Complex regional pain syndrome

References

Key articles

Merskey H, Bogduk N, eds. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. 2nd ed. Task force on Taxonomy of the International Association for the Study of Pain. Seattle, WA: IASP Press; 1994:39-43.

Goebel A, Birklein F, Brunner F, et al. The Valencia consensus-based adaptation of the IASP complex regional pain syndrome diagnostic criteria. Pain. 2021 Sep 1;162(9):2346-8.Full text  Abstract

Goebel A, Barker C, Birklein F, et al. Standards for the diagnosis and management of complex regional pain syndrome: results of a European Pain Federation task force. Eur J Pain. 2019 Apr;23(4):641-51.Full text  Abstract

Harden RN, McCabe CS, Goebel A, et al. Complex regional pain syndrome: practical diagnostic and treatment guidelines, 5th Edition. Pain Med. 2022 Jun 10;23(suppl 1):S1-53.Full text  Abstract

Cruccu G, Aziz TZ, Garcia-Larrea L, et al. European Federation of Neurological Societies (EFNS) guidelines on neurostimulation therapy for neuropathic pain. Eur J Neurol. 2007 Sep;14(9):952-70.Full text  Abstract

Reference articles

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3. Goebel A, Birklein F, Brunner F, et al. The Valencia consensus-based adaptation of the IASP complex regional pain syndrome diagnostic criteria. Pain. 2021 Sep 1;162(9):2346-8.Full text  Abstract

4. Sandroni P, Benrud-Larson LM, McClelland RL, et al. Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study. Pain. 2003 May;103(1-2):199-207. Abstract

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17. Birklein F, Schmelz M. Neuropeptides, neurogenic inflammation and complex regional pain syndrome (CRPS). Neurosci Lett. 2008 Jun 6;437(3):199-202. Abstract

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21. Parkitny L, McAuley JH, Di Pietro F, et al. Inflammation in complex regional pain syndrome: a systematic review and meta-analysis. Neurology. 2013 Jan 1;80(1):106-17.Full text  Abstract

22. Birklein F, Drummond P, Li W, et al. Activation of cutaneous immune responses in complex regional pain syndrome. J Pain. 2014 May;15(5):485-95.Full text  Abstract

23. Goebel A, Blaes F. Complex regional pain syndrome, prototype of a novel kind of autoimmune disease. Autoimmun Rev. 2013 Apr;12(6):682-6. Abstract

24. Tékus V, Hajna Z, Borbély É, et al. A CRPS-IgG-transfer-trauma model reproducing inflammatory and positive sensory signs associated with complex regional pain syndrome. Pain. 2014 Feb;155(2):299-308. Abstract

25. Li WW, Guo TZ, Shi X, et al. Autoimmunity contributes to nociceptive sensitization in a mouse model of complex regional pain syndrome. Pain. 2014 Nov;155(11):2377-89.Full text  Abstract

26. Kohr D, Singh P, Tschernatsch M, et al. Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome. Pain. 2011 Dec;152(12):2690-700. Abstract

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33. Shenker N, Goebel A, Rockett M, et al. Establishing the characteristics for patients with chronic Complex Regional Pain Syndrome: the value of the CRPS-UK Registry. Br J Pain. 2015 May;9(2):122-8.Full text  Abstract

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35. Giustra F, Bosco F, Aprato A, et al. Vitamin C could prevent complex regional pain syndrome type I in trauma and orthopedic care? A systematic review of the literature and current findings. Sisli Etfal Hastan Tip Bul. 2021;55(2):139-45.Full text  Abstract

36. Goebel A, Barker C, Birklein F, et al. Standards for the diagnosis and management of complex regional pain syndrome: results of a European Pain Federation task force. Eur J Pain. 2019 Apr;23(4):641-51.Full text  Abstract

37. Lewis JS, Schweinhardt P. Perceptions of the painful body: the relationship between body perception disturbance, pain and tactile discrimination in complex regional pain syndrome. Eur J Pain. 2012 Oct;16(9):1320-30. Abstract

38. Kuttikat A, Noreika V, Chennu S, et al. Altered neurocognitive processing of tactile stimuli in patients with complex regional pain syndrome. J Pain. 2018 Apr;19(4):395-409. Abstract

39. Oaklander AL, Rissmiller JG, Gelman LB, et al. Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy). Pain. 2006 Feb;120(3):235-43. Abstract

