harrison-Balestra C, Perez OA, et al. Treatment of keloid scars post-shave excision with imiquimod 5% cream: a prospective, double-blind, placebo-controlled pilot study. J Drugs Dermatol. 2009 May;8(5):455-8. Abstract

45. D'Andrea F, Brongo S, Ferraro G, et al. Prevention and treatment of keloids with intralesional verapamil. Dermatology. 2002;204(1):60-2. Abstract

46. Shanthi M, Ernest K, Dhanraj P. Comparison of intralesional verapamil with intralesional triamcinolone in the treatment of hypertrophic scars and keloids. Indian J Dermatol Venereol Leprol. 2008 Jul-Aug;74(4):343-8.Full text  Abstract

47. Copcu E, Sivrioglu N, Oztan Y. Combination of surgery and intralesional verapamil injection in the treatment of the keloid. J Burn Care Rehabil. 2004 Jan-Feb;25(1):1-7. Abstract

48. Meier K, Nanney LB. Emerging new drugs for scar reduction. Expert Opin Emerg Drugs. 2006 Mar;11(1):39-47. Abstract

49. Asilian A, Darougheh A, Shariati F. New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg. 2006 Jul;32(7):907-15. Abstract

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