40. Wüppenhorst N, Maier C, Frettlöh J, et al. Sensitivity and specificity of 3-phase bone scintigraphy in the diagnosis of complex regional pain syndrome of the upper extremity. Clin J Pain. 2010 Mar-Apr;26(3):182-9. Abstract

41. Wertli MM, Kessels AG, Perez RS, et al. Rational pain management in complex regional pain syndrome 1 (CRPS 1)--a network meta-analysis. Pain Med. 2014 Sep;15(9):1575-89.Full text  Abstract

42. Oehler N, Rolvien T, Schmidt T, et al. Bone microstructure is significantly altered in CRPS-affected distal tibiae as detected by HR-pQCT: a retrospective cross-sectional study. J Bone Miner Metab. 2019 Jul;37(4):741-8. Abstract

43. Krämer HH, Hofbauer LC, Szalay G, et al. Osteoprotegerin: a new biomarker for impaired bone metabolism in complex regional pain syndrome? Pain. 2014 May;155(5):889-95. Abstract

44. Bazika-Gerasch B, Maier C, Kumowski N, et al. Compared to limb pain of other origin, ultrasonographic osteodensitometry reveals loss of bone density in complex regional pain syndrome. Pain. 2019 Jun;160(6):1261-9. Abstract

45. Nishida Y, Saito Y, Yokota T, et al. Skeletal muscle MRI in complex regional pain syndrome. Intern Med. 2009;48(4):209-12.Full text  Abstract

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47. Burton AW, Lubenow TR, Raj PP. Traditional interventional therapies. In: Wilson PR, Stanton-Hicks M, Harden RN, eds. CRPS: current diagnosis and therapy. Seattle, WA: IASP Press; 2005:217-33.

48. Ringer R, Wertli M, Bachmann LM, et al. Concordance of qualitative bone scintigraphy results with presence of clinical complex regional pain syndrome 1: meta-analysis of test accuracy studies. Eur J Pain. 2012 Nov;16(10):1347-56.Full text  Abstract

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50. Birklein F, O’Neill D, Schlereth T. Complex regional pain syndrome: an optimistic perspective. Neurology. 2015 Jan 6;84(1):89-96. Abstract

51. Harden RN, McCabe CS, Goebel A, et al. Complex regional pain syndrome: practical diagnostic and treatment guidelines, 5th Edition. Pain Med. 2022 Jun 10;23(suppl 1):S1-53.Full text  Abstract

52. Birklein F, Dimova V. Complex regional pain syndrome-up-to-date. Pain Rep. 2017 Nov;2(6):e624.Full text  Abstract

53. Daly AE, Bialocerkowski AE. Does evidence support physiotherapy management of adult complex regional pain syndrome type one? A systematic review. Eur J Pain. 2009 Apr;13(4):339-53. Abstract

54. O'Connell NE, Wand BM, McAuley J, et al. Interventions for treating pain and disability in adults with complex regional pain syndrome. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD009416.Full text  Abstract

55. Smart KM, Ferraro MC, Wand BM, et al. Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II. Cochrane Database Syst Rev. 2022 May 17;5(5):CD010853.Full text  Abstract

56. Schilder JC, Sigtermans MJ, Schouten AC, et al. Pain relief is associated with improvement in motor function in complex regional pain syndrome type 1: secondary analysis of a placebo-controlled study on the effects of ketamine. J Pain. 2013 Nov;14(11):1514-21. Abstract

57. Harden RN, Swan M, King A, et al. Treatment of complex regional pain syndrome: functional restoration. Clin J Pain. 2006 Jun;22(5):420-4. Abstract

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59. Sayegh SA, Filén T, Johansson M, et al. Mirror therapy for complex regional pain syndrome (CRPS) – a literature review and an illustrative case report. Scand J Pain. 2013 Oct 1;4(4):200-7. Abstract

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71. Cohen SP, Bhatia A, Buvanendran A, et al. Consensus guidelines on the use of intravenous ketamine infusions for chronic pain from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists. Reg Anesth Pain Med. 2018 Jul;43(5): 521-46.Full text  Abstract

72. Zhao J, Wang Y, Wang D. The effect of ketamine infusion in the treatment of complex regional pain syndrome: a systemic review and meta-analysis. Curr Pain Headache Rep. 2018 Feb 5;22(2):12. Abstract

73. Chitneni A, Patil A, Dalal S, et al. Use of ketamine infusions for treatment of complex regional pain syndrome: a systematic review. Cureus. 2021 Oct;13(10):e18910.Full text  Abstract

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83. Cepeda MS, Lau J, Carr DB. Defining the therapeutic role of local anesthetic sympathetic blockade in complex regional pain syndrome: a narrative and systematic review. Clin J Pain. 2002 Jul-Aug;18(4):216-33. Abstract

84. O'Connell NE, Wand BM, Gibson W, et al. Local anaesthetic sympathetic blockade for complex regional pain syndrome. Cochrane Database Syst Rev. 2016 Jul 28;(7):CD004598.Full text  Abstract

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86. de Oliveira Rocha R, Teixeira MJ, Yeng LT, et al. Thoracic sympathetic block for the treatment of complex regional pain syndrome type I: a double-blind randomized controlled study. Pain. 2014 Nov;155(11):2274-81. Abstract

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91. Turner JA, Loeser JD, Deyo RA, et al. Spinal cord stimulation for patients with failed back surgery syndrome or complex regional pain syndrome: a systematic review of effectiveness and complications. Pain. 2004 Mar;108(1-2):137-47. Abstract

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93. Cruccu G, Aziz TZ, Garcia-Larrea L, et al. European Federation of Neurological Societies (EFNS) guidelines on neurostimulation therapy for neuropathic pain. Eur J Neurol. 2007 Sep;14(9):952-70.Full text  Abstract

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96. Atalay NS, Ercidogan O, Akkaya N, et al. Prednisolone in complex regional pain syndrome. Pain Physician. 2014 Mar-Apr;17(2):179-85.Full text  Abstract

97. Carroll I, Clark JD, Mackey S. Sympathetic block with botulinum toxin to treat complex regional pain syndrome. Ann Neurol. 2009 Mar;65(3):348-51.Full text  Abstract

98. Lee Y, Lee CJ, Choi E, et al. Lumbar sympathetic block with botulinum toxin type A and type B for the complex regional pain syndrome. Toxins (Basel). 2018 Apr 19;10(4).Full text  Abstract

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100. Fulas OA, Laferriere A, Stein RS, et al. Topical combination of meldonium and N-acetyl cysteine relieves allodynia in rat models of CRPS-1 and peripheral neuropathic pain by enhancing NO-mediated tissue oxygenation. J Neurochem. 2020 Mar;152(5):570-84.Full text  Abstract

101. Tihista M, Robinson E, Polmear M, et al. Pharmacologic treatments in upper extremity complex regional pain syndrome: a review and analysis of quality of evidence. Hand (N Y). 2022 Nov 24:15589447221131847. Abstract

102. Kirveskari E, Vartiainen NV, Gockel M, et al. Motor cortex dysfunction in complex regional pain syndrome. Clin Neurophysiol. 2010 Jul;121(7):1085-91. Abstract

103. Velasco F, Carrillo-Ruiz JD, Castro G, et al. Motor cortex electrical stimulation applied to patients with complex regional pain syndrome. Pain. 2009 Dec 15;147(1-3):91-8. Abstract

104. Lopez WO, Barbosa DC, Teixera MJ, et al. Pain relief in CRPS-II after spinal cord and motor cortex simultaneous dual stimulation. Pain Physician. 2016 May;19(4):E631-5. Abstract

105. Dirckx M, Stronks DL, Groeneweg G, et al. Effect of immunomodulating medications in complex regional pain syndrome: a systematic review. Clin J Pain. 2012 May;28(4):355-63. Abstract

106. Goebel A, Bisla J, Carganillo R, et al. Low-dose intravenous immunoglobulin treatment for long-standing complex regional pain syndrome: a randomized trial. Ann Intern Med. 2017 Oct 3;167(7):476-83.Full text  Abstract

107. Chopra P, Cooper MS. Treatment of Complex Regional Pain Syndrome (CRPS) using low dose naltrexone (LDN). J Neuroimmune Pharmacol. 2013 Jun;8(3):470-6.Full text  Abstract

108. ClinicalTrials.gov. Low-Dose Naltrexone for the treatment of Complex Regional Pain Syndrome (LDN-CRPS). Clinical Trials.gov identifier: NCT02502162. Apr 2023 [internet publication].Full text

109. Kapural L, Lokey K, Leong MS, et al. Intrathecal ziconotide for complex regional pain syndrome: seven case reports. Pain Pract. 2009 Jul-Aug;9(4):296-303. Abstract

110. Herring EZ, Frizon LA, Hogue O, et al. Long-term outcomes using intrathecal drug delivery systems in complex regional pain syndrome. Pain Med. 2019 Mar 1;20(3):515-20.Full text  Abstract

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